• 한국발생생물학회지:발생과생식
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• 제15권1호
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• pp.53-59
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• 2011

Sex steroid hormones are key molecules to prepare the decidual response and their levels are important in this process. Imbalances of the levels of steroid hormones are cause of implantation failure and other diseases including physical weakness. Androgen replacement therapy or selective androgen receptor modulator are used to overcome various diseases but long-term use may cause of side effects. In previous report, it is suggested that the steroid hormonal complexes derived from pig enhance the proliferation of satellite cell. Therefore, to evaluate the possible usage of steroid hormonal complex derived from pig testis (tS-C), the effects of tS-C on uterine response were studied using the model of artificial decidua. tS-C did not disturb the rhythmical estrus cycle. Artificial-induced decidual response was normally induced in tS-C administered mice. The histological characters of the decidua of tS-C administered mice were not different from the vehicle. The expression patterns of molecular markers of decidua were not different between vehicle and tS-C group. Collectively these results suggested that tS-C does not disturb the uterine responsibility to the embryo. In addition, our results suggested that tS-C can be applied to overcome the various problems such as loss of muscle mass and anemia.

• 대한지역사회영양학회지
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• 제6권5호
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• pp.744-754
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• 2001

This study examined the effect of self-perception of health and related factors of flood life and disease on health floods intakes among the middle aged(150 men and 159 women) in the Jeonbuk region. The health foods were classified into 4 groups including Chinese medicine(CM), toner foods(TF), nutritional supplements(NS), and other manufactured health foods supplements(MHFS). Differences of BMI and self-perception for body shape was that overweight was 30% in men and 24.5% in women on BMI, but conversely was 21.3% in men and 43.4% in women on self-perception for body shape. Men thought themselves more than normal weight, but women thought themselves less than normal weight for the criteria of normal weight. Consumption of CM was high in the overweight group on BMI and was a low in the overweight group on self-perception for bodyshape Men thought themselves better than women and those in their 40's thought better than those in their 50's on self perception of health status, and women were better than men on self-perception of food habits. The difference of health foods intakes according to the self-perception of health status and food habits was not significant. The points of food habits, food attitude and nutrition knowledge were 11.21 $\pm$ 2.43, 68.18 $\pm$ 15.56 and 15.53 $\pm$ 1.59 in women and 10.49 $\pm$ 2.71, 67.53 $\pm$ 14.41, and 15.11 $\pm$ 1.79 in men respectively. The points of all were higher for women than for men. Consumption of CM (p < 0.01) and TF(p < 0.01) were a low in groups that scored high points on nutrition knowledge. The points of climacteric symptoms were that men were 48.36 $\pm$ 6.30 and woman were 46.43 $\pm$ 6.70. Men thought themselves in good condition more than women(p < 0.01), and those in their 40's thought themselves in good condition as opposed to those in their 50's in men(p < 0.05). Consumption of TF and NS were high in the low points group on climacteric symptoms(p < 0.01). Women were higher than men on morbidity, but men were more than women on cases of liver disease(p < 0.01). Consumption of CM was high in the liver disease group(p < 0.05), MHFS was high in the kidney disease group(p < 0.05), TF and NS were hgih in the bone disease group(p < 0.05) and NS was hgih in the endocrine disease group(p < 0.05). People in their 40's were higher than those in their 50's in men on morbidity of cold(p < 0.05), women were higher than men by about 2 times on constipation (p < 0.01), those in their 40's were higher than those in their 50's in mein on gastritis(p < 0.05). Consumption of NS was highest for those with diseases in respiratory organs and gastrointestinal tracts. This study suggests that nutritional education for the right recognition of self-perception of health status and food habits, and nutrition knowledge are needed to select for health floods. Consumption of health foods was different according to kinds of diseases. Thus, recognition of etiology, symptoms and dietetics of diseases is needed to select adequate health foods for diseases in middle age.

