• Journal of Microbiology and Biotechnology
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• 제29권1호
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• pp.151-159
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• 2019

Lipoteichoic acid isolated from Lactobacillus plantarum K8 (pLTA) alleviates lipopolysaccharide (LPS)-induced excessive inflammation through inhibition of $TNF-{\alpha}$ and interleukin (IL)-6. In addition, pLTA increases the survival rate of mice in a septic shock model. In the current study, we have found that pLTA contributes to homeostasis through regulation of pro- and anti-inflammatory cytokine production. In detail, pLTA decreased the production of IL-10 by phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells stimulated with prostaglandin E2 (PGE-2) and LPS. However, $TNF-{\alpha}$ production which was inhibited by PGE-2+LPS increased by pLTA treatment. The regulatory effects of IL-10 and $TNF-{\alpha}$ induced by PGE-2 and LPS in PMA-differentiated THP-1 cells were mediated by pLTA, but not by other LTAs isolated from either Staphylococcus aureus (aLTA) or L. sakei (sLTA). Further studies revealed that pLTA-mediated IL-10 inhibition and $TNF-{\alpha}$ induction in PGE-2+LPS-stimulated PMA-differentiated THP-1 cells were mediated by dephosphorylation of p38 and phosphorylation of c-Jun N-terminal kinase (JNK), respectively. Reduction of pLTA-mediated IL-10 inhibited the metastasis of breast cancer cells (MDA-MB-231), which was induced by IL-10 or conditioned media prepared from PGE-2+LPS-stimulated PMA-differentiated THP-1 cells. Taken together, our data suggest that pLTA contributes to inflammatory homeostasis through induction of repressed pro-inflammatory cytokines as well as inhibition of excessive anti-inflammatory cytokines.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1453-1457
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• 2014

Background: The association of colorectal cancer with human cytomegalovirus (HCMV) is a controversial issue in cancer research. This study aimed to identify the HCMV virus in colorectal cancer tissues and to investigate the association of HCMV with colorectal cancer. In this study, 50 cancer tissue samples and 50 samples without colon cancer were studied in order to identify the HCMV virus through nested-polymerase chain reaction. The virus was identified in 15 cases of colorectal cancer tissues (15/50) and in 5 cases of normal tissues (5/50). Eight cases of adenocarcinoma tissues were in a moderately differentiated stage, and 7 cases had well-differentiated stage tissues that were positive for viral DNA. The findings were statistically evaluated at a significance level of p<0.05. The HCMV virus could playa role in creating malignancy and the progress of cancer through the process of oncomodulation.

• 한국정보통신학회논문지
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• 제6권4호
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• pp.552-558
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• 2002

차별 서비스 모델은 IP 기반 네트워크에서 서비스 품질을 제공하기 위한 새로운 구조 모델이다. RIO 는 차별 서비스 네트워크 환경에서 라우터의 큐 관리 메커니즘으로 가장 널리 적용되고 있다. 본 논문은 패킷 길이에 따른 처리율의 영향을 완화하는 개선된 RIO 메커니즘을 제안한다. 트래픽 조절 기능인 TSW 기능과 결합하여 시뮬레이션을 수행한 결과, 제안된 메커니즘은 적절히 배치된 네트워크 상황에서 패킷 길이에 무관하게 안정된 처리율을 보장하고, 대역폭의 공평한 분배를 제공하는 것으로 분석된다.

• 한국수정란이식학회지
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• 제28권4호
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• pp.303-305
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• 2013

A 11-year, 9-month-old female Shih-tzu was referred for evaluation of the body conditions. According to the physical examination and ultrasonography, the left ovarian mass was detected. For the removal of ovarian mass, an ovariohysterectomy was performed. Grossly, the ovarian mass was full of hairmatrix on the cut surface of the mass. Histopathological findings revealed a characteristic of teratoma, such as laminated keratines, hair, sebaceous glands, neuron tissue, differentiated bone and cartilage. The ovarian mass was well-differentiated components of 2 germ layers, and diagnosed as a mature teratoma.

