• 제목/요약/키워드: Wome

검색결과 13건 처리시간 0.024초

Intravenous and Intra-arterial Delivery of Plasmid DNA/Cationic Lipiodol Emulsion Complexes

  • Chae, Min-Jung;Chung , Hes-Son;Kwon, Ick-Chan;Chung, Jin-Wook;Park, Jae-Hyung;Sohn, Young-Taek;Jeong, Seo-Young
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.226.3-227
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    • 2003
  • A cationic lipid emulsion (o/w) containing lipiodol and 1, 2-dioleoyl-sn- glycero-3-trimethylammonium-propane (DOTAP) has been prepared as a gene delivery system. In order to increase the transfection efficiency of the lipiodol emulsion, 1 2-dioleoyl-sn-glycero-3-phospho-ethanolamine (DOPE) and polyoxyethylene sorbitan monooleate (Tween 80) were incorporated as additional lipids. By including DOPE and Tween 80, the cationic emulsion became a more potent gene carrier under in vitro condition in the presence of serum, and under in vivo condition. (omitted)

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근이영양증에 대한 착상전 유전진단에서 Duplex-nested PCR과 Fluorescent PCR 방법의 효용성 (Efficacy of Duplex-nested PCR and Fluorescent PCR in the Preimplantation Genetic Diagnosis for Duchenne Muscular Dystrophy)

  • 이형송;최혜원;임천규;박소연;김진영;궁미경;전진현;강인수
    • Clinical and Experimental Reproductive Medicine
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    • 제32권1호
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    • pp.17-26
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    • 2005
  • Objective: Preimplantation genetic diagnosis (PGD) is reserved for couples with a risk of transmitting a serious and incurable disease, and hence avoids the undesirable therapeutic abortion. In this study, we evaluated the efficacy of PGD for Duchenne muscular dystrophy (DMD) cases by the fluorescent PCR with polymorphic linked markers and the conventional duplex-nested PCR methods. Methods: Biopsy of one or two blastomeres was done from the embryos fertilized by ICSI on the third day after fertilization. We performed two cases of PGD-DMD by the duplex-nested PCR for the causative mutation loci and the SRY gene on Y chromosome. The triplex fluorescent PCR for the mutation loci, the SRY gene and the polymorphic microsatellite marker on X chromosome was applied for two cases of PGD-DMD. Results: By the duplex-nested PCR, successful diagnosis rate was 95.5% (21/22), but we could not discriminate the female embryos whether normal or carrier in this X-linked recessive disease. However, the triplex fluorescent PCR method showed 100% (27/27) of successful diagnosis rate, and all female embryos (n=17) were distinguished normal (n=10) from carrier (n=7) embryos. Unaffected and normal embryos were transferred into mother's uterus after diagnosis. A healthy normal male was achieved after PGD with the duplex-nested PCR method and a twin, a male and a female, were delivered with triplex fluorescent PCR method. The normality of dystrophin gene was confirmed by amniocentesis and postnatal genetic analysis in all offsprings. Conclusion: The fluorescent PCR with polymorphic marker might be useful in improving the specificity and reliability of PGD for single gene disorders.

한국인의 리보플라빈 일일필요량 측정을 위한 인체대사연구 (A Human Metabolic Study for Determination of Daily Requirement of Riboflavin)

  • 윤진숙
    • Journal of Nutrition and Health
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    • 제22권6호
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    • pp.507-515
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    • 1989
  • Ten healthy wome 2-~25 years participated in a 5-week metabolic study to investigate the daily riboflavin requirement of Korean women. Three daily menu and meal patterns were used. Low riboflavin(LR) diet provided riboflavin at a level of 0.71mg / 1000Kcal based on food composition table. High riboflavin(HR) diet provided 1.14mg / 1000Kcal. The riboflavin status was assessed by erythrocyte glutathione reductase activity coefficient(EGRAC) and urinary exretion of riboflavin. Mean EGRAC of LR period and HR period were 1.17+0.08 and 1.01+0.03, repectively. There were discrepanices of riboflavin content of experimental diet between chemical analysis and calculation by Korean food composition table. Urinary riboflavin excretion of subjects was acceptable over the whole study period. It appeared that 0.71mg / 1000Kcal is requirement of riboflavin to maintain EGRAC withing normal range. Thus, it is suggested that current recommendation of 0.6mg / 1000Kcal of riboflavin intake may not be adequate as RDA level in Korea.

