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Medetomidine Sedation and Its Antagonism by Yohimbine in Dogs  

Heo, Keong-Hee (College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University)
Lee, Jae-Yeon (College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University)
Choi, Kyeong-Ha (College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University)
Cho, Jin-Haeng (College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University)
Park, Chang-Sik (Division of Animal Science & Resources, Research Center for Transgenic Cloned Pigs, Chungnam National University)
Kim, Myung-Cheol (College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.27, no.4, 2010 , pp. 343-347 More about this Journal
Abstract
The purpose of this study was to determine the antagonistic effects of yohimbine on sedation induced in dogs with medetomidine. Six mixed breed dogs were repeatedly used at a 2 weeks withdrawal time in this study. The dogs received $40\;{\mu}g/kg$ of medetomidine followed 15 minutes later by 0.2 ml/kg saline solution (group M) or 0.11 mg/kg yohimbine (group MY). All the dogs were examined before and 5, 15, 30, 45, 60, 75, 90, 120 and 150 minutes after the injection of medetomidine, and the induction and recovery times, vital signs, blood biochemistry and anesthetic quality were recorded. There were significant differences in the recovery of anesthesia between the groups. In both groups the heart rate decreased rapidly down to five minutes after the administration of medetomidine. The activity of ALT, AST and the protein concentration did not change significantly in either group and there was no significant difference between them at any time. Response to noise, muscle tone and analgesic score in the MY group at 30 minutes were significantly lower than those of the M group. When recovering from anesthesia, the dogs treated with yohimbine took less time to achieve sternal recumbency and less time to be able to stand and walk. It was concluded that yohimbine reversed effectively medetomidine sedation in dogs.
Keywords
medetomidine; sedation; yohimbine; antagonism;
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