Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Preparation and Properties of Biodegradable Superabsorbent Gels Based on Poly(aspartic acid)s with Amino Acid Pendants

아미노산 곁사슬 치환 폴리아스팔트산계 생분해성 고흡수성 젤의 제조와 물성

  • Son, Chang-Mo (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University) ;
  • Jeon, Young-Sil (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University) ;
  • Kim, Ji-Heung (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
  • 손창모 (성균관대학교 화학공학부, 고분자기술연구소) ;
  • 전영실 (성균관대학교 화학공학부, 고분자기술연구소) ;
  • 김지흥 (성균관대학교 화학공학부, 고분자기술연구소)
  • Received : 2011.04.20
  • Accepted : 2011.06.14
  • Published : 2011.11.25
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Abstract

The biocompatibility and biodegradability of poly(amino acid) make them ideal candidates for many bio-related applications. Poly(aspartic acid), PASP, is one of synthetic water-soluble polymers with proteinlike structure, and has been extensively explored for the potential industrial and biomedical applications due to its biodegradable, biocompatible and pH-responsive properties. In this work, amino acid-conjugated PASPs were prepared by aminolysis reaction onto polysuccinimide (PSI) using ${\gamma}$-aminobutylic acid(GABA) and ${\beta}$-alanine methyl ester and a subsequent hydrolysis process. Their chemical gels were prepared by crosslinking reaction with ethylene glycol diglycidyl ether (EGDE). The hydrogels were investigated for their basic swelling behavior, hydrolytic degradation and morphology. The crosslinked gels showed a responsive swelling behavior, which was dependent on pH and salt concentration in aqueous solution, and relatively fast hydrolytic degradation.

생체적합하고 생분해성을 갖는 폴리아미노산의 하나인 폴리아스팔트산은 팹타이드 결합으로 이루어진 수용성 합성고분자로서 의료용 소재 및 다양한 응용분야의 연구가 흥미있게 진행되어 왔다. 본 연구에서는 아미노산인 GABA(${\gamma}$-aminobutylic acid)와 ${\beta}$-alanine을 곁사슬에 도입한 폴리아스팔트산 유도체 고분자를 제조하고, 이들을 서로 다른 함량의 ethylene glycol diglycidyl ether(EGDE)를 사용하여 가교시켜 고흡수성 하이드로젤을 제조하였다. 각 하이드로젤에 대해 증류수와 PBS 용액에서 기본적인 팽윤물성, 젤의 가수분해 거동과 모폴로지를 조사하였다. 제조한 하이드로젤은 수용액에서 pH와 염(salt) 농도에 의존하는 민감성 팽윤거동을 보였으며, 또한 비교적 빠른 가수분해 거동을 나타내었다.

Keywords

References

  1. A. J. Domb, J. Kost, and D. M. Wiseman, Handbook of Biodegradable Polymer, Hardwood Academic, Amsterdam, 1997.
  2. S. Dumitriu, Polymeric Biomaterials, CRC Press, New York, 2001.
  3. S. B. Jang, News Inf. Chem. Eng., 32, 414 (2000).
  4. B. D. Rafner, A. S. Hoffman, F. J. Schoen, and J. S. Lamons, Biomaterials Science, Academic Press, Elsevier, London, 2004.
  5. L. Nair and C. T. Laurencin, Prog. Polym. Sci., 32, 762 (2007). https://doi.org/10.1016/j.progpolymsci.2007.05.017
  6. K. Y. Lee and D. J. Mooney, Chem. Rev., 101, 1869 (2001). https://doi.org/10.1021/cr000108x
  7. A. S. Hoffman, Adv. Drug Deliv. Rev., 43, 3 (2002).
  8. R. Langer and N. A. Peppas, AICHE J., 49, 2990 (2003). https://doi.org/10.1002/aic.690491202
  9. J. M. Fosiak, J. Control. Release, 31, 9 (1994). https://doi.org/10.1016/0168-3659(94)90246-1
  10. E. S. Gil and S. M. Hudson, Prog. Polym. Sci., 29, 1173 (2004). https://doi.org/10.1016/j.progpolymsci.2004.08.003
  11. C. H. Alarcon, S. Pemadam, and C. Alexander, Chem. Soc. Rev., 34, 276 (2005). https://doi.org/10.1039/b406727d
  12. S, K. Wolk, G. Swift, Y. H. Paik, K. M. Yocom, R. L. Smith, and E. S. Simon, Macromolecules, 27, 7613 (1994). https://doi.org/10.1021/ma00104a016
  13. T. Nakato, A. Kusuno, and A. Kakucho, J. Polym. Sci. Part A: Polym. Chem., 38, 117 (2000). https://doi.org/10.1002/(SICI)1099-0518(20000101)38:1<117::AID-POLA15>3.0.CO;2-F
  14. A. P. Wheeler and L. P. Kosan, Mat. Res. Soc. Symp. Proc., 292, 279 (1994).
  15. P. Neri, G. Antani, F. Benvenuti, F. Colola, and G. Gazzei, J. Med. Chem., 16, 893 (1972).
  16. J. Mosig, C. H. Gooding, and A. P. Wheeler, Ind. Eng. Chem. Res., 36, 2163 (1997). https://doi.org/10.1021/ie960678g
  17. H. D. Park, J.-H. Kim, S. H. Kim, and Y. H. Kim, Polymer (Korea), 23, 247 (1997).
  18. J.-H. Kim, J. H. Lee, and S.　W. Yoon, J. Ind. Eng. Chem., 8, 138 (2002).
  19. J. Lei, Y. S. Jeon, and J.-H. Kim, Macromol. Res., 16, 45 (2008). https://doi.org/10.1007/BF03218959
  20. S. K. Min, S. H. Kim, and J.-H. Kim, J. Ind. Eng. Chem., 6, 276 (2000).
  21. S. I. Kim, S. K. Min, and J.-H. Kim, Bull. Korean Chem. Soc., 29, 1887 (2008). https://doi.org/10.5012/bkcs.2008.29.10.1887
  22. S. I. Kim, C. M. Son, Y. S. Jeon, and J.-H. Kim, Bull. Korean Chem. Soc., 30, 3025 (2009). https://doi.org/10.5012/bkcs.2009.30.12.3025
  23. J.-H. Kim, C. M. Son, Y. S. Jeon, and W. S. Choe, J. Polym. Res., 18, 881 (2011). https://doi.org/10.1007/s10965-010-9485-2