• 제목/요약/키워드: Whole-core

검색결과 455건 처리시간 0.024초

Long-term cosmesis following a novel schedule of accelerated partial breast radiation in selected early stage breast cancer: result of a prospective clinical trial

  • Sayan, Mutlay;Hard, Daphne;Wilson, Karen;Nelson, Carl;Gagne, Havaleh;Rubin, Deborah;Heimann, Ruth
    • Radiation Oncology Journal
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    • 제35권4호
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    • pp.325-331
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    • 2017
  • Purpose: There is controversy regarding the cosmetic outcome after accelerated partial breast radiation (APBR). We report the cosmetic outcome from a single-arm prospective clinical trial of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I breast cancer (BC), using a novel fractionation schedule. Materials and Methods: Forty-two patients aged ${\geq}65$, with Stage I BC who underwent breast-conserving surgery were enrolled in a phase I/II study evaluating a 2-week course of APBR. Thirty eligible patients received 40 Gy in 4 Gy daily fractions. Cosmetic outcome was assessed subjectively by physician/patient and objectively by using a computer program (BCCT.core) before APBR, during, and after completion of the treatment. Results: The median age was 72 years, the median tumor size was 0.8 cm, and the median follow-up was 50.5 months. The 5-year locoregional control in this cohort was 97% and overall survival 87%. At the last follow-up, patients and physicians rated cosmesis as 'excellent' or 'good' in 100% and 91 %, respectively. The BCCT.core program scored the cosmesis as 'excellent' or 'good' in 87% of the patients at baseline and 81% at the last follow-up. The median $V_{50}$ (20 Gy) of the whole breast volume (WBV) was 37.2%, with the median WBV $V_{100}$ (40 Gy) of 10.9%. Conclusion: An excellent rate of tumor control was observed in this prospective trial. By using multiple assessment techniques, we are showing acceptable cosmesis, supporting the use of IMRT planned APBR with daily schedule in elderly patients with early stage BC.

덕인식론에서 역량과 성품의 개념적 이해: 『논어(論語)』에서 '총명(聰明)'과 '정직함'을 중심으로 (A Conceptual Contour of Character and Capacity in Virtue Epistemology: Focusing on sagacity and honesty in the Analects)

  • 이찬
    • 철학연구
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    • 제123호
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    • pp.239-264
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    • 2018
  • 덕인식론과 지행론의 전체적인 구도를 이해하기 위한 선행 과제로서 나는 이 글에서 덕(德)과 관련한 개념들 가운데 역량과 성품이 지적 덕성과 어떤 연관에 놓여 있는지 정리하고자 한다. 애초 이 글은 똑똑하다고 칭찬받는 사람들이 왜 나쁜 일들을 스스럼없이 저지르는가에 대한 소박한 의문에서 출발한다. 이런 의문은 윤리적인 문제일 수도, 인식론적인 주제일 수도 있다. 왜냐하면무엇을 어떻게 인식할 것인가라는 인식론적인 질문은 결국 인식론이 규범적인영역에 속하며 인식론적인 평가에서 지적인 행위자와 그 공동체를 중시해야 한다는 것을 의미하기 때문이다. 이것은 '덕인식론'의 핵심적인 관점이다. 지식의정당화에 있어서 덕인식론이 '덕성'에 초점을 맞추고 있다는 점은 동아시아 전통의 '지행론'과 닮았지만 그 문제의식은 다르다. 따라서 덕인식론과 지행론의같고 다른 점을 우선 살펴보고 "논어"를 중심으로 역량, 성품, 지적 덕성의 관계를 검토할 것이다. 이 작업에서 나는 역량과 성품이 규범적인 가치의 문맥으로 조율되지 않으면 올바른 행위를 산출하는 지적 덕성이 되기에 부족함을 말할 것이다.

