• Journal of the Korean Society for Library and Information Science
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• v.9
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• pp.53-74
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• 1982

On admet Jusqu'ici que le XVe siecle est une $\acute{e}poque$ phare de l'histoire de l'imprimerie avec l'apparition de la typographie en Orient et en Occident, $c'est-\acute{a}-dire$ en $Cor\acute{e}e$ sur le Rhim. Cependant, $l'\acute{e}poque$ de l'invention typographique en $Cor\acute{e}e$ doit $\hat{e}tre$ $devanc\acute{e}e$ encore d'un ou deux siecle. Outre cette question, il est $\acute{a}$ noter ici que les caracteres mobiles $m\acute{e}talliques$ Kyemi, fondus en 1403, ont $jou\acute{e}$ un $r\hat{o}le$ $tr\acute{e}s$ important dans l'histoire de la typographie mondiale et que les $caract\acute{e}res$ kabin qui leur $succ\acute{e}derent$ en 1434 menerent la typographie $cor\acute{e}enne$ a son $apog\acute{e}e$. Or, les recherches $cor\acute{e}ennes$ se satifait de la primaute de l'invention en Coree des caracteres mobiles metalliques, mais n'adoptent pas une attitude suffisament critique. Aussi, l'auteur a-toil voulu s'interroger sur la veritable valeur de la typographie de la dynastie de Choson tant au point de vue de l'histoire de l'imprimerie mondiale. En premier lieu, on etudie, comme une chronique, les caracteres mobiles metalliques importants tout au long de la dynastie de Choson sans donner une interpretation nouvelle. C'est dans deux derniers, qu'on essaie de developper ses idees sur la typographie en Coree notamment la question technologique qui devrait etre le fond des recherches. Aussi, on y etudie, la technique de la typographie ancienne en Coree interpretee selon une methode scientifique et moderne et, enfin, le bilan synthetique en cherchant les raisons qui freinerent son developpement en Coree malgre la performance de ses debuts. A l'issue de ces recherches, on ne peut s'empecher d'eprouver une certaine insatisfaction a cause de l'ambiguite des explications que l'on trouve dans des documents fondamentaux. Avec ce difficulte on a voulu, au moins, exposer des points discutatables qui devraient etre les recherches a futur.

• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.471-479
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• 2018

Objectives: This study was aimed to analyze the correlation of clinical characteristics of cancer patients treated with Korean Medicine and their natural killer cell activity (NKA). Methods: The medical records of 52 cancer patients who conducted NKA test at Cheonan Korean Medicine Hospital of Daejeon University from March 2016 to May 2018 were reviewed. NKA was determined at Seegene Medical institute using NK Vue Gold(R) kit, evaluating activated $IFN-{\gamma}$ by enzyme immunoassay after incubation of whole blood. Careful investigations were conducted by categorizing the patients by their sex, origin, stage, ECOG scale, and conventional treatment type. We used data from the medical records and statistical analysis using SPSS 25.0 V. Results: The average NKA of all patients was $623.1{\pm}722.0pg/mL$. The NKA value was higher for females than for males. No correlation was evident between age and NKA, but patients aged over 70 years had the lowest NKA average result. Stage III and IV patients showed clearly lower NKA values when compared to stage I and II patients. NKA and ECOG scale values showed no evident relationship. Conclusions: This study presented the characteristics of NKA in cancer patients treated with Korean medicine. The NKA result differed by gender and stage. Based on these findings, further study is needed regarding the clinical meaning of NKA.

• Economic and Environmental Geology
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• v.37 no.2
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• pp.235-244
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• 2004

The shear strength of deep-sea core sediments from the nofheast equatorial Pacific was measured in various conditions to ensure precision of results. The comparison items were 1) two different measuring systems (hand-held vane and motorized vane), 2) in different places of on-board immediately after collecting the core samples and on-land laboratories after storing these samples for three months in a cold room, 3) two different core samples from a multiple corer within a sampling station, and 4) four different measuring points (holes) from a core sample. In this experiment, the values of shear strength in deep-sea sediments show significant change with depth which increase toward the bottom of core. Also, the results of two cores recovered at the same station indicate that vertical variation of shear strength is mainly caused by the change of physical properties. They strongly support the fact that the difference of vue syrtem and/or experimental conditions are not major factor in the variation of geotechnical properties.

