• Radiation Oncology Journal
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• 제31권1호
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• pp.34-40
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• 2013

Purpose: To evaluate the predictive factors of radiation pneumonitis (RP) and associated changes in pulmonary function after definitive concurrent chemoradiotherapy (CCRT) in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Medical records of 60 patients with NSCLC who received definitive CCRT were retrospectively reviewed. Dose volumetric (DV) parameters, clinical factors, and pulmonary function test (PFT) data were analyzed. RP was graded according to the CTCAE ver. 4.0. Percentage of lung volume that received a dose of threshold (Vdose) and mean lung dose (MLD) were analyzed for potential DV predictors. PFT changes were calculated as the difference between pre-RT and post-RT values at 3, 6, and 12 months after RT. Results: Twenty-two patients (37%) developed grade ${\geq}2$ RP. Among clinical factors, tumor location in lower lobe was associated with RP. Among the DV parameters, only MLD >15 Gy was associated with grade ${\geq}2$ RP. There were statistically significant decreases in PFT at all points compared with pre-RT values in grade ${\geq}2$ RP group. MLD was associated with forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) changes at 6 and 12 months. V10 was associated with FVC changes at 12 months. V20 and V30 were associated with FEV1 changes at 6 months and FVC changes at 12 months. Conclusion: After definitive CCRT in patients with NSCLC, MLD >15 Gy and lower lobe tumor location were predictors of grade ${\geq}2$ RP. Pulmonary functions were decreased after CCRT and the magnitude of changes was associated with DV parameters.

• Journal of Chest Surgery
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• 제24권4호
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• pp.338-344
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• 1991

If the postoperative pulmonary function can be predicted in the patients undergoing pneumonectomy for lung cancer preoperatively, it will be helpful for identifying them as high or low risk candidates. Perfusion lung scan and spirometry were performed in 12 patients with lung cancer pre-operatively and the predicted postoperative Vital Capacity, FVC, FEV1.0, FEF25 - 75% and MVV were estimated by multiplying the preoperative values by the percentage of perfusion of the nonsurgical lung. Three months postoperation the patients were reinvestigated with spirometry and the obtained values were compared with the predicted values. The linear regression lines derived from the correlation between predicted values [X] and observed values [Y] were as follows; VC; R=0.532, Y=0.48X+1.28, P=0.075 FVC; R=0.566, Y=O 54X+1.15, P=0.055 FEV1.0; R=0.832, Y=0.68X+0.70, P=0.001 FEF25 ~ 75%; R=0.781, Y=0.68X+0.54, P=0.003 MVV; R=0.718, Y=0.67X+34.75, P=0.009 The prediction of postoperative FEV1.0, FEF25 ~ 75% and MVV in lung cancer patients undergoing pneumonectomy appear to be valid for evaluating preoperative pulmonary function.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2009년도 춘계학술발표논문집
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• pp.587-590
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• 2009

천식환자의 폐활량 측정 및 관리는 정기적으로 검사되어 관리될 필요가 있는 매우 중요한 관리 항목이다. 본 연구는 천식환자의 폐활량을 정기적으로 관리할 수 있도록 PC-기반 폐활량기를 이용한 천식환자의 폐활량 측정 및 관리 시스템의 설계 및 구현에 관한 연구이다. 폐활량 검사는 크게 3종류 구성되며, 본 연구는 노력성 폐활량 검사(Forced Vital Capacity Test)를 1차적으로 설계 및 구현 방법을 제안하였다. FVC 검사의 목적은 폐질환의 진단, 중증도 그리고 치료효과 판정, 기관지 천식의 진단 및 관리, 수술시 마취방식의 결정 등으로 무엇보다 정확한 검사와 정기적인 검사를 필요로 하는 중요한 검사이다. FVC 검사는 검사과정에서 천식환자에게 많은 노력을 필요로 하는 힘든 검사로서 검사자의 도움이 필수적이므로 폐활량 검사 프로그램 개발에 있어 고려되어 알고리즘이 효율적으로 개발되어야 한다. 본 시스템은 휴대형 폐활량기(Spirometer)를 PC에 연결하고, 폐활량을 측정할 수 있도록 구성되었고, 검사 내용은 PC의 DB에 저장하고, 추후에 정기적으로 서버의 DB로 전송함으로서 보다 더 폭넓은 관리를 가능하도록 하며 천식환자는 서버가 제공하는 웹 사이트를 이용함으로서 자신의 건강관리를 가능하도록 구성된다. FVC 검사 프로그램은 정확한 검사와 편리한 사용자 인터페이스를 제공하도록 설계 및 구현하였고 따라서 자체 개발된 폐활량기를 PC-기반 프로그램으로 제어 가능함으로서 추후 다양한 임상실험의 데이터 확보, 기능의 확장과 성능의 개선을 할 수 있고, 좀 더 편리하고, 정확한 폐활량측정이 가능 할 것이다.

