• 전자공학회논문지 IE
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• 제45권1호
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• pp.15-23
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• 2008

본 논문에서는 차세대 패킷 네트워크에서의 서비스 품질 기능 고도화를 목적으로 절대적 지연 차별화 기능을 제공하는 알고리듬을 제시하고 시뮬레이션을 통해 성능 분석을 수행한다. 또한, 제안된 알고리듬을 XPC 850 CPU 기반의 시험 보드상에서 VHDL로 구현하여 실제 트래픽 입력 상황하에서의 성능 분석을 수행한다. 제안된 알고리듬은 매 시간 구간마다 입력되는 트래픽을 측정하고 이를 기반으로 다음 시간 구간 동안 입력될 트래픽의 양을 예측한 후 실제로 다음 시간 구간 동안에 입력된 트래픽과 비교하여 오차분을 도출하여 이를 다음 타임 슬롯의 지연 차별화 동작에 지속적으로 반영하는 것이 특징적 요소이므로 오차분을 고려하지 않는 기존 방식에 비해 버스트 트래픽에 대하여 우수한 적응성을 보여준다. 제안된 방식의 성능은 시뮬레이션과 실제 보드상에서의 시험을 통해 절대적 지연 목표를 충족시킴과 동시에 기존 방식에 비해 버스트 트래픽에 대하여 성능 개선 효과가 달성됨이 확인된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3677-3680
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• 2013

We aimed to assess the role of XPG, XPC and MMS19L polymorphisms on response to chemotherapy in osteosarcomas, and the clinical outcomes. One hundred and eighty five osteosarcoma patients who were histologically confirmed were enrolled in our study between January 2007 and December 2009. Genotyping of XPG, XPC and MMS19L was performed in a 384-well plate format on the MassARRAY$^{(R)}$ platform. Individuals with XPG TT genotype and T allele were more likely to be better response to chemotherapy than CC genotype, with the OR (95% CI) of 4.17 (1.64-11.54) and 2.66 (1.39-5.11), respectively. Those carrying MMS19L TT genotype and T allele showed better response to chemotherapy, with ORs (95% CI) of 4.8 (1.56-17.7) and 2.3 (1.22-4.36), respectively. Patients carrying TT genotype of XPG and MMS19L showed a significantly longer overall survival than CC genotype, with a 0.47 and 0.30-fold risk of death when compared with the wild-type of the gene. XPG and MMS19L are correlated with response to chemotherapy and prognosis of osteosarcoma, so that they could be used as predictive markers for prognosis.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.2049-2052
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• 2013

The effects of polymorphisms in ERCC5, ERCC6, XPC, CCNH and MMS19L on osteosarcoma response to chemotherapy and the survival of the affected patients were assessed. Genotyping of ERCC5, ERCC6, XPC, CCNH and MMS19L was performed by PCR-RFLP assay. The median PFS was 12.8 months, and the median OS was 18.6 months. Individuals carrying homozygous genotypes of ERCC5 rs17655 and ERCC5 rs1047768 were more like to have good response to treatment, while those carrying homozygous genotypes of MMS19L rs29001322 showed poor response. Osteosarcoma patients carrying TT genotype of ERCC5 rs1047768 showed a significantly longer PFS (16.8 months) and OS (21.4 months) than CC genotype, with HRs(95% CI) of 0.31 (0.10-0.93) and 0.32 (0.06-0.97), respectively. Conversely, those with the TT genotype of MMS19L rs29001322 demonstrated shorter PFS and OS, the HRs (95% CI) being 2.23 (1.08-4.15) and 4.62 (1.45-16.08), respectively. Our findings showed polymorphisms in ERCC5 rs1047768 and MMS19L rs29001322 to be associated with clinical outcome of osteosarcoma patients undergoing chemotherapy.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5839-5842
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• 2013