• Korean Journal of Radiology
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• v.22 no.5
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• pp.801-810
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• 2021

Objective: To investigate imaging biomarkers of microperfusion in contrast-induced nephropathy (CIN) using contrast-enhanced ultrasound (CEUS). Materials and Methods: The CIN model was fabricated by administering indomethacin (10 mg/kg), L-NAME (15 mg/kg), and iopamidol (10 mL/kg) to Sprague-Dawley rats. After 24 hours, CEUS was performed on CIN (n = 6) and control (n = 6) rats with sulphur hexafluoride microbubbles (SonoVue). From time-intensity curves obtained from the kidney arriving time (AT), acceleration time (AC), time to peak (TTP), and peak enhancement (PE) were measured and compared between the groups. After CEUS, the rats were sacrificed, and cell apoptosis markers were evaluated to confirm the development of CIN. Results: Among CEUS parameters, AT (7.8 ± 1.6 vs. 4.2 ± 0.5 s, p = 0.002), AC (4.7 ± 1.4 vs. 2.0 ± 0.4 s, p = 0.002), and TTP (12.5 ± 2.9 vs. 6.2 ± 0.6 s, p = 0.002) were significantly prolonged in the CIN group compared to controls. PE was significantly higher in the control group than in the CIN group (17.1 ± 1.9 vs. 12.2 ± 2.0 dB, p = 0.004). In kidney tissue, mRNA and protein levels of the apoptotic makers were significantly higher in the CIN group than in the control group (p = 0.003 and p = 0.002). Conclusion: CEUS parameters can be used as imaging biomarkers for microperfusion in CIN. In rats with CIN, AT, AC, and TTP were significantly prolonged, while PE was significantly lower compared to controls.

• Korean Journal of Radiology
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• v.20 no.5
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• pp.781-790
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• 2019

Objective: To assess the relationship between contrast-enhanced ultrasound (CEUS) parameters and perfusion CT (PCT) parameters of gastric cancers and their correlation with histologic features. Materials and Methods: This prospective study was approved by our Institutional Review Board. We included 43 patients with pathologically-proven gastric cancers undergoing CEUS using SonoVue^® (Bracco) and PCT on the same day. Correlation between the CEUS parameters (peak intensity [PI], area under the curve [AUC], rise time [RT] from 10% to 90% of PI, time to peak [TTP_US], and mean transit time [MTT_US]) and PCT parameters (blood flow, blood volume, TTP_CT, MTT_CT, and permeability surface product) of gastric cancers were analyzed using Spearman's rank correlation test. In cases of surgical resection, the CEUS and PCT parameters were compared according to histologic features using Mann-Whitney test. Results: CEUS studies were of diagnostic quality in 88.4% (38/43) of patients. Among the CEUS parameters of gastric cancers, RT and TTP_US showed significant positive correlations with TTP_CT (rho = 0.327 and 0.374, p = 0.045 and 0.021, respectively); PI and AUC were significantly higher in well-differentiated or moderately-differentiated tumors (n = 4) than poorly-differentiated tumors (n = 18) (p = 0.026 and 0.033, respectively), whereas MTT_CT showed significant differences according to histologic types (poorly cohesive carcinoma [PCC] vs. non-PCC), T-staging (≤ T2 vs. ≥ T3), N-staging (N0 vs. N-positive), and epidermal growth factor receptor expression (≤ faint vs. ≥ moderate staining) (p values < 0.05). Conclusion: In patients with gastric cancers, CEUS is technically feasible for the quantification of tumor perfusion and may provide correlative and complementary information to that of PCT, which may allow prediction of histologic features.

