Browse > Article

Association of Calcium Intake and Bone Mineral Density by Vitamin D Receptor Genotype among Elderly Women Living in Rural a Area  

Kim Ji-Sun (Korean Food Research Institute)
Kim Hee-Seon (Department of Food Science and Nutrition, Soonchunhyang University)
Publication Information
Korean Journal of Community Nutrition / v.11, no.4, 2006 , pp. 534-540 More about this Journal
Abstract
Recent studies have shown that environmental, biochemical, nutritional or genetic factors affect bone mineral density (BMD). The purpose of the present study was to investigate the effect of vitamin D receptor (VDR) gentotype and nutritional status on BMD of elderly women living in a rural area. Three hundred thirty five elderly women over 65 years in Asan participated the study. Data for demographic and nutrient intakes were obtained by survey with a two day 24 hr recall method. BMD was measured by broadband ultrasound attenuation (BUA) using quantitative ultrasound (QUS). VDR genotypes of the subjects analyzed with Bsm I restriction enzyme were bb (92%), Bb (7%) and BB (1%). No differences were found between genotypes bb and Bb/BB in age, menopausal age, body mass index and body fat. BUA of bb genotype was higher (62.5 $\pm$ 15.6 dB/MHz) than Bb/BB genotype (56.1 $\pm$ 17.6 dB/MHz) by Student's t-tests. Correlation analyses showed strong negative correlation of BMD and age, but positive correlation with BMI, energy and calcium intake. When subgroup analyses were conducted after stratification by the median calcium intake level (412.9 mg/d), the above median calcium intake group showed significant difference in BUA by VDR genotype while the lower median calcium intake group did not show significant difference. The current study confirmed interaction of calcium intake and VDR genotype in association with BMD. Further nutritional intervention will be needed to improve calcium status of the elderly women living in rural areas.
Keywords
vitamin D receptor gene polymorphism; bone mineral density; broadband ultrasound attenuation; calcium intake; postmenopausal women;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Ferrari SL, Rizzoli R, Slosman DO, Bonjour JP (1998): Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms? J Bone Min Res 13(3): 363-370   DOI   ScienceOn
2 Kim HS (2004): Assessment of nutritional status by estimation of nutrients and food intakes of Korean elderly women living in residential homes. J Comm Nutr 6(1): 12-17
3 Kung AWC, Yeung SSC, Lau KS (1998): Vitamin D receptor gene polymorphisms and peak bone mass in Southern Chinese Women. Bone 22(4): 389-393   DOI   ScienceOn
4 Looney JE, Yoon HK, Fischer M, Farley SM, Farley JR, Wergedal JE, Baylink DJ (1995): Lack of a high prevalence of the BB vitamin D receptor genotype in severely osteoporotic woman. JCEM 80: 2158-2162
5 National Statistics Office, http://www.nso.go.kr/
6 Oh HJ, Kim JH, Chung HY, Yoon HK, Han IK (1999): Broadband ultrasound attenuation in Korean women measured by QUS-2: Normative data. J Kor Soc Menopause 5(1): 40-47
7 Richelson LS, Wahner HW, Melton LJ, Riggs BL (1984): Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. N Engl Med 311: 1273-1275   DOI   ScienceOn
8 Smith DM, Nance WE, Kang KW, Christlansen JC, Johnston CC (1986): Genetic factors in determing Bone loss. J Clin Inrest 52: 2800-2808
9 Tokita A, Mastumoto H, Morrison MA, Tawa T, Miura Y, Fukamuchi K, Mitsuhashi N, Irimoto M, Yamamori S, Miura M, Watanabe T, Kuwabara, Yabuta K, Eisman JA (1996): Vitamin D receptor alleles, bone mineral density, and turnover in premenopausal Japanese women. J Bone Miner Res 11: 1003-1009   DOI   ScienceOn
10 Tsai KS, Hsu SHJ, Cheng WC, Chen CK, Chieng PU, Pan WH (1996): Bone mineral density and bone markers in relation to vitamin D receptor gene polymorphisms in Chinese men and women. Bone 19(5): 513-518   DOI   ScienceOn
11 Vogel JM, Davis JW, Nomura A, Wasnich RD, Ross PD (1997): The effects of smoking on bone mass and the rates of bone loss among elderly Japanese-American man. J Bone Miner Res 12(9): 1495-1501   DOI   ScienceOn
12 Holbrook TL, Barrett-Connor E (1993): A prospective study of alcohol consumption and bone mineral density. Br Med J 306: 1506-1509   DOI   ScienceOn
13 Kwon IS, Kim IG, Kang CM, Yoo T, Park BJ, Kang HS, Lee HS, Kim C, Cho HC, Bae SH, Park SC (2001): Vitamin D and estrogen receptor gene polymorphism and their interaction associated with bone mineral density in Korean postmenopausal women. Kor J Med 60 (5): 421-431