Aim: We assessed the association between genetic variants of XPG, XPA, XPD, CSB, XPC and CCNH in the nucleotide excision repair (NER) pathway and risk of prostate cancer. Methods: We genotyped the XPG, XPA, XPD, CSB, XPC and CCNH polymorphisms by a 384-well plate format on the MassARRAY(R) platform. Multivariate logistical regression analysis was used to assess the associations between the six gene polymorphisms and risk of prostate cancer. Results: Individuals carrying the XPG rs229614 TT (OR=2.01, 95%CI=1.35-3.27) genotype and T allele (OR=1.73, 95%CI=1.37-2.57) were moderately significantly associated with a higher risk of prostate cancer. Subjects with XPD rs13181 G allele had a marginally increased risk of prostate cancer, with adjusted OR(95%CI) of 1.53 (1.04-2.37). Moreover, individuals carrying with CSB rs2228526 GG genotype (OR=2.05, 95% CI=1.23-3.52) and G allele (OR=1.56, 95%CI=1.17-2.05) were associated with a higher increased risk of prostate cancer. The combination genotype of XPG rs2296147 T and CSB rs2228526 G allele had accumulative effect on the risk of this cancer, with an OR (95% CI) of 2.23(1.37-3.59). Conclusions: Our study indicates that XPG rs2296147 and CSB rs2228526 polymorphisms are significantly associated with increased risk of prostate cancer, and that combination of XPG rs2296147 T allele and CSB rs2228526 G allele is strongly associated with an increased risk.

• 융합보안논문지
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• 제7권2호
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• pp.17-25
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• 2007

본 논문에서는 차세대 패킷 네트워크에서의 서비스 품질 기능 고도화를 목적으로 상대적 지연 차별화 기능을 제공하는 알고리듬을 제시하고 시뮬레이션을 통해 성능 분석을 수행한다. 또한, 제안된 알고리듬을 XPC 860 CPU 기반의 시험 보드상에서 VHDL로 구현하여 실제 트래픽 입력 상황하에서의 성능 분석을 수행한다. 제안된 알고리듬은 매 시간 구간마다 입력되는 트래픽을 측정하고 이를 기반으로 다음 시간 구간 동안 입력될 트래픽의 양을 예측한 후 실제로 다음 시간 구간 동안에 입력된 트래픽과 비교하여 오차분을 도출하여 이를 다음 타임 슬롯의 지연 차별화 동작에 지속적으로 반영하는 것이 특징적 요소이므로 오차분을 고려하지 않는 기존 방식에 비해 버스트 트래픽에 대하여 우수한 적응성을 보여준다. 제안된 방식의 성능은 시뮬레이션과 실제 보드상에서의 시험을 통해 절대적 지연 목표를 충족시킴과 동시에 기존 방식에 비해 버스트 트래픽에 대하여 성능 개선 효과가 달성됨이 확인된다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2002년도 추계학술발표논문집 (중)
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• pp.1371-1374
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• 2002

본 논문에서는 내장형 리눅스를 기반으로 무선 네트웍과 실시간 음성처리 VoIP 와의 연동시스템을 설계 구현한다. 설계 구현하는 시스템의 하드웨어 스펙은 Motorola-XPC860 프로세서를 기반으로 설계되었으며, 음성 코덱칩을 사용하여 실시간으로 음성데이터를 처리하도록 설계하였다. 또한 2.4GHz 무선 통신 규약인 Bluetooth 를 무선 네트웍 인터페이스로 사용하였다. 실시간 음성데이터의 효과적인 처리를 위하여 실시간 운영 체제인 RTLinux 를 사용하였으며, 무선 네트워크의 동시다중 서비스 지원을 위해 커널레벨의 문자 디바이스 형태로의 Bluetooth 인터페이스 구현에 대해 살펴보도록 하겠다.

