• 통합자연과학논문집
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• 제6권1호
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• pp.1-7
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• 2013

Polyurethane resin containing isocyanate is marked by excellent tensile and mechanical strengths and this test aims to gauge its applicability as a medical high polymer. Tris [2-(acryloyloxy)ethyl]isocyanurate and hexamethylenediisocyanate were added to a basic mixing ratio of HEMA (2-hydroxyethyl methacrylate), MMA (methyl methacrylate), NVP (n-vinyl-2-pyrrolidone) and crosslink agent, EGDMA (ethylene glycol dimethacrylate) with increasing proportions and copolymerized respectively. Also, the basic physical properties of the polymerized high polymers including refraction rate, tensile strength, light transmission and water content were measured to confirm that they are appropriate as hydrogelcontact lenses. After measuring the physical properties of high performance polymers produced by adding tris [2-(acryloyloxy) ethyl]isocyanurate, it was found that the average tensile strengths of sample TRIS1 to TRIS10 were between 0.285 and 0.612 kgf, while the average values of refractive index were ranged from 1.441 to 1.449 with water content from 30.00 to 37.35%.The measurement of physical properties of the copolymers generated by adding hexamethylenediisocyanate showed that the average tensile strength of sample HEXA1 to HEXA10 ranged from 0.267 to 1.742 kgf, the refractive index ranged from 1.443 to 1.475 and water contents were in the range of 21.22 to 35.58%. In all combinations the transmission rates satisfied the transmittance of general hydrogel contact lenses. From theresults, it is possible to conclude that the produced copolymers can be used as contact lens materials with excellent tensile strength.

• 디지털융복합연구
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• 제11권1호
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• pp.423-430
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• 2013

정보통신기술의 발달은 다양한 디지털매체와 소셜네트워크(SNS) 출연을 가져왔으며, 정보와 지식을 전달하는 방법에 있어서 '객관적지식'에서 '경험적지식'을 실시간 이야기하고 감성을 소통가능하게 하였다. 본 연구에서는 가족의 역사, 개인의 인물사등 선형적인 서사 장르의 이야기를 가지고 다양한 형태로 이야기를 생성할 수 있는 인터렉티브 스토리텔링 시스템을 연구하고자 한다. CEO이야기나 특정 조직이야기, 가족이야기등 다양한 콘텐츠 가운데 가족이야기(familyHistory)를 본 연구의 사례연구 관점에서 내러티브인터뷰, 직접관찰, 문서 및 영상자료수집 등을 통해 수집 분석 한 후 장르별 DB와 키워드DB 설계를 하여 분류 저장하였다. 저장된 자료는 인터렉티브 스토리텔링 서술구조를 통하여 사용자가 가족의 역사와 이야기에 대한 스토리텔링을 재구성하여 사용함으로써 이야기의 가치와 활용도를 높이고자 하였다. 본 연구를 통하여 각 세대간의 소통의 도구가 부족한 한국의 현황에서 1세대와 3세대 간의 텍스트, 이미지, 영상등 다양한 형태의 디지털 매체를 사용하는 저작시스템의 데이터모델을 작성하였으며, 더 나아가 DB화된 다양한 장르의 가족이야기를 가지고 인터렉티브 스토리텔링 창작 도구로 연동 가능한 시스템 설계를 연구하였다.

• The Korean Journal of Pain
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• 제6권1호
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• pp.32-39
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• 1993

전북대학교 병원에 입원하여 하복부 수술을 받는 미국 마취과학회 전신상태 분류상 class I, II인 환자 40명을 대상으로 수술후 morphine(1군)과 ketorolac(2군)을 지속적으로 정주한 결과 다음과 같은 결론을 얻었다. 1) 1군과 2군 모두 수술후 통증에 의의 있는 감소를 보였으며 군 간의 차이는 없었다. 2) 1군에서 2군보다 부작용의 빈도가 많았다. 이상의 결과로 수술후 통증 관리에 있어서 morphine과 ketorolac의 지속적 정맥 주입 방법은 모두 효과적이었으며, ketorolac이 morphine보다 부작용의 발현 빈도가 더 적은것으로 보아 morphine을 대신할 수 있는 유용한 약물로 사료된다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제8권5호
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• pp.205-212
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• 2019

