• Archives of Pharmacal Research
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• v.29 no.10
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• pp.840-844
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• 2006

For the exploration of pharmacophoric moiety of malloapelta B (1) possessing the inhibitory activity of $NF-{\kappa}B$ activation, structural variation of ${\alpha},{\beta}-unsaturated$ carbonyl motif was attempted. 1 was reduced by catalytic hydrogenation, sodium borohydride, and lithium aluminumhydride. Catalytic hydrogenation with 30 psi or 15 psi of $H_2$ gas of 1 generated 8-butyl-5,7-dimethoxy-2,2-dimethylchroman (2) and 1-(5,7-dimethoxy-2,2-dimethylchroman-8-yl)butan-1-one (3), respectively. Reduction with sodium borohydride occurred at the double bond of ${\alpha},{\beta}-unsaturated$ ketone of 1 to give 1-(5,7-dimethoxy-2,2-dimethyl-2H-chromen-8-yl)butan-1-one (4). Reduction of 1 with lithium aluminumhydride and then quenched with methanol and water produced unexpected products, 1-(5,7-dimethoxy-2,2-dimethyl-2H-chromen-8-yl)-3-methoxy-1-butene (5) and 1-(5,7-dimethoxy-2,2-dimethyl-2H-chromen-8-yl)-3-hydroxy-1-butene (6). These are formed from the isomerization of initial product 9 through the continuous conjugate carbocation intermediate 11. Addition of ethylmagnesium bromide and dimethyl malonate anion to 1 gave the conjugate adducts 7 and 8. Ethylmagesium bromide and sodium borohydride reduction unusually gave the conjugate addition due to steric congestion around carbonyl group of 1. Compound 2 exhibits the reduced inhibitory activity against $NF-{\kappa}B$ activation and the others do not show the activity. Therefore ${\alpha},{\beta}-unsaturated$ carbonyl group of 1 should be important for its inhibitory activity.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2002.10a
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• pp.100-107
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• 2002

This study investigates the seasonal variation and spatial distribution characteristics of pollutant load, as executing the quantity valuation of pollutant load inflowing into Yeong-Il bay from on-land including the Hyeong-san river. Annual total pollutant generating rate from Yeong-Il bay region are 202ton to BOD, 620ton to SS, 42ton to T-N, 16ton to T-P respectively, if expressly point out, pollutant generating rate from the Hyeong-san river is the greatest, which BOD ratio is 78.2%, SS 88.5%, T-N 62.5%, T-P 73.1%. As calculating Tank model with input value of daily precipitation and evaporation of 2001 year in drainage basin of the Hyeong-san river, Estimated result of the annual total river discharge effluencing from this river is $830{\times}106m^3$. As result to estimating annual total effluence rate outflowing at the rivers from each drainage basins, annual total inflow pollutant rate are BOD 10,633ton, SS 19,302ton, T-N 15,369ton, T-P 305ton. The III basin which is population congestion region of the Pohang-city drain away a good many pollutant load than the V basin including the Neang-Chun with wide drainage area. Especially, a great many T-N than T-P inflow into Yeong-Il bay. The accumulation of pollutant load effluenced from on-land will happen on at the inner coast region of Yeong-Il bay, finally we would make a prediction that the water quality will take a bad turn.

• Journal of the Korean association of regional geographers
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• v.8 no.1
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• pp.40-64
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• 2002

The locational characteristics of ceramic industry in Miryang city, Kyongnam province, were clarified by means of examining the process of its formation, spatial variation, locations and their changes. The government policy on industry and the business fluctuation are important in the quantitative changes of the industry. The spatial variation of industry toward the outer part of area are the results of equilibrium between the decrease of firms in inner city and the increase of firms in outer part. The births and deaths of firms played important role in the processes of spatial variations. The industry location has lasted by the accumulation of location decision of 'potential entrepreneurs' who learned knowledges on the industry and had personal contacts with the business-related persons for long time. The main factors on the locational decision of firms are personal factor, raw materials, land, water and market. The locational problems have mainly related with plant expansion, land, marketing, labour and capital. They caused investment changes and caused relocations of firms. Such disadvantages as raw material exhaustion, shortage of land and congestion within the agglomeration area, development of road transportation and local government policy on industry location, induced recent decentralization of industry to outer part.

• Korean Journal of Pharmacognosy
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• v.43 no.1
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• pp.66-71
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• 2012

Cirsium japonicum var. ussuriense is often used in treatment of human disease such as hemorrhage, blood congestion and inflammation. This study was accomplished to evaluate the antioxidant properties of the leaf (CLE) and flower (CFE) extracts of C. japonicum var. ussuriense to protect normal human red blood cells (RBC) and plasma samples against oxidative damage in vitro. CLE and CFE were prepared by extracting with hot water. In red blood cells and plasma, oxidative hemolysis and lipid peroxidation induced by the aqueous peroxyl radical generator [2,2'-azobis (2-amidinopropane) dihydrochloride, AAPH] were significantly suppressed by CLE or CFE in a dose-dependent manner at the same time. CLE and CFE also prevented the depletion of cytosolic antioxidant glutathione (GSH) in RBC. These results suggest that the leaves and flowers of C. japonicum var. ussuriense may have the antioxidant properties.

