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Non-disturbing of Decidual Response by Steroid Hormonal Complexes of Pig Testis  

Yoo, Ja-Hyun (School of Biosciences and Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University)
Byun, Jee-Hyun (School of Biosciences and Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University)
Jeon, So-Ra (School of Biosciences and Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University)
Lee, Dong-Mok (School of Biotechnology, Yeungnam University)
Chun, Tae-Hoon (School of Life Sciences and Biotechnology, Korea University)
Lee, Ki-Ho (Dept. of Biochemistry and Molecular Biology, Eulji University School of Medicine)
Choi, In-Ho (School of Biotechnology, Yeungnam University)
Cheon, Yong-Pil (School of Biosciences and Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University)
Publication Information
Development and Reproduction / v.15, no.1, 2011 , pp. 53-59 More about this Journal
Abstract
Sex steroid hormones are key molecules to prepare the decidual response and their levels are important in this process. Imbalances of the levels of steroid hormones are cause of implantation failure and other diseases including physical weakness. Androgen replacement therapy or selective androgen receptor modulator are used to overcome various diseases but long-term use may cause of side effects. In previous report, it is suggested that the steroid hormonal complexes derived from pig enhance the proliferation of satellite cell. Therefore, to evaluate the possible usage of steroid hormonal complex derived from pig testis (tS-C), the effects of tS-C on uterine response were studied using the model of artificial decidua. tS-C did not disturb the rhythmical estrus cycle. Artificial-induced decidual response was normally induced in tS-C administered mice. The histological characters of the decidua of tS-C administered mice were not different from the vehicle. The expression patterns of molecular markers of decidua were not different between vehicle and tS-C group. Collectively these results suggested that tS-C does not disturb the uterine responsibility to the embryo. In addition, our results suggested that tS-C can be applied to overcome the various problems such as loss of muscle mass and anemia.
Keywords
Testis derived steroid hormonal complex; Artificial decidualization; Uterine responsibility;
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Times Cited By KSCI : 2  (Citation Analysis)
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