• Journal of Korea Multimedia Society
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• v.24 no.7
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• pp.933-941
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• 2021

When people enjoy something, they want to be repeated and focus on actions that are rewarded. The same applies to games. The purpose of this study is to ensure that the game continues to enjoy itself over and over again. Based on the artificial reward of the game, two reward methods of the game are studied. It finds Converged Difficulty Reward elements of action game through Confirmatory factor analysis in AMOS.

• Proceedings of the Korea Contents Association Conference
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• 2019.05a
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• pp.239-240
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• 2019

최근 가상현실(Virtual Reality)기술이 급격히 발전하고 있다. VR기술의 가장 큰 특징은 몰입감 증대를 통해 가상현실에서 시각적 정보를 구현한다는 것이다. 현재 군사 교육 엔터테인먼트 의료 등 매우 다양한 분야에서 콘텐츠의 개발이 활발하게 이루어지고 있다. 그 중 게임 산업에서 주로 활용도를 높이는 것을 배경으로 하여, 본 논문에서는 VR기술의 발전사로부터 VR구현 장비인 HMD의 기술적 발전방향 연구를 통해서 미래형 HMD디자인의 방향을 고찰하고자 한다. 탐구 이를 기반으로 향호 게임마니아의 니즈에 부합한 HMD 디자인을 제시하고자 한다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2020.07a
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• pp.385-386
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• 2020

In this paper, we propose a collaborative filtering recommendation algorithm based on the LDA2Vec topic model. By extracting and analyzing the article's content, calculate their semantic similarity then combine the traditional collaborative filtering algorithm to recommend. This approach may promote the system's recommend accuracy.

• Honam Mathematical Journal
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• v.46 no.1
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• pp.136-145
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• 2024

In this paper we obtained several properties that the characteristic polynomial of the unit-primitive matrix satisfies. In addition, using these properties we have shown that the recurrence relation given as in the formula (1) is true. In fact, Xin and Zhong ([4]) showed it earlier. However, we provide a simpler method here.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.3901-3906
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• 2014

Aim: The purpose of this study was to investigate anti-tumor effects and safety of DH332, a new ${\beta}$-carboline alkaloids derivatives in vitro and in vivo. Materials and Methods: The effects of DH332 on human (RAMOS RA.1) and mouse (J558) B lymphoma cell lines were detected using a CCK-8 kit (Cell Counting Kit-8), and apoptosis was detected by flow cytometry with PI/annexinV staining. Western blotting was used to detected caspase-3 and caspase-8. Neurotoxic and anti-tumor effects were evaluated in animal experiments. Results: DH332 exerts a lower neurotoxicity compared with harmine. It also possesses strong antitumor effects against two B cell lymphoma cell lines with low $IC_{50s}$. Moreover, DH332 could inhibit the proliferation and induce the apoptosis of RAMOS RA.1 and J558 cell lines in a dose-dependent manner. Our results suggest that DH332 triggers apoptosis by mainly activating the caspase signaling pathway. In vivo studies of tumor-bearing BALB/c mice showed that DH332 significantly inhibited growth of J558 xenograft tumors. Conclusions: DH332 exerts effective antitumor activity in vitro and in vivo, and has the potential to be a promising drug candidate for lymphoma therapy.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3855-3859
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• 2013

Purpose: Liver cancer, one of the most common cancers in China, is reported to feature relatively high morbidity and mortality. Curcumin (Cum) is considered as a drug possessing anti-angiogenic, anti-inflammation and anti-oxidation effect. Previous research has demonstrated antitumor effects in a series of cancers. Materials and Methods: In this study the in vitro cytotoxicity of Cum was measured by MTT assay and pro-apoptotic effects were assessed by DAPI staining and measurement of caspase-3 activity. In vivo anti-hepatoma efficacy of Cum was assessed with HepG2 xenografts. Results: It is found that Cum dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis. Moreover, Cum delayed the growth of liver cancer in a dose-dependent manner in nude mice. Conclusions: Cum might be a promising phytomedicine in cancer therapy and further efforts are needed to explore this therapeutic strategy.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1743-1745
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• 2015

