Protective Effect of Water Extract of Leonurus japonicus Houttuyn against HCl/EtOH-induced Gastric Mucosal Damage and Genotoxicity Evaluation using Micronucleus Test |
Nho, Jong Hyun
(National Institute for Korean Medicine Development)
Lee, Hyun Joo (National Institute for Korean Medicine Development) Jang, Ji Hun (National Institute for Korean Medicine Development) Yang, Beo Dul (National Institute for Korean Medicine Development) Woo, Kyeong Wan (National Institute for Korean Medicine Development) Kim, A Hyeon (National Institute for Korean Medicine Development) Seo, Jae Wan (National Institute for Korean Medicine Development) Kim, Sun Young (National Institute for Korean Medicine Development) Cho, Hyun Woo (National Institute for Korean Medicine Development) Jung, Ho Kyung (National Institute for Korean Medicine Development) |
1 | Alrashdi, A.S., S.M. Slalma, S.S. Alkiyumi, M.A. Abdulla, A.H. Hadi, S.I. Abdelwahab, M.M. Taha and N. Asykin. 2012. Mechanisms of gastroprotective effects of ethanolic leaf extract of Jasminum sambac against HCl/ethanolinduced gastric mucosal injury in rats. Evid. based Complement Alternat. Med. 2012:786426. |
2 | Andrews, F.M., C.R. Reinemeyer, M.D. Mccracken, J.T. Blackford, J.A. Nadeau, L. Saabye, M. Sotell and A. Saxton. 2002. comparison of endoscopic, necropsy and histology scoring of equine gastric ulcers. Equine. Vet. J. 34:475-478. |
3 | Chamberlain, C.E. 1993. Acute hemorrhagic gastritis. Gastroenterol. Clin. North Am. 22:843-873. DOI |
4 | Chen, T., W. Jiang, H. Zhang, X. You, M. Liu, L. Wang, P. Xiang, L. Xu, D. Zheng, X. Zhang, H. Ji, K. Hao and T. Yan. 2016. Protective effect of trillin against ethanol-induced acute gastric lesions in an animal model. RSC. Adv. 6:20081-20088. DOI |
5 | Choi, W.S., D.Y. Jang, G.R. Lee and S.H Kim. 2012. Protective effect of HEAC and its primary active compound on HClethanol induced gastritis in rats. J. Korea Acad. Industr. Coop. Soc. 13:1769-1776. DOI |
6 | Corvi, R.S., Albertini, T. Hartung, S. Hoffmann, D. Maurici, S. Pfuhler, J. Benthem and P. Vanparys. 2008. ECVAM retro spective validation of in vitro micronucleus test (MNT). Mutagen 23:271-283. DOI |
7 | Gao, L., M.N. Weck, C. Stegmaier, D. Rothenbacher and H. Brenner. 2009. Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from Germany. Int. J. Cancer 125:2918-2922. DOI |
8 | Hoshino, T., S. Tsutsumi, W. Tomisato, H.J. Hwang, T. Tsuchiya and T. Mizushima. 2003. Prostaglandin protects gastric muscosal cells from apoptosis via and receptor activation. J. Biol. Chem. 287:12752-12758. |
9 | Hwang, I.Y. and C.S Jeong. 2013. A study on the antigastiritic effect of Rheum species extracts and their active components. J. Fd. Hyg. Safety 28:330-336. DOI |
10 | Hwang, I.Y., S.Y. Lee, S.Y. Kyung and C.S. Jeong. 2016. Inhibitory effects of Polygala tenuifolia Willd., Polygala japonica and Polygala tenuifolia on HCl.ethanol-induced gastritis in rats. Yakhak Hoeji. 61:24-29. DOI |
11 | Jeon, W.Y., M.Y. Lee, I.S. Shin, S.E. Jin and H. Ha. 2015. Curcuma aromatica water extract attenuates ethanol-induced gastritis via enhancement of antioxidant status. Evid. Based Complement Alternat. Med. 2015:582496. |
12 | Jin, S.E., M.Y. Lee, I.S Shin, W.Y. Jeon and H. Ha. 2016. Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats. Mol. Med. Rep. 14:361-366. DOI |
13 | Jo, Y.K. 2013. The development of anti-wrinkle cosmeceutical ingredients from Leonuri herba extract. Korean J. Food Preserv. 20:592-596. DOI |
14 | Jung, Y.H., Y.M. Ham, S.A. Yoon, D.J. Oh, C.S. Kim and W.J. Yoon. 2018. Antioxidant and anti-inflammatory effects of Ficus erecta var. sieboldii leaf extract in murine macrophage RAW 264.7 cells. Korean J. Plant Res. 31:303-311. DOI |
15 | Kandulski, A., M. Selgrad and P. Malfertheiner. 2008. Helicobacter pylori infection: a clinical overview. Dig. Liver Dis. 40:619-626. DOI |
16 | Khan, S.O. Shehzad, H.G. Jin, E.R. Woo, S.S. Kang, S.W. Baek, J. Kim and Y.S. Kim. 2012. Anti-inflammatory mechanism of 15, 16-Epoxy-3-hydroxylabda-8, 13(16), 14-trien-7-one via inhibition of LPS-induced multicellular signaling pathways. J. Nat. Prod. 75:61-71. |
