• Korean Journal of Clinical Pharmacy
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• v.12 no.1
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• pp.7-12
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• 2002

Pharmacokinetic parameters and dosage of aminoglycosides (AGs) were studied retrospectively in 36 patients with neutropenic fever after stem cell transplantation in Seoul National University Hospital from July 1996 to June 2001. AGs pharmacokinetic parameters were calculated with steady-state peak and trough serum drug concentrations by the method of Sawchuk and Zaske et at. The calculated aminoglycosides volume of distribution and clearance were greater than population value $(0.36\pm0.06\;L/kg,\;116\pm32\;ml/min/1.73\;m^2,\;respectively)$. The average dosage of aminoglycosides required to maintain optimal serum AGs concentration was also greater than recommended dose in insert paper. The average dosage of amikacin was $11\pm2.1$ mg/kg every 12 hours (In case of tobramycin, $2.09\pm0.37$ mg/kg every 8 hours or $2.59\pm0.20$ mg/kg every 12 hours). The relationship between AGs volume of distribution and sex, serum albumin (g/dl), body mass index $(kg/m^2)$, body weight change $(\%)$, the amount of fluid inpu (ml/kg/day), the degree of hematocrit decrease $(\%)$ were studied respectively. Univariate anlysis revealed that body mass index $(kg/m^2)$, the amount of fluid input (ml/kg/day) and the degree of hematocrit decrease $(\%)$ had significant correlation with aminoglycosides volume of distribution. But sex, serum albumin, body weight change $(\%)$ had no significant correlation with aminoglycosides volume of distribution.

• Korean Journal of Clinical Pharmacy
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• v.1 no.1
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• pp.31-36
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• 1991

Tobramycin is one of the most frequently selected agents for pharmacokinetic drug monitoring because of its narrow therapeutic index and essential role for the management of serious infections, especially gram-negative infections. Its pharmacokinetic parameters are dependent on race, sex, age, ideal body weight. disease states, and etc. Therefore, to schedule the dosing of tobramycin, the individual pharmacokinetic parameters such as half-life and volume of distribution are needed. However, these pharmacokinetic parameters have never been reported in Koreans. The purposes of this study were to evaluate the volume of distribution of tobramycin in cancer patients who had normal renal function, to compare the mean values of Vd reported in the literature, and to compare the measured half-life with the expected half-life based on ABW, LBW, and IBW, respectively. Venous blood samples were collected just before and thirty minutes after dosing during steady state. Serum tobramycin concentrations were determined by $TD_x$ (fluorescence immunoassay). IBW were measured by the method of Devine: and LBW were measured by the method of Hallynck. Creatinine clearances (CLcr) of the patients were estimated using the Cockcroft and Gault equation. Elimination rate constants (kel) were determined using the Welling and Craig equation. Infusion rate (ko), volume of distribution (Vd), and half-life $(t_{1/2})$ were determined using the Saw chuk and Zaske equation. The volume of distribution Was $27\%$ greater than the Schentag's study (0.26 vs 0.33 l/kg), but the half-life was similar to the Levy's study. The predicted half-lives based on IBW were the closest to actual half-lives (1.85 vs 2.01 hr).

• Journal of Korean Neurosurgical Society
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• v.52 no.5
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• pp.435-440
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• 2012

Objective : The purpose of this study is to find the optimal stiffness and volume of bone cement and their biomechanical effects on the adjacent vertebrae to determine a better strategy for conducting vertebroplasty. Methods : A three-dimensional finite-element model of a functional spinal unit was developed using computed tomography scans of a normal motion segment, comprising the T11, T12 and L1 vertebrae. Volumes of bone cement, with appropriate mechanical properties, were inserted into the trabecular core of the T12 vertebra. Parametric studies were done by varying the volume and stiffness of the bone cement. Results : When the bone cement filling volume reached 30% of the volume of a vertebral body, the level of stiffness was restored to that of normal bone, and when higher bone cement exceeded 30% of the volume, the result was stiffness in excess of that of normal bone. When the bone cement volume was varied, local stress in the bony structures (cortical shell, trabecular bone and endplate) of each vertebra monotonically increased. Low-modulus bone cement has the effect of reducing strain in the augmented body, but only in cases of relatively high volumes of bone cement (>50%). Furthermore, varying the stiffness of bone cement has a negligible effect on the stress distribution of vertebral bodies. Conclusion : The volume of cement was considered to be the most important determinant in endplate fracture. Changing the stiffness of bone cement has a negligible effect on the stress distribution of vertebral bodies.

• Journal of Korean Society of Transportation
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• v.25 no.4
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• pp.109-121
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• 2007

In this study, an imputation model using circular probability distribution was developed in order to overcome problems of missing data from a traffic survey. The existing ad-hoc or heuristic, model-based and algorithm-based imputation techniques were reviewed through previous studies, and then their limitations for imputing missing traffic volume data were revealed. The statistical computing language 'R' was employed for model construction, and a mixture of von Mises probability distribution, which is classified as symmetric, and unimodal circular probability were finally fitted on the basis of traffic volume data at survey stations in urban and rural areas, respectively. The circular probability distribution model largely proved to outperform a dummy variable regression model in regards to various evaluation conditions. It turned out that circular probability distribution models depict circularity of hourly volumes well and are very cost-effective and robust to changes in missing mechanisms.

