• 생명과학회지
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• 제20권11호
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• pp.1675-1682
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• 2010

해조류 감태의 기능성을 증명하기 위하여 열수 추출하여 여러 가지 생리활성에 대하여 조사하였다. 우선, 감태열수 추출물의 항산화능을 조사하기 위하여 DPPH radical 소거능, SOD 유사활성, XO 저해능을 측정하였다. 그 결과 감태 열수 추출물의 농도가 증가 할수록 높은 항산화능이 나타났으며 항산화제로 잘 알려져 있는 BHA, VitC, catechin의 활성보다 높거나 유사하게 보였다. 아질산염 소거능 측정 실험에서 positive control인 VitC와 감태 열수 추출물은 시료농도가 증가할수록 pH가 낮을수록 증가하였다. 특히, pH 1.2에서 감태 열수 추출물의 경우 VitC 보다 약간 높은 아질산염 소거능을 나타내었다. 감태 열수 추출물의 숙취해소 효능은 ADH와 ALDH 활성증진에 감태 열수 추출물이 미치는 영향을 조사함으로써 증명하고자 하였다. 그 결과, 감태 열수 추출물은 알콜과 acetaldehyde 분해능을 모두 가지고 있을 뿐만 아니라 acetaldehyde의 분해능은 상당히 높게 나타났다. 감태 열수 추출물의 미용효능은 tyrosinase와 elastaase 억제 효과를 분석함으로써 증명하고자 하였다. Tyrosinase 저해능 분석에서 positive control로 사용한 kojic acid는 0.1 mg/ml의 농도에서 65%의 tyrosinase 억제효과를 나타낸 반면, 감태 열수 추출물의 경우 10 mg/ml의 농도에서 58%의 저해효능을 보였다. 비록, 그 효능이 충분히 높지는 않지만 감태 열수 추출물의 농도가 증가함에 따라서 tyrosinase 저해활성이 증가하므로 충분한 미백효능을 기대할 수 있을 것으로 판단된다. Elastase 억제 효능 분석에서는 감태 열수 추출물 0.5 mg/ml에서 38%, 1 mg/ml에서 44%의 저해활성이 나타났다. Positive control로 elastase 저해 활성 효과가 알려진 VitC는 1 mg/ml의 농도에서 36%의 저해활성이 나타났고 elastase 활성저해제인 oleanolic acid는 농도 0.5 mg/ml에서 elastase를 32% 정도 저해하는 것으로 알려져 있으므로 주름 예방 효능에 있어서 감태 열수 추출물의 우수한 기능성이 예상된다.

• 대한지역사회영양학회지
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• 제6권3호
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• pp.271-281
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• 2001

This study was performed to compare the anthropometric and the food and nutrient intake of the adolescents between urban areas and islands in south Kyungnam and to identify their nutritional problems. A questionnaire survey was distributed among 383 middle school students for the food and nutrient consumption and other nutritional attitudes including socioecomonic status. The height and weight of the students were measured as well. Socioeconomic status, such as income, educational level, and jobs of the urban students parents was better than that of the island students. There was no significant difference in height between the students of both areas, but the body weight of the urban male students was far heavier than that of the other group. It is very interesting to note that the energy intake of the urban male students was much lower than that of the island male students. The students of the two areas consumed more protein, Vit B$_1$, Vit B$_2$, niacin and Vit C than the recommended daily allowances(RDA) but the intake of Ca, Fe, Vit A was less. As to the sources of animal fat, the urban males consumed much more. Regarding the taste preference, the study shows that urban male students are more likely to choose sweet, salty and soft tastes than island male students. In the case of female students, although island students prefer a rather hot taste, urban students are more likely to prefer sweet and soft tastes. The favorite foods of urban students are meat products, fastfoods, chocolate, cheese and milkshakes, while foods like cooked rice with assorted vegetable are the favorite of the island students. In general, the preference degree for meat products and fruits rates higher than for vegetables. Conclusively the urban students had a tendency of being obese and the intake of all nutrients by the urban adolescents was much lower than that of the islanders. In this study, the cause can be found in significant differences in consuming animal fat, of taste preference and of choosing favorite food. Accordingly a nutritional intervention or educational program is required to adjust the imbalanced intake of some nutrients for the adolescents in this province.