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계수 표현 모델을 이용한 3차원 모델링 기법에 관한 연구 (A Study on 3D Modeling Technique using Parametric Representation)

  • 김태은
    • 디지털콘텐츠학회 논문지
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    • 제5권3호
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    • pp.176-179
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    • 2004
  • 효율적인 물체인식을 위해서는 물체의 형상특징을 직선적으로 기술할 수 있는 체적소 기반 물체 표현 방법이 필요하다. 본 논문에서는 몇 개의 계수를 가지고 3차원 정보를 효과적으로 표현할 수 있는 superquadric을 이용하여 기본적인 3차원 물체를 모델링 한다. 그리고 보다 복잡하고 정교한 물체의 표현을 위해서 변형된 superquadric을 함에 이용한다. 이렇게 만들어진 개개의 3차원 모델에 z-buffer 알고리즘을 적용하여 하나의 완전한 3차원 물체로 표현하는 방법을 제시하고 실험을 통해 그 유용성을 입증하였다.

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브래지어 원형 설계 - 75A를 중심으로- (Development of the Basic brassiere pattern - focusing on 75A -)

  • 박유신;장은영
    • 패션비즈니스
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    • 제12권1호
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    • pp.109-119
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    • 2008
  • The purpose of this study is to dvelop the basic pattern of wome which are fitting for 75A. The collected data were statistcally processed usig the SPSS 10.0 for Mans Standard Deiation, Cronbach's $\alpha$, etc. This study suggested a size chart for body measurement for constructing basic brssiere patterns with size of 75A. The construction of this experimental brassiere were lower cup, upper cup, front panel and wing and characterized by a round cup wired as well as a full cup embrcing the entire breasts. The drafting method for constructing basic brassiere patterns for 75A was completed by selecting a total of 11subjects, and two wearing tests were carried out with the subjects. the dimensions and shapes of the basic brassiere pattern suggested in this research proved to be fitting and to have a wearing effect that brings together and supports the breasts.

보건소 건강교실 참여가 중,고령 여성의 대사증후군과 질병 발병 위험에 미치는 효과 (The Effect of Public Health Center Program participation on Metabolic Syndrome and Risk of Disease in Middle- aged and Elderly Women)

  • 이용수
    • 한국융합학회논문지
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    • 제7권6호
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    • pp.317-325
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    • 2016
  • 본 연구의 목적은 30세 이상의 보건소 건강교실에 자발적으로 참여한 여성을 대상으로 대사증후군 개선을 위한 운동과 영양 프로그램으로서 교육 중재프로그램의 제공 효과를 검증하는 것이다. 서울시 동북부 지역에 위치한 보건소 비만클리닉 참여자 400명 중 12주간의 비만 클리닉 프로그램을 이수한 120명의 여성을 대상으로 하였다. 운동 및 영양 프로그램으로 구성된 건강교실 프로그램을 매주 1일, 운동과 영양 각 1시간씩 12주간 실시하여 보건소 건강교실 참여자의 대사증후군 위험요인에 미치는 영향을 평가하였다. 중재 전, 후의 대사증후군 위험인자와 형태요인 변화량과 변화율 분석을 통하여 대사증후군과 질병발병 위험율의 개선 여부를 검증하였다. 주1회, 회당 2시간, 12주간의 건강교실 프로그램 제공을 통해 참가자들의 허리둘레(p<.001), 수축기혈압(p<.001), 이완기혈압(p<.001), 체질량지수(p<.001) 감소를 확인하였다. 또한 50대 이후 연령대에 비해 50대 이전 연령대에서 체중(p<.01), 허리둘레(p<.05), BMI(p<.01), 지방량(p<.05)가 더 많이 감소하였다.

