Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Effects of DIDS on single $Ca^{2+}$ release channel behavior of skeletal muscle

  • Seo, In-Ra (Department of Life Science, Kwangju Institute of Science and Technology) ;
  • Kim, Do-Han (Department of Life Science, Kwangju Institute of Science and Technology)
  • Published : 2001.06.01
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Abstract

Evidence has suggested that an anion channel blocker, 4, 4'-diisothiocyanatostilbene-2, 2' disulfonic acid (DIDS) could trigger Ca release from skeletal sarcoplasmic reticulum (SR) by binding to a 30 kDa SR protein. Since the high molecular weight $Ca^{2＋}$ release channel (CRC)/ryanodine receptor (RyR) is the main SR protein that conducts $Ca^{2＋}$ efflux in skeletal muscles, the relationship between CRC and the 30kDa protein remains to be elucidated.(omitted)

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