장면 그래프는 영상 내 물체들과 각 물체 간의 관계를 나타내는 지식 그래프를 의미한다. 본 논문에서는 3차원 실내 환경을 위한 3차원 장면 그래프를 생성하는 모델을 제안한다. 3차원 장면 그래프는 물체들의 종류와 위치, 그리고 속성들뿐만 아니라, 물체들 간의 3차원 공간 관계들도 포함한다. 따라서 3차원 장면 그래프는 에이전트가 활동할 실내 환경을 묘사하는 하나의 사전 지식 베이스로 볼 수 있다. 이러한 3차원 장면 그래프는 영상 기반의 질문과 응답, 서비스 로봇 등과 같은 다양한 분야에서 유용하게 활용될 수 있다. 본 논문에서 제안하는 3차원 장면 그래프 생성 모델은 크게 물체 탐지 네트워크(ObjNet), 속성 예측 네트워크(AttNet), 변환 네트워크(TransNet), 관계 예측 네트워크(RelNet) 등 총 4가지 부분 네트워크들로 구성된다. AI2-THOR가 제공하는 3차원 실내 가상환경들을 이용한 다양한 실험들을 통해, 본 논문에서 제안한 모델의 높은 성능을 확인할 수 있었다.

• Clinics in Shoulder and Elbow
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• 제25권1호
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• pp.73-89
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• 2022

Background: To evaluate the efficacy of autologous platelet-rich plasma (PRP) injections in the treatment of common shoulder diseases. Methods: The PubMed, Medline, and Central databases and trial registries were searched from their inception to October 2020 for randomized controlled trials of autologous PRP injections for shoulder diseases versus placebo or any control intervention. Preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed in the selection, analysis, and reporting of findings. The primary outcome was pain intensity (visual analog scale), and secondary outcomes were changes in function and quality of life (QoL). Results: A total of 17 randomized controlled trials of PRP versus control were analyzed. From 8-12 weeks to ≥1 year, PRP injections were associated with better pain relief and functional outcomes than control interventions. PRP injections were also associated with greater QoL, with an effect size of 2.61 (95% confidence interval, 2.01-14.17) at medium-term follow-up. Compared with placebo and corticosteroid injections, PRP injections provided better pain relief and functional improvement. In subgroup analyses, trials in which PRP was prepared by the double centrifugation technique, the platelet concentration in the PRP was enriched ≥5 times, leucocyte-rich PRP was used, or an activating agent was used before application reported the most effective pain relief at 6-7 months. Conclusions: PRP injections could provide better pain relief and functional outcomes than other treatments for persons presenting with common shoulder diseases. PRP injections have a greater capacity to improve shoulder-related QoL than other interventions.

• Journal of Ginseng Research
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• 제47권1호
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• pp.65-73
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• 2023

Background: Age-related macular degeneration (AMD) is a significant visual disease that induces impaired vision and irreversible blindness in the elderly. However, the effects of ginseng berry extract (GBE) on the retina have not been studied. Therefore, this study aimed to investigate the protective effects of GBE on blue light (BL)-induced retinal damage and elucidate its underlying mechanisms in human retinal pigment epithelial cells (ARPE-19 cells) and Balb/c retina. Methods: To investigate the effects and underlying mechanisms of GBE on retinal damage in vitro, we performed cell viability assay, pre-and post-treatment of sample, reactive oxygen species (ROS) assay, quantitative real-time PCR (qRT-PCR), and western immunoblotting using A2E-laden ARPE-19 cells with BL exposure. In addition, Balb/c mice were irradiated with BL to induce retinal degeneration and orally administrated with GBE (50, 100, 200 mg/kg). Using the harvested retina, we performed histological analysis (thickness of retinal layers), qRT-PCR, and western immunoblotting to elucidate the effects and mechanisms of GBE against retinal damage in vivo. Results: GBE significantly inhibited BL-induced cell damage in ARPE-19 cells by activating the SIRT1/PGC-1α pathway, regulating NF-kB translocation, caspase 3 activation, PARP cleavage, expressions of apoptosis-related factors (BAX/BCL-2, LC3-II, and p62), and ROS production. Furthermore, GBE prevented BL-induced retinal degeneration by restoring the thickness of retinal layers and suppressed inflammation and apoptosis via regulation of NF-kB and SIRT1/PGC-1α pathway, cleavage of caspase 3 and PARP, and expressions of apoptosis-related factors in vivo. Conclusions: GBE could be a potential agent to prevent dry AMD and progression to wet AMD.