생명 문화 정립을 위한 시론적 모색 (Contemporary Explorations to Establish Life Culture)

  • 이재복
    • 비교문화연구
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    • 제21권
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    • pp.165-188
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    • 2010
  • One of the things that should be done first in establishing the cosmic life culture is to reflect on the old human-oriented culture. If the cosmic life culture absolutizes everything except for humans according to the logic of reason, its foundation will weaken or eventually get lost. Separating humans from the universe is just like separating life from it. Given that all life, whether it is humans or the earth, originated from the universe, such an effort for separation merely values an individual life by excluding all life or whole life. When the human body and the cosmic chi' blood are not in an active flow, it means there is a problem with life. What is in the greatest need in such a case is the sincere human mind that follows the principle of cosmic life. It is like the sincerity found in the pasonri singer, who mellows all the hardships and difficulties in the world out and create songs out of them like the shadow. It is the pansori singer's shadow that changes the universe. It is only when the extreme force of human mind communicates with that of the universe that the cosmic life or cosmic life culture can be created. In that sense, it is urgent to create life out of the universe inside me and create a universe out of all life in and outside me. It is such a grave plan in human history in that it involves finding the "Sanal" which is the core of life living hidden inside the body whose life force gradually goes away or inside the universe, and creating the culture of Bokseung in which it bursts out. The most important thing in life is the flow, and the mankind is currently standing in the life flow of the massive universe's chaosmos. The greatest task the mankind is currently faced with is to think over how to deal with the period of Big Chaos in the massive universe's chaosmos reversely and establish the cosmic life culture anew.

국제 바칼로레아를 접목한 창의적 스토리텔링 교재 교육 효과 분석 (Analysis of the Educational Effect of Creative Storytelling Textbooks Incorporating International Baccalaureate)

  • 최은선;박남제
    • 한국융합학회논문지
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    • 제12권1호
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    • pp.143-151
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    • 2021
  • 첨단 기술과 소프트웨어의 중요성이 부각되는 4차 산업 혁명 시대에는 단편적 지식의 습득으로 이루어진 3차 산업 시대의 교육에서 탈피해야 한다는 목소리가 높아짐에 따라, 인간과 미래에 대해 깊이 사유하고 인류 전체에 기여할 수 있는 창의적 인간을 길러내는 교육이 요구된다. 본 논문은 제주대학교 과학기술사회연구센터에서 개발한 『혼자서도 쉽게 하는 창의 스토리텔링』 교재에 접목된 창의적 스토리텔링 교수법 활용 교육에 적용할 수 있도록 국제 바칼로레아의 지향점에 따라 분석한 핵심 역량 및 평가를 도입할 수 있는 방안을 제안하고 이에 대한 교육적 함의를 고찰하여 교육적 효과를 분석하고자 한다. 또한, IB를 접목하여 제안된 핵심역량, 평가 기준 및 그 방안을 기존 수업에 유연하게 적용하여 활용의 기회를 확대하도록 하였다. 본 논문으로 국내 IB 도입에 긍정적 가능성을 여는데 도움이 되길 바라며, 나아가 국제적으로 인정받는 창의 융합 인재 양성에 기여할 것으로 기대한다.

Verification of a novel fuel burnup algorithm in the RAPID code system based on Serpent-2 simulation of the TRIGA Mark II research reactor

  • Anze Pungercic;Valerio Mascolino ;Alireza Haghighat;Luka Snoj
    • Nuclear Engineering and Technology
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    • 제55권10호
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    • pp.3732-3753
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    • 2023
  • The Real-time Analysis for Particle-transport and In-situ Detection (RAPID) Code System, developed based on the Multi-stage Response-function Transport (MRT) methodology, enables real-time simulation of nuclear systems such as reactor cores, spent nuclear fuel pools and casks, and sub-critical facilities. This paper presents the application of a novel fission matrix-based burnup methodology to the well-characterized JSI TRIGA Mark II research reactor. This methodology allows for calculation of nuclear fuel depletion by combination and interpolation of RAPID's burnup dependent fission matrix (FM) coefficients to take into account core changes due to burnup. The methodology is compared to experimentally validated Serpent-2 Monte Carlo depletion calculations. The results show that the burnup methodology for RAPID (bRAPID) implemented into RAPID is capable of accurately calculating the keff burnup changes of the reactor core as the average discrepancies throughout the whole burnup interval are 37 pcm. Furthermore, capability of accurately describing 3D fission source distribution changes with burnup is demonstrated by having less than 1% relative discrepancies compared to Serpent-2. Good agreement is observed for axially and pin-wise dependent fuel burnup and nuclear fuel nuclide composition as a function of burnup. It is demonstrated that bRAPID accurately describes burnup in areas with high gradients of neutron flux (e.g. vicinity of control rods). Observed discrepancies for some isotopes are explained by analyzing the neutron spectrum. This paper presents a powerful depletion calculation tool that is capable of characterization of spent nuclear fuel on the fly while the reactor is in operation.

