• Journal of Veterinary Clinics
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• v.27 no.4
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• pp.343-347
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• 2010

The purpose of this study was to determine the antagonistic effects of yohimbine on sedation induced in dogs with medetomidine. Six mixed breed dogs were repeatedly used at a 2 weeks withdrawal time in this study. The dogs received $40\;{\mu}g/kg$ of medetomidine followed 15 minutes later by 0.2 ml/kg saline solution (group M) or 0.11 mg/kg yohimbine (group MY). All the dogs were examined before and 5, 15, 30, 45, 60, 75, 90, 120 and 150 minutes after the injection of medetomidine, and the induction and recovery times, vital signs, blood biochemistry and anesthetic quality were recorded. There were significant differences in the recovery of anesthesia between the groups. In both groups the heart rate decreased rapidly down to five minutes after the administration of medetomidine. The activity of ALT, AST and the protein concentration did not change significantly in either group and there was no significant difference between them at any time. Response to noise, muscle tone and analgesic score in the MY group at 30 minutes were significantly lower than those of the M group. When recovering from anesthesia, the dogs treated with yohimbine took less time to achieve sternal recumbency and less time to be able to stand and walk. It was concluded that yohimbine reversed effectively medetomidine sedation in dogs.

• Tuberculosis and Respiratory Diseases
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• v.60 no.1
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• pp.83-91
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• 2006

Background : For unknown reasons, the serum ferritin concentrations are higher in patients with acute lung injury. A pretreatment with aspirin reduces the acute lung injury in rats subjected severe hemorrhage, and increases the rate of ferritin synthesis in vitro. This study investigated the effect of aspirin on the serum ferritin changes in rats subjected to severe hemorrhage. Methods : Hemorrhagic shock was induced by withdrawing blood (20 ml/kg of B.W.) through the femoral artery for 5 min. The rats were pretreated with aspirin (10 mg/kg, i.v.) 30 min before hemorrhage. Results : The protein content and leukocyte count in the bronchoalveolar lavage fluid, lung tissue myeloperoxidase activities were significantly higher after hemorrhage. The aspirin pretreatment prevented these changes. The serum and lavage fluid ferritin concentrations were elevated higher after hemorrhage. These were also attenuated by the aspirin pretreatment. Conclusion : The changes in the serum and lung lavage ferritin level might be closely related to the severity of hemorrhage-induced acute lung injury. Therefore, the serum and lavage ferritin concentrations can be a useful biomarker for patients with precipitating conditions.

• The KIPS Transactions:PartD
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• v.9D no.4
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• pp.587-602
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• 2002

Replicated database system was emerged to resolve the problem of reduction of the availability and the reliability due to the communication failures and site errors generated at centralized database system. But if update transactions are many occurred, the update is equally executed for all replicated data. Therefore, there are many problems the same thing a message overhead generated by synchronization and the reduce of concurrency happened because of delaying the transaction. In this paper, I propose a new concurrency control algorithm for enhancing the degree of parallelism of the transaction in fully replicated database designed to improve the availability and the reliability. To improve the system performance in the replicated database should be performed the last operations in the submitted site of transactions and be independently executed update-only transactions composed of write-only transactions in all sites. I propose concurrency control method to maintain the consistency of the replicated database and reflect the result of update-only transactions in all sites. The superiority of the proposed method has been tested from the respondence and withdrawal rate. The results confirm the superiority of the proposed technique over classical correlation based method.

• Journal of Korea Water Resources Association
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• v.53 no.8
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• pp.605-616
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• 2020

The purpose of this study is to assess the future hydrological and water quality change of Man-gyeong river basin (1,602 ㎢) based on future extreme climate change scenarios and reduction of inter-basin water transfer amount using SWAT (Soil and Water Assessment Tool). The SWAT was calibrated (2012~2014) and validated (2016~2018) at 2 water level observation stations (DC, JJ) and 2 water quality observation stations (SR, GJ) considering inter-basin water transfer amount, stream water withdrawal, and point source data. For the streamflow, the coefficient of determination (R²) was 0.70 and the average Nash-Sutcliffe efficiency (NSE) was 0.51 respectively. For the water quality of SS, T-N, and T-P, the R² was 0.72, 0.80 and 0.72 respectively. The future average streamflow under climate change scenarios increased up to 459 mm/yr, and average SS, T-N and T-P yields also increased up to 19,548 ton/yr, 68,748 kg/yr, and 13,728 kg/yr respectively. When the amount of inter basin water transfer decreased, the streamflow especially decreased in spring and winter periods, and the future water quality yields increased under the influence of precipitation. In order to solve the deterioration of water quality due to decrease in the flow rate and an increase in the load, the amount of inter basin water transfer should be maintained to a certain level.

