• Environmental Analysis Health and Toxicology
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• v.21 no.2 s.53
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• pp.153-163
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• 2006

Essential metals have been known to interact with non-essential toxic metals in the aspects of absorption, transport and deposition in the body. Iron deficiency has been reported to increase lead and/or cadmium absorption. The relation between iron and lead has been understood well in children but not in adults. Two hundred seventy adults (118 males and 152 females) were recruited from 3 different residental areas (rural, coastal and urban) to investigate the effects of environmental lead exposure on body iron status. The subjects were interviewed for life-style and diet of the last 24 hours, and measured for blood lead and body iron. The lead concentration in the whole blood was determined by a flameless method using an atomic absorption spectrophotometry. The body iron was evaluated with values of hemoglobin, hematocrit, RBCs, serum total iron, unsaturated iron binding capacity, total iron binding capacity and ferritin. The mean concentration of blood lead in adult was $3.31{\mu}g/dL$. The concentration was higher in male ($3.97{\mu}g/dL$) than in female ($2.86{\mu}g/dL$). The blood lead was influenced by residental area, life-style, smoking and drinking, occupation and diet habit of subjects, but not by age. A positive correlation was observed between the blood lead level and the serum iron or ferritin. These results suggest that environmental lead exposure in Korean adult may not be higher than other developed and developing countries. It is further indicated that blood lead in adult could be influenced by life-style, and environmental and genetic factors but no inverse relation with body iron as shown in children.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4367-4375
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• 2016

The objective of the present study was to evaluate the anticancer and radio-sensitizing efficacy of a Withania somnifera extract/Gadolinium III oxide nanocomposite (WSGNC) in mice. WSGNC was injected to solid Ehrlich carcinoma-bearing mice via i.p. (227 mg/kg body weight) 3 times/week during 3 weeks. Irradiation was performed by whole body fractionated exposure to 6Gy, applied in 3 doses of 2 Gy/week over 3 weeks. Biochemical analyses as well as DNA fragmentation were performed. Treatment of solid Ehrlich carcinoma bearing mice with WSGNC combined with ${\gamma}$-radiation led to a significant decrease in the tumor size and weight associated with a significant decrease in mitochondrial enzyme activities, GSH content and SOD activity as well as a significant increase in caspase-3 activity, MDA concentration and DNA fragmentation in cancer tissues. Combined treatment of WSGNC and low dose of ${\gamma}$-radiation showed great amelioration in lipid peroxidation and antioxidant status (GSH content and SOD activity) in liver tissues in animals bearing tumors. It is concluded that WSGNC can be considered as a radio-sensitizer and anticancer modulator, suggesting a possible role in reducing the radiation exposure dose during radiotherapy.

• Journal of Biosystems Engineering
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• v.18 no.3
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• pp.191-198
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• 1993

Vertical and horizontal ride vibrations of the selected agricultural tractors were measured and evaluated with respect to the ISO 2631 'guide for the evaluation of human exposure to whole body vibration'. Evaluation showed that at the normal transportation speeds of 1.4~20km/h on both the concret and ground surfaces tractor drivers were exposed to the vibrations whose magnitudes exceed the 8 hour fatigue decreased proficiency boundary in the frequency ranges of 2~16Hz in vertical and 1~2Hz in horizontal directions. Considering that tractor operation becomes as one of the specialized job for the future farming in Korea, measures must be made to protect the drivers against harmful ride vibrations of agricultural tractors.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.05a
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• pp.1088-1093
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• 2001

This paper introduces new approaches attempted to evaluate quantitatively the effects of repeated shocks exposed to human. This attempt, by the members of ISO TC 108 / CS4, has been made to add a standardised draft of ISO 2631 Part 1 which covers newly the human response to repeated shocks. It contains the review of previous work related to shocks responses to human and suggests a mathematical model to predict the three-axis lumbar spine accelerations from the measured seat accelerations. The predicted accelerations are used to evaluate the vibration dose to the spine. The evaluated dose values are shown to enable the assessment of adverse health effects.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.05a
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• pp.1100-1104
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• 2001