• The Korean Journal of Nuclear Medicine Technology
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• v.21 no.2
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• pp.31-36
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• 2017

Purpose Recently, the performance of PET/CT scanner has been improved and various techniques have been developed to increase the image quality such as Sensitivity and Resolution. The purpose of this study is to evaluate the usefulness of Q.Clear (a fully convergent iterative reconstruction) technique of GE Discovery IQ equipment to enhance the image quality. Materials and Methods All scans were acquired by Discovery IQ (GE Healthcare, MI, USA). In NEMA IEC Body Phantom test, Background to Hot-sphere (10 mm, 13 mm, 17 mm, 22 mm) ratio was 1:4 and scan time was 3 minutes. The images were reconstructed by VPHDs (VUE Point High-Definition + SharpIR) and Q.Clear to evaluate each Contrast. We injected 18F-FDG 187 M㏃ to PET/SPECT Performance Phantom. And then it was scanned for 4 minutes to evaluate Resolution and Uniformity. T-test statistical analysis was performed on SUVmax of small lesions less than 2 cm in 100 clinical patients regardless of disease type. Results In the NEMA IEC Body Phantom, the Contrast was $63.6{\pm}5.7%$ (VPHDs) and $75{\pm}4.8%$ (Q.Clear). In the PET/SPECT Performance Phantom, the Resolution was 9.2 mm (VPHDs) and 7.3 mm (Q.Clear). Uniformity of Q.Clear was 10.8% better than VPHDs. T-test statistic of the clinical patients showed a significant difference of p value of 0.021. Conclusion Both the phantom test and the clinical results showed that the quality of the image was improved in Q.Clear was applied. The SUVmax was highly measured in Q.Clear and the lesions were clearly distinguished visually. Therefore Q.Clear can be useful in various aspects such as dose-reduction, patients evaluation and image analysis.

• Korean Journal of Clinical Laboratory Science
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• v.49 no.4
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• pp.390-394
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• 2017

Unexpected antibody screening and identification tests are highly important in the prevention of hemolytic transfusion reactions. Therefore, it is highly recommended to perform unexpected antibody screening test in all transfusion candidates. Here, the frequency and distribution of unexpected antibodies identified in Jeju for the past 3 years were evaluated. Between Jan 2014 and Dec 2016, unexpected antibody screening test was performed for 10,360 sera of transfusion candidates in Jeju general hospital using a column agglutination method with the Ortho BioVue system (Ortho-clinical Diagnostics, Raritan, NJ, USA). Eighty-seven (0.84%) of 10,360 cases that underwent unexpected antibiotics screening showed positive results. Among them, unexpected antibodies were identified in 41 cases (0.40%). Unidentified antibodies were detected in 8 cases (19.51%) and autoantibodies were detected in 3 cases (7.32%). The anti-E antibody included in warm antibodies were detected most frequently in 8 cases (19.51%); 6 cases (14.63%) of anti-E + anti-c antibody and 3 cases (7.32%) of $anti-Le^a+anti-Le^b$. $Anti-Le^a$ and $anti-Le^b$ antibodies were detected in 2 cases (4.88%), respectively. The anti-D, $anti-Di^a$, $anti-Fy^b$, $anti-Jk^a$, $anti-Jk^b$, anti-M and anti-P1 were detected in 1 case (2.44%). Complex antibodies were detected in 1 case (2.44%) in anti-C+anti-D and anti-E+anti-c+$anti-Jk^b$, respectively. In this study, we analyzed the frequency and distribution of unexpected antibodies in one general hospital for the past 3 years. However, there has been a general increase in multicultural families and foreign workers in Jeju, and it would be a meaningful study to compare the frequency and distribution of unexpected antibodies.

• Korean Journal of Remote Sensing
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• v.37 no.6_3
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• pp.1985-1999
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• 2021

The purpose of this study is to apply urban heat island reduction techniques(green roof, cool roof, and cool pavements using heat insulation paint or blocks) recommended by the Environmental Protection Agency (EPA) to our study area and determine their actual effects through a comparative analysis between land cover objects. To this end, the area of Mugye-ri, Jangyu-myeon, Gimhae, Gyeongsangnam-do was selected as a study area, and measurements were taken using a drone DJI Matrice 300 RTK, which was equipped with a thermal infrared sensor FLIR Vue Pro R and a visible spectrum sensor H20T 1/2.3" CMOS, 12 MP. A total of nine heat maps, land cover objects (711) as a control group, and heat island reduction technique-applied land covering objects (180) were extracted every 1 hour and 30 minutes from 7:15 am to 7:15 pm on July 27. After calculating the effect values for each of the 180 objects extracted, the effects of each technique were integrated. Through the analysis based on daytime hours, the effect of reducing heat islands was found to be 4.71℃ for cool roof; 3.40℃ for green roof; and 0.43℃ and -0.85℃ for cool pavements using heat insulation paint and blocks, respectively. Comparing the effect by time period, it was found that the heat island reduction effect of the techniques was highest at 13:00, which is near the culmination hour, on the imaging date. Between 13:00 and 14:30, the efficiency of temperature reduction changed, with -8.19℃ for cool roof, -5.56℃ for green roof, and -1.78℃ and -1.57℃ for cool pavements using heat insulation paint and blocks, respectively. This study was a case study that verified the effects of urban heat island reduction techniques through the use of high-resolution images taken with drones. In the future, it is considered that it will be possible to present case studies that directly utilize micro-satellites with high-precision spatial resolution.

