• Archives of Pharmacal Research
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• v.27 no.7
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• pp.806-810
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• 2004

Metformin is a biguanide antihyperglycemic agent often used for the treatment of non-insulin dependent diabetics (NIDDM). In this study, the pharmacokinetics and pharmacodynamics of metformin were investigated in Korean healthy volunteers during a fasting state for over 10 h. In order to evaluate the amount of glucose-lowering effect of metformin, the plasma concentrations of glucose were measured for a period of 10 h followed by the administration of metformin (oral 500 mg) or placebo. In addition, the concentration of metformin in blood samples was determined by HPLC assay for the drug. All volunteers were consumed with 12 g of white sugar 10 minutes after drug intake to maintain initial plasma glucose concentration. The time courses of the plasma concentration of metformin and the glucose-lowering effect were analyzed by nonlinear regression analysis. The estimated $C_{max}$, $T_{max}$, $CL_{t}$/F (apparent clearance), V/F(apparent volume of distribution), and half-life of metformin were 1.42$\{pm}$0.07 $\mu\textrm{g}$/mL, 2.59$\{pm}$0.18h, 66.12$\{pm}$4.6 L/h, 26.63 L, and 1.54 h respectively. Since a significant counterclock-wise hysteresis was found for the metformin concentration in the plasma-effect relationship, indirect response model was used to evaluate pharmacodynamic parameters for metformin. The mean concentration at half-maximum inhibition $IC_{50}$, $k_{in}$, $k_{out}$ were 2.26 $\mu\textrm{g}$/mL, 83.26 $H^{-1}$, and 0.68 $H^{-1}$, respectively. Therefore, the pharmacokinetic-pharmacodynamic model may be useful in the description for the relationship between plasma concentration of metformin and its glucose-lowering effect.

• Computers and Concrete
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• v.21 no.6
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• pp.717-726
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• 2018

Concrete pipelines are the most efficient and safe means for gas and oil transportation over a long distance. The use of nano materials and nono-engineering can be considered for enhancing concrete pipelines properties. the tests show that $SiO_2$ nanoparticles can improve the mechanical behavior of concrete. Moreover, severe hazard for pipelines is seismic ground motion. Over the years, scientists have attempted to understand pipe behavior against earthquake most frequently via numerical modeling and simulation. Therefore, in this paper, the dynamic response of underwater nanocomposite submerged pipeline conveying fluid is studied. The structure is subjected to the dynamic loads caused by earthquake and the governing equations of the system are derived using mathematical model via Classic shell theory and Hamilton's principle. Navier-Stokes equation is employed to calculate the force due to the fluid in the pipe. As well, the effect of external fluid is modeled with an external force. Mori-Tanaka approach is used to estimate the equivalent material properties of the nanocomposite. 1978 Tabas earthquake in Iran is considered for modelling seismic load. The dynamic displacement of the structure is extracted using differential quadrature method (DQM) and Newmark method. The effects of different parameters such as $SiO_2$ nanoparticles volume percent, boundary conditions, thickness to radius ratios, length to radius ratios, internal and external fluid pressure and earthquake intensity are discussed on the seismic response of the structure. From results obtained in this paper, it can be found that the dynamic response of the pipe is increased in the presence of internal and external fluid. Furthermore, the use of $SiO_2$ nanoparticles in concrete pipeline reduces the displacement of the structure during an earthquake.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.1
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• pp.63-70
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• 2019

We aimed to propose a novel computational approach to predict the electromechanical performance of pre- and post-mitral valve cerclage annuloplasty (MVCA). Furthermore, we tested a virtual estimation method to optimize the left ventricular basement tightening scheme using a pre-MVCA computer model. The present model combines the three-dimensional (3D) electromechanics of the ventricles with the vascular hemodynamics implemented in a lumped parameter model. 3D models of pre- and post-MVCA were reconstructed from the computed tomography (CT) images of two patients and simulated by solving the electromechanical-governing equations with the finite element method. Computed results indicate that reduction of the dilated heart chambers volume (reverse remodeling) appears to be dependent on ventricular stress distribution. Reduced ventricular stresses in the basement after MVCA treatment were observed in the patients who showed reverse remodeling of heart during follow up over 6 months. In the case who failed to show reverse remodeling after MVCA, more virtual tightening of the ventricular basement diameter than the actual model can induce stress unloading, aiding in heart recovery. The simulation result that virtual tightening of the ventricular basement resulted in a marked increase of myocardial stress unloading provides in silico evidence for a functional impact of MVCA treatment on cardiac mechanics and post-operative heart recovery. This technique contributes to establishing a pre-operative virtual rehearsal procedure before MVCA treatment by using patient-specific cardiac electromechanical modeling of pre-MVCA.

