• 대한토목학회논문집
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• 제6권2호
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• pp.45-55
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• 1986

본(本) 연구(硏究)는 도시교통계획(都市交通計劃)에서 장래교통발생예측시(將來交通發生豫測時) 항상 문제(問題)로 되는 설명변수선택(說明變數選擇)의 애매성(曖昧性)을 해결(解決)하기 위하여 교통발생(交通發生)의 설명지표(說明指標)를 제안(提案)하는 동시(同時)에 최량(最良)의 도시교통발생(都市交通發生) Model을 작성(作成)하였다. 제안(提案)된 설명지표(說明指標)를 사용(使用)하여 목적별(目的別) 교통발생중회귀(交通發生重回歸) 모델을 작성(作成)하고, 단일변수(單一變數)로 설명(說明)이 가능(可能)한 것은 교통발생(交通발生)의 비손성(非負性)을 확보(確保)하기 위하여 단회귀(單回歸)모델로 수정(修正)하였다. 그러나 다변수(多變數)가 도입(導入)되어도 설명(說明)이 불충분(不充分)한 목적별(目的別) 교통(交通)(등교집중(等校集中)과 자유목적(自由目的)의 발생(發生)모델)은 동질(同質)의 토지이용활동(土地利用活動)으로부터 발생(發生)하는 교통(交通)의 발생특성(發生特性)이 유이(類似)함에 주목(注目)하여 각(各) zone을 특성별(特性別)로 분류(分類)하고 zone 군별(群別)로 교통발생(交通發生) 모델을 작성(作成)하여 통계적(統計的)으로 유의성(有意性)을 검토(檢討)하였다. 그리고 장래교통발생예측(將來交通發生豫測)은 단순(單純)하면서도 예측정도(豫測精度)의 제고(提高)가 바람직하므로 토지이용활동별(土地利用活動別)로 교통발생원단위(交通發生原單位)를 작성(作成)하고 안정성(安定性)을 고찰(考察)하여 교통발생예측시(交通發生豫測時) 실용가능(實用可能)한 원단위(原單位)를 제안(提案)하였다.

• 한국의학물리학회지:의학물리
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• 제29권3호
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• pp.92-100
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• 2018

The manufacturer of a linear accelerator (LINAC) has reported that the target melting phenomenon could be caused by a non-recommended output setting and the excessive use of monitor unit (MU) with intensity-modulated radiation therapy (IMRT). Due to these reasons, we observed an unexpected beam interruption during the treatment of a patient in our institution. The target status was inspected and a replacement of the target was determined. After the target replacement, the beam profile was adjusted to the machine commissioning beam data, and the absolute doses-to-water for 6 MV and 10 MV photon beams were calibrated according to American Association of Physicists in Medicine (AAPM) Task Group (TG)-51 protocol. To verify the beam data after target replacement, the beam flatness, symmetry, output factor, and percent depth dose (PDD) were measured and compared with the commissioning data. The difference between the referenced and measured data for flatness and symmetry exhibited a coincidence within 0.3% for both 6 MV and 10 MV, and the difference of the PDD at 10 cm depth ($PDD_{10}$) was also within 0.3% for both photon energies. Also, patient-specific quality assurances (QAs) were performed with gamma analysis using a 2-D diode and ion chamber array detector for eight patients. The average gamma passing rates for all patients for the relative dose distribution was $99.1%{\pm}1.0%$, and those for absolute dose distribution was $97.2%{\pm}2.7%$, which means the gamma analysis results were all clinically acceptable. In this study, we recommend that the beam characteristics, such as beam profile, depth dose, and output factors, should be examined. Further, patient-specific QAs should be performed to verify the changes in the overall beam delivery system when a target replacement is inevitable; although it is more important to check the beam output in a daily routine.

• Asian-Australasian Journal of Animal Sciences
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• 제28권5호
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• pp.654-661
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• 2015

