• Nutrition Research and Practice
• /
• 제1권4호
• /
• pp.266-272
• /
• 2007

The present study evaluated the effect of various dosages of soybean isoflavone extract on body weight changes, glucose tolerance and liver function in streptozotocin-induced diabetic rats. One group of normal rats (normal control) was fed an AIN-76-based experimental diet and four groups of diabetic rats were fed the same diet supplemented with four different levels of soybean isoflavone extract for seven weeks. The daily dosages of pure isoflavone for four diabetic groups were set to be 0 mg (diabetic control), 0.5 mg (ISO-I), 3.0 mg (ISO-II) and 30.0 mg (ISO-III) per kilogram of body weight, respectively. The daily consumption of isoflavone at the level of 3.0mg per kilogram of body weight resulted in the suppression of body weight loss and increased the survival rate of diabetic animals one and half times compared to that of the diabetic control group. Blood glucose levels in a fasting state and after the oral administration of glucose were significantly lower in the ISO-II group during the oral glucose tolerance test. The ISO-II group showed a tendency to elongate the gastrointestinal transit time. The activity of serum aminotransferases, indicator of liver function, was not negatively affected by any intake level of isoflavone. The present study demonstrated that the soybean isoflavone extract may be beneficial to diabetic animals by improving their glucose tolerance and suppressing weight loss without incurring hepatotoxicity at the daily dosage of 3.0 mg per kg of body weight.

• 한국조경학회지
• /
• 제33권4호
• /
• pp.97-107
• /
• 2005

This study was carried out to construct accurate and scientific system of assessment indicators in selection of National Trust conservation areas, which was new concept of domestic environment movement and offer the raw data of new analytic method by introducing the fuzzy theory and weight for overcoming the uncertainty of ranking decision. To transform the Likert's scale granted to assessment indicators into the type of triangular fuzzy number(a, b, c), there was conversion to each minimum(a), median(b), and maximum(c) in applying membership function, and in using the center of gravity and eigenvalue, there was to decide the ranking. The rankings of converted values applied a mean importance and weight were confirmed that they were generally changed. Therefore, the ranking decision was better to accomplish objective and rational ranking decision by applying weight that was calculated in grouping of indicator than to judge the singular concept and to be useful in assessment of diverse National Trust site. In the future, because AHP, which was general method of calculating weight, was lacked, there was to understand the critical point to fix a pertinent weight, and to carry out the study applying engineering concept like fuzzy integral using $\lambda-measure$.

• 전자공학회논문지
• /
• 제52권9호
• /
• pp.45-53
• /
• 2015

적응적 가중치 윈도우 알고리즘은 기존의 지역적 정합방법의 단점인 낮은 정합률을 보완하면서 전역적 방법에 비하여 실시간 하드웨어 설계가 용이하다는 장점을 갖고 있다. 본 논문에서는 객체를 분리하는데 더 유리한 지오데식 가중치 윈도우 알고리즘을 사용하여 실시간 처리가 가능한 시스템을 설계하였다. 효율적인 하드웨어 설계와 처리 효율을 높이기 위해 데이터 의존성에 따른 스케줄링을 분석하였고 계산시간이 가장 긴 가중치 계산을 기준으로 계산 단계를 최소화하여 병렬 처리를 적용하였다. 지수함수 연산은 에러분석을 기반으로 계단(step) 함수로 구현하여 하드웨어 자원을 줄이고 설계 효율을 높였다. 설계한 시스템은 verilogHDL로 설계되었으며 동부하이텍 0.18um 라이브러리를 사용하여 Synopsis를 통해 합성하였고 츠쿠바 영상을 기준으로 2.22%의 에러율과 260MHz(25fps)의 최대 동작주파수, 182K 게이트의 하드웨어 자원을 사용한다.