14 Johansson G, Wiman A, Ahren AM, Hallmans G, Johansson I (2000): Underreporting of energy intake in repeatd 24-hr recalls related to gender, age, weight status, day of interview, educational level, reported food intake, smoking habits and are of living. Pub Helath Nutr 4: 919-925
15 Kim HS. Kim JS, Song RY (2001): Assessment of vitamine E status of female nursing-home residents. J Korean Living Sci Res 10(4): 411-419
16 Prentice A, Bonjour JP, Branca F, Cooper C, Flynn A, Garabedian M, Muller D, Pannemans D, Weber P (2003): PASSCLAIM- Bone health and osteopososis. Eur J Nutr 42(S1): 28-49
17 Dawson-Hughes B, Harris SS, Finneran S (1995): Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. J Clin Endocrinol Metab 80: 3657-3661   DOI
18 Byun DW, Suh KI, Yoo MH, Kim KB, Kim SW, Moon IG, Han IG (1995): Study on Restriction Fragment Length Polymorphisms of Vitamin - D Receptor Gene in relation to Bone Mineral Density and Bone Markers in Pre - and Postmenopausal Korean Women. J Kor Soc Endocrinol 10(3): 249-261
19 Ilich JZ, Brownbill RA, Tamborini L (2003): Bone and nutrition in elderly women: protein, energy and calcium as main determinant of bone mineral density. Eur J Clin Nutr 57: 554-565   DOI   ScienceOn
20 Lee HJ (1996): The Relationship of Exercise to Bone Mineral Density of Korean Women in Taegu. Kor J Nutr 29(7): 806-820
21 Nguyen TV, Kelly PJ, Sambrook PN, Gilbert C (1994): Lifestyle factors and bone density in the elderly: Implications for osteoporosis prevention. J Bone Miner Res 9(9): 1339-1346   DOI   ScienceOn
22 Prafitt Am (1983): Dietary risk factors for age-related bone loss and fractures. Lancet 19: 1181
23 Hansen MA, Overgaard K, Riis BJ, Christiansen C (1991): Role of peak bone mass and bone loss in postmenopausal osteoporosis: A 12 year study. Br Med J 303: 961-964   DOI   ScienceOn
24 Arnand CD, Sanchez SD (1990): The role of calcium in osteoporosis. Ann Rev Nutr 10: 379-414
25 Chung DJ, Kim JM, Kim JY, Kim YS, Park JH, Yang SW, Jung MY, Lee TH, Park JT, Lee MY, Lee JH, Choi C (1998): Vitamin D Receptor Gene Polymorphisms and Bone Mineral Density in Korean Women. J Kor Soc Endocrinol 13(3): 394-409
26 Uitterlinden AG, Pols HAP, van Daele PLA, Algra D, Hofman A, Birkenhager JC, van Leenwen JPTM (1995): Vitamin D receptor genotype is associated with bone mineral density in humans. Calcif Tissue Int 56(5): 474
27 Christian JC, Yu PL, Slemenda CW, Johnston CC (1989): Heritability of bone mass: A longitudinal study in aging males twins. Am J Hum Genet 44: 429-433
28 Korean Nutrition Society (2000): Recommended Dietary Allowances for Koreans, 7th Revision, 2000, Jungang Munhwasa, Seoul
29 Morrison Na, Ai JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA (1994): Prediction of bone density form vitamin D receptor alleles. Nature 367: 284-287   DOI   ScienceOn
30 Nelson DA, Vande Vord PJ, Wooley PH (2000): Polymorphisom in the vitamin D receptor gene and bone mass in African-American and white mother and children: a preliminary report. Ann Rheum Dis 59: 626-630   DOI   ScienceOn
31 Koh JM, Nam-Goong IS, Hong JS, Kim HK, Kim JS, Kim SY, Kim GS (2004): Oestrogen receptor alpha genotype, and interactions between vitamin D receptor and transforming growth factor-beta1 genotypes are associated with quantitative calcaneal ultrasound in postmenopausal women. Clin Endocrinol 60: 232-240   DOI   ScienceOn
32 Lim SK, Park YS, Park JM, Song YD, Lee EJ, Kim KR, Lee HC, Huh KB (1995): Lack of association between vitamin D receptor genotype and osteoporosis in Koreans. J Clin Endocrinol Metab 80(12): 3677-3681   DOI
33 WHO study group (1994): Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series 843. Switzerland
34 Murakami F, Hagino H, Shimomura T, Ikawa S, Hirano Y, Iijima K, Yamamota K (1998): Association of bone mineral density with vitamin D receptor gene polymorphism-changes in radial bone mineral density with long-term follow-up: longitudinal study. Rinsho Byori 46(8): 766-773
35 Melhus H, Kindmark A, Amer S, Wilen B, Lindh E, Ljungahall S (1994): Vitamin D receptor genotypes in osteoporosis. Lancet 344: 949-950
36 Norman AW, Collins ED (1994): Correlation between vitamin D receptor allele and bone mineral density. Nutr Rev 52: 147-149   DOI   ScienceOn
37 Wasnich RD (1991): Bone mass measurements in diagnosis and assessment of therapy. Am J Med 91(suppl): 54s-58s
38 Ministry of Health and Welfare (2002): 2001 National Health and Nutrition Survey Report. KHIDI, Seoul, Korea
39 Jorgensen HL, Scholler J, Sand JC, Bjuring M, Hassager C, Christiansen C (1995): Relation of common allelic variation at vitamin D receptor locus to bone mineral density and postmenopausal bone loss: cross sectional and longitudinal population study. Br Med J 313: 586-590