• Journal of the Korea Convergence Society
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• v.10 no.6
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• pp.33-39
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• 2019

As cyber attack methods are becoming more intelligent, incidents such as security breaches and international crimes are increasing. In order to predict and respond to these cyber attacks, the characteristics, methods, and types of attack techniques should be identified. To this end, many security companies are publishing security intelligence reports to quickly identify various attack patterns and prevent further damage. However, the reports that each company distributes are not structured, yet, the number of published intelligence reports are ever-increasing. In this paper, we propose a method to extract structured data from unstructured security intelligence reports. We also propose an automatic intelligence report analysis system that divides a large volume of reports into sub-groups based on their topics, making the report analysis process more effective and efficient.

• Computers and Concrete
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• v.24 no.2
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• pp.125-135
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• 2019

Concrete pipelines are the most efficient and safe means for gas and oil transportation over a long distance. The use of nano materials and nono-engineering can be considered for enhancing concrete pipelines properties. the tests show that SiO2 nanoparticles can improve the mechanical behavior of concrete. Moreover, severe hazard for pipelines is seismic ground motion. Over the years, scientists have attempted to understand pipe behavior against earthquake most frequently via numerical modeling and simulation. Therefore, in this paper, the dynamic response of underwater nanocomposite submerged pipeline conveying fluid is studied. The structure is subjected to the dynamic loads caused by earthquake and the governing equations of the system are derived using mathematical model via Classic shell theory and Hamilton's principle. Navier-Stokes equation is employed to calculate the force due to the fluid in the pipe. As well, the effect of external fluid is modeled with an external force. Mori-Tanaka approach is used to estimate the equivalent material properties of the nanocomposite. 1978 Tabas earthquake in Iran is considered for modelling seismic load. The dynamic displacement of the structure is extracted using differential quadrature method (DQM) and Newmark method. The effects of different parameters such as SiO2 nanoparticles volume percent, boundary conditions, thickness to radius ratios, length to radius ratios, internal and external fluid pressure and earthquake intensity are discussed on the seismic response of the structure. From results obtained in this paper, it can be found that the dynamic response of the pipe is increased in the presence of internal and external fluid. Furthermore, the use of SiO2 nanoparticles in concrete pipeline reduces the displacement of the structure during an earthquake.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.18 no.3
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• pp.66-73
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• 2019

Recently, FDM-type 3D printer technology has been developed, and efforts have been made to improve the output formability and characteristics further. Through this, 3D printers are used in various fields, and printer technologies are suggested according to usage, such as FDM, SLA, DLP, and SLM. In particular, the FDM method is the most widely used, and the FDM method technology is being developed further. The characteristics of the output are produced by the FDM-type 3D printer, which is determined by various factors, and particularly the perspective of the Inter-Layer Fill Factor, which is the volume ratio of the laminated material that exerts a direct influence. In this study, the Inter-Layer Fill Factor is theoretically obtained by presenting the internal space between each layer according to the laminate thickness as a cross-sectional shape model, and the cross section of the actual laminated sample is compared with the theoretical model through experiments. Then, the equation for the theoretical model is defined, and the strength change according to each condition (tensile strength of material, reduction slope, strength reduction rate, and output strength) is confirmed. In addition, we investigated the influence on the correlation and strength between laminate thickness and the Inter-Layer Fill Factor.