Two experiments were conducted to determine the digestible energy (DE) and metabolizable energy (ME) content of 19 rice bran samples and to develop prediction equations for DE and ME based on their chemical composition. The 19 rice bran samples came from different rice varieties, processing methods and regions. The basal diet was formulated using corn and soybean meal (74.43% corn and 22.91% soybean meal and 2.66% vitamins and minerals). The 19 experimental diets based on a mixture of corn, soybean meal and 29.2% of each source of rice bran, respectively. In Exp. 1, 108 growing barrows ($32.1{\pm}4.2kg$) were allotted to 1 of 18 treatments according to a completely randomized design with 6 pigs per treatment. The treatment 1 was the control group which was fed with basal diet. The treatments 2 to 18 were fed with experimental diets. In Exp. 2, two additional rice bran samples were measured to verify the prediction equations developed in Exp. 1. A control diet and two rice bran diets were fed to 18 growing barrows ($34.6{\pm}3.5kg$). The control and experimental diets formulations were the same as diets in Exp. 1. The results showed that the DE ranged from 14.48 to 16.85 (mean 15.84) MJ/kg of dry matter while the ME ranged from 12.49 to 15.84 (mean 14.31) MJ/kg of dry matter. The predicted values of DE and ME of the two additional samples in Exp. 2 were very close to the measured values.

• Asian-Australasian Journal of Animal Sciences
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• 제27권12호
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• pp.1695-1704
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• 2014

Maternal malnutrition during pregnancy may give rise to female offspring with disrupted ovary functions in adult age. Neonatal ovary development predisposes adult ovary function, yet the effect of maternal nutrition on the neonatal ovary has not been described. Therefore, here we show the impact of maternal protein restriction on the expression of folliculogenic and steroidogenic genes, their regulatory microRNAs and promoter DNA methylation in the ovary of neonatal piglets. Sows were fed either standard-protein (SP, 15% crude protein) or low-protein (LP, 7.5% crude protein) diets throughout gestation. Female piglets born to LP sows showed significantly decreased ovary weight relative to body weight (p<0.05) at birth, which was accompanied with an increased serum estradiol level (p<0.05). The LP piglets demonstrated higher ratio of bcl-2 associated X protein/B cell lymphoma/leukemia-2 mRNA (p<0.01), which was associated with up-regulated mRNA expression of bone morphogenic protein 4 (BMP4) (p<0.05) and proliferating cell nuclear antigen (PCNA) (p<0.05). The steroidogenic gene, cytochrome P450 aromatase (CYP19A1) was significantly down-regulated (p<0.05) in LP piglets. The alterations in ovarian gene expression were associated with a significant down-regulation of follicle-stimulating hormone receptor mRNA expression (p<0.05) in LP piglets. Moreover, three microRNAs, including miR-423-5p targeting both CYP19A1 and PCNA, miR-378 targeting CYP19A1 and miR-210 targeting BMP4, were significantly down-regulated (p<0.05) in the ovary of LP piglets. These results suggest that microRNAs are involved in mediating the effect of maternal protein restriction on ovarian function through regulating the expression of folliculogenic and steroidogenic genes in newborn piglets.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3229-3235
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• 2013

Background: Many breast cancers are caused by certain rare and familial mutations in the high or moderate penetrance genes BRCA1, BRCA2 and CHEK2. The aim of this study was to examine the allele and genotype frequencies of seven mutations in BRCA1, BRCA2 and CHEK2 genes in breast cancer patients and to investigate their isolated and combined associations with breast cancer risk. Methods: We genotyped seven mutations in BRCA1, BRCA2 and CHEK2 genes and then analyzed single variations and haplotype associations in 106 breast cancer patients and 80 healthy controls. Results: We found significant associations in the analyses of CHEK2- 1100delC (p=0.001) and BRCA1-5382insC (p=0.021) mutations in breast cancer patients compared to controls. The highest risk was observed among breast cancer patients carrying both CHEK2-1100delC and BRCA2- Met784Val mutations (OR=0.093; 95%CI 0.021-0.423; p=0.001). We identified one previously undescribed BRCA2 and a CHEK2 four-marker haplotype of A-C-G-C which was overrepresented ($X^2$=7.655; p=0.0057) in the patient group compared to controls. Conclusion: In this study, we identified a previously undescribed BRCA2 and CHEK2 A-C-G-C haplotype in association with the breast cancer in our population. Our results further suggest that the CHEK2-1100delC mutation in combination with BRCA2-Met784Val may lead to an unexpected high risk which needs to be confirmed in larger cohorts in order to better understand their role in the development and prognosis of breast cancer.