• Toxicological Research
• /
• 제20권4호
• /
• pp.329-337
• /
• 2004

Primiphos-methyl and methidathion as organophosphorus (OP) pesticides were tested for their immunotoxic effects on Balb/c mice. Three dose levels of primiphos-methyl (10, 60, or 120 mg/kg/day) and methidathion (0.5, 2.5 or 5.0 mg/kg/day) were administered orally in the mice for 4 weeks. After, changes in body weight gain, relative weight of spleen and thymus, viable splenic cell numbers, surface marker on immune cell, and proliferation activity were investigated. Results showed that neither Pirimiphos-methyl nor methidathion dosages changed significantly body weight, relative thymus and spleen weight, and thymus and spleen cellularities of the mice, but high dose treatment (120 mg/kg) of pirimiphos-methyl significantly decreased relative spleen weight and spleen cellularity of the mice. No alterations were observed in changes of LPS-proliferation response of splenocytes by exposure to any dose of pirimiphos-methyl and methidathion. However, pirimiphos-methyl dosages reduced ConA-proliferation response of splenocytes and both methidathion and pirimiphos-methyl decreased the ability of antibody production to SRBC. The results indicate that 28 days exposure to the high dose of pirimiphos-methyl suppress the function of splenic T and B cell function, and methidathion reduce the immune responsibility of B cell in mice without the changes in lymphoid organ weight or viability of splenocytes. Pirimiphos-methyl is more immunotoxic than methidathion although this has higher general toxicity than that.

• 한국산업보건학회지
• /
• 제24권3호
• /
• pp.321-329
• /
• 2014

Objectives: This study was performed to produce data on the pulmonary toxicity of neodymium oxide($Nd_2O_3$) by intratracheal instillation. Methods: Two groups of rats were exposed to neodymium oxide by intratracheal instillation with doses of 0.5 mg and 2.0 mg, respectively. At two days, four weeks and 12 weeks after exposure, body weight change, organ weight change and histopathological change were observed. At 12 weeks after exposure, lung function change was measured. Results: The body weight of rats in the high concentration group decreased after 12 weeks by 4-5% compared with the control group. At four weeks and 12 weeks after the administration of neodymium oxide, the absolute weight of the lungs of the high concentration group were significantly increased when compared with the control group(p<0.05). At 12 weeks after the injection of neodymium oxide, breath frequency and respiratory minute volume were increased, but inhalation time and expiratory time were decreased. Bronchiolar epithelial hyperplasia, alveolar type II cell hypertrophy/hyperplasia and foreign body granulomatous inflammation were observed in the high exposure group. Conclusions: Body weight decrease, lung absolute weight and breath frequency increase, and pathological lung change were all observed. We found that pulmonary toxicity of neodymium oxide nanoparticles by intratracheal instillation could be confirmed.

• Communications for Statistical Applications and Methods
• /
• 제21권3호
• /
• pp.213-224
• /
• 2014

In this paper, we study the problem of transforming to normality. We propose to estimate the transformation parameter by minimizing a weighted squared distance between the empirical characteristic function of transformed data and the characteristic function of the normal distribution. Our approach also allows for other symmetric target characteristic functions. Asymptotics are established for a random sample selected from an unknown distribution. The proofs show that the weight function $t^{-2}$ needs to be modified to have thinner tails. We also propose the method to compute the influence function for M-equation taking the form of U-statistics. The influence function calculations and a small Monte Carlo simulation show that our estimates are less sensitive to a few outliers than the maximum likelihood estimates.

• Asian-Australasian Journal of Animal Sciences
• /
• 제20권1호
• /
• pp.106-111
• /
• 2007

The current study was conducted to determine the optimum length of feed withdrawal for pre-harvest broilers. A total of three hundred broilers were sampled from an industrial population, and 30 chicks for each weight group (e.g., 1.5 and 2.5 kg) were randomly assigned to feed withdrawal treatments for 0, 3, 6, 9 and 12 h. Weight loss, yield, muscle pH, objective meat color and weights of gastro intestinal contents, crop, gizzard, provenriculus, small intestine, caecum, and rectum were determined. Live weight loss was significantly (p<0.05) increased as length of feed withdrawal extended. A significant (p<0.05) carcass yield for both 1.5 and 2.5 kg groups coincided after 9 and 6 h feed withdrawal, respectively. Net weights of intestinal contents for crop and gizzard were significantly (p<0.05) reduced by 6 h, and the reduction for proventriculus and small intestine occurred from 3 h. A noticeable effect of feed withdrawal on pH for breast muscle at 3 h postmortem occurred only when chicks were fasted for 3 h of which pH (6.05) was significantly (p<0.05) higher than that for other groups including the control (5.74). There was a linear tendency of higher lightness (Hunter L* value) numerically for chicks fasted for longer periods. The highest coefficient of determinations of regression models to estimate weight loss as a function of fasting period and body weights were achieved, when the models included both linear and quadratic terms for fasting period, and linear term for both 1.5 ($R^2=0.76$) and 2.5 kg ($R^2=0.78$) body weight groups. Given the practical aspect, approximately 1.5 kg of body weight is dominant, weight loss could be predicted by the following function; live weight $loss=26.6-0.28{\times}(fasting period)^2+12.34{\times}pasting\;period-0.012{\times}body\;weight$, $R^2=0.76$. Current data implied that the optimum fasting time for pre-slaughter chicks varied depending on slaughter weight; 6 and 9-h fasting were recommendable for 2.5 and 1.5 kg chicks, with little effect on objective meat color.