• 대한정형도수물리치료학회지
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• 제21권1호
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• pp.13-20
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• 2015

Background: To evaluate the effect of thoracic mobility exercise and deep breathing exercise applied to stroke patients on pulmonary function. Methods: The subjects were divided into two group. Twenty-five patients with stroke were randomly assigned to DB (deep breathing exercise) group (n=13) and TM (combination of deep breathing exercise and thoracic mobility exercise) group (n=12). During four weeks, DB group were carried out deep breathing exercises for 5~10 minutes twice a day and TM Group were carried out deep breathing exercises for 5~10 minutes and thoracic mobility exercise for 20~30 minutes twice a day. All tests were completed before and after experiment. The pulmonary functions were measured by PowerBreathe K5 (Hab International Ltd, England) and tape measure respectively. For each case, the experimental data were obtained in 4 items; average of inspiratory load, inspiratory flow speed, inspiratory flow volume and chest expansion. Results: The results of this study were as follows: 1. In DB group, the statistically significants were shown on average of inspiratory flow speed, inspiratory flow volume and chest expansion (p<.05). 2. In TM group, the statistically significants were shown on all items (p<.05). 3. There was a statistically significant difference on all items between DB group and TM group (p<.05). Conclusions: The above results revealed that DB and TM group can be used to improve pulmonary function in stroke patients. In comparison of DB and TM group, TM group was more improved. In conclude, thoracic mobility exercise helped improving function of vital capacity and chest expansion in stroke patients.

• 대한정형도수물리치료학회지
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• 제20권1호
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• pp.21-26
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• 2014

Background: This study was aimed to determine the effects of deep abdominal muscle exercises (DAME) and thoracic mobility exercises (TME) on pulmonary function. Methods: This study was conducted with 22 college students who are in their 20s and have no problem carrying out activities of daily living. All subjects were randomly assigned to either the DAME group (11) or the TME group (11) to undertake the exercises for 2 weeks. To measure pulmonary function of subjects, forced vital capacity (FVC), forced exploratory volume in 1 second (FEV1) and peak expiratory flow (PEF) were measured using chest graph. Chest expansion of subjects was also measured with tape ruler. These measurements were performed on the first day before the exercise program started and on the next day after the 2-week exercise program was completed. A paired-t test was performed to compare the differences in pulmonary function before and after the exercise program, and an independent t-test was performed to compare the two groups. Results: The results of this study were as follows: 1) In comparison of pre- and post-exercise changes in the DAME and TME groups, both groups showed significant increase in chest expansion and PEF after the exercise program, compared with the baseline data (p<.05). Both groups also demonstrated improvements in FVC and FEV1 after the exercise program, compared with the baseline data. However, the differences were not statistically significant (p>.05). 2) The comparison of the DAME and TME groups revealed no significant differences in chest expansion, FVC, FEV1 and PEF (p>.05). Conclusion: It is therefore concluded that both DAME and TME were effective in improving pulmonary function.

• Tuberculosis and Respiratory Diseases
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• 제81권2호
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• pp.156-162
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• 2018

Background: Eosinophilia is well recognized in specific conditions. The objective of the present study was to determine clinico-radiologic characteristics of eosinophilia and changes in prevalence over 10 years in recipients of private health screening program at a tertiary hospital in Korea. Methods: Data of private health screening program recipients at the health promotion center of Chung-Ang University Hospital from 2004 to 2013 were collected. Health-related questionnaires and laboratory findings of private health screening program with possible relation with eosinophilia were reviewed. Results of enzyme-linked immunosorbent assay (ELISA) for parasite, chest computed tomography, and pulmonary function test were also reviewed. Results: The cumulative prevalence of eosinophilia was 4.0% (1,963 of 48,928). Prevalence of eosinophilia showed a decreased trend from 2004 to 2013. Most cases (96.6%) had mild degree of eosinophilia. Eosinophilic subjects were older and male-predominant. They showed lower levels of forced expiratory volume in 1 second ($FEV_1%$), forced vital capacity (FVC%), and $FEV_1/FVC$ than those without eosinophilia. Eosinophilic subjects showed higher positive rate for common parasite in ELISA than those without eosinophilia. On radiologic findings, consolidation and ground glass opacities were positively associated with the degree of eosinophilia. When eosinophil was classified based on severity, statistically significant correlation between the severity of eosinophil and radiologic abnormalities was found. Conclusion: Eosinophilia is uncommon in healthy population. It usually occurs at a mild degree. Eosinophilic patients have more radiologic abnormalities compared to those without eosinophilia. Such radiologic abnormalities are associated with the severity of eosinophilia.

