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Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis

  • Duan, Lei;Zeng, Rong;Yang, Ke-Hu;Tian, Jin-Hui;Wu, Xiao-Lu;Dai, Qiang;Niu, Xiao-Dong;Ma, Di-Wa
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.2
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    • pp.911-915
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    • 2014
  • Aim: This study was to evaluate the effect of whole brain radiation (WBRT) combined with stereotactic radiotherapy (SRS) versus stereotactic radiotherapy alone for patients with brain metastases using a meta-analysis. Materials and Methods: We searched PubMed, EMBASE, Cochrane Library from their inception up to October 2013. Randomized controlled trials involving whole brain radiation combined with stereotactic radiotherapy versus stereotactic radiotherapy alone for brain metastases were included. Statistical analyses were performed using RevMan5.2 software. Results: Four randomized controlled trials including 903 patients were included. The meta-analysis showed statistically significant lowering of the local recurrence rate (OR=0.29, 95%CI: 0.17~0.49), new brain metastasis rate (OR=0.45, 95%CI: 0.28~0.71) and symptomatic late neurologic radiation toxicity rate (OR=3.92, 95%CI: 1.37~11.20) in the combined group. No statistically significant difference existed in the 1-year survival rate (OR=0.78, 95%CI: 0.60~1.03). Conclusions: The results indicate that whole brain radiotherapy combined with stereotactic radiotherapy has advantages in local recurrence and new brain metastasis rates, but stereotactic radiotherapy alone is associated with better neurological function. However, as the samples included were not large, more high-quality, large-sample size studies are necessary for confirmation.

A verification on the physical effectiveness of therapeutic horseback riding exercise: Focused on the EMG analysis

  • Kim, You-Sin;Yang, Jae-Young;Lee, Namju
    • Journal of the Korean Applied Science and Technology
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    • v.35 no.2
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    • pp.317-324
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    • 2018
  • Various studies related to therapeutic horseback riding have been reported to be positive for the therapeutic effect of patients with cerebral palsy; however, most of the previous studies focused on to muscle development with training period related to the physical effects of therapeutic horseback riding. To identify the causes and phenomena of muscular activation of the body through actual therapeutic horseback riding exercise and to promote the excellence of physical effects of therapeutic horseback riding. This study was a nonrandomized prospective positive-controlled trial design. Twelve teenaged males with cerebral palsy were selected who had experienced riding exercise for 8-12 months. This study measured 8 muscle activities of the pectoralis major muscle (PM), biceps brachii (BB), rectus abdominis muscle (RA), latissimus dorsi muscle (LD), spinal erector muscle (SE), rectus femoris muscle (RF), anterior tibial muscle (AT), and external gastrocnemius muscle (EG) by using electromyography (EMG). Muscle activity was significantly higher in horse riding position than sitting on the common chair in all muscles (PM, BB, RA, LD, SE, RF, AT, and EG). The activity of the body muscles according to the difference of horse walking method (walk: WA; sitting trot: ST; and riding trot: RT) of therapeutic horse riding showed the highest muscle activity in the PM muscle at ST, and the highest activity at BB, RA, LD, SE, and AT muscles at ST and RT, and showed the highest muscle activity in RF and EG muscle at RT. The results of this study suggest that intervention for the treatment of cerebral palsy patients can use therapeutic riding exercise as a rehabilitation method.

Fish Fuana in Southern River of Bukcheong and Brackish Lakes, the Shinpo District, North Korea (북한 신포지구내 북청 남대천과 기수호의 어류상)

  • Gil, Joon-Woo;Hong, Young-Pyo;Kim, Say-Wa
    • Korean Journal of Environmental Biology
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    • v.25 no.3
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    • pp.279-287
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    • 2007
  • The purpose of the study was to introduce the fish fauna and distribution in the Shinpo district, North Korea. Sampling was carried out in October 1997, July 1998, May and October 2002, in sites located in the upstream, middle and down of the southern river of Bukcheong and three brackish lakes of Hommanpo, Daein and Hyunkum, respectively. A total of 29 species belonging to 11 families were found. Family Cyprinidae showed the prosperity in species number, comprising 28% among total species found. No natural monument fishes or rare fishes were captured. Ten commercial species, five anadromous ones and five brackish ones were identified. Feeding guilds was identified as 11 carnivores, 2 herbivores and 7 omnivores. Twenty species belonging to 7 families inhabited in the river, 18 species of 6 families in Lake Homanpo, 21 of 7 in Lake Hyunkum and 23 of 8 in Lake Daein, respectively. Ecological indices of richness, diversity and evenness were highest in Lake Daein and the dominace index was highest in Lake Hyunkum.

