• Macromolecular Research
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• 제8권3호
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• pp.131-136
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• 2000

The synthesis of poly(2-ethynylpyridine) having glycidyl functionality was performed by the direct polymerization of 2-ethynylpyridine and epibromohydrin under mild reaction conditions without any initiator and catalysts. The polymerization proceeded well to give the resulting poly(2-ethynylpyridinium bromide) with a glycidyl functionality having relativity high molecular weight in high yields. The polymer structure was characterized by various instrumental methods to have the conjugated polymer backbone structure having glycidyl functionality. This ionic polymer was completely soluble in water, methanol, DMF, DMSO, and N,N-dimethylacetamide, but insoluble in THF, toluene, acetone, nitrobenzene, and n-hexane. This polymer system exhibited the UV-visible absorption around 300 and 520 nm and red photoluminescence spectrum around 725 nm.

• 약학회지
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• 제48권1호
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• pp.82-87
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• 2004

Mungbean trypsin inhibitor (MBTI) was isolated and purified from Mung bean which has been used as a galenic and traditional food. MBTI and poly(ethylene glycol) were conjugated by using water soluble carbodiimide. We evaluated the therapeutic value of the MBTI and MBTI-PEG conjugate using animal models, sublethal septic shock model in guinea pig caused by pseudomonal elastase, shock model in rat caused by lipopolysaccharide, and the vascular permeability test by using pseudomonal elastase. In two shock model in guinea p Is and in rat, hypotesion shock was inhibited by pretreatment of MBTI. And also the vascular permeability caused by pseudomonal elastase reduced by pretreatment of MBTI. Also, therapeutic value of the MBTI-PEG conjugate was evaluated by using the sublethal septic shock model caused by pseudomonal elastase. The MBTI-PEG conjugate was more effective than native MBTI against pseudomonal elastase induced septic shock in guinea pig model.

• KSBB Journal
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• 제31권4호
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• pp.300-311
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• 2016

Recently gene delivery has been designed newly using bioactive biomaterial and applied in the various field by many researchers. In this study, we proposed a new gene delivery system which has the capability of targeting effect in the specific tissue and remarkably enhanced transfection efficiency. We investigated $^1H-NMR$ spectroscopy, particle size analyzer and gel retardation to confirm the correct preparation of gene delivery. Also, we identified the hemo-compatibility of gene delivery by hemolysis assay, non-cytotoxicity by MTT test and transfection efficiency. The uptake mechanism of the gene carrier was confirmed using inhibitor agent such as sodium azide, indomethacin, quercetin, colchicine, and chloropromazine. As a results, it was identified that gene carrier prepared by in this study entered in the cell by the microtubule-dependent, energy-dependent and clathrin-mediated endocytosis pathway.

• 폴리머
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• 제38권1호
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• pp.38-42
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• 2014

Poly[(9,9-bis((6'-(N,N,N-trimethylammonium)hexyl)-2,7-fluorene)-alt-(9,9-bis(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-9-fluorene)) dibromide(WPF-6-oxy-F)]와 graphene oxide(GO)를 혼합하여 WPF-6-oxy-F-GO를 제조한 후 공기 중에서 감마선을 조사하였다. WPF-6-oxy-F-GO 복합재는 유기태양전지(organic solar cells, OSCs)의 정공수송층(hole transporting layer, HTL)으로서 적용하였다. GO와 비교해 보았을 때, 조사된 WPF-6-oxy-F-GO의 면저항(sheet resistance, $R_{sheet}$)은 약 2배 정도 감소하였다. 이는 감마선 조사를 통하여 WPF-6-oxy-F와 GO 사이의 C-N 결합의 형성으로 인한 ${\pi}-{\pi}$ 공유 결합의 영향과 효율적인 packing 때문이다. 결과적으로, 조사된 WPF-6-oxy-F-GO를 정공수송층으로 적용하였을 때 유기태양전지의 효율은 6.10%까지 증가하였다. 수용성 고분자 WPF-6-oxy-F-GO는 정공수송층으로서 사용되고 있는 PEDOT:PSS를 대체하는 대안 소재로서, 높은 효율과 저가의 유기태양전지를 구현할 수 있을 것으로 기대된다.

• 폴리머
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• 제34권6호
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• pp.501-506
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• 2010

물에 잘 녹지 않는 고분자량의 키토산을 가수분해하여 수용성을 갖는 저분자량 키토산을 제조하였다. 키토산을 효율적인 유전자 전달체로 개발하기 위하여 항산화제의 일종인 리포산과 결합하여 빗살 형태의 공중합체를 제조하였다. 양친성을 가지는 공중합체는 수용액 상에서 자기조립을 하여 나노입자를 형성하였다. 나노입자의 평균크기는 217.6 nm이었고 유전자와 복합체를 이루었을 때의 평균크기는 170 nm로 나타났다. 새롭게 만들어진 키토산-리포산 공중합체는 낮은 세포독성을 나타내었고 순수한 키토산에 비하여 10배 정도 높은 형질 발현효율을 보여주었다.

• 폴리머
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• 제35권6호
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• pp.558-564
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• 2011

생체적합하고 생분해성을 갖는 폴리아미노산의 하나인 폴리아스팔트산은 팹타이드 결합으로 이루어진 수용성 합성고분자로서 의료용 소재 및 다양한 응용분야의 연구가 흥미있게 진행되어 왔다. 본 연구에서는 아미노산인 GABA(${\gamma}$-aminobutylic acid)와 ${\beta}$-alanine을 곁사슬에 도입한 폴리아스팔트산 유도체 고분자를 제조하고, 이들을 서로 다른 함량의 ethylene glycol diglycidyl ether(EGDE)를 사용하여 가교시켜 고흡수성 하이드로젤을 제조하였다. 각 하이드로젤에 대해 증류수와 PBS 용액에서 기본적인 팽윤물성, 젤의 가수분해 거동과 모폴로지를 조사하였다. 제조한 하이드로젤은 수용액에서 pH와 염(salt) 농도에 의존하는 민감성 팽윤거동을 보였으며, 또한 비교적 빠른 가수분해 거동을 나타내었다.

• Macromolecular Research
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• 제16권1호
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• pp.57-61
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• 2008

Chitosan is normally acylated and subsequently conjugated with drugs for biomedical applications. This study examined the relationship between the succinylation and gelation behaviors of glycol chitosan. Glycol chitosan was acylated with succinic anhydride under a wide variety of reaction conditions, such as different molar ratios of succinic anhydride to glucosamine, different methanol content in the reaction media, and different reaction temperatures. Among these reaction parameters, the methanol content in the solvent played an important role in determining the regioseletive succinylating site. N-succinylation and N-N cross-linking occurred regardless of the reaction conditions. However, O-succinylation was observed under specific conditions, i.e. a methanol content> 0.6 (v/v) and a reaction temperature> $25^{\circ}C$. O-succinylation accelerated the N-O cross-linking of glycol chitosan, and led to gelation. The N-succinylated glycol chitosans were water-soluble, whereas the N-and O-succinylated glycol chitosans fonned a gel. These physico-chemical structural differences in the succinylated glycol chitosans would definitely influence subsequent drug-conjugation reactions and consequently the drug loading and release kinetics.