• Fire Science and Engineering
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• v.31 no.5
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• pp.63-69
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• 2017

This study describes the development of a long-distance hose for ultra-high pressure operation, which can be used in conjunction with an ultra-high pressure pump and can be effectively applied to the fire suppression of high-rise buildings and a long, large tunnels. Also, it has phosphorescent properties, which can help to secure the withdrawal route of the fire-fighters when they are threatened by the fire. We developed an ultra-high pressure hose aiming at a pressure of 3 MPa and a flow rate of 2000 lpm and developed an ultra-high pressure fire hose that can withstand this very high pressure by using a double jacket, triple polyurethane coating and warf (Wp) of 52. In order to ensure the performance of the developed ultra-high pressure hose, its structure, appearance, leakage at high pressure, length and elongation were inspected by a certified certification agency, who also subjected it to a peeling test, friction test, breaking pressure test and free fall test. Also, it was studied in addition to the luminescent high-pressure hose for fire-fighting. In the phosphorescence test, the luminance measurement value was more than the reference value of the luminance test after 40 minutes, which confirmed that its performance was satisfactory for fire-fighting products. In the future, if such an ultra-high pressure fire hose were commercialized and applied in the field, it could contribute to securing improved fire suppression and safer exit from fires, as compared to the fire hoses currently used in the suppression of fires in skyscraper buildings and long tunnels.

• Korea Trade Review
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• v.43 no.5
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• pp.25-45
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• 2018

This paper estimates the export losses of the Korean domestic automobile industry due to US trade pressure and its economic ripple effects. Using the HS 6 digit tariff and export data from 2010 to 2017, this paper estimates the tariff elasticity of Korea's US automobile exports against a US tariff increase by applying the Poisson Pseudo maximum likelihood estimation method. After estimating Korea's export losses to the US in three trade pressure scenarios, we estimate its impact on Korean domestic production, value-added and job creation by applying the tariff impact accumulation model based on the industry input-output analysis. Empirical results show that the impact of 25% global tariff by the US on the Korean domestic economy is estimated to result in $30.8 billion in export losses for the five years from 2019 to 2023, about 300 thousand job losses, 88.0 trillion in production inducement losses, and 24.0 trillion in value-added inducement losses. The impacts of withdrawal of the automobile tariff concession are estimated at $4.27 billion export losses and 41.7 thousand job losses. A 15% tariff rate on automobile parts for 3 years is estimated to result in $1.93 billion export losses and 18.7 thousand job losses.

• Korea Trade Review
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• v.41 no.2
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• pp.61-96
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• 2016

This study investigates the effects of M&A experience of Chinese firms and characteristics of deal partners in cross border M&A deal failures. 1,610 firms that participated in 1,558 cross border M&As from 2000 to November 2015 are used as samples. The dependent variable is the M&A transaction failures, which were cases of deal pending or withdrawal of Chinese firms. Major independent variables are the nationality diversity of transaction partner firm, the partner firm belonging to a developed country, domestic M&A experience of the Chinese firms, M&A experience in a particular target country, etc. After conducting a probit model analysis, we find that deal partner firm's nationality diversity increases the failure rate of M&A. While prior domestic M&A experience in China has no influence on deal failure, prior M&A experience of Chinese and focal firms in a particular country have a negative effect on the probability of deal failure. This study has academic implication on figuring out why firms are likely to fail in the process of strategic activities based on the inter-organizational learning through partnerships perspective.

• The Korean Society of Law and Medicine
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• v.17 no.1
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• pp.299-346
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• 2016