• ETRI Journal
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• 제30권2호
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• pp.227-237
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• 2008

In this paper, an algorithm that provides absolute and proportional differentiation of packet delays is proposed with the objective of enhancing quality of service in future packet networks. It features an adaptive scheme that adjusts the target delay for every time slot to compensate the deviation from the target delay, which is caused by prediction error on the traffic to arrive at the next time slot. It predicts the traffic to arrive at the beginning of a time slot and measures the actual arrived traffic at the end of the time slot. The difference between them is utilized by the delay control operation for the next time slot to offset it. Because the proposed algorithm compensates the prediction error continuously, it shows superior adaptability to bursty traffic and exponential traffic. Through simulations we demonstrate that the algorithm meets the quantitative delay bounds and is robust to traffic fluctuation in comparison with the conventional non-adaptive mechanism. The algorithm is implemented with VHDL on a Xilinx Spartan XC3S1500 FPGA, and the performance is verified under the test board based on the XPC860P CPU.

• BMB Reports
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• 제36권1호
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• pp.35-42
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• 2003

Heterocyclic amines (HCAs) are potent mutagens generated during the cooking of meat and fish, and several of these compounds produce tumors in conventional experimental animals. During the past 5 years or so, HCAs have been tested in a number of novel in vivo murine models, including the following: lacZ, lacI, cII, c-myc/lacZ, rpsL, and $gpt{\Delta}$ transgenics, $XPA^{-/-}$, $XPC^{-/-}$, $Msh2^{+/-}$, $Msh2^{-/-}$ and $p53^{+/-}$ knock-outs, Apc mutant mice ($Apc^{{\Delta}716}$, $Apc^{1638N}$, $Apc^{min}$), and $A33^{{\Delta}N{\beta}-cat}$ knock-in mice. Several of these models have provided insights into the mutation spectra induced in vivo by HCAs in target and non-target organs for tumorigenesis, as well as demonstrating enhanced susceptibility to HCA-induced tumors and preneoplastic lesions. This review describes several of the more recent reports in which novel animal models were used to examine HCA-induced mutagenesis and carcinogenesis in vivo, including a number of studies which assessed the inhibitory activities of chemopreventive agents such as 1,2-dithiole-3-thione, conjugated linoleic acids, tea, curcumin, chlorophyllin-chitosan, and sulindac.

• 한국정보컨버전스학회:학술대회논문집
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• 한국정보컨버전스학회 2008년도 International conference on information convergence
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• pp.117-120
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• 2008

If the management through the center server is unnecessary and JXTA is connected to a network, a communication with any kind of devices or some device is possible. And features that a communication with heterogeneous P2P systems is possible have. The important module of the designed Data exchange system an interworking between the P2P system which it is made we used API and the each other different protocol the possible data for replacement Data exchange system were designed this kind of a feature was to the utmost utilized may account for the XML Parser Component(XPC) which we use it parses the or about a request and the generated request, and the structure of the XML Making Component(XMC) which we use in generating the inappropriate a request and response.

• 한국통신학회논문지
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• 제27권12C호
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• pp.1282-1287
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• 2002

본 논문에서는 가정 내의 전화선을 이용한 홈 네트워크 기술인 10Mbps HomePNA(Home Phoneline Networking Alliance) 20 PHY 회로의 설계 및 그에 대한 검증방법을 보여 준다. HomePNA 2.0 PHY 회로는 MII(Media Independent Interface)와 AFE 인터페이스에 의해 외부와 연결된다. 설계된 10Mbps HomePNA 2.0 PHY의 회로의 전체 구조는 Management block IEEE 802.3 CSMA/CD MAC(Media Access Control) block, 변조 및 복조 block으로 크게 구성된다. 설계된 회로는 프로토타입 FPGA PCB 보드를 이용하여 검증하였다. 또한, Linux 기반의 드라이버 프로그램을 개발하여 HomePNA 프레임 데이터 전송의 기본적인 동작을 확인하였으며, HomePNA 2.0 링크 계층 프로토콜의 RNCF(Rate Negotiation Control Function)에 의하여 전송속도의 변화를 확인하였다.