• 척추신경추나의학회지
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• 제8권1호
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• pp.1-13
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• 2013

Objectives: The present study examines the domestic trend of Chuna manual therapy on cervical spinal disorders in Korea. Methods: We investigated the studies on Chuna manual therapy for cervical spinal disorders via searching 6 Korean web databases. As a result, 51 research papers were found to be analyzed according to their published year, published institution, the titles of journals, the types of study, the techniques of Chuna, the instruments for assessment, the Chuna technique and the number of the treatment trials by the cases of cervical spinal disorders and ethical approvals. Results: The number of the research papers published tended to increase every year. The studies on Chuna manual therapy for cervical spinal disorders were mainly published in The Journal of Korea CHUNA Manual Medicine for Spine & Nerves. The most frequently adopted technique of Chuna in the examined studies was Chuna spine manipulation therapy - cervical spine technique. Visual analogue scale (VAS), neck disability index(NDI) were used as primary means of assessments. The ethical problems of the examined studies needed to be improved. Conclusions: Reviewing the domestic trend of studies on Chuna manual therapy for cervical spinal disorders and examining the strong and weak points of those treatments are essential for the future studies. It is anticipated that this review benefits the future in-depth study on the treatments for Chuna in Korean medicine.

• 척추신경추나의학회지
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• 제8권1호
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• pp.49-61
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• 2013

Objectives: The aim of this study was to analyse the domestic trends of Chuna treatments techniques in Korean literature. Methods: We searched the clinical trials on Chuna treatments through both electronic search(used keyword 'chuna') and hand search in 3 Korean web databases(OASIS, NDSL, RISS) and 4 related journals(The Journal of Korea CHUNA Manual Medicine for Spine & Nerves, Journal of Oriental Rehabilitation Medicine, The Journal of Korean Acupuncture & Moxibustion Society, Journal of Korean Medicine Society). All relevant clinical trials were selected and extracted to be analyzed according to their published year, journals, types of study, used techniques. Results: The number of the clinical studies tends to increase every year. The studies on Chuna treatments were mainly published in The Journal of Korea Chuna Manual Medicine for Spine & Nerves. In case of types of study, case reports and case series were predominant. The most frequently adopted techniques of Chuna in studies were flexion distraction technique for lumbar spine and JS supine position cervical spine distraction. Conclusions: Through the results of this study, we hope that the more qualitative education could be conducted by strengthening the techniques which often used. Also analysis of the reason of rarely used techniques should be conducted and the modification or developing techinques should be followed as a counter measures. As applying more rigorous methodology, more qualitative evidence based Chuna studies should be conducted in future clinical research.

• Clinical and Experimental Pediatrics
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• 제63권2호
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• pp.34-43
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• 2020

Phenylketonuria is a disease caused by congenital defects in phenylalanine metabolism that leads to irreversible nerve cell damage. However, its detection in the early days of life can reduce its severity. Thus, many countries have started disease screening programs for neonates. The present study aimed to determine the worldwide prevalence of classic phenylketonuria using the data of neonatal screening studies.The PubMed, Web of Sciences, Sciences Direct, ProQuest, and Scopus databases were searched for related articles. Article quality was evaluated using the Joanna Briggs Institute Critical Appraisal Evaluation Checklist. A random effect was used to calculate the pooled prevalence, and a phenylketonuria prevalence per 100,000 neonates was reported. A total of 53 studies with 119,152,905 participants conducted in 1964-2017 were included in this systematic review. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand. A total of 46 studies were entered into the meta-analysis for pooled prevalence estimation. The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates (95% confidence interval, 5.07-6.93). The meta-regression test showed high heterogeneity in the worldwide disease prevalence (I²=99%). Heterogeneity in the worldwide prevalence of phenylketonuria is high, possibly due to differences in factors affecting the disease, such as consanguineous marriages and genetic reserves in different countries, study performance, diagnostic tests, cutoff points, and sample size.

• 한국산업정보학회논문지
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• 제11권5호
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• pp.37-52
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• 2006

본 연구에서는 Tagfree 의 XML 개발 툴을 이용하여 XML, DTD, XML 스키마 등의 문서를 실제로 개발하여 이들 간의 상관관계를 봄으로써 XML 프로그래밍과 문법을 쉽게 해득하여 웹 문서를 보다 용이하게 개발하고 또한 XML 데이터와 MS SQL 과 같은 RDB 데이터의 저장관리와 매핑과정을 구현해 봄으로써 트리개념의 XML 문서와 테이블개념의 데이터베이스가 어떻게 이론적으로 연동되며 실제 구현시의 한계와 장단점은 없는지를 규명해 봄으로써 전자상거래나 무선인터넷 구축 시 XML 문서의 이용 효율성을 높이는데 그 목적이 있다.