• 대한세포병리학회지
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• 제19권1호
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• pp.1-8
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• 2008

The role of respiratory cytology is to detect and classify pulmonary disease, with an emphasis of neoplastic disease, so that proper therapy can be instituted. As in many branches of cytology, the recognition of malignancy in the cells obtained from the respiratory tract is more straightforward than identifying the type of tumor cell. It is important to accurately determine the true cytopathological cell type in cases of primary lung cancer and to know the accuracy of the diagnosis achieved by the cytological procedures. The well differentiated tumors have characteristic cytoplasmic and nuclear abnormalities that enable physicians to firmly categorize these lesions, as in squamous cell or adenocarcinoma, but some moderately and most poorly differentiated tumors show few distinctive features. This article reviews the malignant and reactive pulmonary cytologic findings and we also report on some of their pitfalls and the cytologic criteria.

• 전기전자학회논문지
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• 제5권2호
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• pp.136-145
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• 2001

인터넷에서 VoIP, VPN과 같은 QoS 보장을 요구하는 새로운 어플리케이션이 등장함에 따라, IP QoS 문제가 차세대 인터넷에서 가장 중요한 이슈중 하나이다. IETF는 인터넷에서 IP QoS를 제공하기 위하여 통합서비스 모델(Int-Serv)와 차별화된 서비스 모델(Diff-Serv)을 정의하였다. 통합서비스 모델은 각 IP 흐름의 상태 정보를 사용하기 때문에, 트래픽 특성에 따라 QoS를 만족시킬 수 있지만, 흐름수가 증가함에 따라 상태 정보양이 증가하게 된다. 차별화된 서비스 모델은 PHP를 사용하며, 지연 및 손실 민감도에 따라 서로 다른 트래픽에 서로 다른 서비스를 제공하는 잘 정의된 클래스가 있다. 차별화된 서비스 모델은 각 흐름에 대한 어떠한 상태 및 신호 정보를 갖지 않기 때문에 인터넷에서 다양한 서비스를 제공할 수 있다. MPLS는 라벨에 기초한 패킷 포워딩 기술을 사용하기 때문에, 네트워크에서 트래픽 엔지니어링을 쉽게 구현할 수 있다. MPLS는 서로 다른 파라미터를 가진 경로를 구축가능하고, 각 경로에 특정 클래스의 서비스를 할당해 줄 수 있다. 그러므로 잘 정의된 클래스를 가진 차별화된 서비스 모델를 지원하는 것이 가능하다. 따라서 본 논문에서는 인터넷에서 여러 가지 서비스 클래스를 보장하기 위하여 MPLS 네트워크에서 차별화된 서비스 모델의 성능향상을 비교분석 한다.

• 대한골관절종양학회지
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• 제14권2호
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• pp.192-197
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• 2008

지방육종은 연부 조직 종양 중 가장 흔한 종양 중 하나로 알려져 있다. 주로 50세 이상의 노년층에서 주로 발생하는 것으로 알려져 있고, 사지에서 발생할 경우 근위부에서 발생한다. 저자들은 67세 남자의 좌측 대퇴부의 거대 지방육종을 변연절제술을 이용한 종양 적출술로 치료하였다. 다른 부위로의 전이는 없었으며, 종양은 변연절제에 의해 성공적으로 적출 하였으며, 종양적출 후 6개월간 재발하지 않았다. 환자의 신장은 153 cm이며, 체중은 43 kg인데 반하여 종양은 $34{\times}20{\times}9\;cm$, 2.82 kg이였다. 환자의 신장과 체중에 비하여 종양은 매우 거대하였으며, 조직학적 검사상 잘 분화된 지방육종(well-differentiated liposarcoma)으로 판명되었다. 저자들은 조직학적 분화도와 크기에 관련된 증례가 많지 않고 이에 따른 치료 방법이 명확하지 않다고 생각되어 변연절제를 이용한 종양 적출술로 치료한 잘 분화된 거대지방육종 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7671-7674
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• 2015