• 한국생활과학회지
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• 제16권3호
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• pp.631-642
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• 2007

This study was an investigation of obesity, food habits and daily nutrient intakes of the 4th grade elementary school students in daejeon. A total of 148 children(male:71, female:77) participated in the study. We classified the subjects into normal group and obese group according to the grade of obesity indices by body fat ratio(BFR), 70% of the male and 31% of the female were obese group. The average height, weight were $140.1{\pm}4.9cm$, $33.0{\pm}3.6kg$(obese group), $141.9{\pm}5.7cm$, $42.0{\pm}3.6kg$(normal group) for the male, $141.2{\pm}6.4cm$, $42.4{\pm}6.2kg$(obese group), $139.5{\pm}6.4cm$, $33.0{\pm}4.5kg$(normal group) for the female. Weight showed a noticeable increase in the obese group, but height was not statistically significant. In dietary habits, it wasn't statistically significant but male obese group showed statistically increase in terms of eating fast(p>0.05) and eating snacks before sleeping(p>0.01) and female obese group was higher in frequency of eating out a month than normal group. Energy intakes of obese group was more than normal group and the average intakes of Vit. A, folic acid, Ca, were below the RI. The average intakes of vit A, vit C, folic acid, Ca, were also below the RI in normal group. The average intakes of vit A, folic acid, Ca, Fe were below the RI in female. Especially in female the intake of Ca was only 53.6%(obese group), 56.4%(normal group) of RI. From these results, we knew prevalence of obesity in elementary school students were high and obese groups were high in energy intakes but low in essential nutrients. Therefore we have to try to prevent and treat childhood obesity. So nutrition education of balanced diet and good dietary habits is needed for elementary school students.

• Anatomy and Cell Biology
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• 제56권4호
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• pp.526-537
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• 2023

Hepatitis C virus (HCV) infection is a major health problem worldwide and its eradication is mandatory. Direct acting HCV polymerase inhibitors, such as Sofosbuvir (SOF), is an effective regimen. However, it has some side effects like mutagenesis, carcinogenesis, and the impairment of testicular function. It is important to evaluate the safety of SOF on the ovary, as there are no studies yet. Increasing the production of Reactive Oxygen Species (ROS), causes oxidative stress, which affects ovulation process, female reproduction, and fertility. Accumulation of SOF in the cells was demonstrated to promote ROS generation. Vitamin E (Vit E) is an antioxidant agent that has an essential role in the female reproductive system, its deficiency can cause infertility. We explored the effect of SOF treatment alone and co-treated with Vit E on ovarian ROS level and ovarian morphology experimentally using biochemical and immunohistochemical studies. Significant changes in oxidative stress markers; nitric oxide and malondialdehyde lipid peroxidation, antioxidant enzymes; catalase, super oxide dismutase, and reduced glutathione, proliferating markers; proliferation cell nuclear antigen and Ki-67 antigen and caspase 3 apoptotic marker were demonstrated. It was shown that where SOF induced oxidative stress, it also aggravated ovarian dysfunction. The essential role of Vit E as an antioxidant agent in protecting the ovarian tissue from the effect of oxidative stress markers and preserving its function was also displayed. This could be guidance to add Vit E supplements to SOF regimens to limit its injurious effect on ovarian function.

• 대한수학회지
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• 제55권5호
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• pp.1019-1030
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• 2018

In [12,13] the researchers introduced universally convex, universally starlike and universally prestarlike functions in the slit domain ${\mathbb{C}}{\backslash}[1,{\infty})$. These papers extended the corresponding notions from the unit disc to other discs and half-planes containing the origin. In this paper, we introduce universally prestarlike generalized functions of order ${\alpha}$ with ${\alpha}{\leq}1$ and we obtain upper bounds of the second Hankel determinant ${\mid}a_2a_4-a^2_3{\mid}$ for such functions.

• ETRI Journal
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• 제43권1호
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• pp.64-73
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• 2021

Two-dimensional torus network nodes are typically interconnected using XY routing algorithm for transmitting a packet from a source node to a destination node. In XY routing, if all the paths are used efficiently, the throughput and latency can be improved. In this paper, to utilize all the paths efficiently, we propose a novel binary optical routing algorithm (BORA) to improve the throughput and latency. The throughput is calculated according to the injection rate and number of packets received at the destination. The XY routing algorithm and proposed BORA are implemented using objective modular network testbed in C++ simulation software and the results are analyzed and compared. In this paper, the simulation results show that the network latency reduces to 50% while using the proposed algorithm; moreover, the throughput is also improved.

• Journal of Acupuncture Research
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• 제21권5호
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• pp.69-78
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• 2004

Objective : This study was undertaken to determine the inhibitory effect of Whallak-tang against Nitric Oxide, the scavenging effect of Whallak-tang on DPPH radical. Methods : Both nitric concentration 1, 3, 6 and 24 hours after treatment with Vit. C and Whallak-tang at 0.1, 1, 10 mg/ml and scavenging effect 10, 20, 30 and 60 minute after treatment with Vit. C and Whallak-tang at 0.1, 1, 10 mg/ml were estimated. Results : The inhibitory effect of Whallak-tang against Nitric Oxide was dose-dependent. The scavenging effect of Whallak-tang on DPPH radical was dose-dependent. Conclusion : These results would provide important basic data on the possibility of the clinical treatment of Whallak-tang in musculoskeletal disease.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2006년도 춘계학술대회 논문집
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• pp.417-420
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• 2006