• 사상체질의학회지
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• 제17권2호
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• pp.27-31
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• 2005

1. Objectives This study is written to investigate the biblographical facts on the book ${\ulcorner}$ Geumge Bibang${\lrcorner}$(Secret Prescriptions of Sasang (Golden Box). 2. Methods The Biblographical study through chronological research of several books concerning Sasang Constitutional Medicine including ${\ulcorner}$Dongyisusebowon${\lrcorner}$,${\ulcorner}$Dongyisasangjintyoeuijeon${\lrcorner}$after Dr. Lee Je-Ma's death was accomplished. 3. Results and Conclusions There are so many herb medicines using just one herb drug not several herb drugs according to many diseases in this book. Accrording to the writer of this book, Lee Min- Bong, JUSt one herb drug to each disease was a useful way to treat that disease in a poor countryside life. There are 85 adult's diseases, 8 women's diseases, 47 children's disease, 11 smallpox's diseases and 30 grotesque diseases. This book of ${\ulcorner}$Geumgebibang${\lrcorner}$ was written by Lee Minbong not by Cheondeoksanin in 1935 and published in 1936 and it was the first book covering the herb drug and diets to treat diseases according to Sasang Constitutional Types. It was first found in this book that Sasang could be explained with Yin- Yang relationship and Sasang Constitutional Types could be explained with characters like dragon, cow, donkey and horse, and with classrncatibn of faces and behaviors.

• BMB Reports
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• 제44권8호
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• pp.506-511
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• 2011

Mammalian Target of Rapamycin (mTOR) is a serine/threonine kinase and that forms two multiprotein complexes known as the mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTOR regulates cell growth, proliferation and survival. mTORC1 is composed of the mTOR catalytic subunit and three associated proteins: raptor, mLST8/$G{\beta}L$ and PRAS40. mTORC2 contains mTOR, rictor, mLST8/$G{\beta}L$, mSin1, and protor. Here, we discuss mTOR as a promising anti-ischemic agent. It is believed that mTORC2 lies down-stream of Akt and acts as a direct activator of Akt. The different functions of mTOR can be explained by the existence of two distinct mTOR complexes containing unique interacting proteins. The loss of TSC2, which is upstream of mTOR, activates S6K1, promotes cell growth and survival, activates mTOR kinase activities, inhibits mTORC1 and mTORC2 via mTOR inhibitors, and suppresses S6K1 and Akt. Although mTOR signaling pathways are often activated in human diseases, such as cancer, mTOR signaling pathways are deactivated in ischemic diseases. From Drosophila to humans, mTOR is necessary for Ser473 phosphorylation of Akt, and the regulation of Akt-mTOR signaling pathways may have a potential role in ischemic disease. This review evaluates the potential functions of mTOR in ischemic diseases. A novel mTOR-interacting protein deregulates over-expression in ischemic disease, representing a new mechanism for controlling mTOR signaling pathways and potential therapeutic strategies for ischemic diseases.

• 한방비만학회지
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• 제7권1호
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• pp.31-38
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• 2007

Objective : Women's obesity brings prblems not only appearance but also health which men do not have. This study was conducted to investigate the different factors of obesity between men and women. Materials and Methods : We searched papers usin key words (women, gender, and obesity) on pubmed and obesity journal. Result : Women's obesity leads to amenorrhea, abnormal uterine bleeding, infertility, poly cystic ovarian syndrome, abortion, and luteal phase inadequacy. Obesity induces metabolic syndrome, type-2 diabetes, cardiovascular problems, hypertension, cancer, and psychophysiologic diseases. The difference in body morphology and in particular fat distribution between the sexes leads to gender-specific differences in prevalence of chronic diseases, and unique problems for each sex including infertility, problems during pregnancy, polycystic ovarian syndrome, and endometrial carcinoma in women, and prostate and testicular cancer in men. The influence of gender on obesity is had by genetic view, hormones, pregnancy, delivery, and menopause. Conclusion : Obese women have higher risk factors than men by the influence of gender.

• Biomolecules & Therapeutics
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• 제9권3호
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• pp.183-187
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• 2001

Nitric oxide (NO) produced in large amounts by the inducible nitric oxide synthase (iNOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of Chinese medicinal plants and screened their inhibitory activity against NO production in lipopolysaccharide (LPS)-activated macrophages. Among the 80 kinds of extracts of herbal drugs, 15 extracts showed potent inhibitory activity of NO production above 80% at the concentration o$50\mu\textrm{g}/ml$. These potent extracts showed dose dependent inhibition of NO production of LPS-activated macrophages at the concentration of 50, 30,$10\mu\textrm{g}/ml$. Especially, Rhus chinensis, Senecio scandens and Wikstroemia indica showed most potent inhibition above 50% at the concentration of $10\mu\textrm{g}/ml$. These plants are promising candidates for the study of the activity-guided purification of active compounds and would be useful for the treatment of inflammatory diseases and endotoxemia accompanying the overproduction of NO.