• Toxicological Research
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• v.18 no.1
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• pp.23-29
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• 2002

Disodium disulphite, the HPV chemical, was assigned to Korea in order to implement OECD SIDS program in 1999. It was produced about 3,200 ton/year in 1998. This report evaluates the toxic potency of disodium disulphite based on the environmental and mammalian effects as well as human exposure. Oral $LD_{50}$ in rats is 1,540 mg/kg b.w. and effects was observed to the stomach, liver and the GI track that was filled with blood. For repeated dose toxicity, the predominant effect was the induction of stomach lesion due to local irritation. The no observed adverse effect lever for local (stomach irritation) was about 217 mg/kg bw/day. There is no evidence that disodium disulphite is genotoxic in vivo. No reproductive or developmental toxicty of disodium disulphite was observed for the period up to 2 yr and over three generation. In humans, urticaria and asthma with itching, edema, rhinitis, and nasal congestion were reported. Disodium disulphite is unlikely to induce respiratory sensitization but may enhance symptom of asthma in sensitive individuals. This chemical would be mainly transported to water compartment when released to environmental compartments since it is highly water soluble (470 g/l at 20). Low K oc (2.447) indicates disodium disulphite is so mobile in soil that it may not stay in the terrestrial compartment. The chemical has been tested in a limited number of aquatic species. hem acute toxicity test to fish, 96 hr-$LC_{50}$ was > 100 mg/1. For algae, 72 hr-$XC_{50}$ was 48.1 mg/1. For daphnid, the acute toxicity value of 48 hr-$EC_{50}$ was 88.76 mg/1, and chronic value of 21day-NOEC was > 10 mg/1. Therefore, PNEC of 0.1 mg/l for the aquatic organism was obtained from the chronic value of daphnid using the assessment factor of 100. Based on these data the disodium disulphite was recommended as low priority for further post-SIDS work in OECD.

• Korean Journal of Environment and Ecology
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• v.30 no.3
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• pp.320-327
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• 2016

Intertidal zone has been restored by the Sihwa Lake tidal power plant is operating in 2012. After restoration, to check the difference of bird group's community change out, the examination has been carried out from 2009 to 2014 when sea dike sluicer runs, the intertidal zone area was increased to $20.3km^2$ after restoring in $5.3km^2$. There was no significant difference in the number of individuals congestion of the whole, but the results of analysis of the differences between the six bird group by number of individuals, it showed a significant difference in Diving ducks(p = 0.237) the Herons (p<0.001), Swans and Geese (p<0.01), Dabbling ducks (p<0.001), showed a significant difference in the Shore birds (p<0.001) gulls (p<0.001) except for diving of ducks. Sihwa Lake intertidal zone was only just been restored, but environment and the improvement of benthic ecosystem has been carried out, It is determined that waterfowls that living based on intertidal zone are also affected. This study is a good example of the restoration of the intertidal zone that disappeared, which hard to find a similar case. It will be utilized as basic data of ecological monitoring for the conservation and management of the future of the intertidal zone later.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.10
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• pp.1425-1434
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• 2011

This experiment was designed to evaluate the effects of the processing method of common vetch seed (CVS) (Vicia sativa) on laying performance, egg quality, metabolic parameters and liver histopatology during the peak production period in hens. Lohman layers, 46 wk of age in 6 replicate cages each containing 4 hens, were allocated randomly to one of four dietary treatments. Diets were control (C) diet containing no common vetch and experimental diets containing 25% raw common vetch (RCV), 25% soaked in water for 72 h with exchange of water every 24 h (SCV) and 25% soaked&boiled at $100^{\circ}C$ for 30 minute common vetch (SBCV). Inclusion of RCV into the diet deteriorated all laying performance variables. SCV did not alleviate the adverse effect of raw common vetch on feed intake, egg weight, feed conversion, final weight and weight change. SCV partially alleviated egg production (p<0.001). SBCV diminished the adverse effect on feed intake, egg weight, feed conversion, final weight and weight change compared to raw vicia sativa (p<0.001). No significant difference was detected between SBCV and the control group in terms of egg production, feed conversion, final weight and weight change. Regardless of the processing method, all the common vetch groups had lower shell strength compared to the control group. Haugh units did differ between all groups (p<0.001). Inclusion of RCV and SCV into the basal diet decreased triglyceride, cholesterol, total protein and serum glucose concentrations (p<0.001). Hovewer, inclusion of SBCV into the basal diet increased these parameters. Liver samples were stained with Hematoxylin and eosin (HE) and evaluated by light microscopy. A biopsy of native liver tissue was used as a control. No histopathologic finding was present in the control group. Raw V. sativa compared with the control caused lipid accumulations in hepatocytes, severe congestion of hepatic blood vessels, inflammation, increased numbers of Kupffer cells and sinusoidal dilatations. Whereas, the livers from groups given treated V. sativa showed only different degrees of sinusoidal dilatations. Findings from the present study point out the risk of increased hepatic damage due to use of raw Vicia sativa. Increasing treatment of V. sativa lead to a decrease of liver damages. Inclusion of raw and soaked vetch seeds in rations affected adversely all parameters examined in laying hens. But alleviation was observed when soaked and boiled vetch seeds (SBCV) were fed. The results of these experiments indicated that soaked&boiled Vicia sativa seeds may safely be used at a 25% level in rations of laying hens.