• Journal of Ginseng Research
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• 제28권1호
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• pp.18-26
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• 2004

The effect of Panax ginseng administration in muscle inflammatory process induced after eccentric exercise, that causes myofibrillar disruption, was studied. Changes in lipid peroxidation, inflammation, glycogen levels in muscle and release of myocellular proteins to blood were measured. The analyses were performed immediately after eccentric exercise and over week since this period are necessary for the muscle damage-repair cycle. The ginseng extract (100 mg kg$^{-1}$ ) was orally administered to rats for three months, before the eccentric exercise performance. The results showed the protective role of ginseng against skeletal muscle damage. This effect could be associated with their membrane stabilising capacity since creatine kinase (CK) activity was significantly decreased 96 h post-exercise from 523$\pm$70 to 381$\pm$53 and 120 h post-exercise from 443$\pm$85 to 327$\pm$75 in treated animals. $\beta$-glucuronidase activity, as indicator of inflammation, showed a significant reduction of about 15-25% in soleus, vastus and triceps in these post-exercise times. The lipid peroxidation, measured by malondyaldehyde levels, was significantly decreased in the 24 h post-exercise period in soleus and vastus intermedius muscles and on the recovery period. Finally ginseng administration reduced significantly the decrease of the glycogen levels immediately after exercise and when the regenerative process took place (72-168 h post exercise). Collectively, the results have showed that ginseng did not inhibit the vital inflammatory response process associated with the muscle damage-repair cycle but presumably ameliorate the injury.

• Journal of Ginseng Research
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• 제42권4호
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• pp.476-484
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• 2018

Background: Korean Red Ginseng (steamed and dried white ginseng, Panax ginseng Meyer) is well known for enhancing vital energy and immune capacity and for inhibiting cancer cell growth. Some clinical studies also demonstrated a therapeutic potential of ginseng extract for treating lung inflammatory disorders. This study was conducted to establish the therapeutic potential of ginseng saponins on the lung inflammatory response. Methods: From Korean Red Ginseng, 11 ginsenosides (Rb1, Rb2, Rb3, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, and Rh2) were isolated. Their inhibitory potential and action mechanism were evaluated using a mouse model of lung inflammation, acute lung injury induced by intranasal lipopolysaccharide administration. Their anti-inflammatory activities were also examined in lung epithelial cell line (A549) and alveolar macrophage (MH-S). Results: All ginsenosides orally administered at 20 mg/kg showed 11.5-51.6% reduction of total cell numbers in bronchoalveolar lavage fluid (BALF). Among the ginsenosides, Rc, Re, Rg1, and Rh2 exhibited significant inhibitory action by reducing total cell numbers in the BALF by 34.1-51.6% (n = 5). Particularly, Re showed strong and comparable inhibitory potency with that of dexamethasone, as judged by the number of infiltrated cells and histological observations. Re treatment clearly inhibited the activation of mitogen-activated protein kinases, nuclear factor-${\kappa}B$, and the c-Fos component in the lung tissue (n = 3). Conclusion: Certain ginsenosides inhibit lung inflammatory responses by interrupting these signaling molecules and they are potential therapeutics for inflammatory lung diseases.

• 융합정보논문지
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• 제10권2호
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• pp.176-183
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• 2020

본 연구의 목적은 복부압박벨트가 뇌졸중 환자의 폐 기능, 균형 및 보행능력에 미치는 영향을 즉각적으로 알아보고자 함이다. 20명의 뇌졸중 환자를 대상으로 복부압박벨트 착용 전에 폐기능, 압력중심, 버그균형검사, 일어서서 걷기 검사, 10m 보행, 기능적 보행검사를 실시하였다. 복부압박벨트를 착용한 직후에 사후 평가를 실시하였다. 연구 결과 복부압박벨트를 착용하였을 때 노력성 폐활량과 1초간 노력성 날숨 유량을 제외한 모든 결과값이 유의한 변화를 보였다. 본 연구를 통해 뇌졸중 환자가 복부압박벨트를 착용하였을 때 균형과 보행 능력의 증가에 즉각적인 영향을 미친다는 것을 알 수 있었다. 향후 연구에서는 폐 기능을 개선시키기 위해 압박 수준과 자세 변경과 같은 노력이 필요할 것이다.

• Tuberculosis and Respiratory Diseases
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• 제71권1호
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• pp.37-45
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• 2011

Background: Pulmonary emphysema (PE) is major cause of obstructive pulmonary function impairment (OPFI), which is diagnosed by spirometry. PE by high resolution CT is known to be correlated with OPFI. Recently, low dose CT (LDCT) has been increasingly used for screening interstitial lung diseases including PE. The aim of this study was to evaluate OPFI risks of subjects with PE detected by LDCT compared with those detected by simple digital radiography (SDR). Methods: LDCT and spirometry were administered to 266 inorganic dust exposed retired workers, from May 30, 2007 to August 31, 2008. This study was approved by our institutional review board and informed consent was obtained. OPFI risk was defined as less than 0.7 of forced expiratory volume in one second (FEV1)/forced vital capacity (FVC), and relative risk (RR) of OPFI of PE was calculated by multiple logistic regression analysis. Results: Of the 266 subjects, PE was found in 28 subjects (10.5%) by LDCT and in 11 subjects (4.1%) by SDR; agreement was relatively low (kappa value=0.32, p<0.001). FEV1 and FEV1/FVC were significantly different between PE and no PE groups determined by either SDR or LDCT. The differences between groups were larger when the groups were divided by the findings of SDR. When PE was present in either LDCT or SDR assays, the RRs of OPFI were 2.34 and 8.65, respectively. Conclusion: LDCT showed significantly higher sensitivity than SDR for detecting PE, especially low grade PE, in which pulmonary function is not affected. As a result, the OPFI risks in the PE group by LDCT was lower than that in the PE group by SDR.