• Korean Journal of Metals and Materials
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• v.48 no.5
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• pp.469-475
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• 2010

In this study, the interfacial bond strength of a squeeze infiltrated $Al_{18}B_{4}O_{33}$/AS52 Mg composite was investigated by using a finite element method. Three types of Mg composites with volume fractions of 15, 25 and 35% were fabricated. Three-dimensional models of the composite were developed by using a unit cell model in order to determine the effective elastic modulus of the metal matrix composite and the interfacial bond strength between the whisker and magnesium matrix. After modeling, numerical results were compared with the experimental tensile test results of $Al_{18}B_{4}O_{33}$/AS52 Mg composites. The results showed that the effective modulus of the composite strongly depended on the interfacial strength between the matrix and reinforcement. Based on the numerical and experimental findings, it was found that the strong interfacial bond was achieved by the interfacial reaction product of 30 nm thick MgO, which led to an improvement in the mechanical properties of the $Al_{18}B_{4}O_{33}$/AS52 Mg composites.

• International Journal of Computer Science & Network Security
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• v.21 no.3
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• pp.287-294
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• 2021

Modern small farms are important link components in the structure of the world agro-industrial complex. It ensures the food and nutritional sustainability of the country exclusively at the local regional level. The purpose of the research is to examine the role of farming in ensuring nutritional security and food stability based on the analysis of the Food Sustainability Index (FSI). Research methods: modeling, abstraction, analogy, analysis, synthesis, formalization, logical abstraction, theoretical cognition, systematization and classification, abstract-logical, etc. Results. Having analyzed the Food Sustainability Index for 2018, it has been established that there is a lack of a clear relationship between the pace of economic development and the level of food and nutritional sustainability. In addition, this study has identified the countries with the largest number of small farms, as well as the number of farms within the region. The correlation between the size of the farm and the area of agricultural land that it cultivates has been determined. The problems faced by small farms in the process of their activity have been analyzed. The programs implemented in the field of agro-industrial complex development by international profile institutions have been systematized. Particularly, the regional structure of agricultural development programs under the guidance of IFAD is defined, as well as the areas to which they are directed. Specific measures taken by governments to stimulate the development of small farms have been outlined. Reasonable conclusions have been formed based on the study. The direction of future research is seen in the assessment of the export potential of small farms in terms of range, volume of export deliveries and geographical direction of movement of their products.

• Journal of Sensor Science and Technology
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• v.30 no.6
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• pp.388-394
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• 2021

The conventional microelectromechanical system (MEMS) process has been used to fabricate sensors with high costs and high-volume productions. Emerging 3D printing can utilize various materials and quickly fabricate a product using low-cost equipment rather than traditional manufacturing processes. 3D printing also can produce the sensor using various materials and design its sensing structure with freely optimized shapes. Hence, 3D printing is expected to be a new technology that can produce sensors on-site and respond to on-demand demand by combining it with open platform technology. Therefore, this paper reviews three standard 3D printing technologies, such as Fused Deposition Modeling (FDM), Direct Ink Writing (DIW), and Digital Light Processing (DLP), which can apply to the sensor fabrication process. The review focuses on strain/load sensors having both sensing material features and structural features as well. NCPC (Nano Carbon Piezoresistive Composite) is also introduced as a promising 3D material due to its favorable sensing characteristics.

• Nuclear Engineering and Technology
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• v.54 no.10
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• pp.3631-3640
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• 2022

Uranium mill tailing ponds (UMTPs) are risk source of debris flow and a critical source of environmental U and Rn pollution. The technology of microbial induced calcium carbonate precipitation (MICP) has been extensively studied on reinforcement of UMTs, while little attention has been paid to the effects of MICP on U & Rn release, especially when incorporation of metakaolin and bacillus subtilis (MBS). In this study, the reinforcement and U & Rn immobilization role of MBS -MICP solidification in different grouting cycle for uranium mill tailings (UMTs) was comprehensively investigated. The results showed that under the action of about 166.7 g/L metakaolin and ~50% bacillus subtilis, the solidification cycle of MICP was shortened by 50%, the solidified bodies became brittle, and the axial stress increased by up to 7.9%, and U immobilization rates and Rn exhalation rates decrease by 12.6% and 0.8%, respectively. Therefore, the incorporation of MBS can enhance the triaxial compressive strength and improve the immobilization capacity of U and Rn of the UMTs bodies solidified during MICP, due to the reduction of pore volume and surface area, the formation of more crystals general gypsum and gismondine, as well as the enhancing of coprecipitation and encapsulation capacity.