• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.6
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• pp.1349-1354
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• 1999

This study was carried out to investigate the protective effect of Korean red ginseng water extract (KRG WE) on clinical chemical parameters in male guinea pigs acutely exposed to 2,3,7,8 tetrachlorodibenzo p dioxin(TCDD). Forty male guinea pigs(200 $\pm$20g) were divided into 4 groups. Normal controls(group 1) received vehicle and saline; group 2(single TCDD treated) received TCDD(5 g/kg, single dose) intraperitoneally; group 3 received KRG WE(200mg/kg, i.p.) for 2 weeks from 1 week before TCDD exposure; group 4 received KRG WE for 1 week since the day of TCDD exposure. Increase in body weight was retarded greatly by TCDD exposure. Body weight of animals in group 2 was significantly decreased starting 2 days after TCDD exposure. However, body weight of animals in group 3 increased throughout the experimental period, although the increasing rate was slower than that of group 1. Decrease in body weight was not observed during the experimental period in group 4. Increases in blood glucose, amylase, lipase, total cholesterol, triglyceride, GOT, GPT, and LDH levels by TCDD intoxication were significantly attenuated by the KRG WE treatment(p<0.05). These results provide a strong evidence that Korean red ginseng might be a useful protective agent against TCDD, an endocrine disruptor.

• Archives of Obesity and Metabolism
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• v.2 no.2
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• pp.45-53
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• 2023

Despite the emergence of obesity as a significant public health concern, artificial sweeteners have made their way into various food products due to the perception, that they serve as substitutes for sugar. Artificial sweeteners are used to supposedly achieve weight management and health improvement. However, their efficacy and safety remain debatable. Commonly used artificial sweeteners include aspartame, acesulfame potassium, saccharin, and sucralose. This article discusses the effects of artificial sweetener consumption on weight loss, appetite regulation, blood glucose control, and gut microbiota. Research findings, concerning the consumption of artificial sweeteners and their association with body weight, have shown inconsistencies between randomized controlled trials and cohort studies. Studies, comparing artificial sweeteners to sugar, have reported no significant differences in satiety. Although artificial sweeteners have no calories, they can affect blood sugar levels through the cephalic phase insulin response. A recent study suggested that artificial sweeteners influenced the occurrence of diabetes. Due to limitations in the study design, excluding diabetes-influencing factors was not feasible. The evidence showed that artificial sweeteners harbored potential health risks, necessitating further investigation. According to recent studies, the consumption of artificial sweeteners was associated with gut microbiota changes and individual blood sugar responses. It is important to note that artificial sweeteners cannot be considered safe alternatives to sugar, and further research is required.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.10
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• pp.1378-1385
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• 2002

The importance of direct genetic, maternal, heterosis and epistatic effects were examined on post-weaning weight, height, length, girth, fat depth and muscle (ratio of stifle to hip width) with dry and wet season gains in these traits. The breeds used were two pure breeds (Jersey and Limousin), the Limousin${\times}$Jersey $F_1$, and two backcrosses ($F_1{\times}$Jersey dams and $F_1{\times}$Limousin dams). Direct genetic effects were large (p<0.001) for all traits except for length. Jersey maternal effects were large for weight, girth, fat depth and muscle in the post-weaning wet season gains which is an evidence of the impact of Jersey dam on progeny beyond weaning. There were large heterosis effects on fat depth and muscle relative to other traits. Epistatic effects were observed for post-weaning performance in weight, girth, fat depth and muscle. There are indications that there were different genetic effects for post-weaning compared to preweaning growth traits. Thus, it could be hypothesized from this study that different quantitative trait loci (QTL) affect early and late growth in Jersey and Limousin cross cattle breeds. The follow up work will examine the different chromosomal gene effects on pre- and post-weaning growth.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.141.2-142
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• 2003

beta-Amyloid (A$\beta$) peptide is the major component of senile plaques and considered to have a causal role in the development and progression of Alzheimer's disease. There has been compelling evidence supporting that $A\beta$-induced cytotoxicity is mediated through oxidative and/or nitrosative stress. Recently, considerable attention has been focused on dietary manipulation of oxidative and/or nitrosative damage. L-Egrothioneine (EGT) is a low-molecular weight naturally occurring thiol compound of dietary origin which exists in milimolar concentrations in the brain, liver, kindney, erythrocytes, ocular tissues and in seminal fluids of mammals. (omitted)

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.3
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• pp.316-324
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• 2021

Purpose: The use of soy-based infant formula has increased widely in infants with cow's milk allergy (CMA). This study aimed to provide evidence on the growth pattern of CMA infants fed with soy-based infant formula in an Indonesian setting. Methods: A multi-site, intervention study was conducted among full-term and normal birth weight CMA infants. Within six months, the subjects were provided with a soy-based infant formula. Weight, height, and head circumference were measured at baseline, weeks 4, 8, 12, 16, 20, and 24. Adverse events were recorded by scoring atopic dermatitis and symptom-based clinical scores. Results: Based on the World Health Organization growth chart, we found that most of subjects had normal nutritional status for weight-for-age, length-for-age, weight-for-length, and head-circumference-for-age. There were statistically significant differences between baseline and end-line for weight-for-age, length-for-age, weight-for-length, and head circumference-for-age nutritional status. No allergic symptoms or intolerance toward soy formula were observed at the end of the intervention period. Conclusion: These results show that infants fed with soy-based infant formula have a normal pattern of growth.

