• Genomics & Informatics
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• v.7 no.2
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• pp.122-130
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• 2009

A systems biology approach for the identification of perturbed molecular functions is required to understand the complex progressive disease such as breast cancer. In this study, we analyze the microarray data with Gene Ontology terms of molecular functions to select perturbed molecular functional modules in breast cancer tissues based on the definition of Gene ontology Functional Code. The Gene Ontology is three structured vocabularies describing genes and its products in terms of their associated biological processes, cellular components and molecular functions. The Gene Ontology is hierarchically classified as a directed acyclic graph. However, it is difficult to visualize Gene Ontology as a directed tree since a Gene Ontology term may have more than one parent by providing multiple paths from the root. Therefore, we applied the definition of Gene Ontology codes by defining one or more GO code(s) to each GO term to visualize the hierarchical classification of GO terms as a network. The selected molecular functions could be considered as perturbed molecular functional modules that putatively contributes to the progression of disease. We evaluated the method by analyzing microarray dataset of breast cancer tissues; i.e., normal and invasive breast cancer tissues. Based on the integration approach, we selected several interesting perturbed molecular functions that are implicated in the progression of breast cancers. Moreover, these selected molecular functions include several known breast cancer-related genes. It is concluded from this study that the present strategy is capable of selecting perturbed molecular functions that putatively play roles in the progression of diseases and provides an improved interpretability of GO terms based on the definition of Gene Ontology codes.

• Journal of the Korea Society of Computer and Information
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• v.18 no.3
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• pp.119-126
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• 2013

In this paper, we propose and describe the system to visualize the story of contents such as movies and novels. Character-net is applied as story model in order to visualize story. However, it is the form to be accumulated for total movie story, though it can depict the relationship between characters. We have developed the system that analyzes and shows the variation of Character-net and characters' tendency in order to represent story variation depending on movie progression. This system is composed by two windows that can play and analyze sequential Character-nets by time, and can analyze time variant graph of characters' degree centrality. First window has a function that supports to find important story points like the scenes that main characters appear or meet firstly. Second window supports a function that track each character's tendency or a variation of his tendency through analyzing in-degree graph and out-degree. This paper describes the proposed system and discusses additional requirements.

• 한국지구물리탐사학회:학술대회논문집
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• 2000.09a
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• pp.158-172
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• 2000

In order to visualize mine cavities, 3D seismic reflection data were acquired at the ground subsidence sites near Nampung coal mine area, Neukguri, Dogye, Samchuck. Full range 3D array with complete range of azimuths on the bins was considered in the data acquisition design. Because of poor S/N data, we estimated the stacking velocities by CVS method, and we estimated the shot and receiver statics on the shot and receiver stack data. We could confirm that features of ground collapse that were expected from the subsidence. In order to visualize the cavities, we need to apply more sophisticated processing schemes, such as velocity analysis, residual statics correction.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.23 no.2
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• pp.109-132
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• 2012

This study examines the social network of scholars in the field of communication by using author cocitation data. A matrix containing the number of cocited documents between pairs of authors is created for social network analysis of scholars who are on the editorial board of Journal of Communication, and the networked map of the scholars is used to visualize the knowledge structure of the field by identifying groups of authors who are more central than others. In addition, the study compares the previous analysis performed in 2008 and the current analysis on the editorial board of the journal, which increased from 146 to 254 scholars in numbers. Author cocitation data was collected using Social Science Citation Index (SSCI) through the Web of Science database, and UCInet was used to create and visualize the author cocitation network and to analyze the correlation between the cocitation network and the factors that may have affected the structure of the cocitation network.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.582-585
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• 2018

As traffic volume increases and road networks become more complicated, identifying for accurate traffic flow and driving smooth traffic flow are a concern of many countries. There are various analytical techniques and studies which desire to study about effective traffic flow. However, the necessary activity is finding the traffic flow pattern through data visualization including location information. In this paper aim to study a real-world urban traffic trajectory and visualize a pattern of traffic flow with a simulation tool. Our experiment is installing the sensor module in 40 taxis and our dataset is generated along 24 hours and unscheduled routes. After pre-processing data, we improved an open source traffic visualize tools to suitable for our experiment. Then we simulate our vehicle trajectory data with a dots animation over a period of time, which allows clearly view a traffic flow simulation and a understand the direction of movement of the vehicle or route pattern. In addition we further propose some novel timelines to show spatial-temporal features to improve an urban environment due to the traffic flow.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.31 no.6 s.261
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• pp.635-643
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• 2007

As many engineers and technicians are involved in the design process of large scale and/or complex products, there are a lot of miss matches and interferences due to designers' faults and several kinds of CAD systems. Recently, CAD systems are applied to verify and check the assembly process. Digital Mock-Up(DMU) system, a tool to build a virtual mock-up in the design stage, has been used to prevent the interferences and miss matches during precision design processes. Using the virtual assembly tool, engineers are able to design precision and interference free parts without physical mock-ups. Instead of a single CAD source, several CAD systems are used to design a complex product. Several organizations are involved in the distributed design environment for heterogeneous multi-CAD assembly. XML and the lightweight CAD file are proposed for the multi-CAD assembly. XML data contains hierarchy of the heterogenenous multi-CAD assembly. STEP PDM schema and STEP ISO 10303-28 formations are applied to construct the XML data. The lightweight CAD file produced from various CAD files through ACIS kernel and InterOp not only contains mesn, B-Rep and topological data, but also is used to visualize CAD data and to verify dimensions. Developed system is executed on the desktop computers. It does not require commercial CAD systems to visualize 3D assembly data. Real-time interference and fitness checks, dimensional verification, and design and assembly verification are performed on the developed system. Assembly of heterogeneous models for a car is conducted to verify the effectiveness of the developed DMU system on the Internet.