The composition and structure of dendrite phase within $Zr_{76.11}Ti_{4.20}Cu_{4.51}Ni_{3.16}Be_{1.49}Nb_{10.53}$ bulk metallic glass (BMG) were confirmed by using an EPMA, XRD and TEM, respectively. The chief elements of dendrite phase were Zr-Ti-Nb and had a BCC structure. The thermal properties of this BMG have been then subsequently investigated by using a differential scanning calorimeter (DSC). The glass transition and crystallization onset temperatures were determined as $339.7^{\circ}C$ and $375.8^{\circ}C$ for this alloy, respectively. Mechanical properties have also been examined by conducting a series of uniaxial compression tests at various temperatures within supercooled liquid region under the strain rates between $10^{-4}/s$ and $3{\times}10^{-2}/s$. The deformation behavior of BMG composite within supercooled liquid region is similar to one of Vit-1 exhibiting amorphous single phase alloy. The flow stresses of BMG composite, however, are entirely higher than those of Vit-1 because dendrite phases are interfere with moving of atoms.

• Journal of Acupuncture Research
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• 제32권4호
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• pp.109-118
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• 2015

Objectives : The purpose of this study was to investigate the anti-oxidative effect of Suhwagije-decoction (SGT) pharmacopuncture solution on the liver and spleen cells of aged rats. Methods : The liver and spleen cells of 10, 52, and 72 week old Sprague Dawley (SD) rats were divided into three groups: distilled water (DW), Vit.C, and SGT groups, which were treated with DW, Vit.C and SGT pharmacopuncture solution respectively. The levels of superoxide dismutase (SOD), glutathione (GSH) and nitric oxide (NO) were then measured. Results : 1. Treatment of SGT pharmacopuncture solution significantly decreased NO concentration in spleen cells of 52 week old rats as compared with that of other groups. 2. Treatment of SGT pharmacopuncture solution significantly increased SOD activity in spleen cells of 72 week old rats as compared with that of other groups. Conclusions : Suhwagije-decoction (SGT) pharmacopuncture solution may have an anti-oxidative effect in the spleen cells of aged rats.

• 한국식품영양과학회지
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• 제29권4호
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• pp.701-711
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• 2000

본 연구는 우리나라의 식생활에 적절한 영양 평 가 방법을 제시하는데 기여하고자 하는 목적으로, 경북지역에 거주하는 성인 남녀 196명을 대상으로 24시간 회상법을 통해 개인별 영양소 섭취상태를 조사한 후 영양상태를 질적, 양 적으로 평가하였다. 본 연구의 결과는 다음과 같다. 경북지역 성인 남녀의 일일 평균 영양소 섭취량은 비교적 양호한 편이나, 칼슘과 비타민 A에서 영양 권장량보다 적은 83%, 77%를 섭취했으며, 칼슘을 제외한 모든 영양소에서 남자의 평균 섭취량이 여자의 평균 섭취량보다 많았다. INQ로 살펴본 영양소 섭취의 질적 평가는 비타민 C가 2.39로 가장 높게 나왔으며, 비타민 A가 0.84, 칼슘이 0.89의 점수를 보여 Ca과 비타민 A는 양과 질 측면에서 우려되는 것으로 조사되었다. 평균 영양소 적정도는 남자가 0.88, 여자가 0.86으로 남녀 간에 차이가 없었다. 영양소 섭취량과 각 용니과의 상관관계에서 남자의 경우에는 영양소 섭취량과 유의 한 관계를 나타내는 요인으로서 지방과 연령 사이에만 유의한 양의 관계가 나타난 반면 여 자의 경우에는 나이, 식사 섭취 횟수는 대부분의 영양소에서 유의적인 양의 상관관계를 보 였다. 남자는 가계 총수입이 높을수록 식사 중의 비타민 B2 영양밀도가 높았으며 여자의 경 우에는 INQ 중에서 인(p<0.050)과 철분(p<0.05)이 연령과 유의한 양의 상관관계를 보였다. MAR은 여자의 경우에 한하여 연령(p<0.05)과 양의 상관관계를, 학력(p<0.01)과 유의적인 음의 상관관계를 보였으며 하루식사횟수(p<0.001)와도 유의한 양의 관계를 나타내었다. 이 상을 종합해 볼 때 경북지역에 거주하는 성인의 경우 남자가 여자에 비해 영양섭취상태가 전반적으로 양호하다고 할 수 있으며 여자 20대의 경우에 영양섭취가 가장 저조하였고 특히 칼슘과 비타민 A의 섭취가 부족하였다. 이연령층은 임신, 출산과 연결되는 영양취약집단이 므로 이들을 대상으로 규칙적인 식사의 중요성과 다양한 식품의 섭취를 홍보하는 영양교육 이 보건소를 통해 강화되어야 하리라고 보여진다.