• Journal of Electrochemical Science and Technology
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• 제14권1호
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• pp.59-65
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• 2023

Sodium hydroxide solutions are often employed as sterilization agents in the pharmaceutical industry. Here, the chloride content is considered as a critical impurity. In this study, an electrochemical method was developed to remove chloride ions (Cl^-) through the oxidative deposition of AgCl on a Ag anode. The Cl^- content in the commercially available 50% w/w NaOH solution employed was approximately 100 mg Cl^-/kg NaOH. As the OH^- content is approximately 18,000 times higher than the Cl^- content, the formation of AgCl may be expected to be thermodynamically less favorable than the formation of Ag₂O. However, activation energies for AgCl and Ag₂O formation have been reported to be approximately 3.8 and 31.2 kJ/mol, respectively, and indicate that AgCl formation is favored. AgCl can be selectively produced by controlling the anode potential. Here, the Cl^- concentration was reduced to less than 50 mg Cl^-/kg NaOH when an anode potential of 0.18 or 0.19 V vs. Hg/HgO (reference electrode) was applied for one hour at 50℃. XRD analysis and visual monitoring of the Ag anode confirmed the oxidative deposition of AgCl on the anode surface as well as the electrochemical desalination of the concentrated NaOH solution.

• 한국초지조사료학회지
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• 제18권4호
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• pp.323-328
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• 1998

본 시험은 속성건조에 의한 가을연맥의 건초 조제 가능성을 알아보고자 조생계통인 Swan을 공시하여 8월 24일 파종한 다음, 건초 조제시기(수잉후기, 출수기, 개화기)와 건조방법(건조제, Conditioning, 건조제 + Conditioning 및 대조구)을 달리하여 1996년 가을 축산기술연구소에서 수행되었다. 화학제인 건조제는 $K_2CO_3$ 2%를 수확 직전 기계 분무하였으며, 물리적인 Conditioning은 모델 GMR 2800 Mower Conditioner(trail type)를 사용하였고, 포장건조 후 각형 곤포를 조제하였으며, 건초의 건물손실과 외관평가는 2개월간 보관저장 후 조사하였다. 수잉후기, 출수기, 개화기로 수확이 늦어질수록 연맥의 건물수량은 증가하고 건물률은 높아진 반면 사료가치는 크게 낮아졌다. 건조속도는 건초 조제시기에 관계없이 5일간의 포장건조에도 불구하고 수분 함량이 높아 건초 조제 적기에 도달하지 못하였으며, 특히 개화기에서는 수분감소가 거의 없었다. 건조방법별 건조효과는 전반적으로 건조효과가 낮았으나 Conditioning구에서 대조구에 비해 2일정도 포장 건조기간을 단축시킬 수 있었으며 건조제 처리효과는 없었다. 건초의 건물손실은 수잉 후기에서 51.4%로 매우 높았으며, 출수기도 21.1%로 높았고, 건조방법별로는 Conditioning구와 건조제 + Conditioning 처리구에서 손실이 적은 경향이었다. 건초의 외관평가에서 수잉 후기로 조제시기가 빠를 때에는 수분 함량이 너무 높아 품질은 크게 불량하였으며, 출수기의 Conditioning구와 건조제 + Conditioning 처리구에서 80점으로 양호할 뿐 전반적으로 가을연맥 건초의 외관평점은 매우 낮았다. 이상의 결과로서 포장에서의 건조기간 단축과 건초의 품질향상을 위한 건조제 처리효과는 인정되지 않았으며 Conditioner 사용이 추천되었으나, 우리 나라에서 가을연맥의 건초 조제는 실용화하기 매우 어려운 것으로 판단되었다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제28권2호
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• pp.95-110
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• 2006