• Proceedings of the Korean Biophysical Society Conference
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• 2001.06a
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• pp.46-46
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• 2001

Evidence has suggested that an anion channel blocker, 4, 4'-diisothiocyanatostilbene-2, 2' disulfonic acid (DIDS) could trigger Ca release from skeletal sarcoplasmic reticulum (SR) by binding to a 30 kDa SR protein. Since the high molecular weight $Ca^{2＋}$ release channel (CRC)/ryanodine receptor (RyR) is the main SR protein that conducts $Ca^{2＋}$ efflux in skeletal muscles, the relationship between CRC and the 30kDa protein remains to be elucidated.(omitted)

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.160.1-160.1
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• 2003

Persistent organic pollutants (POPs) have spread throughout the global environment to threaten human health and damage ecosystems. with evidence of POPs contamination in wildlife, human blood. and breast milk documented worldwide. Breast milk is an ideal medium for assessing exposures to POPs. POPs enter humans largely as contaminants of dietary animal products, where they sequester in adipose tissue, serum, and breast milk and equilibrate at similar levels on a fat weight basis. (omitted)

• Journal of Nutrition and Health
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• v.56 no.4
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• pp.349-360
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• 2023

Purpose: Ketogenic diets (KDs) have anti-obesity effects that may be related to glucose control and the gut microbiota. This paper hypothesizes that KD reduces body weight and changes the insulin sensitivity and gut microbiota composition in a mouse model of diet-induced obesity. Methods: In this study, C57BL/6 male mice were assigned randomly to 3 groups. The assigned diets were provided to the control and high-fat (HF) diet groups for 14 weeks. The KD group was given a HF diet for 8 weeks to induce obesity, followed by feeding the KD for the next 6 weeks. Results: After the treatment period, the KD group exhibited a 35.82% decrease in body weight gain compared to the HF group. In addition, the KD group demonstrated enhanced glucose control, as shown by the lower levels of serum fasting glucose, serum fasting insulin, and the homeostatic model assessment of insulin resistance, compared to the HF group. An analysis of the gut microbiota using 16S ribosomal RNA sequencing revealed a significant decrease in the proportion of Firmicutes when the KD was administered. In addition, feeding the KD reduced the overall alpha-diversity measures and caused a notable separation of microbial composition compared to the HF diet group. The KD also led to a decrease in the relative abundance of specific species, such as Acetatifactor_muris, Ligilactobacillus_apodemi, and Muribaculum_intestinale, compared with the HF group. These species were positively correlated with the body weight, whereas the abundant species in the KD group (Kineothrix_alysoides and Saccharofermentans_acetigenes) showed a negative correlation with body weight. Conclusion: The current study presents supporting evidence that KD reduced the body weight and altered the insulin sensitivity and gut microbiota composition in a mouse model of diet-induced obesity.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2001.11a
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• pp.383-384
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• 2001

대기 중 formaldehyde는 눈, 코, 목을 자극하고 기관지 천식, 피부 알레르기를 일으킬 뿐만 아니라 동물실험 결과 발암 가능성 물질로 여겨지고 있다(황윤정, 등 1996). 미국 EPA는 formaldehyde를 유력한 인체발암물질(probable human carcinogen, weight of evidence-Group "B1")로 분류하고 있다(IARC, 1982; Edward 등, 1991). (중략)

• Journal of the Korean Society of Clothing and Textiles
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• v.16 no.4 s.44
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• pp.405-416
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• 1992

This study was performed to investigate correlation between total body weight loss and local sweat rate and to find out any possible method that can estimate total body weight loss judging from local sweat rate. Twelve adult females were kept at 44 $\pm1^{\circ}C$, 50 ${\pm}5\%$ R.H. (1) Physiological responses such as total body weight loss, local sweat rate, rectal temperature, skin temperature, blood pressure and pulse, (2) micro climate inside garment and (3) subjective sensation were examined. Two types of garment such as long-sleeves with long pants (Type I) and half·sleeves with short pants (Type II) were used to observe the effect of garment types on sweating response. Both clothing weight was equal (132$\pm$3 g/$m^{2}$). The results were as follows: 1. Regardless of the different types, total body weight loss was more interrelated with the sweat rate on forehead than any other parts of the body. Except the forehead, different parts of body with different types of garment influenced on body weight loss quite differently. 2. Total body weight loss was more interrelated with the weight gain of garment than the local sweat rate. 3. Under the environment of 44$\pm1^{\circ}C,\;50{\pm}5\%$R.H., body weight loss during 1 hour of subject clothed and silted was 275.2 g/hr and weight loss per body surface area was 178.9 g/$m^{2}/hr$ Garment types have no influences on total body weight loss. 4. Local sweat rate (mg/7.07 $cm^{2}/hr$) was 208.0,191.0, 133.0, 115.0,81 0, 75.1 and 66.3 on scruff, breast, forehead, forearm, thigh, upper arm, leg respectively No evidence has been found that garment types influenced on local sweat rate (p<0.1). 5. No interrelationships between rectal temperature and total body weight loss, local skin temperature and total body weight loss, and local skin temperature and local sweat rate were found. From this study, some possible method that we can estimate total body' weight loss judging from weight loss of garment. But considering the fact that clothing design factor, the physical characteristics of fabric and environmental factor such as humidity and wind velocity should be concerned in weight loss of garment, it should be studied further whether the total body weight loss can be estimated properly from the weight loss of garment. This experiment suggest that different parts of body with different types of garment can influence on body weight loss quite differently. Therefore, in order to get more precise results, more studies under the diversity of garment types should be done in the near future.