Properties of Charcoal Board Manufactured from Domestic Wood Waste

  • Seo, In-Su;Lee, Hwa-Hyoung
    • Journal of the Korea Furniture Society
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    • v.21 no.3
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    • pp.237-247
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    • 2010
  • This research was carried out to examine the properties of black charcoal board, in order to find the proper manufacturing condition for the black charcoal-board made of the charcoal. The charcoal in this study was distillated from domestic wood waste, and it were also the purpose of this study to see if the black charcoal-board has the advantageous properties of charcoal as a well-being building material against the sick house problem. Domestic wood waste was consisted of MDF 40%, PB 30%, plywood 15% and wood 15%, respectively. Black charcoal board was produced by hot pressing with following conditions; temperature $170^{\circ}C$, three stage pressing cycle of $40-10-40\;kgf/cm^2$(1min.-2.5min.-5min.) and non formaldehyde adhesives [P15%+M5%:MDI(M), poly vinyl acetate emulsion(P). Fine mixed particle size [#6-12(16.9%), #12-18(16.7%), #12-40(47.2%), #40-60(9.5%), #60-100(5.9%), less than #100(3.8%)] gave better results than larger particle size [over #6(33.8%), #12-18(17.7%), #12-40(37.7%), #40-60(6.4%), #60-100(2.6%), less than #100(1.8%)]. Final moisture content of the mat was best at 36%. Black charcoal-board showed less MOR and IB(internal bond), more WA(water absorption) than that of white charcoal-board. Black charcoal board showed not only the same gas adsorption and dimensional stability as white charcoal board but also good cutting, nailing and drilling for indoor environment systems.

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Serotype and Nucleotide Analysis of Human Rotavirus Isolates in Korea (국내분리 유아 로타바이러스의 혈청형과 염기서열 분석)

  • Cha, Kwang-Jong;Song, Jin-Ook;Cho, Hong-Chan;Kim, Yong-Hee;Yu, Dae-Yeul;Lee, Joong-Bok;Lee, Chong-Kee;Koki, Taniguchi;Yu, Jae-Hyeun
    • The Journal of Korean Society of Virology
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    • v.29 no.2
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    • pp.75-86
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    • 1999
  • Rotaviruses belong to Reoviridae causes diarrhea in human beings as well as domestic animals. This study was conducted to see what type of human rotaviruses are distributed in Seoul and Kyung-gi province. Twenty two of 81 patients showed rotavirus positive with diagnostic kit and RNA electropherosis. We isolated all of rotaviruses from the patients. Electropherotypes of 22 isolates showed 4:2:3:2 pattern whereas those migration patterns were long type. All of those isolates belonged to group A. Twenty out of 22 isolates reacted with monoclonal antibodies specific to G1, P1A and subgroup II, whereas rest of them, A-29 and K-30 reacted with subgroup I specific monoclonal antibody. The nucleotide sequence of an isolate K-21 showed $98{\sim}100%$ and $90{\sim}96%$ homologies with those of Wa and KU strain, respectively.

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Postthyroidectomy Hypocalcemia (갑상선수술후의 저칼슘혈증)

  • Choi Daeh-Wa;Kim Kyu-Yul;Ko Byung-Kyun;Nam Chang-Woo;Yu Hwa-Kyung;Cho Hong-Rae
    • Korean Journal of Head & Neck Oncology
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    • v.15 no.1
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    • pp.52-60
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    • 1999
  • Objectives: For investigation of the differentiation between transient and permanent hypocalcemia, we focused on a postoperative calcium requirement and an interval of normalization in serum hypocalcemic level and studied for the causes of postoperative hypocalcemia. Material and Method: Postthyroidectomy hypocalcemia was studied in 193 patients who were admitted from January, 1991 to December, 1998 and underwent lobectomy, subtotal thyroidectomy or total thyroidectomy. We compared postoperative serum calcium, phosphate and ionized calcium levels among three groups which were lobectomy, subtotal thyroidectomy and total thyroidectomy, respectively. Result: All patients revealed postoperative decline in serum calcium and ionized calcium, especially, the lowest serum calcium level was seen in 48 hours after surgery. Serum calcium level was returned to normal in five to six postoperative days in most patients. But 24 patients required calcium supplementation due to symptomatic hypocalcemia. In this series, we discovered that the important period for monitoring of serum calcium level was 24 to 96 hours after surgery. If the calcium replacement therapy was not required in the first 72 hours after surgery, it would not be needed during the remainder of the patient's hospital course. Symptomatic transient hypocalcemia was 22 cases(11.4%) and permanent hypocalcemia was 2 cases(1%). Conclusion : We found that hypoalbuminemia, preoperative hyperthyroidism and impairment of blood supply to parathyroid were the main causes of postthyroidectomy hypocalcemia. We also thought that the interval from initial medication to normalization in serum calcium level, and the increase of requirement in calcium and vitamin D were the important factors for differentiation between transient and permanent hypocalcemia.

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A Study on Setting Quality Level of Fastener Tape for Military Textile Products (군용 섬유제품에 적합한 파스너 테이프의 품질수준 연구)

  • Kim, Seongwook;Lee, Minhee;Hong, Seongdon;Lee, Jung-Soon
    • Textile Coloration and Finishing
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    • v.29 no.3
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    • pp.162-170
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    • 2017
  • Fastener tapes are widely used as auxiliary materials in textile products, and military textiles products are also applied. However, in Korea, the HL3-WA class of KS K 1309 was applied to military uniforms without consideration of the operating environment. Instead of adopting the standard of initial strength for Korean military uniforms, the US military applied the value after 3 washings, and presented different properties according to the items. Also in Japan, the standard was applied differently according to products in general clothing. The purpose of this study in to examine the quality level of fastener tapes used for military materials. The changes of tensile shear strength and peel strength of military and commercial fastener tape were studied after washing. As a result, the initial strength of the current military fastener tapes was higher than commercial one, but the strength retention rate was rapidly decreased as the number of washing. So it was confirmed that the decrease in strength was relatively lower than commercial one. It is necessary to improve the durability by adjusting the adhesive strength to suit the purpose of the product, and it is necessary to consider the priority of maintaining the durability according to the initial performance and repeated use according to the use environment, respectively.

