• Asian-Australasian Journal of Animal Sciences
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• 제24권2호
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• pp.246-249
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• 2011

The present study was carried out on broilers to study the effect of oral administration of vitamin E and selenium (E-care Se) on growth performance, haematological and biochemical parameters for a period of 42 days (6 weeks). A total of 90 oneday-old broiler chicks were divided into three equal groups: $T_1$, $T_2$ and $T_3$. Group T1 was maintained as control and was fed only with the basal diet throughout the experimental period. Two experimental diets, $T_2$ and $T_3$, were formulated to contain an additional 100 g (150 IU vitamin E/kg+0.5 mg Se/kg) and 200 g (300 IU vitamin E/kg+1.0 mg Se/kg) of E-care Se which was the source of vitamin E and selenium. Body weight was significantly (p<0.05) higher in antioxidant-treated groups compared to the control group. There were no significant differences in feed conversion ratio (FCR). Blood samples were collected from the jugular vein for haematological (TEC, Hb, PCV and ESR) and biochemical (GOT and GPT) study. Body weight was increased significantly in both treated groups compared with the control group and highest body weights were recorded in group $T_2$. TEC, PCV and Hb content increased significantly (p<0.01) in the treated groups as compared to the control group, but ESR, GOT and GPT values decreased significantly (p<0.01) in both treated groups as compared to the control group. The result reveals that use of antioxidants (vitamin E and selenium) is an effective way of getting the best result in terms of body weight gain and haemato-biochemical profiles in broiler birds at high altitude.

• KSBB Journal
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• 제16권6호
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• pp.614-619
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• 2001

두충의 골다공증 억제 효과를 연구하였다. 난소절제된 흰쥐에 기본사료, 칼슘, 비타민 D$_3$, 비타민 $K_1$를 함유하는 조성물과 두충추출물을 추가한 조성물을 7개월간 투여한 후 기본사료만 투여한 대조군과 비교하였다. 골 흡수 지표로 deoxypyridinoline을 분석한 결과 칼슘 비타민 조성물 투여군의 경우 대조군과 비교하여 9.0%, 두충 추가 조성물 투여군의 경우 26.9% 감소하였다. 경골의 trabecular 골면적을 측정한 결과 칼슘 비타민 조성물 투여군의 경우 대조군과 비교하여 9.9%, 두충 추가 조성물 투여군의 경우 42.0% 증가하여 골다공증 억제 효과를 확인할 수 있었다.

• 한국식품영양과학회지
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• 제35권10호
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• pp.1329-1335
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• 2006

AIDS로의 진행과정은 단순히 몇몇 기작에 의한 것이 아니라 여러 경로를 거쳐 발생하며 그 진행속도도 개개인에 따라 다양하게 나타나고 있다. 본 연구에서는 쥐 AIDS 모델을 이용하여 항산화호르몬으로 알려진 DHEAS의 면역조절 효과를 확인하고자 하였다. DHEAS의 투여는 LP-BM5 retrovirus 감염으로 인한 T와 B 임파구의 mitogenesis를 증가시켰으며 Th1/Th2 type cytokines의 발현에도 영향을 미쳤는데 주로 전사수준에서 작용한 것으로 생각된다/ 또한 retrovirus 감염으로 인한 간조직의 지질과산화 유발을 억제하여 조직 내의 항산화제인 vitamin E의 함량을 유지시킴으로 NF-kB의 활성화를 통한 retrovirus의 복제를 억제시켜 Th1/Th2 type cytokines의 불균형적인 발현을 저해하였을 것으로 여겨진다. 따라서 쥐 AIDS모델에 있어서 DHEAS의 면역조절 효과를 확인한 본 연구는 향후 HIV감염 이후 AIDS로의 진행 과정 시 항산화제의 역할과 기작 규명에 대한 가능성을 제시할 수 있을 것으로 생각된다.

• Nutrition Research and Practice
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• 제3권1호
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• pp.43-48
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• 2009

We investigated the nutritional state of B vitamins and the neuropsychological functions in 25 subjects, aged $63.1{\pm}6.3$ years, residing in rural areas of Korea. Nutritional states of thiamin, riboflavin, and pyridoxine were assessed enzymatically in the erythrocytes, and folate concentrations were measured microbiologically in the plasma and erythrocytes. A battery of composite neuropsychological test was administered to the subjects. Plasma folate was correlated with the total intelligence score (p=0.049). Folate levels in the erythrocytes were correlated with the performance intelligence scores such as block design (p=0.017) and picture arrangement (p=0.016). The red cell folate was correlated with memory scores such as general memory (p=0.009) and delayed recall (p=0.000). Although it did not reach statistical significance, verbal memory (p=0.053) was highly correlated with the red cell folate. The red cell folate was also correlated positively with the percent of conceptual level response number score (p=0.029), and negatively with the grooved pegboard test score for the non-dominant hand (p=0.010). Fine motor coordination was also influenced by folate nutrition, as finger tapping scores in both hands were significantly correlated with red cell folate (dominant hand; p=0.026, non-dominant hand; p=0.004). Other B vitamins such as thiamin, riboflavin, and vitamin $B_6$ were not as strongly correlated with neuropsychological function test scores as folate was. These results suggest that folate nutrition influences neuropsychological function test scores significantly in humans. Further studies are needed to explore the relationship between folate or other vitamin B nutrition and neuropsychological functions and the implications thereof.