• Korean Chemical Engineering Research
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• v.59 no.3
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• pp.366-372
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• 2021

Cadherin-Catenin complex is thought to play an essential role in the transmission of force at adherens junction. Due to the lack of proper tools to visualize and detect mechanical force signals, the underlying mechanism by which the cadherin-catenin complex regulates force transmission at intercellular junctions remains elusive. In this study, we visualize cadherin-mediated force transmission using an engineered α-Catenin sensor based on fluorescence resonance energy transfer. Our results reveal that α-catenin is a key force transducer in cadherin-mediated mechanotransduction at cell-cell junctions. Thus, our finding will provide important insights for studying the effects of chemical and physical signals on cell-cell communication and the relationship between physiological and pathological phenomena.

• Journal of the Korea Society of Computer and Information
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• v.25 no.12
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• pp.173-186
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• 2020

In this paper, we design and implement a service system for mobile devices to utilize the integrated underground geospatial information map in underground exploration fields. The field utilization service system for mobile devices is designed to visualize tiled maps, 3D terrain information, underground structures, underground facilities, and ground information provided by the Integrated Underground Geospatial Information Map Management System according to current position. And It is designed to reflect the results obtained from field exploration in real time. Also, the proposed system is implemented to transfer and visualize the integrated underground geospatial information map in the form of a glTF format due to constraints on wireless networks and device characteristics of mobile devices. Implemented mobile service systems can prevent accidents in underground exploration field from occurring by providing users with accurate and integrated underground geospatial data by visualizing maps and geospatial objects in three dimensions at underground exploration fields. In addition, updated underground geospatial data is transmitted in real time to the Integrated Underground Geospatial Information Map Management Systems, which can maintain up to date and accuracy.

• Archives of Plastic Surgery
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• v.49 no.1
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• pp.99-107
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• 2022

Background Dermal backflow (DBF), which refers to lymphatic reflux due to lymphatic valve insufficiency, is a diagnostic finding in lymphedema. However, the three-dimensional structure of DBF remains unknown. Photoacoustic lymphangiography (PAL) is a new technique that enables the visualization of the distribution of light-absorbing molecules, such as hemoglobin or indocyanine green (ICG), and can provide three-dimensional images of superficial lymphatic vessels and the venous system. This study reports the use of PAL to visualize DBF structures in the extremities of patients with lymphedema after cancer surgery. Methods Patients with a clinical or lymphographic diagnosis of lymphedema who previously underwent surgery for cancer at one of two participating hospitals were included in this study. PAL was performed using the PAI-05 system. ICG was administered subcutaneously in the affected hand or foot, and ICG fluorescence lymphography was performed using a near-infrared camera system prior to PAL. Results Between April 2018 and January 2019, 21 patients were enrolled and examined using PAL. The DBF was composed of dense, interconnecting, three-dimensional lymphatic vessels. It was classified into three patterns according to the composition of the lymphatic vessels: a linear structure of lymphatic collectors (pattern 1), a network of lymphatic capillaries and lymphatic collectors in an underlying layer (pattern 2), and lymphatic capillaries and precollectors with no lymphatic collectors (pattern 3). Conclusions PAL showed the structure of DBF more precisely than ICG fluorescence lymphography. The use of PAL to visualize DBF assists in understanding the pathophysiology and assessing the severity of cancer-related lymphedema.

• Journal of Biomedical Engineering Research
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• v.43 no.4
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• pp.193-198
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• 2022

Contrast enhanced magnetic resonance imaging using gadolinium-based contrast agent (GBCA) is a very useful in vivo technique to visualize the inner ear pathology including endolymphatic hydrops. Although systemic intravenous (IV) administration can visualize the perilymph space, the visualization was possible by indirect passage of contrast agent through blood-perilymph barrier. All animal experimental procedures were performed under anesthesia with 5% isoflurane. Lipopolysaccharide (LPS) was instilled into the left tympanic cavity through the tympanic membrane using a sterile 27gauge needle to induce hydrops model. Tucker-Davis Technologies system was used to measure Auditory Brainstem Responses (ABRs). For intracerebroven-tricular (ICV) administration, 25 µmol of GADOVIST (Bayer, Berlin, Germany) was used and diluted GADOVIST injection was 10 µl. MR imaging was acquired with a 9.4 Tesla MRI scanner. Transmit-receive volume coil with 40 mm inner diameter and 75 mm out diameter was used. ICV administration well demonstrated the strong enhancement along the cerebrospinal fluid (CSF) microcirculation pathway including CSF fluid in the subarachnoid space and CSF space of the inner ear structures. On the other hand, IV administration showed no contrast enhancement along the CSF microcirculation pathway and showed weak enhancement in the inner ear structures. In case of rat hydrops model, ICV administration showed that the reduced contrast enhancement in the perilymph space of the hydrops induced inner ear compared to the contrast enhancement in the perilymph space of the normal inner ear. New systemic ICV administration method provide contrast enhancement of GBCA in the inner ear through CSF microcirculation pathway.