• Journal of electromagnetic engineering and science
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• 제15권3호
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• pp.151-157
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• 2015

The increasing use of mobile phones has raised public concern about the possible biological effects of radiofrequency electromagnetic field (RF-EMF) exposure on the human brain. To investigate the potential effect of RF-EMF exposure on the brain, we examined the behaviors and hippocampal morphology of C57BL/6 mice after sub-chronic exposure to RF-EMFs with a relatively high SAR level (5.0 W/kg). We applied a 2-hour daily exposure of WCDMA 1,950 MHz using a reverberation chamber that was designed for whole-body exposure for 60 days. In the behavioral tests, RF-EMF did not alter the physical activity or long-term memory of mice. Moreover, no alteration was found in the neuronal and glial cells in the hippocampus by RF-EMFs. In this study, we showed that sub-chronic whole body RF exposure did not produce memory impairment and hippocampal morphological alteration in C57BL/6 mice.

• 대한방사선치료학회지
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• 제29권1호
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• pp.57-68
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• 2017

목 적: 본 연구는 모양이 불규칙하고 손상위험장기(Organ At Risk, OAR)에 매우 인접한 타겟(Target)의 방사선 치료 시, 비동일평면상(Non-coplanar)의 빔(Beam)을 이용한 Fixed-field 세기변조 방사선치료(Intensity Modulated Radiation Therapy, IMRT)와 용적변조회전 방사선치료(Volumetric Modulated Arc Therapy, VMAT) 치료계획의 유용성을 평가 및 비교해 보고자 하였다. 대상 및 방법: 본원에서 True Beam STX(Varian Medical Systems, USA)를 이용하여 전체 두피(Whole Scalp), 부분적 두피(Partial Scalp), 그리고 전체 뇌실(Whole Ventricle)에 방사선 치료를 받은 환자 중 각 부위별로 2명 씩, 총 6명을 대상으로 하였다. VMAT 치료계획 시, Beamlet에 포함되는 OAR의 용적을 최소화하기 위해 Coplanar 또는 Non-coplanar 빔을 이용하였고, Fixed-field IMRT는 6명 모두 2개 이상의 카우치(Couch) 각도를 이용한 Non-coplanar IMRT(이하 ncIMRT)로 치료계획 하였다. 결 과: 양측 수정체, 양측 시신경, 시신경 교차, 그리고 뇌 줄기의 최대선량과 양측 안구와 해마의 평균선량을 측정하였고, 6명 모두 9개의 OAR 중 6개 이상에서 VMAT 치료계획이 ncIMRT보다 1.1배에서 8.2배가량 높은 선량 값을 나타내었다. 전체 두피와 부분적 두피의 치료 시, 20 Gy가 조사되는 뇌의 용적은 VMAT이 ncIMRT의 2배 이상이었고, 전체 뇌실의 치료 시에는 두 치료계획이 큰 차이를 보이지 않았다. 타겟 Coverage는 두 치료계획 모두 $PTV_{100%}=95%$를 만족시켰고, 타겟 내 최대선량과 치료 시 필요한 총 Monitor Unit(MU)은 ncIMRT가 VMAT보다 높았으며 두 치료계획 모두 임상적용을 위한 Gamma test 시행 결과, 2 mm/2 % 조건을 통과하였다. 결 론: 본 연구 결과, ncIMRT는 VMAT에 비해 치료 시 필요한 MU가 높아 치료시간과 장비의 로딩(Loading)을 증가시키므로 치료의 효율성은 다소 떨어지지만, VMAT과 비슷한 타겟 Coverage를 유지하면서, OAR의 선량은 훨씬 감소시키는 것을 알 수 있었다. 따라서 모양이 불규칙하고 OAR에 매우 인접해 있는 타겟의 방사선 치료 시에는 ncIMRT 치료계획을 고려해 볼 필요가 있다고 사료된다.

• Biomolecules & Therapeutics
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• 제20권4호
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• pp.357-370
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• 2012

Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major significance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large field or whole brain radiation every year in the United States. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional deficits in brain several months to years after treatment. In particular, whole brain radiation therapy results in a significant reduction in learning and memory in brain tumor patients as long-term consequences of treatment. Although a number of in vitro and in vivo studies have demonstrated the pathogenesis of radiation-mediated brain injury, the cellular and molecular mechanisms by which radiation induces damage to normal tissue in brain remain largely unknown. Therefore, this review focuses on the pathophysiological mechanisms of whole brain radiation-induced cognitive impairment and the identification of novel therapeutic targets. Specifically, we review the current knowledge about the effects of whole brain radiation on pro-oxidative and pro-inflammatory pathways, matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) system and extracellular matrix (ECM), and physiological angiogenesis in brain. These studies may provide a foundation for defining a new cellular and molecular basis related to the etiology of cognitive impairment that occurs among patients in response to whole brain radiation therapy. It may also lead to new opportunities for therapeutic interventions for brain tumor patients who are undergoing whole brain radiation therapy.