• Journal of fish pathology
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• v.23 no.3
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• pp.281-291
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• 2010

Crytocaryon irritans infection of rock bream was investigated in embankment fish farm from July to December 2009. Prevalence variation was 20.0~88.0% that was high in september and was low in July. While no mortality was found in July and August, it occurred after mid september. Environmental conditions during the survey period were water temperature $19.3{\sim}24.3^{\circ}C$, dissolved oxygen $5.0{\sim}7.1\;mg\;L^{-1}$ and salinity 31.9~33.7 psu, and the water temperature during mortality season was $24.0^{\circ}C$. External symptom of the rock bream was secretion mucus but swimming showed fine in the early infected period. While, the symptoms in the severe outbreak season were excess of mucus, falling off tail and congestion, bleeding spot the surface and weakened swimming. We observed free living and parasitic stages in the gills and body surface of rock bream. Hepato somatic index (HSI) was $1.9{\pm}1.1{\sim}3.5{\pm}1.7%$, which was low in the September being mortality season but was high in November. The percentages of hematocrit infected with Crytocaryon irritans were 37.3% and 41.0% in July and August, respectively while they gradually decreased to 32.1% and 24.2% in september and October, respectively. Total cholesterol and Triglyceride values rapidly decreased by October. After mortality, AST and ALT were 7 and 5 folds higher compared to non-mortality season.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.4
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• pp.377-386
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• 2021

In dense cities, which are covered by many impermeable areas, rainwater flows quickly along the roads and collects in certain areas. The surface runoff that fails to get intercepted by the roadside rain gutters results in a wider flow of water along the sides, which in turn increases the amount of water on the road and causes traffic congestion as well as accidents due to slippage. Based on these issues, this study was carried out in order to propose an intercepted flow calculation formula. To this end, the maximum longitudinal slopes of arterial roads and expressways were reflected to depict a road condition of 2~10 %, while a general traverse slope of 2 % was selected for the traverse slope on the side. As for the road lane condition, two, three, and four lanes were chosen for the area from the centerline to the sidewalk. As for the experimental flow rate, the rainwater runoffs at the actual design frequency of 5, 10, 20, and 30 years for road conditions were converted into experimental flow rates, and as a result, flow rates ranging from 1.36 l/s to 3.96 l/s were divided into ten flow rates for a hydraulic experiment. Also, an equation taking into consideration the inflow velocity and flow width along the roadsides was proposed. The results of the experiment showed an increase in flow width and a decrease in interception rate. Also, the inflow velocity at a traverse slope of 2 % was measured, while increasing the longitudinal slope. Accordingly, an equation for calculating the flow intercepted by rain gutters at a flow width reflecting the longitudinal slope of the road and rainwater runoff, according to the design frequency, was derived by performing a regression analysis using IBM SPSS Statistics 24. It is deemed that the equation derived in this study will be useful in designing rain gutters for roads.

• Korean Journal of Plant Resources
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• v.32 no.4
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• pp.282-289
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• 2019

Gastritis is an inflammatory disease involving the stomach and is caused by several factors, including stress, non-steroidal anti-inflammatory drugs such as aspirin, liquor, and Helicobacter pylori. In Korea, Leonurus japonicus Houttuyn (LJW) has been used as traditional medicine for vaginal bleeding, hematuria, and bruise. Previous studies have reported that LJW exhibited hepatoprotective, cardioprotective, and anti-hyperlipidemic effect. However, the effect of the water extract of LJW on gastritis was not elucidated. Thus, we evaluated the anti-gastric effect and genotoxicity of LJW. LJW effectively prevented the degeneration of surface mucous cells and glandular epithelial cells and vascular congestion induced by HCl/EtOH. Micronucleus assay indicated that the rate of micronucleated polychromatic erythrocytes/polychromatic erythrocytes was not significantly different compared that of the control. Further experiments are required to determine the role of LJW in the gastric injury process such as cyclooxygenase signaling pathway and the secretion of mucus in the stomach.