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http://dx.doi.org/10.7314/APJCP.2015.16.5.1743

Clinical Observation of Three Dimensional Conformal Radiotherapy with Tamoxifen in Treatment of Postoperative Malignant Glioma  

Zhou, Shao-Bing (Department of Radiation Oncology, Affiliated People's Hospital of Yangzhou University)
Liu, Yang-Chen (Department of Radiation Oncology, Affiliated People's Hospital of Yangzhou University)
Yin, Xiao-Xiang (Department of Radiation Oncology, Affiliated People's Hospital of Yangzhou University)
Ding, Wen-Xiu (Department of Radiation Oncology, Affiliated People's Hospital of Yangzhou University)
Guo, Xin-Wei (Department of Radiation Oncology, Affiliated People's Hospital of Yangzhou University)
Gu, Liang (Department of Radiation Oncology, Affiliated People's Hospital of Yangzhou University)
Huang, Xin-En (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.5, 2015 , pp. 1743-1745 More about this Journal
Abstract
Objective: To evaluate the efficacy and adverse effects of three dimensional conformal radiotherapy (3D-CRT) with tamoxifen in treating patients with postoperative malignant glioma. Patients and Methods: 60 patients of postoperative malignant glioma were randomly assigned into two groups, 30 patients were treated with 3D-CRT plus tamoxifen (treatment group), and the other 30 patients with 3D-CRT plus temozolomide (control group). All patients were radiated by 6MV X-ray, 2.0Gy per fraction, once daily, with a total dose (DT) of 56~60Gy. Tamoxifen was delivered at $60mg/m^2/d$, temozolomide was given at $75mg/m^2/d$. All patients were treated with concurrent radiotherapy. Results: One, 2, 3 year survival rates of treatment and control group were 63.3%, 30.0%, 23.0% and 70.0%, 33.3%, 26.7%, respectively (${\chi}^2=0.01$, 0.23, 0.09, P>0.05). The rate of thromboembolism in treatment group was 6.7%. Conclusion: Therapeutic efficacy of two groups was similar, but it was more cost-effective in treatment group, and toxicity did not increase.
Keywords
Malignant glioma; three dimensional conformal radiotherapy; tamoxifen;
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