Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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A Case of Treating with Desoxycorticosterone Pivalate(DOCP) against Canine Hypoadrenocorticism uncontrolled with Fludrocortisone

Fludrocortisone으로 조절되지 않는 부신피질기능저하증 개를 DOCP로 치료한 1례

  • Sohn, Suh-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science) ;
  • Seo, Kyoung-Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science) ;
  • Kim, Sae-Um (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science) ;
  • Hwang, Cheol-Yong (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science) ;
  • Youn, Hwa-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science)
  • 손서영 (서울대학교 수의과대학 내과.BK21 수의과학연구인력양성사업단) ;
  • 서경원 (서울대학교 수의과대학 내과.BK21 수의과학연구인력양성사업단) ;
  • 김새움 (서울대학교 수의과대학 내과.BK21 수의과학연구인력양성사업단) ;
  • 황철용 (서울대학교 수의과대학 내과.BK21 수의과학연구인력양성사업단) ;
  • 윤화영 (서울대학교 수의과대학 내과.BK21 수의과학연구인력양성사업단)
  • Published : 2009.10.31
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Abstract

A 3-year old, female Cocker Spaniel dog was referred to Seoul National University Hospital for Animals with depression and vomiting. The dog was diagnosed as hypoadrenocorticism based on the typical electrolyte alteration and the result of adrenocorticotropic hormone (ACTH) stimulation test. Initial treatment with oral fludrocortisone at a dose rate of 0.02 mg/kg/q24h for 6 weeks period was ineffective at maintaining serum electrolyte concentrations within normal limits. Although a dose rate of oral fludrocortisone was significantly increased up to 0.06 mg/kg/q24h during 24 weeks period, the treatment was still ineffective. Moreover, the patient showed side effects related to the glucocorticoid excess including PU/PD, weight gain and lipemia. After alternation with desoxycorticosterone pivalate (DOCP, 2.2 mg/kg, IM) every 25 day, the clinical signs was disappeared and the electrolyte balance was maintain with no side effect. Therefore, DOCP may be suggested as an effective drug in canine hypoadrenocorticism uncontrolled with oral fludrocortisone.

Keywords

References

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