• The Korean Journal of Pain
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• 제8권2호
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• pp.331-335
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• 1995

Asthma is a disease of the airways that is characterized by increased responsiveness of the tracheobronchial tree to a multiplicity of stimuli. A number of causes have been postulated for the increased airway reactivity of asthma is conservative as beta-adrenergic agonist, methylxanthines, glucocorticoids, anticholinergics and mast cell stabilizing agent. Stellate ganglion block for the treatment of bronchial asthma has its controversies. Stellate ganglion block was performed for the treatment of 3 patients with bronchial asthma. After stellate ganglion blocks, dyspnea, coughing and wheezing was markedly reduced. Lung function test improved with 1 st case. Two asthma cases were able to discontinue medication for asthma. No severe aggrevation of bronchial symptoms were noted after stellate ganglion blocks. It suggested that stellate ganglion block can be safely performed on bronchial asthmatic patients.

• 대한물리치료과학회지
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• 제9권1호
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• pp.9-15
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• 2002

The asthma is a clinical syndrome having three symptoms; dyspnea, wheezing and coughing, due to the narrowing of trachea in pulmonary system. Specially the asthma is common in children. The study was designed to identify the effect of Kinesio Taping Treatment as to asthmatic children. The Kinesio Taping Treatment was used on the Pectoralis major and Posterior diaphragm of twenty five asthmatic children(19 male, 6 female) for the period from September 1, 2001 to September 20, 2001. Peak expiratory flow rate(PEFR) for the condition of pulmonary function was measured using the Pocket Peak and wheeling and coughing symptom were measured using questionnaire. The results of this study are as follows: 1. There were statistically significant differences between before using the taping and after the kinesio taping increase of the PEFR(p<0.001). 2 There were statistically significant differences between before using the kinesio taping and after the kinesio taping improvement of the wheezing sign(p<0.001). 3. There were statistically significant differences between before using the kinesio taping and after the kinesio taping improvement of the coughing symptom(p<0.001).

• Clinical and Experimental Pediatrics
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• 제49권3호
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• pp.298-304
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• 2006

목 적 : 소아 천식이 급격히 증가하고 있다. 영유아 시기의 천명을 보이는 환아들에서 천식 발생을 예측할 수 있는 고위험군을 선별하는 지표들이 알려져 있다. 저자들은 Tucson Children's Respiratory Study Group에서 제시한 천식 예측 지표 API와 변형한 천식 예측 지표 mAPI를 한국 영유아 천명 환아들에게 적용하여 의미있는 예측 지표를 규명하고자 하였다. 방 법 : 반복성 천명을 주소로 서울아산병원 소아과를 방문한 262명의 환아들을 대상으로 API와 mAPI를 적용하여 고위험군과 저위험군으로 나누었다. 각 군에서 알레르기 지표 뿐만 아니라 환아와 가족들의 알레르기 질환의 병력을 조사하였다. 결 과 : API 고위험군 환아(n=131)는 저위험군 환아(n=131) 보다 성별은 차이가 없었고 연령, 총호산구수, 호산구 비율, 혈중 ECP, 총 IgE가 높았으며, 흔한 항원에 대한 감작 여부가 포함되지 않았지만 흡입항원과 식품항원에 대한 감작률이 더 높게 나타났다. mAPI 고위험군 환아(n=141)는 저위험군 환아(n=121) 보다 총호산구수, 호산구 비율, 혈중 ECP, 총 IgE, egg, milk, D.p-, D.f-특이 IgE 농도가 높았으며 성별과 연령의 차이는 없었다. 위험군별 다변량 분석에서는 API군에서는 흡입항원에 대한 감작 여부가 고위험군을 결정하는 유의한 지표로 나타났으며 mAPI군에서는 혈중 ECP 농도가 유의한 지표로 나타났다. 대상군 중 6세 이상 추적 관찰된 환아는 모두 29명이었으며 최근 1년간 천명의 병력이 확인되고 임상적으로 천식으로 진단된 환아는 15명이었다. API의 민감도, 특이도, 양성예측률, 음성예측률은 66.7%, 50.0%, 58.8%, 58.3%이었으며, mAPI는 93.3%, 57.1%, 70.0%, 88.9%로서 mAPI가 더 높았다. 결 론 : API와 mAPI를 적용한 고위험군 환아에서 흔한 흡입 항원과 식품항원에 대한 감작률이 높아서, 영유아 천명 환아에서 주관적인 증상에 의한 진단보다는 객관적인 흡입항원과 식품항원에 대한 감작 여부를 지표로 사용하는 것이 더 의미 있을 것으로 생각한다. 또한 한국 영유아 천명 환아에서는 mAPI가 소아 천식의 발생을 예측하는데 더 도움이 될 것으로 생각한다. 그러나 본 연구는 29명의 소수의 환아들만 추적 관찰된 결과이므로 이후로 보다 더 많은 환아들을 추적 관찰하는 것이 필요할 것이다.