Background: Overexpression of HER2-neu has been reported in many epithelial malignancies, including cancers of the breast, ovaries, lungs, prostate, bladder, pancreas, colorectum and stomach as well as osteosarcomas. The aim of this study was evaluation of expression of HER2-neu immunohistochemistry (IHC) status and clinicopathologic features in a series of colonic adenocarcinomas. Materials and Methods: In this descriptive and analytical study, we surveyed 211 samples of colon adenocarcinoma from 182 patients (86.3%) undergoing total or partial colectomy and 29 (7.13%) with biopsies by colonoscopy. A sufficient sample size was obtained from all cases and the slides were stained with hematoxylin and eosin and also by IHC (HER2) staining. Results: The mean age for the patients at diagnosis was 57.9 years (range, 15-88 years). One hundred and twenty one patients (57.3%) were male. Of all patients, 201 samples (95.3%) were conventional adenocarcinomas (159, 29 and 13 cases were well, moderately and poorly differentiated, respectively) and 10 (4.7%) were mucinous type. Out of 211 cases, 171 were checked for lymph nodes metastasis and 64 were positive. There is a correlation between HER2 scores and differentiation, most score 3 cases being well differentiated (P<0.05). Conclusions: In patients with advanced colon cancer, surgery alone is not curative and other forms of therapy may be required to prolong patient survival. HER2 overexpression was found in some cases and this could be a guideline to new adjuvant therapy for these patients.

• 건축역사연구
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• 제14권1호
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• pp.123-134
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• 2005

This study is focused on a space for man in upper classes house that is one of appeared characteristics as Korea, China and Japan imported Confucianism become common cultural base in these countries. Because a space for man in these countries has the same nature represented as a typical space in a upper classes house, and this space is differentiated by regional features, a way of thinking, a way of life and social structure as well, these characteristics are compared one another. Import of Confucianism influenced formation of a upper classes house and the spaces of the house are divided by generation, sexuality and classes. A space for man become a center of the house as well as a space for reception in accordance with patriarchism because this space stands for hierarchy of the house. A space for man of each country, Korea, China and Japan, has differences; that is, Chinese Jeongbang is used as a space for family as well as for guests; Korean Sarangchae is for only men and used as a reception space; Japanese Zasiki is used just for reception. These differences among countries are caused by owner's class, a civil officer or a military officer, and this class differentiated the characteristics of reception for guest. Even though the these countries take the space for man for meeting, Chinese is for family, Korean is for ancestors and Japanese is for guests.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3419-3423
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• 2015

Background: Liposarcoma of the spermatic cord is rare and frequently misdiagnosed. The standard therapeutic approach has been radical inguinal orchiectomy with wide local resection of surrounding soft tissues. The current trend of organ preservation in the treatment of several cancers has started to evolve. Herein we present our testis-sparing surgery experience in the treatment of spermatic cord liposarcoma and a pooled analysis on this topic. Materials and Methods: Clinical information from patient receiving organ-sparing surgery was described. Clinical studies evaluating this issue were identified by using a predefined search strategy, e.g., Pubmed database with no restriction on date of published papers. The literature search used the following terms: epidemiology, surgery, chemotherapy, radiotherapy, testis sparing surgery, spermatic cord sarcomas/liposarcomas. Results: Patient received a complete excision of the lesion, preserving the spermatic cord and the testis. The final pathological report showed a well differentiated liposarcoma with negative surgical margins and no signs of local invasion. After 2-year of follow-up, there was no evidence of local recurrence. Since the first case reported in 1952, a total of about 200 well-documented spermatic cord liposarcoma cases have been published in English literature. Among these patients, only three instances were reported to have received an organ-sparing surgery in the treatment of spermatic cord liposarcoma. Conclusions: Radical inguinal orchiectomy and resection of the tumor with a negative microscopic margin is the recommended treatment for liposarcoma of the spermatic cord. But for small, especially well-differentiated, lesions, testis-sparing surgery might be a good option if an adequate negative surgical margin is assured.