• 한국가축번식학회지
• /
• 제27권2호
• /
• pp.135-142
• /
• 2003

본 실험은 한우 종빈우의 임신말기에 Se과 Vit. E 투여가 종빈우의 번식기능에 미치는 요인과 종빈우에서 태어난 송아지의 발육능력을 조사하였다. 1 분만 1개월전 Se과 Vit. E을 투여한 구에서 송아지의 발육성적을 조사한 결과, 생시체중은 각각 23.33, 24.00, 24.00, 24.50, 24.00 및 25.60kg으로서 처리구가 대조구보다 다소 높은 성적을 나타냈다. 또한 이유시 체중과 일당증체량도 투여구가 대조구보다 다소 높은 성적을 나타냈으며, 이유시 일령은 투여구가 대조구보다 이유시 일령이 다소 적었으나 처리구간 유의적인 차이는 없었다(P>0.05). 2. 종빈우의 번식능력을 조사한 결과, 분만 후 초발정과 인공수정 휫수는 투여구가 대조구보다 초발정이 빨리 도래하였고, 수태당 인공수정 휫수도 적었으나 처리구간 유의적인 차이는 없었다(P>0.05). 3. Se과 Vit. E를 분만 2개월전에 4회 투여한 한우 종빈우에서 태어난 송아지의 생시체중, 이유시 체중 및 일당증체량은 투여구가 대조구보다 높은 성적을 나타냈으며, 이유시 일령은 투여구가 대조구보다 이유시 일령이 짧았으나 처리구간 유의적인 차이는 없었다(P>0.05). 4. 한우 종빈우의 번식능력을 조사한 결과, 분만 후 초발정은 유의적인 차이는 없었으며(P> 0.05), 수태 당 인공수정 횟수는 각각 2.00, 1.63, 1.25, 1.50, 1.33 및 1.46회로서 투여구가 대조구보다 인공수정 횟수가 적었으나 처리구간 커다란 차이가 없었다(P>0.05).

• Bulletin of the Korean Chemical Society
• /
• 제34권6호
• /
• pp.1715-1721
• /
• 2013

Magnetic properties of magnetite ferrofluid are studied by measuring magnetic weights under different magnetic fields with a conventional electronic balance. Magnetite nanoparticles of 11 nm diameter are synthesized to make the ferrofluid. Magnetization calculated from the magnetic weight reveals the hysteresis and deviates from the Langevin function at high magnetic fields. Magnetic weight shifts instantaneously with magnetic field change by Neel and Brown mechanism. When high magnetic field is applied to the sample, slower change of magnetic weight is accompanied with the instantaneous shift via agglomeration of nanoparticles. The slow change of the magnetic weight shows the stretched exponential kinetics. The temporal change of the magnetic weight and the magnetization of the ferrofluid at high magnetic fields suggest that the superparamagnetic sample turns into superspin glass by strong magnetic interparticle interactions.

• Food Science and Biotechnology
• /
• 제16권3호
• /
• pp.434-438
• /
• 2007

The aim of the present study was to assess the effects of onion (Allium cepa) skin extract (OSE) on pancreatic lipase (PL), the key enzyme of the digestion and absorption of dietary fat in the small intestine, and to evaluate its potential for the inhibition of body-weight gain. OSE inhibited PL with an $IC_{50}$ of 53.70 mg/mL, which means as potent as 0.07635% of the activity of orlistat. At 3 and 4 hr after administration of OSE, the plasma triacylglycerol concentration was significantly lower in the OSE-treated rats than control. Body-weight gain and parametrial adipose tissue weights were significantly lower in mice fed the high-fat diet (fat comprises 31% of total calories) with 5%(w/w) OSE than in control. The results suggest that OSE may be an effective nutraceutical for the inhibition of body-weight gain.