• 대한약침학회지
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• 제20권3호
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• pp.158-172
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• 2017

Nigella sativa (N. sativa, family Ranunculaceae) is a medicinal plant that has been widely used for centuries throughout the world as a natural remedy. A wide range of chemical compounds found in N. sativa expresses its vast therapeutic effects. Thymoquinone (TQ) is the main component (up to 50%) in the essential oil of N. sativa. Also, pinene (up to 15%), p-cymene (40%), thymohydroquinone (THQ), thymol (THY), and dithymoquinone (DTQ) are other pharmacologically active compounds of its oil. Other terpenoid compounds, such as carvacrol, carvone, 4-terpineol, limonenes, and citronellol, are also found in small quantities in its oil. The main pharmacological characteristics of this plant are immune system stimulatory, anti-inflammatory, hypotensive, hepatoprotective, antioxidant, anti-cancer, hypoglycemic, anti-tussive, milk production, uricosuric, choleretic, anti-fertility, and spasmolytic properties. In this regard, we have searched the scientific databases PubMed, Web of Science, and Google Scholar with keywords of N. sativa, anti-cancer, apoptotic effect, antitumor, antioxidant, and malignancy over the period from 2000 to 2017. The effectiveness of N. sativa against cancer in the blood system, kidneys, lungs, prostate, liver, and breast and on many malignant cell lines has been shown in many studies, but the molecular mechanisms behind that anti-cancer role are still not clearly understood. From among the many effects of N. sativa, including its anti-proliferative effect, cell cycle arrest, apoptosis induction, ROS generation, anti-metastasis/anti-angiogenesis effects, Akt pathway control, modulation of multiple molecular targets, including p53, p73, STAT-3, PTEN, and $PPAR-{\gamma}$, and activation of caspases, the main suggestive anti-cancer mechanisms of N. sativa are its free radical scavenger activity and the preservation of various anti-oxidant enzyme activities, such as glutathione peroxidase, catalase, and glutathione-S-transferase. In this review, we highlight the molecular mechanisms of apoptosis and the anti-cancer effects of N. sativa, with a focus on its molecular targets in apoptosis pathways.

• 대한약침학회지
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• 제20권3호
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• pp.179-193
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• 2017

Objectives: Nigella sativa (black seed or black cumin), which belongs to the Ranunculacea family, is an annual herb with many pharmacological properties. Among its many active constituents, thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa (N. sativa) seeds, and it is the constituent to which most properties of this herb are attributed. Methods: PubMed-Medline, Scopus, and Web of Science databases were searched to identify randomized control trials (RCTs) investigating the therapeutic effects of N. sativa and/or TQ. In this review, we investigated the clinical uses of N. sativa and TQ in the prevention and the treatment of different diseases and morbidity conditions in humans. Results: Black seed and TQ are shown to possess multiple useful effects for the treatment of patients with several diseases, such as inflammatory and auto-immune disorders, as well as metabolic syndrome. Also, other advantages, including antimicrobial, anti-nociceptive and anti-epileptic properties, have been documented. The side effects of this herbal medicine appear not to be serious, so it can be applied in clinical trials because of its many advantages. Conclusion: Some effects of N. sativa, such as its hypoglycemic, hypolipidemic and bronchodilatory effects, have been sufficiently studied and are sufficiently understood to allow for the next phase of clinical trials or drug developments. However, most of its other effects and applications require further clinical and animal studies.

• 한방재활의학과학회지
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• 제25권2호
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• pp.89-96
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• 2015

Objectives This study is to investigate domestic trends of chuna manual therapy on traffic accident for recent 10 years. Methods We searched the studies on chuna manual therapy for traffic accident in 6 Korean web databases. Consequently, 17 research papers were founded. We analyzed these papers according to their published year, the titles of journal, the type of study, the number of cases, the sites of injury, assessment scales of study, and ethics of research. Results 17 papers were published since 2005. The studies on chuna manual therapy about traffic accident were mainly published in the journal of korean society of chuna manual medicine for spine & nerves and the journal of korean medicine rehabilitation. All papers were clinical research include 2 case series, 2 non randomized controlled trials (NRCTs), 13 randomized controlled trials (RCTs). The most frequently occured symptom was neck pain. In assessment scales, visual analog scale (VAS) was mainly used. All clinical studies were not mentioned about approval of institutional review board (IRB). Conclusions In this study, we analyzed the trends of chuna manual therapy on traffic accident in Korea from 2005 to 2014. In reviewing published papers, we found several weak points in methods of research and quality of study protocol. It is needed to adjust these problems for development of future researches.