This paper introduces experimental results related to the vibration ride conditions that a korean male subject experienced in the railway trains and the express bus. Two types of railway train's, Samaulho and Mugunghwaho, and the express bus were chosen to measure how much the whole-body vibrations of the back, hip and feet are exposes to the subject. Measured vibration signals were analysed to assess the ride conditions quantitatively and qualitatively. Analysed results are illustrated to see how much typical public transportation systems in korea expose vibration to passengers.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.06a
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• pp.227-230
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• 2000

This paper introduces international and Korean standards related to human-related vibration. It reviews recent standards of ISO and KS and compares them. This comparison and analysis reveals that the current direction and activity in ISO is in progress and presents logical ways of updating Korean standards in the future. Finally, the current activity of upgrading Korean standards in the Korean TC 108/SC4 is introduced.

• Journal of Korean Society on Water Environment
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• v.28 no.5
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• pp.762-767
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• 2012

The ecotoxicity assessment of nanomaterials (NMs) in the environment is actively conducted throughout the world because of the concerns about their potential risk from usage and release into the environment, as well as their unique physiochemical properties. Ecotoxicity tests for NMs have been conducted using various species and methods; however, in spite of these efforts, the characteristics and toxicity of NMs have not been defined. The fish embryo toxicity test (FET) has been conducted extensively to evaluate the toxicity of NMs as an alternative to a whole-body test in fish. In this study, we collected and analyzed the trends of nanotoxicity on the early development of freshwater fish. The model nanomaterials are carbon NMs ($C_{60},\;C_{70},\;C_{60}$(OH)n and carbon nanotube). Their adverse effects were extensively investigated based on the properties of NMs, test species, and diverse exposure conditions.

• Proceedings of the KSR Conference
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• 2003.05a
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• pp.388-392
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• 2003

In this study, various railroad geotechnical informations were standardized. The standardization was progressed by classifying the informations as basic properties, railroad vibrations and design plans. Basic informations included soil properties(27), dynamic property(1), geophysical prospecting(1), and elastic wave prospecting(4). Specification for 'human exposure to whole-body vibration' was used to construct the information of railroad vibration. And in the case of the information of design plan, the way to save by graphic files was chosen. Thus standardized informations examined their application by setting up database. Entity-Relation(E-R) model was used in the design of database and by this, the database system was constructed. This database system will be able to serve the performance enhancement of railroad system.

• International journal of thyroidology
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• v.10 no.1
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• pp.50-55
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• 2017

Sweet's syndrome, or acute febrile neutrophilic dermatosis, occurs in association with autoimmune diseases such as Hashimoto's thyroiditis but is rare in Graves' disease, in which all cases are induced by propylthiouracil (PTU). We report a case of Sweet's syndrome in a patient with Graves' disease treated with methimazole (MMI) during three weeks. A 34-year-old man presented with the acute onset of high fever, skin rashes on the whole body, arthralgia, and acroparesthesia. Laboratory results showed leukocytosis and elevated C-reactive protein. MMI first stopped and antibiotics and antihistamine therapy started, but his symptoms dramatically improved after oral prednisolone. Graves' disease has again been treated by MMI because of his aggravated ophthalmopathy. After one year of retreatment with MMI, there has been no recurrence of Sweet's syndrome, supporting that Sweet's syndrome in this case was not related to MMI exposure. To our knowledge, this is the first report of Sweet's syndrome associated with Graves' disease per se but not PTU or MMI use.

• Korean Journal of Pharmacognosy
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• v.34 no.4 s.135
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• pp.339-343
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• 2003

We investigated the effects of Rhus verniciflua Stokes (RVS) on high fat diet- induced obesity in C57BL/6 that received ad libitum exposure to a high fat diet for 8 weeks. Male C57BL/6 mice weighing $20.1{\pm}0.95\;g$ were divided into four groups and the body weight and food intake were weighed for 8 weeks. After the administration of RVS extract, the liver, subcutaneous and retroperitoneal adipose tissue in the mice were weighed and common blood count in whole blood and biochemical parameters in plasma were measured. It was founded that body weight increase was significantly suppressed by the oral administration of RVS extract in group with high fat diet. Weight of subcutaneous adipose tissue and concentration of triglyceride in plasma from mice which were administrated RVS extract were lower than obesity control group. These results suggest that RVS extract may effect on inhibition of diet-induced obesity.