• Journal of Animal Science and Technology
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• 제61권5호
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• pp.278-284
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• 2019

This study was carried out to investigate the effects of seeding dates on the yield and feed value of whole-crop barley cultivated in paddy soil. The field experiment was conceived as a randomized block design performed in triplicate with seeding dates of Oct. 19 (T1 as treatment 1), Oct. 26 (T2 as treatment 2), Nov. 2 (T3 as treatment 3), Nov. 9 (T4 as treatment 4), and Nov. 16 (T5 as treatment 5) as treatments. The barley grown in all treatments was harvested on May 21 of the following year. Plant length, fresh yield, dry matter yield, and total digestible nutrient (TDN) yield were higher (p < 0.05) in barley with early seeding dates, whereas crude protein and ether extract were higher (p < 0.05) with late seeding dates. Crude fiber and neutral detergent fiber were highest in the T3 treatment and lowest in the T1 treatment. There was no significant difference between acid detergent fiber and TDN among the different seeding dates. Total mineral contents were higher in the order T1 > T2 > T3 > T4 > T5 (p < 0.05), whereas the total amino acid content increased significantly (p < 0.05) with a delay in seeding date. Free sugar contents (fructose, glucose, and sucrose) were higher with early seeding dates (p < 0.05). Collectively, the results obtained in this study indicate that it is favorable to seed soon after harvesting rice to increase dry matter and TDN yields and mineral and free sugar contents of whole-crop barley in the midlands of Korea.

• 천문학회보
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• 제35권1호
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• pp.26.2-26.2
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• 2010

It has been a puzzle in solar physics how a low-lying magnetic structure such as a solar prominence surrounded by a strongly line-tied overlying field sometimes intrudes through the latter and goes into eruption. A numerical simulation study of the solar coronal plasma reveals that a ballooning instability can explain this type of eruptive process. We consider an idealized situation with two flux ropes merging. When magnetic field lines from different flux ropes reconnect, a new field line connecting farther footpoints is generated. Since the field line length abruptly increases, the field line expands outward. If the plasma beta is low, this expansion takes place more or less evenly over the whole field line. If, on the other hand, the plasma beta is high enough somewhere in this field line, the outward expansion is not even, but is localized as in a bulging balloon. This ballooning section of the magnetic field penetrates out of the overlying field, and eventually the originally underlying field and the overlying field come to interchange their apex positions. This process may explain how a field structure that has stably been confined by an overlying field can occasionally show a localized eruptive behavior.

• 생명과학회지
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• 제25권2호
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• pp.151-157
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• 2015

Zebrafish는 약리학 연구에 널리 사용되는 실험 동물 중 하나이다. Oxytetracycline은 넓은 항균 범위를 가지는 항생제로써 단백질 합성을 억제하여 정균 작용을 가진 항생제이다. 본 연구의 목적은 OTC에 노출이 되었을 때 zebrafish에게서 나타나는 행동변화와 내분비계의 변화를 관찰하였다. OTC (50, 100 or 200 mg/l)에 노출된 zebrafish의 행동변화를 확인하기 위해 novel tank test와 open field test를 진행하였다. 또한 내분비계의 변화를 확인하기 위하여 whole-body cortisol의 수치를 cortisol kit를 이용하여 측정하였다. Novel tank test 결과 상층부에서 머문 시간과 부동 시간에서 OTC를 약욕하였을 때 통계적으로 유의성이 있는 증가현상이 확인되었다. 반면에, 총 이동거리, 과행동 시간, 유영 속도 그리고 상하 변위에서 OTC를 약욕하였을 때 통계적으로 유의성 있는 감소 현상이 확인되었다. Open field test 결과 부동시간에서 OTC를 약욕 하였을 때 통계적으로 유의성 있는 증가 현상이 확인 되었다. 그러나 OTC를 약욕 하였을 때 총 이동거리, 움직인 시간, 유영 속도에서 통계적으로 유의성이 있는 감소 현상이 확인 되었다. Whole-body cortisol에서는 zebrafish에게 약욕을 하였을 때 증가하는 경향이 관찰되었다. 이러한 결과를 통하여 OTC가 zebrafish에게 화학적 스트레스로 작용한 것으로 사료된다.