• 한국수산과학회지
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• 제45권4호
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• pp.351-357
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• 2012

To determine whether the seaweed Saccharina japonica can effectively utilize dissolved nutrients from Sebastes schlegeli fish cultures, a laboratory experiment was conducted in a static system for 7 days at ESFRI, NFRDI in Korea. The experiment included an S. schlegeli monoculture system and an S. schlegeli-S. japonica IMTA system. Saccharina schlegeli density ($415{\pm}24g$; mean${\pm}$SE) remained the same in all treatments, whereas seaweed density varied across treatments of 0, 0.5, 1, 2, and 3 kg (control and T1-T4, respectively). During the experiment, nutrient ($NH_4^+$ and $PO_4^{3-}$) concentrations were measured at 24-h intervals. $NH_4^+$ concentration of the control group increased from $0.117{\pm}0.021mg/L$ at the start of experiment to $5.836{\pm}0.904mg/L$ at the end of experiment. $NH_4^+$ concentrations of each treatment were $3.004{\pm}0.040$, $2.086{\pm}0.133$, $1.642{\pm}0.121$ and $0.775{\pm}0.007mg/L$ in T1, T2, T3, and T4, respectively, at the end of experiment. The concentration of $PO_4^{3-}$ exhibited a similar trend to $NH_4^+$ concentration. $NH_4^+$ and $PO_4^{3-}$ concentrations significantly decreased with increased S. japonica thallus density each day (P<0.05). The nutrient removal efficiency (NRE) and nutrient uptake rate (NUR) showed different relationships with changes in thallus density; NRE increased but NUR decreased as thallus density increased. Based on measured concentrations of $NH_4^+$ and S. japonica weight, regression analysis defined the relationship between as an exponential function, $Y=3.8165e^{-0.505X}$ ($R^2$ = 0.9552). Our results demonstrated that S. japonica can function as an efficient component in IMTA with environmental and potentially economic benefits for fish hatcheries.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5145-5151
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• 2013

Background: Numerous carcinogens and reactive oxygen species (ROS) may cause DNA damage including oxidative base lesions that lead to risk of nasopharyngeal carcinoma. Genetic susceptibility has been reported to play a key role in the development of this disease. The base excision repair (BER) pathway can effectively remove oxidative lesions, maintaining genomic stability and normal expression, with X-ray repair crosscomplementing1 (XRCC1), 8-oxoguanine glycosylase-1 (OGG1) and apurinic/apyimidinic endonuclease 1 (APE1) playing important roles. Aims: To analyze polymorphisms of DNA BER genes (OOG1, XRCC1 and APE1) and explore their associations, and the combined effects of these variants, with risk of nasopharyngeal carcinoma. Materials and Methods: We detected SNPs of XRCC1 (Arg399Gln), OGG1 (Ser326Cys), APE1 (Asp148Glu and -141T/G) using the polymerase chain reaction (PCR) with peripheral blood samples from 231 patients with NPC and 300 healthy people, furtherly analyzing their relations with the risk of NPC in multivariate logistic regression models. Results: After adjustment for sex and age, individuals with the XRCC1 399Gln/Gln (OR=1.96; 95%CI:1.02-3.78; p=0.04) and Arg/Gln (OR=1.87; 95%CI:1.29-2.71; p=0.001) genotype variants demonstrated a significantly increased risk of nasopharyngeal carcinoma compared with those having the wild-type Arg/Arg genotype. APE1-141G/G was associated with a significantly reduced risk of NPC (OR=0.40;95%CI:0.18-0.89) in the smoking group. The OR calculated for the combination of XRCC1 399Gln and APE1 148Gln, two homozygous variants, was significantly additive for all cases (OR=2.09; 95% CI: 1.27-3.47; p=0.004). Conclusion: This is the first study to focus on the association between DNA base-excision repair genes (XRCC1, OGG1 and APE1) polymorphism and NPC risk. The XRCC1 Arg399Gln variant genotype is associated with an increased risk of NPC. APE1-141G/G may decrease risk of NPC in current smokers. The combined effects of polymorphisms within BER genes of XRCC1 399Gln and APE1 148Gln may contribute to a high risk of nasopharyngeal carcinoma.