• Korean Journal of Remote Sensing
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• v.38 no.6_2
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• pp.1607-1622
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• 2022

The purpose of this study is to determine the actual performance of cool roof in preventing absorbed solar radiation. The spatial correlation between surface temperature and absorbed solar radiation is the method by which the performance of a cool roof can be understood and evaluated. The research area of this study is the vicinity of Jangyu Mugye-dong, Gimhae-si, Gyeongsangnam-do, where an actual cool roof is applied. FLIR Vue Pro R thermal infrared sensor, Micasense Red-Edge multi-spectral sensor and DJI H20T visible spectral sensor was used for aerial photography, with attached to the drone DJI Matrice 300 RTK. To perform the spatial correlation analysis, thermal infrared orthomosaics, absorbed solar radiation distribution maps were constructed, and land cover features of roof were extracted based on the drone aerial photographs. The temporal scope of this research ranged over 9 points of time at intervals of about 1 hour and 30 minutes from 7:15 to 19:15 on July 27, 2021. The correlation coefficient values of 0.550 for the normal roof and 0.387 for the cool roof were obtained on a daily average basis. However, at 11:30 and 13:00, when the Solar altitude was high on the date of analysis, the difference in correlation coefficient values between the normal roof and the cool roof was 0.022, 0.024, showing similar correlations. In other time series, the values of the correlation coefficient of the normal roof are about 0.1 higher than that of the cool roof. This study assessed and evaluated the potential of an actual cool roof to prevent solar radiation heating a rooftop through correlation comparison with a normal roof, which serves as a control group, by using high-resolution drone images. The results of this research can be used as reference data when local governments or communities seek to adopt strategies to eliminate the phenomenon of urban heat islands.

• Journal of the Korean association of regional geographers
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• v.18 no.3
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• pp.336-350
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• 2012

Cette $\acute{e}$tude a pour objectif d'analyser et d'expliquer le g$\acute{e}$osite de l'$\hat{I}$le de Geum-o pour connaitre les caract$\acute{e}$ristiques de cette r$\acute{e}$gion du point de vue $\acute{e}$cologique, historique et culturel $\grave{a}$ partir de ses ressources g$\acute{e}$omorphiques et g$\acute{e}$ologiques. Il y a plusieurs ressources g$\acute{e}$otouristiques sur $\hat{I}$le de Geum - o: la falaise de 'Miyeokneolbang' et 'Shinseondae'; la plage de Gigpo; la falaise et la caverne marine de 'Gualbaramtong'; le tombolo et l'$\hat{I}$le reli$\acute{e}$e $\grave{a}$ la terre de Choungsan; la coul$\acute{e}$e de roches de Jangji; la plage de cailloux de Jangji; le lieu des tuf et des andesite de la c$\hat{o}$te orientale. On a g$\acute{e}$n$\acute{e}$ralement d$\acute{e}$velopp$\acute{e}$ la couche s$\acute{e}$dimentaire et les roches volcaniques li$\acute{e}$es $\grave{a}$ la derni$\grave{e}$re p$\acute{e}$riode du m$\acute{e}$sozo$\ddot{i}$que. Une route g$\acute{e}$otouristique part de l'embarcad$\grave{e}$re de Hamgoumi sur l'$\hat{I}$le de Geum-o et continue du Nord-Ouest jusqu'au Sud-Est l'autre route part de la c$\hat{o}$te Est et continue en suivant la c$\hat{o}$te orientale. Nous proposons des panneaux d'explication g$\acute{e}$otouristique de Janji centr$\acute{e}$s sur la coul$\acute{e}$e de roches.