• Nutrition Research and Practice
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• 제15권6호
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• pp.673-685
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• 2021

BACKGROUND/OBJECTIVES: Obesity is associated with the impaired regulation of T cells characterized by increased numbers of Th1 and Th17 cells and the dysregulation of vitamin D metabolism. Both obesity and vitamin D have been reported to affect autophagy; however, a limited number of studies have investigated the effects of vitamin D on T cell autophagy in obese mice. Therefore, we aimed to determine whether in vitro treatment with vitamin D affects the proliferation, function, and autophagy of T cells from obese and control mice. MATERIALS/METHODS: Five-week-old male C57BL/6 mice were fed control or high-fat diets (10% or 45% kcal fat: CON or HFDs, respectively) for 12 weeks. Purified T cells were stimulated with anti-CD3 and anti-CD28 monoclonal antibodies and cultured with either 10 nM 1,25(OH)₂D₃ or 0.1% ethanol (vehicle control). The proliferative response; expression of CD25, Foxp3, RORγt, and autophagy-related proteins (LC3A/B, SQSTM1/P62, BECLIN-1, ATG12); and the production of interferon (IFN)-γ, interleukin (IL)-4, IL-17A, and IL-10 by T cells were measured. RESULTS: Compared with the CON group, T cell proliferation tended to be lower, and the production of IFN-γ was higher in the HFD group. IL-17A production was reduced by 1,25(OH)2D₃ treatment in both groups. The LC3 II/I ratio was higher in the HFD group than the CON group, but P62 did not differ. We observed no effect of vitamin D treatment on T cell autophagy. CONCLUSIONS: Our findings suggest that diet-induced obesity may impair the function and inhibit autophagy of T cells, possibly leading to the dysregulation of T cell homeostasis, which may be behind the aggravation of inflammation commonly observed in obesity.

• Journal of Nutrition and Health
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• 제34권2호
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• pp.230-240
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• 2001

This study was designed to develop the nutrition education program for the mothers of preschool children in kindergarten and evaluate its educational effects. Nutrition education program was developed on the basis of the concept which consisted of nutrition, nutrients, menu planning, cooking, recognition of nutrition education, food selection and menu planning, will of nutrition improvement. Subjects consisted of 41 mothers. All the subjects completed a pretest and a posttest. The nutrition knowledge score of pretest was 33.77$\pm$12.53 and that of posttest was 55.25$\pm$16.32 and the difference was significant(p<0.001). The Food attitude score of pretest was 66.40$\pm$6.26 and that of posttest was 70.76$\pm$6.05 and the difference was significant(p<0.001). Food attitude score of high score-group of nutrition knowledge was higher than that of low score-group of nutrition knowledge significantly, in pretest(p<0.001) and posttest(p<0.01) respectively. Nutrition knowledge score and food attitude score of children of educated parents of nutrition program was higher than that of children of uneducated parents of nutrition program but the difference was not significant. The nutrition densities of vitamin A(p<0.001), vitamin B$_1$(p<0.05), vitamin B$_2$(p<0.001), folic acid(p<0.05), Ca(p<0.001), p(p<0.001), calculated using the INQ(Index of Nutritional Quality), was significantly improved by nutrition consult and education program. The MAR(Mean Adequacy Ratio) of pretest was 0.79$\pm$0.23 and that of posttest was 0.91$\pm$0.16 and the difference was significant(p<0.05). (Korean J Nutrition 34(2) : 230-240, 2001)

• 대한지역사회영양학회지
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• 제11권4호
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• pp.534-540
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• 2006