• Spatial Information Research
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• 제17권3호
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• pp.261-268
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• 2009

본 연구는 전국 토양유실분포도와 토양유실위험 등급도를 작성하는 것을 목적으로 하였다. 토양유실분포도는 RUSLE를 이용하였고, 강우-유출 침식성인자(R)는 기상청의 59개 기상관측소의 1977년부터 2006년까지 (30년간)의 강우량 자료를 이용하여 산정하였다. 빈도분석은 FARD를 이용하였고, 전국 R인자를 빈도별로 산정하였다. 전국 R인자 분석에서 낙동강 유역이 가장 작은 값을 한강유역이 큰 값을 갖는 것으로 분석되었다. 토양유실량 분석결과 토지피복별로 초지, 나지 밭의 크기 순서로 토양유실이 발생하고, 전체적으로 약17.2ton/ha 정도의 토양유실이 발생하는 것으로 분석되었다. 단위면적당 평균토양유실량은 나지와 초지에서 많은 토양유실이 발생하고 있다. 5년빈도 강우특성에서 전체 토양유실량은 15,000여 톤의 토양유실이 발생하는 것으로 나타났다. 토지피복별 면적비를 고려하면 논, 산림, 밭작물 재배지역에서 많은 토양유실이 발생하는 것으로 분석되었다. 토양유실 위험 등급도 작성은 토양유실위험 등급을 5개 등급으로 구분하여 수행하였다. 분석결과 토양유실위험 2등급인 보통지역이 전체 토양유실량 위험지역의 78.2%로 가장 많은 부분을 차지하고 있으며, 심각한 토양유실 위험지역은 분석지역 전체 중에서 약 1.1%인 $1,038km^2$정도인 것으로 분석되었다. 토지피복별로 심각한 토양유실 위험지역은 나지, 초지, 밭작물 재배지역의 순으로 각각 $93.5km^2$, $168.1km^2$, $327.4km^2$ 정도가 심각한 등급의 토양유실 위험지역으로 분석되었다.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2001년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall 2001
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• pp.57-64
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• 2001

There are some previous reports that some animals such as rats and birds move in a large group and act abnormally to avoid the large earthquake. This study is to experimentally testify what relations exist between the anomalous animal behavior and electric field effect, which is reported due to the piezoelectric effects in a basement rock before earthquake occurrences. When electric field is applied to the whole bottom of the cage, they show nervous behaviors such as grooming, washing their faces, standing on legs or running around in panic to avoid the electric field. When more strong electric field is applied, they jump with shrieking and mount on the electric line. The rat shows more sensitive anomalous behavior than the bird. Even though the current to the experimental birds and rats is just a few $\mu$A, they react in various ways. The anomalous animal behaviors under the small ground electric field may have some relations to the actual phenomena before great earthquake. This kind of study is quite worthy for the understanding of earthquake precursors.

• 전자공학회논문지A
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• 제32A권3호
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• pp.38-44
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• 1995

The scattered electric field from a multilayered circular dielectric cylinder is caculated. Approximate boundary condition used in on-surface radiation boundary condition(OSRC) method has been applied to all the boundary surface of N-layered dielectric cylinder. It was assumed that scattered electric field at inner boundary surface in one region transmitted to the adjacent region at outer boundary surface. In the whole region, the unknown coefficients of electric field are acquired by the given incident electric field with ease. Electric field distribution at each boundary surface and the scattered electric field in free space are taken with the calculated unknown coefficients. the results obtainted were compared with those results that were used by regular surface boundary condition.

• 한국전기전자재료학회논문지
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• 제17권5호
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• pp.530-535
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• 2004

We have studied 90$^{\circ}$ twisted nematic mode switching by fringe electric field(F-TN mode) using a liquid crystal (LC) with negative dielectric anisotropy. In the device, two polarizers are parallel each other, electrodes exist only on bottom substrate, and one of rubbing direction is coincident with polarizer axis. Therefore, the cell shows a black state before a voltage is applied. With a bias voltage generating fringe-electric field, the LC twists perpendicular to fringe electric field such that the LCs are almost homogeneously aligned except near the bottom surface since the negative type of the LC is used. Consequently, the new device exhibits much wider viewing angle than that of the conventional TN mode due to in-plane switching and relatively high transmittance since the LC director above whole electrode area aligns parallel to the polarizer axis.