Journal of Electrochemical Science and Technology

The Korean Electrochemical Society (한국전기화학회)
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Electrochemical Desalination of a 50% w/w Sodium Hydroxide Solution, a Pharmaceutical Sterilization Agent

  • Jaehong Lee (Department of Chemical and Biomolecular Engineering, Yonsei University) ;
  • Ji-hyun Yang (Department of Chemical and Biomolecular Engineering, Yonsei University) ;
  • Eugene Huh (Department of Chemical and Biomolecular Engineering, Yonsei University) ;
  • Sewon Park (Department of Chemical and Biomolecular Engineering, Yonsei University) ;
  • Bonmoo Koo (BiOCS Co., Ltd.) ;
  • Ik-Sung Ahn (Department of Chemical and Biomolecular Engineering, Yonsei University)
  • Received : 2022.06.14
  • Accepted : 2022.09.14
  • Published : 2023.02.28
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Abstract

Sodium hydroxide solutions are often employed as sterilization agents in the pharmaceutical industry. Here, the chloride content is considered as a critical impurity. In this study, an electrochemical method was developed to remove chloride ions (Cl-) through the oxidative deposition of AgCl on a Ag anode. The Cl- content in the commercially available 50% w/w NaOH solution employed was approximately 100 mg Cl-/kg NaOH. As the OH- content is approximately 18,000 times higher than the Cl- content, the formation of AgCl may be expected to be thermodynamically less favorable than the formation of Ag2O. However, activation energies for AgCl and Ag2O formation have been reported to be approximately 3.8 and 31.2 kJ/mol, respectively, and indicate that AgCl formation is favored. AgCl can be selectively produced by controlling the anode potential. Here, the Cl- concentration was reduced to less than 50 mg Cl-/kg NaOH when an anode potential of 0.18 or 0.19 V vs. Hg/HgO (reference electrode) was applied for one hour at 50℃. XRD analysis and visual monitoring of the Ag anode confirmed the oxidative deposition of AgCl on the anode surface as well as the electrochemical desalination of the concentrated NaOH solution.

Keywords

Acknowledgement

This work was supported by Bio Industrial Technology Development Program (20009668, Development of Sodium Hydroxide (NaOH) Purification Technology for Biomedicine Production) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea). We appreciate Dr. Han Sung Kim in the department of Chemical and Biomolecular Engineering of Yonsei University for the advice in experimental designs and data analysis.

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