17 | Kim, H.N., G.H. Park, J.D. Kim, S.B. Park, H.J. Eo and J.B. Jeong. 2019. Effect of the extracts from the leaves and branches of Sageretia thea on -catenin proteasomal degradation in human colorectal and lung cancer cells. Korean J. Plant Res. 32:153-159. DOI |
18 | Kruger, N. J. 2009. The bradford method for protein quantitation. The Protein Protocols Handbook. Springer, Berlin, Germany. pp. 17-24. |
19 | Kim, S.J., H.S. Han and Y.J. Lee. 2010. Effects of Leonuri herba and Leonuri semen on hypercholesterolemia. Korean J. Herbology 25:73-80. |
20 | Kim, T.Y., S.A. Jang, Y.B. Chae and J.P. Bak. 2016. Antioxidant and protective effects of Leonurus sibiricus L. extract on ultraviolet B (UVB)-induced damage in human keratinocytes. Korean J. Plant Res. 29:11-19. DOI |
21 | Lee, J.Y., O.J. Kwon, J.S Noh and S.S Roh. 2016. Protective effect of red ginseng according to steaming time on HCl/ethanol-induced acute gastritis. J. Appl. Biol. Chem. 59:365-372. DOI |
22 | Li, Y.X., Z. Chen, Z.M. Feng, Y.N Yang, J.S. Jiang and P.C. Zhang. 2012. Hepatoprotective glycosides from Leonurus japonicus Houtt. Carbohydr. Res. 348:42-46. DOI |
23 | Li, Z., C. Wu, L. Li, Z. Wang, H. Xie, X. He and J. Feng. 2017. Effect of long-term proton pump inhibitor administration on gastric mucosal atrophy: a meta analysis. Saudi J. Gastroenterol. 23:222-228. DOI |
24 | Min, B.S. 2012. 13-week repeated-dose toxicity test of Leonuri Herba. KFDA. TRKO201300028832. |
25 | Nho, J.H., J.H. Jang, H.J. Lee, B.D. Yang, K.W. Woo, A.H. Kim, J.W. Seo, T.Y. Hwang, H.W. Cho and H.K. Jung. 2019. Preventive effect of the water extract of Agrimonia pilosa Ledeb and micronucleus assay-based evaluation of genotoxicity in gastritis animal models. Korean J. Medicinal Crop Sci. 27:136-142. DOI |
26 | Park, H.J. and H.S. Kim. 2011. Effects of proton pump inhibitors on atrophic gastritis and gastric cancer: safe perspective. Korean J. Med. 81:1-5. |
27 | Ricciotti, E. and G.A. Fitzgerald. 2011. Prostaglandins and inflammation. Arterioscler. Thromb. Vasc. Biol. 31:986-1000. DOI |
28 | Park, S. K.B. Hahm, T.Y. Oh, J.H. Jin and R. Choue. 2004. Preventive effect of the flavonoid, wogonin, against ethanolinduced gastric mucosal damage in rats. Dig. Dis. Sci. 49:384-394. DOI |
29 | Park, S.B., H.M. Song, H.N. Kim, G.H. Park, H.J. Son, Y. Um, J.A. Park and J.B. Jeong. 2018. Anti-inflammatory effect of Biji (Soybean curd residue) on LPS-stimulated RAW264.7 cells. Korean J. Plant Res. 31:117-123. DOI |
30 | Park, S.B., H.N. Kim, J.D. Kim, G.H. Park, H.J. Eo, M.Y. An and J.B. Jeong. 2019. Inhibitory effect of the branch extracts from Taxillus yadoriki parasitic to Neolitsea sericea against the cell proliferation in human lung cancer cells, A549. Korean J. Plant Res. 32:109-115. DOI |
31 | Sipponen, P and H.I. Maaroos. 2015. Chronic gastritis. Scand. J. Gastroenterol. 50:657-667. DOI |
32 | Takeuchi, K. and K. Amagase. 2017. Roles of prostaglandin E and EP receptors in mucosal protection and ulcer healing in the gastrointestinal tract. Arch. Dig. Disord. 1:8-16. |
33 | Tanigawa, T., T. Watanabe, M. Hamaguchi, E. Sasaki, K. Tominaga, Y. Fujiwara, N. Oshitani, T. Matsumoto, K. Higuchi and T. Arakawa. 2004. Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. Am. J. Physiol. Gastrointest. Liver Physiol. 286:148-156. DOI |
34 | Wallace, J.L. 1992. Prostaglandins, NSAIDs, and cytoprotection. Gastroenterol. Clin. North Am. 21:631-641. DOI |
35 | Woo, H.S., S.M. Lee, J.D. Heo, M.S. Lee, Y.S. Kim and D.W. Kim. 2018. Anti-inflammatory activity of extracts of Hovenia dulcis on lipopolysaccharides-stimulated RAW264.7 cells. Korean J. Plant Res. 31:466-477. DOI |
36 | Yoo, S.R., H. Ha, M.Y. Lee, H.K. Shin, S.C. Han and C.S. Seo. 2017. A 4-week repeated-dose oral toxicity study of Bojungikgitang in Crl:CD Sprague dawley rats. Evid. Based Complement Alternat. Med. 4748904. |
37 | Yeung, H.W., Y.C Kong, W.P. Lay and K.F. Cheng. 1997. The structure and biological effect of leonurine. Planta Med. 31:51-56. DOI |