• Biomolecules & Therapeutics
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• 제29권1호
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• pp.58-63
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• 2021

Asthma is a chronic obstructive lung disease characterized by recurrent episodes of bronchoconstriction and wheezing. Conventional asthma treatment involves the suppression of airway inflammation or improving airway flow. Rosmarinus officialis, also known as rosemary, is a Mediterranean plant that is used for the treatment of inflammatory diseases. Carnosol, a diterpenoid found in rosemary extracts, has been known to exhibit anti-inflammatory, anti-tumor, and anti-oxidant effects. The effect of carnosol on allergic responses has not been tested yet. The effect of carnosol on a murine allergic asthma model were investigated. Carnosol inhibited the degranulation of RBL-2H3 mast cells. Carnosol treatment inhibited the increase in the number of eosinophils in the bronchoalveolar lavage fluids (BALF) of mice treated with ovalbumin. Carnosol treatment also inhibited inflammatory responses and mucin production in histologic studies. Carnosol treatment inhibited the increases of IL-4 and IL-13 cytokines expression in both BALF and the lungs. These results suggest that carnosol may have a potential for allergic asthma therapy.

• IMMUNE NETWORK
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• 제22권6호
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• pp.45.1-45.15
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• 2022

Asthma is a chronic airway inflammatory disease characterized by reversible airway obstruction and airway hyperreactivity to various environmental stimuli, leading to recurrent cough, dyspnea, and wheezing episodes. Regarding inflammatory mechanisms, type 2/eosinophilic inflammation along with activated mast cells is the major one; however, diverse mechanisms, including structural cells-derived and non-type 2/neutrophilic inflammations are involved, presenting heterogenous phenotypes. Although most asthmatic patients could be properly controlled by the guided treatment, patients with severe asthma (SA; classified as a treatment-refractory group) suffer from uncontrolled symptoms with frequent asthma exacerbations even on regular anti-inflammatory medications, raising needs for additional controllers, including biologics that target specific molecules found in asthmatic airway, and achieving the precision medicine for asthma. This review summarizes the immunologic basis of airway inflammatory mechanisms and current biologics for SA in order to address unmet needs for future targets.

• 셀메드
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• 제3권1호
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• pp.6.1-6.6
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• 2013

Asthma is a chronic inflammatory disease of the lungs, characterized by increased sensitivity to bronchoconstriction associated with infiltration of immune cells and mucus hyper secretion. In South Africa, the indigenous plant Siphonochilus aethiopicus, is used by traditional health practitioners to treat colds and flu, wheezing of the chest, coughs, influenza, sinus problems and mild asthma. In this study we aimed to investigate the potential anti-inflammatory and immune-modulating properties of S. aethiopicus in vitro. The dried and powdered S. aethiopicus plant material was extracted with organic solvents. The dried extracts were screened in vitro in the transcription response, NF-${\kappa}B$ and a cytokine assay. Significant activity was observed for organic extracts of the plant in these assays. This study provides evidence that S. aethiopicus has anti-inflammatory and immune-suppressing properties in vitro. These findings may support anecdotal accounts of its effectiveness against allergic asthma.

• Clinical and Experimental Pediatrics
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• 제49권6호
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• pp.581-588
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• 2006

Asthma is a chronic inflammation of the airway associated with increased bronchial hyperresponsiveness that leads to recurrent episodes of cough, wheezing, breathless, chest tightness. According the recent studies, repeated airway inflammation leads to structural changes so called 'airway remodeling' and associated with decreased pulmonary function. Airway remodeling begins form the early stage of asthma and the early diagnosis and management is very important to prevent airway remodeling. Medication for asthma can be classified into acute symptom reliever and chronic controller. Short acting beta2 agonist is a well-known reliever that reduced asthma symptoms within minutes. Controllers should be taken daily as a long-term basis to control airway inflammation. Inhaled corticosteroid(ICS) is the most effective controller in current use. However, in some patients ICS monotherapy is not sufficient to control asthma. In those cases, other medications such as long acting beta2 agonist, leukotriene modifier or sustained-release theophylline should be added to ICS, which called Add-on-Therapy. Combination inhaler devices are easy to use. Oral leukotriene modifier has a good compliance especially in children. Finally, as asthma is a chronic disease, the development of on-going partnership among health care professionals, the patients, and the patients' family is necessary for the effective management of asthma.