Objective: To evaluate the efficacy and adverse effects of three dimensional conformal radiotherapy (3D-CRT) with tamoxifen in treating patients with postoperative malignant glioma. Patients and Methods: 60 patients of postoperative malignant glioma were randomly assigned into two groups, 30 patients were treated with 3D-CRT plus tamoxifen (treatment group), and the other 30 patients with 3D-CRT plus temozolomide (control group). All patients were radiated by 6MV X-ray, 2.0Gy per fraction, once daily, with a total dose (DT) of 56~60Gy. Tamoxifen was delivered at $60mg/m^2/d$, temozolomide was given at $75mg/m^2/d$. All patients were treated with concurrent radiotherapy. Results: One, 2, 3 year survival rates of treatment and control group were 63.3%, 30.0%, 23.0% and 70.0%, 33.3%, 26.7%, respectively (${\chi}^2=0.01$, 0.23, 0.09, P>0.05). The rate of thromboembolism in treatment group was 6.7%. Conclusion: Therapeutic efficacy of two groups was similar, but it was more cost-effective in treatment group, and toxicity did not increase.

• Geomechanics and Engineering
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• v.22 no.6
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• pp.541-552
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• 2020

With the increasing tension of current coal resources and the increasing depth of coal mining, the gob-side entry retaining technology has become a preferred coal mining method in underground coal mines. Among them, the technology of the gob-side entry retaining with the high-water filling material can not only improve the recovery rate of coal resources, but also reduce the amount of roadway excavation. In this paper, based on the characteristics of the high-water filling material, the technological process of gob-side entry retaining with the high-water filling material is introduced. The early and late stress states of the filling body formed by the high-water filling materials are analyzed and studied. Taking the 8th floor No.3 working face of Xin'an coal mine as engineering background, the stress and displacement of surrounding rock of roadway with different filling body width are analyzed through the FLAC^3D numerical simulation software. As the filling body width increases, the supporting ability of the filling body increases and the deformation of the surrounding rock decreases. According to the theoretical calculation and numerical simulation of the filling body width, the filling body width is finally determined to be 3.5m. Through the field observation, the deformation of the surrounding rock of the roadway is within the reasonable range. It is concluded that the gob-side entry retaining with the high-water filling material can control the deformation of the surrounding rock, which provides a reference for gob-side entry retaining technology with similar geological conditions.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2006.11a
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• pp.15-41
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• 2006

The increasing popularity of the concept of technology innovation has been driven by greater international competition in a rapidly globalizing economy. Both countries and enterprises are placing more and more emphasis on it in order to gain competitive advantages. This article gives a general introduction about the research and application of technology innovation in China. At the national level, one obvious fact is that the total R&D expenditure increased rapidly during the year 2001 to year 2005 and reached Y 245 billions, and China made 2,452 international patent applications in 2005 and became the world's 10th largest user of the Patent Cooperation Treaty. At the industry and enterprise level, much progress has also been made in China. This article uses the high-tech industry as an example to introduce the industry and enterprise technology innovation respectively. Corresponding to the practice, scholars also did a great amount of research work related to technology innovation. This article sums up all the work done from the macroscopic aspect (such as national technology innovation strategy, regional innovation system, industry technology innovation) and microcosmic aspect (such as enterprise technology innovation strategy, patterns and evaluation standards). Based on the analysis, this article discusses the limitation of current work and research trend about the technology innovation.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9859-9863
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• 2014

Genetic epidemiological studies have shown that genetic susceptibility to esophageal cancer (EC) is an important cause of its high incidence within families in some areas of China. The purpose of this study was to obtain evidence of a genetic basis of EC in Xin-an and Xin-xiang counties in China. Familial aggregation and complex segregation analyses were performed of 79 EC families in these counties. The heritability of EC was examined using Falconer's method and complex segregation analysis was conducted with the SEGREG program in Statistical Analysis for Genetic Epidemiology (SAGE version 5.3.1). The results showed that the distribution of EC in families did not fit well into a binomial distribution. The heritability of EC among first-degree and second-degree relatives was $67.0{\pm}7.31%$ and $43.1%{\pm}9.80%$, respectively, and the summing up powered heritability was $53.2{\pm}6.74%$. The segregation ratio was 0.045. Complex segregation analysis showed that the genetic model of EC was additive. The current results provide evidence for an inherited propensity to EC in certain high-risk groups in China, and support efforts to identify the genes that confer susceptibility to this disease.