• Korean Journal of Poultry Science
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• v.38 no.2
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• pp.145-154
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• 2011

By a series of positional cloning, we successfully narrowed down the AM candidate region to approximately 1.2 Mbp on GGA2q including 7 functional genes. Subsequently, we identified WWP1 gene as the most likely AM candidate by sequence comparison. The amino acid sequence around the candidate mutation was highly conserved among tetrapods, suggesting that WWP1 is the causative gene of chicken muscular dystrophy. Transfection of mutated WWP1 gene into $C_2C_{12}$ myoblasts disrupted muscle differentiation process. The abnormal muscle differentiation is a characteristic of chicken muscular dystrophy, so we could demonstrate a part of phenotype of the disease. Furthermore, western blotting revealed that accumulation of caveolin-3 protein is limited in damaged muscle of muscular dystrophic chicken, suggesting caveolin-3 may be associated with the pathological change of the disease. We could conclude that WWP1 gene is the responsible one for chicken muscular dystrophy from these results, but the mechanism leading the onset should be clarified in the future. The information will contribute to the study of chicken muscular dystrophy and the corresponding human dystrophies.

• Journal of Advanced Navigation Technology
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• v.6 no.1
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• pp.1-9
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• 2002

본 논문은 현재 무선 LAN 환경에서 적용되고 있는 매체접근제어 프로토콜인 IEEE 802.11 CSMA/CA를 이용함으로써, 음성 위주의 항공이동통신에서 음성과 데이터 채널을 통합하여 사용하도록 하고 있다. 또한, 표준으로 제정되어 있는 기존의 CSMA/CA 매체접근제어 프로토콜에 대한 이해를 바탕으로 성능 개선 방안을 제안하였으며, 이를 바탕으로 채널 효율을 향상시켰다. IEEE 802.11 매체접근제어(MAC, Medium Access Control) 프로토콜은 데이터 유형에 따라 채널을 두 개의 구간(PCF와 DCF 구간)으로 나누어 전송하도록 하고 있다. 본 논문에서는, 데이터 유형별로 적용되는 구간 중, DCF 구간에서의 패킷간의 충돌 가능성을 줄임으로써 데이터 전송 효율을 높이는데 주안점을 두고 있다. 제안 방안으로는 경쟁 구간에서의 전송에서 충돌에 따른 손실을 보완할 수 있도록 Wireless Window Protocol(이하, WWP)을 적용한 후 전송 과정을 제어하였다. Hidden 터미널의 영향이 적으므로 가시권내 통신에 적합한 기존의 2-Way CSMA/CA 프로토콜을 항공통신에 적용하여 상태 천이 과정을 5개에서 6개로 세분화하였고, 주어진 확률에 의하여 나누어진 두 개의 그룹별로 상태 천이 과정을 다르게 적용하였다. 따라서, 채널이 한 항공기에 의해 점유되는 PCF를 제외한, DCF 구간에서의 데이터 전송 효율을 높일 수 있었다. 시뮬레이션은 채널 대역폭과 패킷 크기 등을 파라미터 값으로 하여 수행하였으며, 시뮬레이션 결과 CSMA/CA에 비해 새로 제안한 알고리즘이 데이터 전송 과정에서 발생하는 충돌 가능성을 감소시킴으로써 성능이 향상됨을 알 수 있었다.

• Journal of Construction Engineering and Project Management
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• v.4 no.3
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• pp.1-12
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• 2014

Construction management has been suffering from many problems, which need to be solved or better understood. Most of construction projects have not achieved efficiency as expected. In this context, waste was also considered as a problem of efficiency decrease, and poor production planning was considered as a cause for waste. This study was conducted on the basis of waste concepts and production planning processes based on the philosophies of Lean Construction. A survey to find out the relationship between them was carried out through questionnaire, which was answered by experienced people in construction projects. The results have shown that frequency of wastes occurrence is quite high, and production planning processes are superficially performed in construction phase. There is a significant negative relationship between production planning and waste occurrence (r = -0.262). Weekly Work Plan (WWP) is the most dominant plan for waste control with seventeen in total of nineteen waste factors, and phase plan is the most dominant plan for two remaining waste factors. A case study was adopted to validate the relationship between production planning and waste occurrence. The results showed that the better the project was planned, the fewer the waste would occur on construction sites.

• KSBB Journal
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• v.24 no.3
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• pp.217-226
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• 2009

p53 undergoes various post-translational modifications, including phosphorylation, ubiquitination, sumoylation, acetylation, methylation, and poly(ADP-ribosyl)ation. Modification of p53 widely affects to various functions of p53. Acetylation and phosphorylation of p53 have been studied for regulating its transcriptional activity which is observed in various stress condition. Otherwise, ubiquitination of p53 by Mdm2 has been well-studied as a canonical ubiquitin-mediated proteasomal degradation pathway. Moreover several investigators have recently reported that ubiquitination of p53 modulates not only its proteasome-dependent degradation by poly-ubiquitination but also its localization and transcriptional activity by mono-ubiquitination which usually does not serve the proteasome dependent degradation. Here we review recent studies on the cellular functions of p53 regulated by post-translational modifications, particularly focusing on mechanisms of ubiquitination.