• 한국환경보건학회지
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• 제46권1호
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• pp.11-21
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• 2020

Objectives: The purpose of this study was to assess the association between pet ownership and asthma symptoms in Korean children. Methods: This study used data from the 8th Panel Study on Korean Children in 2015. For the final study, 1598 cases were used. Wheezing as an asthma symptom was self-reported as an outcome variable. Whether children had owned dogs or cats or not was used as an independent variable. Results: A total of 6.8% of children lived with dogs and 2.1% of children lived with cats in their homes. There were 4.0% of children who had asthma symptoms in the past year. When comparing 'children who had owned dogs for more than 12 months' with 'children who had not owned dogs', the adjusted odds ratio (OR) for 'asthma symptoms' were 1.20 (95% confidence interval (CI), 1.10-1.30) among male children and 2.19 (95% CI, 1.94-2.46) among female children. When comparing 'children who had owned cats for more than 12 months' with 'children who had not owned cats', the adjusted ORs for 'asthma symptoms' were 38.94 (95% CI, 35.55-42.65) among male children and 5.32 (95% CI, 4.60-6.16) among female children. When comparing 'children who had owned both dogs and cats for more than 12 months' with 'children who had not owned at all', the adjusted OR for 'asthma symptoms' was 13.22 (95% CI, 11.93-14.65), and when comparing 'children who had owned cats only' with 'children who had not owned at all', the adjusted OR for 'asthma symptoms' was 9.25 (95% CI, 8.50-10.08). Conclusions: As a result, children's asthma symptoms were higher in the case of cats than with dogs, and in the case of cats, boys were more at risk than girls. In the analysis for the risk of asthma symptoms when a dog and a cat are raised at the same time, it was statistically confirmed that the children in the home were more at risk than with single animal ownership. The results of this study can be considered to be of great importance in policy-making and for the use of educational materials in the field of environmental health.

• Tuberculosis and Respiratory Diseases
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• 제80권1호
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• pp.11-20
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• 2017

Approximately one in four patients with chronic obstructive pulmonary disease (COPD) have asthmatic features consisting of wheezing, airway hyper-responsiveness or atopy. The Global initiative for Asthma/Globalinitiative for chronic Obstructive Lung Disease committee recently labelled these patients as having asthma-COPD overlap syndrome or ACOS. ACOS also encompasses patients with asthma, ${\geq}40$ years of age, who have been cigarette smokers (more than 5-10 pack years) or have had significant biomass exposure, and demonstrate persistent airflow limitation defined as a post-bronchodilator forced expiratory volume in 1 second ($FEV_1$)/forced vital capacity of <70%. Data over the past 30 years indicate that patients with ACOS have greater burden of symptoms including dyspnea and cough and show higher risk of COPD exacerbations and hospitalizations than those with pure COPD or pure asthma. Patients with ACOS also have increased risk of rapid $FEV_1$ decline and COPD mortality. Paradoxically, experimental evidence to support therapeutic decisions in ACOS patients is lacking because traditionally, patients with ACOS have been systematically excluded from therapeutic COPD and asthma trials to maintain homogeneity of the study population. In this study, we summarize the current understanding of ACOS, focusing on definitions, epidemiology and patient prognosis.

• Tuberculosis and Respiratory Diseases
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• 제83권1호
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• pp.42-50
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• 2020

Background: Fractional exhaled nitric oxide (FeNO) is regarded as a potential biomarker for identifying eosinophilic inflammation. We aimed to evaluate the clinical implication of FeNO and its influence on inhaled corticosteroids (ICS) prescription rate in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: FeNO level and its association with clinical features were analyzed. Changes in the prescription rate of ICS before and after FeNO measurement were identified. Results: A total of 160 COPD patients were divided into increased (≥25 parts per billion [ppb], n=74) and normal (<25 ppb, n=86) FeNO groups according to the recommendations from the American Thoracic Society. Compared with the normal FeNO group, the adjusted odds ratio for having history of asthma without wheezing and with wheezing in the increased FeNO group were 2.96 (95% confidence interval [CI], 1.40-6.29) and 4.24 (95% CI, 1.37-13.08), respectively. Only 21 out of 74 patients (28.4%) with increased FeNO prescribed ICS-containing inhaler and 18 of 86 patients (20.9%) with normal FeNO were given ICS-containing inhaler. Previous exacerbation, asthma, and wheezing were the major factors to maintain ICS at normal FeNO level and not to initiate ICS at increased FeNO level. Conclusion: Increased FeNO was associated with the history of asthma irrespective of wheezing. However, FeNO seemed to play a subsidiary role in the use of ICS-containing inhalers in real-world clinics, which was determined with prior exacerbation and clinical features suggesting Th2 inflammation.