The treatment for oral and maxillofacial carcinoma with chemotherapeutic agents is evaluated by many effective methods to reduce the tumor mass and cancer cell proliferation. However these chemotherapy have many serious side effects, such as bone marrow suppression, renal toxicity, G-I troubles. Therefore a possible approach to develop a clinically applicable chemotherapeutic agent is to screen anticancer activity of Taxol which is known to have very little side effect and have been used to breast cancer and ovarian carcinoma. Taxol is a new anti-microtubular anti-cancer agent extracted from the bark of the Pacific yew, Taxus brevifolia. Paclitaxel(Taxol) acts by promoting tubulin polymerization and over stabilizing microtubules agianst depolymerization. Despite the constant improvements of methods of the cancer treatment especially chemotherapy, the rate of cancer metastasis and recurrent are not decreased. Thus the investigation of new drug which have very little side effect and a possible clinically application continues to be a high priority. Considering that the Taxol have shown very effective chemotherapeutic agent with relatively low toxicity in many solid tumors, it deserves to evaluate its efficacy in oral squamous cell carcinoma. In this study, to investigate the in-vivo and in-vitro anti-cancer efficacy of Taxol in oral squamous cell carcinoma and lastly, the potency of Paclitaxel in the clinical application for oral cancer was evaluated. In vivo study, after HN22 cell line were xenografted in nude mice, the growth of tumor mass was observed, 3 mg/Kg taxol was injected intraperitoneally into nude mice containing tumor mass. The methods of these study were measurement of total volume of tumor mass, histopathologic study, immunohistochemical study, drug resistance assay, growth curve, MTT assay, flow cytometry, cDNA microarray in vivo and in vitro. The results were obtained as following. 1. The visual inspection of the experimental group showed that the volume of the tumor mass was slightly decreased but no significant difference with control group. 2. Ki-67 index was decreased at weeks 4 in experimental group. 3. Microscopic view of the xenografted tumor mass showed well differentiated squamous cell carcinoma and after Taxol injection, some necrotic tissue was seen weeks 4. 4. The growth curve of the tumor cells were decreased after 1day Taxol treatment. 5. According to the MTT assay, HN22 cell line showed relative drug resistancy above $5\;{\mu}g/ml$ concentrations of Taxol. 6. In drug resistance assay, the decrease of cell counts was seen relatively according to concentration. 7. In Flow cytometry, G2M phase cell arrests were seen in low concentration of the Taxol, while S phase cell arrests were seen in high concentration of the Taxol. 8. Using cDNA microarray technique, variable gene expression of ANGPTL4, TXNRD1, FAS, RRAGA, CTGF, CYCLINEA, P19, DUSP5, CEBPG, BTG1 were detacted in the oral squamous cell carcinoma cell after taxol treatment. In this study paclitaxel is effective against oral squamous cell carcinoma cell lines in vitro, but week effect was observed in vivo. So we need continuous study about anticancer effect of taxol in vivo in oral squamous cell carcinoma.

• 대한디지털의료영상학회논문지
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• 제12권1호
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• pp.27-31
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• 2010

The purpose of this study was to investigated the usefulness of MR perfusion image comparing with SPECT image. A total of pediatric 30 patients(average age : 7.8) with Moyamoya disease were performed MR Perfusion with 32 channel body coil at 3T from March 01, 2010 to June 10, 2010. The MRI sequences and parameters were as followed : gradient Echo-planar imaging(EPI), TR/TE : 2000ms/50ms, FA : $90^{\circ}$, FOV : $240{\times}240$, Matrix : $128{\times}128$, Thickness : 5mm, Gap : 1.5mm. Images were obtained contrast agent administrated at a rate of 1mL/sec after scan start 10s with a total of slice 1000 images(50 phase/1 slice). It was measured with visual color image and digitize data using MRDx software(IDL version 6.2) and also, it was compared of measurement with values of normal and abnormal ratio to analyze hemodynamic change, and a comparison between perfusion MR with technique using Warm Color at SPECT examination. On MR perfusion examination, the color images from abnormal region to the red collar with rCBV(relative cerebral blood volume) and rCBF(relative cerebral blood flow) caused by increase cerebral blood flow with brain vascular occlusion in surrounding collateral circulation advancement, the blood speed relatively was depicted slowly with blue in MTT(Mean Transit Time) and TTP(Time to Peak) images. The region which was visible abnormally from MR perfusion examination visually were detected as comparison with the same SPECT examination region, would be able to confirm the identical results in MMD(Moyamoya disease)judgments. Hymo-dynamic change in MR perfusion examination produced by increase and delay cerebral blood flow. This change with digitize data and being color imaging makes enable to distinguish between normal and abnormal area. Relatively, MR perfusion examination compared with SPECT examination could bring an excellent image with spatial resolution without radiation expose.