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http://dx.doi.org/10.7314/APJCP.2013.14.6.3855

Potential Therapeutic Efficacy of Curcumin in Liver Cancer  

Dai, Xin-Zheng (Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health)
Yin, Hai-Tao (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University)
Sun, Ling-Fei (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University)
Hu, Xiang (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University)
Zhou, Chong (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University)
Zhou, Yun (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University)
Zhang, Wei (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University)
Huang, Xin-En (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research)
Li, Xiang-Cheng (Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.6, 2013 , pp. 3855-3859 More about this Journal
Abstract
Purpose: Liver cancer, one of the most common cancers in China, is reported to feature relatively high morbidity and mortality. Curcumin (Cum) is considered as a drug possessing anti-angiogenic, anti-inflammation and anti-oxidation effect. Previous research has demonstrated antitumor effects in a series of cancers. Materials and Methods: In this study the in vitro cytotoxicity of Cum was measured by MTT assay and pro-apoptotic effects were assessed by DAPI staining and measurement of caspase-3 activity. In vivo anti-hepatoma efficacy of Cum was assessed with HepG2 xenografts. Results: It is found that Cum dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis. Moreover, Cum delayed the growth of liver cancer in a dose-dependent manner in nude mice. Conclusions: Cum might be a promising phytomedicine in cancer therapy and further efforts are needed to explore this therapeutic strategy.
Keywords
Curcumin; apoptosis; liver cancer; in vitro; in vivo;
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