• 한방재활의학과학회지
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• 제26권1호
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• pp.41-47
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• 2016

Objectives The purpose of this study is to investigate the trends of Korean medicine treatments of spondylolisthesis. Methods We investigated the studies on Korean medicine treatments for spondylolisthesis via searching 4 Korean web databases (OASIS, KTKP, RISS, DBpia). We used "Spondylolisthesis", "Lumbar spondylolisthesis" as keyword. Limitations were as follows; Domestic studies, mentioning the treatments of spondylolisthesis in Korean medicine. This study researched and classified the papers according to type of study, published year, titles of journals, published institution, the number of cases, and types of treatments. Results 14 research papers were found to be analyzed according to their published year, the titles of journals, published institution, the types of study, the number of cases, and the types of treatments. 14 papers were published since 2000. The studies on Korean medicine treatments about spondylolisthesis were mainly published in the journal of Korean acupuncture & moxibustion medicine. 7 case reports, 6 case series, 1 RCT had been under research. In 14 cases of the studies, various Korean medicine treatments were used to treat the symptoms. Numeric rating scale (NRS) was used as primary assessments. Conclusions In this study, we analyzed the trends of Korean medicine treatments of spondylolisthesis. Reviewing the domestic trends of studies on Korean medicine treatments of spondylolisthesis and examining the strong and weak points of those treatments are essential for the further studies.

• Safety and Health at Work
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• 제11권2호
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• pp.136-142
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• 2020

Background: Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory arthritis. This meta-analysis was conducted to examine the association between occupational exposure to silica and the risk of developing RA among different workers. Methods: In this meta-analysis, we searched relevant published studies using major electronic databases including Scopus, PubMed, ISI Web of Science, and Google Scholar search engine up to October 2019, and the references of retrieved articles were also checked for further possible sources. A random-effects model was used to account for heterogeneity among the results of the studies using the pooled odds ratios (ORs) and their 95% confidence intervals (CIs). The Q-statistic and I² tests were calculated to assess heterogeneity between the studies. Results: The pooled calculation of OR indicated a significant association between occupational exposure to silica and risk of developing RA among different workers (OR = 2.59, 95% CI = 1.73 to 3.45). In addition, the pooled estimates of OR in smokers were statistically significant (OR = 2.49, 95% CI = 1.13 to 3.86). Conclusions: The findings of the present study reveal that occupational exposure to silica may be associated with increased risk of developing RA.

• 대한화장품학회지
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• 제29권2호
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• pp.233-250
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• 2003

현재 화장품 연구업무 및 수출입업무 종사자들이 많이 사용하고 있는 ICID 및 장원기 등의 화장품 원료규격집과 각종 원료메이커들이 제공하는 원료의 기술자료, MSDS 등의 기술문서를 연관 데이터베이스로 처리하여 인터넷 서버&클라이언트의 구조를 통해 사용자들에게 제공되어질 수 있는 온라인형 데이터베이스 프로그램을 개발하였고, 이를 완성한 도구로서 서버로는 Linux Machine을 사용하였고, 데이터베이스서버로는 MySQL Server를, CGI Tool로는 PHP를 사용하였다. 또한 데이터베이스 구조상 차후 확장성을 대비하여 데이터베이스를 연관구조로 작성하였으며, 이는 데이터의 중복성을 피하여 화장품 원료정보의 검색 효율을 높일 수 있었고, 차후 다른 화장품관련데이터베이스와의 상호 연계의 인터페이스를 마련할 수 있었다. 데이터베이스의 특성상 한번 구축되면 원하는 형태로의 자료변환 및 재구성이 용이하여, 아직까지 화장품 원료 데이터베이스가 구축되어 있지 못한 국내현실을 볼 때 본 프로그램이 화장품업계의 소중한 기초자료로 활용되기를 기대한다.