Recent studies have shown that environmental, biochemical, nutritional or genetic factors affect bone mineral density (BMD). The purpose of the present study was to investigate the effect of vitamin D receptor (VDR) gentotype and nutritional status on BMD of elderly women living in a rural area. Three hundred thirty five elderly women over 65 years in Asan participated the study. Data for demographic and nutrient intakes were obtained by survey with a two day 24 hr recall method. BMD was measured by broadband ultrasound attenuation (BUA) using quantitative ultrasound (QUS). VDR genotypes of the subjects analyzed with Bsm I restriction enzyme were bb (92%), Bb (7%) and BB (1%). No differences were found between genotypes bb and Bb/BB in age, menopausal age, body mass index and body fat. BUA of bb genotype was higher (62.5 $\pm$ 15.6 dB/MHz) than Bb/BB genotype (56.1 $\pm$ 17.6 dB/MHz) by Student's t-tests. Correlation analyses showed strong negative correlation of BMD and age, but positive correlation with BMI, energy and calcium intake. When subgroup analyses were conducted after stratification by the median calcium intake level (412.9 mg/d), the above median calcium intake group showed significant difference in BUA by VDR genotype while the lower median calcium intake group did not show significant difference. The current study confirmed interaction of calcium intake and VDR genotype in association with BMD. Further nutritional intervention will be needed to improve calcium status of the elderly women living in rural areas.

• Journal of Nutrition and Health
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• 제40권4호
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• pp.362-370
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• 2007

The study was designed to assess the effect of iron and cereal supplementation on children's iron nutritional status in social welfare institutions. Dietary survey was carried out methods of food weighing and record by interview (n=74). A nutritional intervention study was carried out through supplementing iron supplements and cereal for 4 weeks in 4-12 years old children. Children received daily 40 mg elemental Fe as iron protein succinylate (n=23) and 3.6 mg elemental Fe as 100 g cereal (n=24), respectively. Blood samples were drawn before and after supplementation. Nutrients which children's intake was less than two-thirds of the RDA were vitamin A, vitamin B-1, vitamin B-2, calcium and iron. The mean daily intake of iron was 5.1 mg for male and 4.9 mg for female, and 52.3% for male and 45.4% for female of Korean RDA. The proportion of children with iron depletion assessed by TIBC (> 360 ${\mu}g$/dl) and serum ferritin (< 20 ng/ml) were 56.6% and 58.7%, respectively. The proportion of children with the iron deficient erythropoiesis assessed by serum iron (< 70 ${\mu}g$/dl), Hb (< 12 g/dl), Hct (< 36%) were 76.0%, 58.7%, 64.0%, respectively. After iron supplements treatment, Hb (p<0.001), Hct(p<0.001), serum iron (p<0.001), transferrin saturation (p<0.001) and serum ferritin (p<0.Ol) increase significantly and only TIBC decreased slightly. After cereal supplementation, in anemic children, Hct (p<0.001), serum iron (p<0.001) and transferrin saturation (p<0.001) were significantly increased. The effect of iron supplements and cereal supplementation in children with iron deficient erythropoiesis were more effective to improve the iron nutritional status than children with iron depletion. It was concluded that cereal supplementation program in anemic children was also effective to improve iron nutritional status.

• Journal of Community Nutrition
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• 제7권2호
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• pp.71-78
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• 2005

This study was performed to investigate dietary habits and nutrient intakes of college students in Gyeonggi-do area. Survey questionnaire and daily intake using 24-hour recall method were recorded by 351 college students (172 males, 179 females) . Nutrient intakes were calculated using Can-pro 2.0, from which $\%$RDA (Recommended dietary allowances), NAR (Nutrient adequacy ratio), MAR (Mean nutrient adequacy ratio), and ND (Nutrient density) were calculated to evaluate the quality of diets. Subjects answered 9 questions on dietary habits and these answers were calculated as 0, 0.5, and 1 point by frequency. Dietary habit was 39.57 $\pm$ 21.82 in male students and 42.12 $\pm$ 20.78 in female students out of total score of 100, showing higher score in female students. In the survey of dietary habits, the ratio of skipping breakfast 6 - 7 days a week in total subjects was $32.9\%$, showing a rather higher ratio of skipping breakfast, and the interest for balanced diet was as low as $13.2\%$ in total subjects. The importance of meals in total subjects was observed in the order of dinner ($47.6\%$), lunch ($40.2\%$), and breakfast($12.3\%$). In NAR of total subjects, nutrients with a score lower than 0.70 were calcium (0.64 $\pm$ 0.26), vitamin $B_2$ (0.66 $\pm$ 0.25), and vitamin C (0.69 $\pm$ 0.29) in ND of them, calcium (0.85 $\pm$ 0.43), zinc (0.89 $\pm$ 0.18), vitamin $B_2$(0.87 $\pm$ 0.34), and folic acid (0.91 $\pm$ 0.96) were nutrients with lower values. In the evaluation of nutrient intakes by the level of dietary habits, better scores of both NAR and ND were observed as the level of dietary habits was higher. There was a great difference in nutrient intakes in terms of $\%$RDA, suggesting the risk of nutritional imbalance. Based on the above results, it is considered that the improvement in dietary habits will contribute to the improvement of nutrition.

• Bulletin of the Korean Chemical Society
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• 제27권6호
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• pp.947-950
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• 2006