Serviceability Performance Evaluation of Vertical Vibration of Waflle Shape and Duble-Tee Precast Concrete Slabs (와플형과 더블티형 프리캐스트 콘크리트 바닥판의 수직진동 사용성 평가)

  • Shin, Jae-Sang;Chung, Lan
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.14 no.4
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    • pp.62-69
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    • 2010
  • In this study, the serviceability performance of Waffle Shaped(WAS) and Double-Tee(DT) precast concrete slabs were evaluated and compared based on the vertical acceleration magnitude induced by walking and heel drop loads. Tests were conducted for practical building structures of which floor systems used WAS and DT slabs. Natural frequencies of the slabs were similar to those obtained by using analytical models. The measured acceleration level was evaluated by vertical floor acceleration criteria presented by ISO-2631, AIJ(1991, Japan) and a previous study regarding floor vibration limit. Test results showed that both WAS and DT slabs satisfied all the criteria and Peak acceleration level of WA slabs was lower than that of DT slabs.

Monopsony Power of General Hospitals in Nurse Labor Market (간호사 노동시장의 수요독점에 대한 연구 - 종합병원을 중심으로 -)

  • Jeong, Hyun-Jin;Yang, Bong-Min
    • Korea Journal of Hospital Management
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    • v.5 no.2
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    • pp.40-58
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    • 2000
  • Nurses are medical personnel, who play a key role in supporting patient care, so it is important to supply them adequately in balance with ever increasing medical demand. But there appears severe shortage of nurses in some hospitals because of their uneven distribution, especially in small sized-hospitals and rural-hospitals. As nationwide distorted distribution of nurses in Korea is just like what monopsony model(a kind of market structure model) tells us, it is attempted to explain this situation of nurse labor market in Korea on the basis of monopsony model and presented in this paper. Specifically, determinants of nurse wage and the level of their relative employment were examined, and monopsony impact on their wage and the level of relative employment controlling those determinants were studied. Major results of this study arc as follows. The most important determinant of nurse wage level in this study was the wage level of a local community where each hospital located Hospital owner's characteristics an educational function of each hospital were also important factors. With these factor controlled, it was found that monopsony power of each hospital was negativel associated with nurse wage level as expected. 1% increase in monopsony power of hospital(measured by Herfindah-Hirschman Index) reduced nurse wage by $5,674{\sim}19,19$ won(in Korean currency). With regard to the level of relative employment, the most important determinant wa the capacity for supplying nurses of the local community. Again, hospital owner characteristics and educational function of each hospital were also important. With these factors controlled, it was found that monopsony power of each hospital was negative associated with the number of nurses per bed, as expected. 1% increase in monopsony power of each hospital(again measured by Herfindah-Hirschman Index) reduced the number of nurses per 100 bed as much as $0.46{\sim}0.67$. In conclusion. structural factors of nurse labor market influence the instability of nurse labor supply in Korea. Further consideration for these market structural characteristics needed for policy making related to nurse resource allocation.

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Short Tandem Repeat Allele Frequencies in Sasang Constitution (사상체질별 Short Tandem Repeat 대립유전자 빈도)

  • Park, Hwa-Yong;Yu, Hyun-Joo;Ku, Im-Hoi;Kim, Jong-Yeol
    • Journal of Sasang Constitutional Medicine
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    • v.21 no.1
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    • pp.227-236
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    • 2009
  • 1. Objectives As a basic trial for identification of Sasang constitutional gene marker, we genotyped and analysed statistical relationships of STR(short tandem repeat) alleles and its distribution in each constitution. 2. Methods After obtaining basic constitutional data with questionnaire (QSCC II), decision of constitution was made by 3 different constitution specialists' diagnosis, and only the samples of specialists' agreement of each constitution by discussion were taken into this research. Using multiplex PCR kit, total 146 constitutional samples were amplified in 16 autosomal STR marker, genotyped, and analysed statistically. Among 16 markers, 15 were analysed in this study excluding the amelogenin marker is used for in gender identification. 3. Results and Conclusions It is difficult to determine the relationship between constitution and STR marker as the sample size is small, however, Penta D and vWA were shown to be related statistically with constitution. It has been know that STRs has no genetic informations, however there are some recent research results showing STRs as a regulatory element, relationship between microsatellite instability and repeat number and size, and post-transcriptional sigualing. STRs which is not known about its function currently, are proposed to have function and/or regulatory activities anyhow with Sasang constitution. It is believed that the results of this study can halp determine and deatify the markers related to Sasang Constitutional Medicien.

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