• Journal of Korean Society of Transportation
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• v.13 no.1
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• pp.167-183
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• 1995

The objective of study is to evaluate highway capaicty estimation alternative and to develop capacity from statistical distribution of observed traffic flow. Speed-Volume relation is analyzed from vehicle's headway distribution eliminating the long headway by confidence intervals 99%, 95%, 90%. Capacity estimate alternatives were evaluated from 95% , 90%, 85% level of cummulative distribution of observed hourly traffic flow adjusted to confidence intervals. The result of investigation revealed that maximum hourly rate of flow is 2, 130pcu at confidence interval of 995, 2, 233pcu at 95%, 2, 315pcu at 90% respectively. Compared to the capacity of 2, 200pcu per hour per lane used in HCM and KHCM(Korea Highway Capacity Manual), capa챠y appears to correspond to confidence interval of 95%. Using the traffic flow rate at confidence interval of 95% the maximum hourly flow rate is 2, 187pcu at 95% of cummulative volume distribution, 2, 153pcu at 90%, 2, 215pcu at 85%. The study suggests that raional capacity esimation alternative is to take the 95% of cummulative distribution of observed hourly traffic flow at 95% confidence headway interval eliminating 5% long headway.(i.e. 95-95 rule)

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.3
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• pp.10-18
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• 2004

It is well known that the stratified charge combustion has many kind of advantages to combustion characteristics, such as higher thermal efficiency and less CO, NOx levels than conventional homogeneous mixture combustion. Although this combustion can be caused low fuel consumption, it is produced the high unburned hydrocarbon and soot levels because of different equivalence ratio in the combustion chamber. Moreover it has a lot of possibility of low output and misfire if the mixture gas would not be in existence around the spark plug. In this paper, fundamental studies for stratified combustion were carried out using a constant volume combustion chamber. The effect of locally mixture gas distribution according to control the direct injection and premixed injection in the chamber were examined experimentally. In addition, the effects of turbulence on stratified charge combustion process were observed by schlieren photography.

• International Journal of Automotive Technology
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• v.3 no.3
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• pp.95-99
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• 2002

The characteristics of soot vaporization induced by a high-energy Pulsed laser were studied in an ethylene-air laminar flame. A system consisting of two pulsed lasers was used for the experiments. The pulse from the first laser was used to vaporize the soot particles, and the delayed pulse from the second laser was used to measure the residual soot volume fraction. Laser-induced soot vaporization was characterized according to the initial particle size distribution. The results indicated that soot particles could not be completely vaporized simply by introducing a high intensity laser pulse. Residual soot volume fractions present after vaporization appeared to be insensitive to the initial soot particle size distribution. Since the soot vaporization effect is more pronounced in the region of high soot concentrations, this laser-induced soot vaporization technique may be a very useful tool for measuring major species in highly sooting flame.

• Korean System Dynamics Review
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• v.12 no.3
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• pp.67-86
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• 2011

This study shows the reduction effect of freight volume by the supply chain redesign for the alliance of distributors with system dynamics simulation. The as-is model is composed of 3 independent companies which one has 3 distribution centers (DCS) and 24 agents, another has 1 dc and 9 agents, the other has 3 DCS and 15 agents each. The to-be model is an integrated logistics model and composed of 1 company having 5 areal DCS and 38 agents. Each agent in the same area is integrated with each other. Two models have same demands but very different result. As a result, the freight volume between DCS and agents is reduced by 33.55%. This case study will be useful to analyze the similar cases about the logistics integration by supply chain redesign.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.29.3-29.3
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• 2020

Cosmology is a study to understand the origin, fundamental property, and evolution of the universe. Nowadays, many observational data of galaxies have become available, and one needs large-volume numerical simulations with good quality of the spatial distribution for a fair comparison with observation data. On the other hand, since galaxies' evolution is affected by both gravitational and baryonic effects, it is nontrivial to populate galaxies only by N-body simulations. However, full hydrodynamic simulations with large volume are computationally costly. Therefore, alternative galaxy assignment methods to N-body simulations are necessary for successful cosmological studies. In this talk, I would like to introduce the MBP-galaxy abundance matching. This novel galaxy assignment method agrees with the spatial distribution of observed galaxies between 0.1Mpc ~ 100Mpc scales. I also would like to introduce mock galaxy catalogs of the Horizon Run 4 and Multiverse simulations, large-volume cosmological N-body simulations done by the Korean community. Finally, I would like to introduce some recent works with those mock galaxies used to understand our universe better.

• Advances in materials Research
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• v.12 no.4
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• pp.331-349
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• 2023

Foam concrete can be considered as environmental friendly material due to its low weight, its minimal cost and a possibility to add waste materials in its production. This paper investigates the possibility of producing foam concrete with waste glass as powder and aggregate. Then, the effect of using waste glass on strength and drying shrinkage of foam concrete was examined. Also, the effect of incorporating polypropylene fibers (12 mm length and proportion of 0.5% of a mix volume) on distribution of waste glass as coarse particles within 1200 kg/m³ foam concrete mixes was evaluated. Waste glass was used as powder (20% of cement weight), as coarse particles (25%, 50% and 100% instead of sand volume) and as fine particles (25% instead of sand volume). From the results, the problem of non-uniform distribution of coarse glass particles was successfully solved by adding polypropylene fibers. It was found that using of waste glass as coarse aggregate led to reduce the strength of foam concrete mixes. However, using it with polypropylene fibers in combination helped in increasing the strength by about 29- 50% for compressive and 55- 71% for splitting tensile and reducing the drying shrinkage by about (31- 40%). In general, not only the fibers role but also the uniformly distributed coarse glass particles helped in improving and enhancing the strength and shrinkage of the investigated foam concrete mixes.