농촌지역 산업 기술지식의 융합과 지식 네트워크: 순창군 장류산업을 중심으로 (Technological Convergence and Knowledge Network in Rural Area: Fermented Soy Product Manufacturing Industry in Sunchang, Korea)

  • 허동숙;박소현;구양미
    • 한국경제지리학회지
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    • 제19권3호
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    • pp.566-582
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    • 2016
  • 본 연구는 기술지식의 융 복합화로 인해 특정 산업에서 다른 부분으로 영역이 확장되는 양상을 확인하는 것으로, 비수도권 농촌 지역인 전라북도 순창군의 장류산업을 중심으로 분석하였다. 이를 위해 특허출원 자료를 이용하여 기술융합분석과 지식네트워크분석을 실시하였다. 분석 결과, 국내 장류산업은 단순 식품, 식료품 제조 기술에서 기계 기기나 의약품 및 화장품 관련 기술로 폭넓게 융합이 이루어지는 반면 순창군의 장류산업은 발효미생물 관련 기술 방향으로 특화되고 있다. 이는 산업 전체의 융합 경향을 따라 여러 기술 분야로 확장하기 보다는 순창이 갖는 지역자산과 인력에 맞추어 지역산업을 특화시킨 결과라고 판단된다. 순창군 장류산업의 지식네트워크는 지방정부와 대학, 진흥원 등 공공부문이 주도적인 역할을 하고 있고, 최근 조합법인 형태의 출원자와 공공부문의 협력을 통해 지역 내 기술 공유와 확산을 가져오는 것으로 나타났다.

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지방테마과학관의 실태분석 및 특성화방안 고찰 (Analysis of Actual Conditions and Consideration of Specification Plan of Local Theme Science Museum)

  • 정진주
    • 한국농촌건축학회논문집
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    • 제11권3호
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    • pp.1-9
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    • 2009
  • Through 'Local Theme Science Museum' aid program that is one of emphasis promotion strategic project by 2007 'Science.Technology.Cultural Project Plan', raises status of scientific technique by national core ability because all people expand base that understand and support scientific technique, and forms a social atmosphere which is scientific technique is important which scientific technique can be spread widely on national life and society whole, and proceeds target that expand local science museum facilities by a base of local science culture spreading and popularization. Accordingly, to plan balanced regional development and utilize to an advanced base of local science culture spreading because offer a science culture experience opportunity to local inhabitants, 'Local theme science museum' project is doing for that establish more 100 science museums for national.public.private institution in whole country until 2012 year. Support 39 projects to 2008 from 1999 thereby, in January, 2009, 13 'Local theme science museum' is opened and operated. This study examined arrangement preferentially about 'Science.Technology.Cultural Project Plan' that is background of 'Local theme science museum' project. Since surveying science museum which is on opening and operation at the present and analyzed actual conditions and facilities and investigated specification necessity and direction of 'Local theme science museum'. Hereafter, to seek plan for propriety of project by characteristic and difference of 'Local theme science museum' is purpose of this study. Now, need set and promotion of following specification direction for right activation of proceeding 'Local theme science museum' by each area. First, differentiation of theme and justifiability of building, Second, propriety of site position, Third, maximization of synergy effect by mixing concept of 'Specialized Economic Zone for Regional Developmental Policy' and Ecomuseum's 'Theme center'.

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S/W 벤처기업의 특성별 경영 현황분석 (An Analysis of the Whole Area of Business Administration by the Characteristics in the Software Venture Business)