There were also various decisions made in medical area in 2015. In the case that an inmate in a sanatorium was injured due to the reason which can be attributable to the sanatorium and the social welfare foundation that operates the sanatorium request treatment of the patient, the court set the standard of fixation of a party in medical contract. In the case that the family of the patient who was declared brain dead required withdrawal of meaningless life sustaining treatment but the hospital rejected and continued the treatment, the court made a decision regarding chargeable fee for such treatment. When it comes to the eye brightening operation which received measure of suspension from the Ministry of Health and Welfare for the first time in February, 2011, because of uncertainty of its safety, the court did not accept the illegality of such operation itself, however, ordered compensation of the whole damage based on the violation of liability for explanation, which is the omission of explanation about the fact that the cost-effectiveness is not sure as it is still in clinical test stage. There were numerous cases that courts actively acknowledged malpractices; in the cases of paresis syndrome after back surgery, quite a few malpractices during the surgery were acknowledged by the court and in the case of nosocomial infection, hospital's negligence to cause such nosocomial infection was acknowledged by the court. There was a decision which acknowledged malpractice by distinguishing the duty of installation of emergency equipment according to the Emergency Medical Service Act and duty of emergency measure in emergency situations, and a decision which acknowledged negligence of a hospital if the hospital did not take appropriate measures, although it was a very rare disease. In connection with the scope of compensation for damage, there were decisions which comply with substantive truth such as; a court applied different labor ability loss rate as the labor ability loss rate decreased after result of reappraisal of physical ability in appeal compared to the one in the first trial, and a court acknowledged lower labor ability loss rate than the result of appraisal of physical ability considering the condition of a patient, etc. In the event of any damage caused by malpractice, in regard to whether there is a limitation on liability in fee charge after such medical malpractice, the court rejected the hospital's claim for setoff saying that if the hospital only continued treatments to cure the patient or prevent aggravation of disease, the hospital cannot charge Medical bills to the patient. In regard to the provision of the Medical Law that prohibit medical advertisement which was not reviewed preliminarily and punish the violation of such, a decision of unconstitutionality was made as it is a precensorship by an administrative agency as the deliberative bodies such as Korean Medical Association, etc. cannot be denied to be considered as administrative bodies. When it comes to the issue whether PRP treatment, which is commonly performed clinically, should be considered as legally determined uninsured treatment, the court made it clear that legally determined uninsured treatment should not be decided by theoretical possibility or actual implementation but should be acknowledged its medical safety and effectiveness and included in medical care or legally determined uninsured treatment. Moreover, court acknowledged the illegality of investigation method or process in the administrative litigation regarding evaluation of suitability of sanatorium, however, denied the compensation liability or restitution of unjust enrichment of the Health Insurance Review & Assessment Service and the National Health Insurance Corporation as the evaluation agents did not cause such violation intentionally or negligently. We hope there will be more decisions which are closer to substantive truth through clear legal principles in respect of variously arisen issues in the future.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.6
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• pp.464-468
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• 2008

Purpose: Effective half life of I-131 ($T_{eff}$) in patients with differentiated thyroid cancer treated by I-131 is must-know value for dose calculation and determination of release time from isolation room. There has been no report about $T_{eff}$ in Koreans. Thus, author tried to measure dose rate without radiation exposure to faculty members and calculated $T_{eff}$. Methods: Probe of radiation survey meter was fixed at the wall of isolation room, and body of survey meter was placed outside the room. With this simple arrangement, author could measure radiation frequently without radiation exposure to faculty members in 68 patient (F=55, M=13, age=$47{\pm}13.7$) treated by I-131 ($3.7{\sim}7.4\;GBq$) for differentiated thyroid cancer from Jan 2006 to Dec 2006. From this data, $T_{eff}$, 48 hr retention rate, and the time necessary to whole body retention of I-131 become less than 1.1 GBq were calculated. Serum creatinine levels were measured before and after thyroid hormone withdrawal. Results: $T_{eff}$ was $15.4{\pm}4.3\;hr$ ($9.4{\sim}32.5\;hr$). There was a loose correlation between $T_{eff}$ and serum creatinine concentration (r=0.45). 48hr retention was $4.9{\pm}4.2%$ ($1{\sim}23%$). Time necessary to whole body retention of I-131 become less than 1.1 GBq was calculated as $47.1{\pm}13.2\;hr$ for 9.25 GBq, $42.1{\pm}11.9\;hr$ for 7.4 GBq, $35.7{\pm}10.0\;hr$ for 5.55 GBq, and $26.7{\pm}7.5\;hr$ for 3.7 GBq dose of I-131. Conclusion: Author successfully measured radiation dose rates in isolated patients treated by high dose of I-131 without radiation exposure to the faculty members with simple arrangement of survey meter probe. Using those data, $T_{eff}$ and some other indices were calculated.

• Journal of fish pathology
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• v.34 no.1
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• pp.71-80
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• 2021

Cephalexin, a semi-synthetic cephalosporin antibiotic, has long been used in fish aquaculture in various countries under legal authorization. The drug is thus widely available for use in other aquatic species except fishes like the crustacean whiteleg shrimp. This study aims to develop a sensitive method for laboratory residue studies to adopt in withdrawal period determinations. Through repeated trials from the existing methods developed for other food animal tissues, it was possible to achieve a sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. The results showed that at a concentration of 0.1 mg/kg, the recovery rate was 81.79%, and C.V. value was 8.2%, which meet the recovery rate and C.V. recommended by Codex guideline. After satisfactory validation of analytical procedures, applicability to the shrimp tissue was confirmed in experimentally cephalexin-treated whiteleg shrimp. As a result, most muscle samples were detected below the limit of quantification (0.05 mg/kg) after day 3, and most hepatopancreas samples were detected below the limit of quantification after day 14. In particular, the limit of quantification 0.05 ppm with the presently developed method suggests sufficient sensitive over the current legal maximum residue limit of 0.2 mg/kg set for fishes.