• 대한치과교정학회지
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• 제26권5호
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• pp.557-568
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• 1996

본연구는 안면성장유형에 있어서의 피개교합심도지수, 전후방부조화지수의 성장에 따른 변화 양상을 알아 보기 위하여 정상교합자 남자 19명, 여자 14명의 10년간 격년으로 촬영한 두부 X-선 규격사진을 Y-axis의 연구기간동안 총변화량에 따라 Drop, Neutral, Forward의 세군으로 나누어 분석하여 각 계측항목에 관하여 다음과 같은 결과를 얻었다. $\cdot$ 남녀 각 안면유형에서 각 연령군의 각 계측항목의 평균과 표준편차를 얻었다. $\cdot$ 안면유형에 따른 세 그룹간 비교에서 전후방부조화지수와 피개교합심도지수는 전 연령구간에서 유의차를 나타내지 않았다(p>0.05). 피개교합심도지수는 남녀 모두 전 연령구간에서 Drop, Neutral, Forward의 크기순으로 나타났다. $\cdot$ 피개교합심도지수와 전후방부조화지수는 전연구기간동안 연령증가에 따른 변화없이(p>0.05) 안정되게 유지되는 양상을 보였다. $\cdot$ Y-axis의 총변화량과 각 계측항목의 상관성 조사에서 A-B plane angle, Facial angle은 남녀 모두에서 상관성을 나타내었고(p<0.05) 전후방부조화지수는 여자에서만 상관성을 나타내었으나(p<0.001) 피개교합심도지수는 남녀 모두에서 상관성을 나타내지 않았다(p>0.05).

• 대한치과교정학회지
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• 제26권5호
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• pp.535-546
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• 1996

이 연구는 한국인 하악치열궁 형태를 분류하고, 교두정에서 브라켓 높이의 협면점까지 거리를 계측하여 이상적인 호선 제작에 도움을 얻기위하여 시행되였다. 13세에서 25세사이의 정상적인 교합자 159명의 석고모형을 대상으로 순측 및 협측 교두정을 지나는 하악치열궁선에서 견치간, 제1대구치간 및 제2대구치간 폭경과 이들의 고경을 계측한 다음, 유클리안 거리를 이용한 평균군집분석을 시행하여 치열궁형태를 5가지로 분류하고, 각각의 6차 다항식과 결정계수를 구하였으며, 교두정에서 브라켓 높이의 협면점까지의 거리를 계측하고 비교검토하여 다음의 결과를 얻었다. 1. 5가지 하악치열궁선을 실제의 크기로 작도하고, 1형, 2형, 3형, 4형 및 5형으로 명명하였다. 2. 각각의 치 열궁선은 하악 제2대구치간 폭경으로 표현되는 6차다항식과 결정 계수를 산출하였으며 이 식으로 $97\%$이상 설명이 가능하였다. 3. 각 치열궁선의 분포는 5형이 $24.5\%$로 가장 많았으며, 2형과 3형이 각각 $20.8\%$ 1형은 $17.6\%$, 4형은 $16.3\%$의 분포를 보였다. 4. 한국인의 하악치열궁선은 프랑스인에 비하여 폭경이 넓고 고경이 낮은 특성을 보였다. 5. 교두정에서 브라켓높이의 협면점까지의 거리는 절치가 1.0, 견치는 1.9, 제1소구치는 2.6, 제1 및 제2 대구치는 2.7 이였다.

• 미생물학회지
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• 제30권1호
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• pp.53-59
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• 1992

자연계로부터 4-chlorobiphenyl (4CB) 을 분해하는 P08, P20, 027 그리고 P1242 균주를 불리하였다. 이들 분해 균주들의 4CB 분해 과정을 UV-spectrophotometry 방법으로 분석한 결과, 4-CB 로 부터 2-hydroxy-6-oxo-6-(4'-chlorophenyl)hexa-2, 4-dienoic acid 와 4-chlorobenzoate(4CBA) 가 생성되었다. 따라서 분해균주들은 공통적으로 meta-cleavage pathway에 의하여 4CB 를 분해하는 것으로 확인되었다. 그러나 DJ-12, P08 그리고 P27 균주는 4CBA 를 계속 분해하여 4-hydroxybenzoate 를 생성하였으나, P20 과 P1242 균주들은 4CBA 를 더이상 분해하지 못 하였다. 각 분해 균주에서 cbp 유전자군의 상동성을 분석하기 위하여 P. pseudoalcaligenes KF707 의 bphABC 유전자군을 DNA probe 로 이용하여 Southern hybridization 을 실시한 결과, DJ-12, P08 그리고 P27 균주들은 XhoI 에 의한 2.2kb 와 1.8 kb, 그리고 EcoRI 에 의한 11 kb 의 genomic DNA 의 절편에서 hybridization 이 일어났다. 따라서 본 연구에서 분리한 4CB 분해 균주들의 cbp 유전자군은 분해경로 및 bph 유전자군과의 상동성에 의거하여 부 group 으로 구분되었다.