  • 손성호;한계섭
    • 한국정보시스템학회지:정보시스템연구
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    • 제10권1호
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    • pp.323-352
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    • 2001
  • Venture business plays a great role in creating national competitive power in every country. In particular, software venture business can mostly belong to manufacturing business, and takes the top seat of core industry as the basis of globalization, informatization and localization as well as the driving force of national competitive power. However, software venture business still has some risks in the whole area of business administration including the process of business starting. There are also problems to be solved in such areas as manager's ability, leadership, talent, level of technical development, marketing channel, recruiting of marketing specialists, financial plan and fund raising. In this respect, this study divides 102 software venture businesses into two; business in the stage of growth and matured business through the analysis of questionnaire and analyzes their present managerial conditions according to their characteristics after classifying them into four categories such as general management, technical development, marketing, finance and accounting. Therefore, this study attempts to provide the basic data useful for business activities of software venture business from now on. The results are as follows; First, it can be judged that software venture businesses make efforts for their technical development in their character, and that they make a great investment in research and development. Consequently, it can be believed that this kind of investment must be continued in the future. Second, it can be seen that they are not much interested in marketing and its manpower. In fact, software venture businesses develop products technically at the risk of their life, while marketing plays an important role in the continuity of business. Thus, it is necessary for them to invest in the supplement of manpower in marketing. Third, it is observed that they generally have some difficulties in raising money from outside. By the way, it. is believed that this problem will be solved by appealing to the persons interested such as investors and creditors, if evaluation system would be developed more exquisitely so that their accounting and technical value may be appraised.

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지속적 개발의 '지속성' 개념에 관한 법학적 접근 (Legal Approach to the Concept of 'Sustainability' in Sustainable Development)

  • 서원상
    • 환경정책연구
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    • 제3권2호
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    • pp.59-87
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    • 2004
  • In its Declaration of Principles, the United Nations Conference on Environment and Development recommends that, "to achieve sustainable development and a higher quality of life for all people, states should reduce and eliminate unsustainable patterns of production and consumption...." This notion of sustainability lies at the core of many "commons" problems, where the central issue is to enable "individuals to sustain long-term, productive use of natural resource systems". In other worlds, a common definition of "sustainability" captures the idea of aligning human consumption with the capacity of ecological systems to supply, over a long period of time, such natural resources as air, soil, or water on which production depends. The concept of sustainability raises all sorts of political, social, and economic questions about the distribution of environmental protection. For sustainable community development to be addressed, these questions must be raised. In order to convince different citizenry of the necessity of sustainability, these questions must also be answered. This is where questions of equity, justice, and fairness arise. Sustainability and equity require that we deal with nature as an undivided whole, with no part being unsustainable. Sustainability and social policy also requires that we deal with the human population as an undivided whole. We simply cannot move people around the planet to either perpetuate past practices of earth exploitation or to implement sustainable planning. Everyone must work with the people inhabiting sensitive ecological areas, especially areas of regeneration. In the sustainable global community, we are as strong as our weakest link, or our most toxic community. This is the undeniable driving force for the infusion of equity into the sustainable development debate.

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공공개발지구 내 주차장용지의 이용실태와 토지공급방법 개선방안 연구 (A Study on the Use of Parking Lots and Improvement Methods of Land Supply in Public Development Zones)

  • 박창률;김시진
    • 토지주택연구
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    • 제10권4호
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    • pp.13-30
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    • 2019
  • Parking lot within housing site contains public interest of relieving parking space shortage problem and subject to public restriction. If auctioned off at higher price by excessive competition in general competitive bid for land bidders, the development of parking lot will be made against its original purpose supply. The core issue is that a bid price is quite often to be blown out of proportion by 150%~ 250% due to extreme competition and, could face serious problem if a winning bidder runs sale business. If it is rental business, although about 30% of the total floor space of the whole building to be used as neighborhood facilities, too high winning bid price cause to lose transparency. In case of sale at aggregate buildings, most business operators would sell 30% of the neighborhood facilities, spare the parking lot and manages thereof separately. According to Aggregate Buildings Act, neighborhood facilities are allowed for individual registration and ownership of parking lot by business operator or designated person by business operator. In this case, the parking lot becomes 70% of the total floor space of the whole building and 70% of the land share which makes the mortgage very valuable and easier for business operator to get financial loan. There used to be many cases such as owners of neighborhood facilities (aggregate buildings partial owners) who run parking lot to repay their loan running parking lot to repay loan, but found that very tough and reached auction and relatively disadvantaged. For parking lot within housing site, it is recommend to exclude the public factors that land has and take into account of public restriction in area (housing site). Business opportunity for operators and protection of property rights for buyers in aggregate buildings, land supply method is recommended to replace from highest bid method into draw or private contract. In terms of price, supply at estimated price (construction price) and restriction on usage (Co-ownership of parking lot) proposals are submitted.