• Biomolecules & Therapeutics
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• 제28권1호
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• pp.1-17
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• 2020

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that exert suppressive function on the immune response. MDSCs expand in tumor-bearing hosts or in the tumor microenvironment and suppress T cell responses via various mechanisms, whereas a reduction in their activities has been observed in autoimmune diseases or infections. It has been reported that the symptoms of various diseases, including malignant tumors, can be alleviated by targeting MDSCs. Moreover, MDSCs can contribute to patient resistance to therapy using immune checkpoint inhibitors. In line with these therapeutic approaches, diverse oligonucleotide-based molecules and small molecules have been evaluated for their therapeutic efficacy in several disease models via the modulation of MDSC activity. In the current review, MDSC-targeting oligonucleotides and small molecules are briefly summarized, and we highlight the immunomodulatory effects on MDSCs in a variety of disease models and the application of MDSC-targeting molecules for immuno-oncologic therapy.

• Journal of Dairy Science and Biotechnology
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• 제37권2호
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• pp.94-101
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• 2019

Probiotics stabilize intestinal microflora, reduce constipation, reduce decay by inhibiting harmful bacteria, and prevent diseases. Probiotics have also been studied for their possible roles in immune activation, treatment of cancer, remediation of cholesterol, treatment of diabetes, alleviation of allergies, and relief of lactose intolerance. However, recent data concerning the side effects of probiotics have prompted debate regarding their efficacy and safety. Major adverse events associated with probiotics are gastrointestinal symptoms, such as diarrhea, gastrointestinal disorders, and vomiting, along with skin rash and urticaria. Probiotics occasionally cause sepsis in infants with poor immunity and elderly people with severe diseases. In contrast to previous studies that described the efficacy of probiotics in intestinal regulation, some recent studies have reported that the activity of intestinal microbes becomes weak as a result of the influx of probiotics. The data indicate that the safety of probiotics is not guaranteed and that further investigations are needed.

• IMMUNE NETWORK
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• 제7권3호
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• pp.133-140
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• 2007

Background: It is well established that cross talk between natural killer (NK) cells and myeloid dendritic cells (DC) leads to NK cell activation and DC maturation. In the present study, we investigated whether type 1-polarized DC (DC1) matured in the presence of IFN-${\gamma}$ and type 2-polarized DC (DC2) matured in the presence of PGE2 can differentially activate NK cells. Methods: In order to generate DC, plastic adherent monocytes were cultured in RPMI 1640 containing GM-CSF and IL-4. At day 6, maturation was induced by culturing the cells for 2 days with cytokines or PGE2 in the presence or absence of LPS. Each population of DC was cocultured with NK cells for 24 h. The antigen expression on DC was analyzed by flow cytometry and cytokine production in culture supernatant was measured by ELISA or a bioassay for TNF-${\alpha}$ determination. NK cell-mediated lysis was determined using a standard 4h chromium release assay. Results: DC2, unlike DC1, had weak, if any, ability to induce NK cell activation as measured by IFN-${\gamma}$ production and cytolytic activity. DC2 were weakly stimulated by activated NK cells compared to DC1. In addition, IFN-${\gamma}$-primed mature DC appeared to be most resistant to active NK cell-mediated lysis even at a high NK cell/DC ratio. On the other hand, PGE2-primed DC were less resistant to feedback regulation by NK cells than IFN-${\gamma}$-primed mature DC. Finally, we showed that the differential effect of two types of DC population on NK cell activity is not due to differences in their ability to form conjugates with NK cells. Conclusion: These results suggest that different combinations of inflammatory mediators differentially affect the effector function of DC and, as a result, the function of NK cells, eventually leading to distinct levels of activation in adaptive immunity.

• Journal of Chest Surgery
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• 제48권5호
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• pp.371-374
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• 2015

We present a rare case of a patient with aortoiliac occlusive disease on the background of type A crossed renal ectopia, for whom open surgical intervention was required. Aortic exposure in patients with concomitant crossed renal ectopia can present technical challenges to the vascular surgeon. The knowledge of variations in the ectopic renal blood supply is of paramount importance when performing surgery to treat this condition and affects the choice of surgical exposure. We present and discuss the operative details of our patient and outline an approach to this subset of patients.