복합운동의 운동유형 순서변화가 비만여성에게 미치는 영향 (The Effect of Changing the Order of Exercise Types on Body Composition and Blood Lipid in Obese Women)

  • 한창수;이규승;이무식;황혜정
    • 한국산학기술학회논문지
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    • 제10권12호
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    • pp.3888-3894
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    • 2009
  • 본 연구는 복합운동 유형 순서 변화에 따른 생리적, 생화학적 변화를 비교 하고자 40대 비만여성(n=18)을 대상으로 12주간 복합운동을 실시하였다. 복합운동 유형은 유산소성 운동과 저항성 운동그룹 A(n=9) 그리고 저항성 운동과 유산소성 운동그룹 B(=9)로 구성하였다. 체지방량의 경우 A그룹의 평균변화량이 B그룹 평균변화량보다 더 많이 감소하였고 통계적으로 유의한 차이를 보였다(p<0.01). 혈당의 경우는 A그룹보다는 B그룹이 더 많이 감소하였으며 통계적으로 유의한 차이를 보였다(p<0.01). 따라서, 비만 중년 여성의 체중감량을 위한 신체구성 변화 유도를 위해서는 복합운동의 순서 변화에 따른 운동유형이 선택적으로 사용되어질 수 있다.

인공임신 중절 경험 부인에 대한 지식, 태도 및 실천에 관한 조사연구 (A study on Knowledge, Attitude and Practice about women who experienced induced abortion)

  • 김상혜
    • 대한간호학회지
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    • 제8권2호
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    • pp.51-61
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    • 1978
  • Important object of this survey is for promoting of maternal health and popularizing a right recognition which analyzed and study about knowledge, Attituded and Practice about women who experienced induced abortion. This surveyed materials obtained from total 300 wome (each 150 cases) who experienced induced abortion at Obstetrics and Gynecological Department in K university hospital and D health center in Seoul for 1 month. (1978. 9. 1.-1978. 9. 30) Their Results are as follows: A. General characteristics of surveyed cases, The highest age distribution was between 30-34 (29.3%) in health center, upper than 40 (32.7%) in University hospital. B. Knowledge 1. Knowledge about the induced abortion obtained mainly from their friends in 36.4% and Hospital in 20.7%. 2. The rate of Women who have dangerous thinking about induced abortion was 63.3%. C. Attitude 1. The rate of women who gained guilt feeling after induced abortion was 52.7%, out of total 41.4% was responsed careless thinking if they have a proper reason. 2. Attitude about induced abortion when they have unwanted baby was absolutely necessary in 57.3%, relatively necessary in 30.6%, that is, most of women showed to want induced abortion if necessary. D. Practice 1. The women who have experienced induced abortion was only one times in 44.7%, two times in 22.0%, three times in 17.7%, total average times were 2.3. 2. The reason for induced abortion was highest due to limitation of family (38.0%), next failure of Contraception (15.8%). 3. The operating sites of induced abortion were local clinics in 93.0%, universal hospital in 7.0%. The difference was remakable. 4. The rate of complicated cases after induced abortion was 54.7%, among them, general weakness in 32.3%, vaginal bleeding or spotting in 23.8% and abdominal discomfortness or lumbago in 17.7%. When symptom appeared, the rate of treated Cases was 74.4%, their sites were general hospitals in 54.1%, local clincis in 18.0%, Herb medications in 15.6% and pharmaceutics in 12.3 in that order. 5. The average times of induced abortion follows by educational level were 2.6 in graduated elimentary school group, each 2.4 in graduated middle school and College group, 2.2 in graduated high school in that order. 6. The average times of induced abortion follows by ages were most with 3.3% in upper than 40 years old. The average times of all surveyed cases were 2.3.

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