• 제목/요약/키워드: Vertebral

검색결과 962건 처리시간 0.034초

Feasibility of Serum Pentosidine Level as a Potential Risk Factor for Osteoporotic Vertebral Compression Fracture

  • Choi, Dong-Hyuk;Lee, Sang-Min;Lim, Sung-An;Choi, Yong-Soo
    • Asian Spine Journal
    • /
    • 제12권6호
    • /
    • pp.992-997
    • /
    • 2018
  • Study Design: Feasibility study. Purpose: To evaluate the feasibility of using serum pentosidine level as a potential marker for osteoporotic vertebral compression fracture (OVCF). Overview of Literature: A review of previous studies suggests a negative correlation between serum pentosidine concentration and bone strength. However, it is unclear whether serum pentosidine level might be a potential marker of OVCF in Koreans. Methods: Forty patients who underwent bone mineral density examination were included in this study, and their serum pentosidine levels were prospectively analyzed. Serum pentosidine level was evaluated using enzyme-linked immunosorbent assay. Among all the patients, 11 with OVCF were assigned to the vertebral fracture group and 29 who did not have vertebral fracture were included in the non-fracture group. In addition, we used the Fracture Risk Assessment (FRAX) tool Korean version for assessing the 10-year probability of fracture. Results: There was a statistically significant difference in the mean serum pentosidine level (p=0.04) of the vertebral fracture group (110.8 ng/mL) and the non-fracture group (64.3 ng/mL). Logistic regression analyses showed that serum pentosidine was significantly associated with OVCF. The vertebral fracture group had significantly higher 10-year probability of major osteoporotic fracture as per FRAX than the non-fracture group. There was a positive correlation between pentosidine level and FRAX results (r=0.35, p=0.02). Conclusions: These results suggest that increased serum pentosidine level could be a potential marker for OVCF.

Effects of vertebral number variations on carcass traits and genotyping of Vertnin candidate gene in Kazakh sheep

  • Zhang, Zhifeng;Sun, Yawei;Du, Wei;He, Sangang;Liu, Mingjun;Tian, Changyan
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제30권9호
    • /
    • pp.1234-1238
    • /
    • 2017
  • Objective: The vertebral number is associated with body length and carcass traits, which represents an economically important trait in farm animals. The variation of vertebral number has been observed in a few mammalian species. However, the variation of vertebral number and quantitative trait loci in sheep breeds have not been well addressed. Methods: In our investigation, the information including gender, age, carcass weight, carcass length and the number of thoracic and lumbar vertebrae from 624 China Kazakh sheep was collected. The effect of vertebral number variation on carcass weight and carcass length was estimated by general linear model. Further, the polymorphic sites of Vertnin (VRTN) gene were identified by sequencing, and the association of the genotype and vertebral number variation was analyzed by the one-way analysis of variance model. Results: The variation of thoracolumbar vertebrae number in Kazakh sheep (18 to 20) was smaller than that in Texel sheep (17 to 21). The individuals with 19 thoracolumbar vertebrae (T13L6) were dominant in Kazakh sheep (79.2%). The association study showed that the numbers of thoracolumbar vertebrae were positively correlated with the carcass length and carcass weight, statistically significant with carcass length. To investigate the association of thoracolumbar vertebrae number with VRTN gene, we genotyped the VRTN gene. A total of 9 polymorphic sites were detected and only a single nucleotide polymorphism (SNP) (rs426367238) was suggested to associate with thoracic vertebral number statistically. Conclusion: The variation of thoracolumbar vertebrae number positively associated with the carcass length and carcass weight, especially with the carcass length. VRTN gene polymorphism of the SNP (rs426367238) with significant effect on thoracic vertebral number could be as a candidate marker to further evaluate its role in influence of thoracolumbar vertebral number.

The Proper Volume and Distribution of Cement Augmentation on Percutaneous Vertebroplasty

  • Kim, Dong-Joon;Kim, Tae-Wan;Park, Kwan-Ho;Chi, Moon-Pyo;Kim, Jae-O
    • Journal of Korean Neurosurgical Society
    • /
    • 제48권2호
    • /
    • pp.125-128
    • /
    • 2010
  • Objective : The purpose of this study was to determine the optimal volume of injected cement and its distribution when used to treat vertebral compression fractures, and to identify factors related to subsequent vertebral fractures. Methods : A retrospective analysis of newly developing vertebral fractures after percutaneous vertebroplasty was done. The inclusion criteria were that the fracture was a single first onset fracture with exclusion of pathologic fractures. Forty-three patients were included in the study with a minimum follow up period of six months. Patients were dichotomized for the analysis by volume of cement, initial vertebral height loss, bone marrow density, and endplate-to-endplate cement augmentation. Results : None of the four study variables was found to be significantly associated with the occurrence of a subsequent vertebral compression fracture. In particular, and injected cement volume of more or less that 3.5 cc was not associated with occurrence (p = 0.2523). No relation was observed between initial vertebral height loss and bone marrow density (p = 0.1652, 0.2064). Furthermore, endplate-to-endplate cement augmentation was also not found to be significantly associated with a subsequent fracture (p = 0.2860) by Fisher's exact test. Conclusion : Neither volume of cement, initial vertebral height loss, bone marrow density, or endplate-to-endplate cement augmentation was found to be significantly related to the occurrence of a subsequent vertebral compression fracture. Our findings suggest that as much cement as possible without causing leakage should be used.

Analysis of Results Using Percutaneous Vertebroplasty for the Treatment of Avascular Necrosis of the Vertebral Body

  • Kim, Han-Woong;Kwon, Austin;Lee, Min-Cheol;Song, Jae-Wook;Kim, Sang-Kyu;Kim, In-Hwan
    • Journal of Korean Neurosurgical Society
    • /
    • 제45권4호
    • /
    • pp.209-212
    • /
    • 2009
  • Objective : Avascular necrosis (AVN) of the vertebral body is known as a relatively uncommon phenomenon in a vertebral compression fracture (VCF). The outstanding radiologic findings of AVN are intravertebral vacuum phenomenon with or without fluid collection. Several reports revealed that PVP or balloon kyphoplasty might be the effective treatment modalities for AVN. We also experienced excellent results when using PVP for the treatment of AVN of the vertebral body, and intend to describe the treatment's efficacy in this report. Methods : Thirty-two patients diagnosed with AVN of the vertebral body were treated with PVP. We measured the pre- and post-operative anterior body height and kyphotic angulation. The visual analogue scale (VAS) was used to determine the relief of back pain. Results : The anterior body height (pre-operative : 1.49 cm, post-operative : 2.22 cm) and kyphotic angulation (pre-operative : 14.47 degrees, post-operative : 6.57 degrees) were significantly restored (p<0.001). VAS was improved from 8.9 to 3.7. Pseudoarthrosis was corrected in all cases, which was confirmed by dynamic radiographs. Fluid collection was found in sixteen cases and was aspirated with serous nature. No organism and tumor cell were noted. Conclusion : PVP proved to be an effective procedure for the treatment of AVN of the vertebral body, which corrected dynamic instability and significantly restored the anterior body height and kyphotic angulation.

골다공증을 동반한 척추체 압박골절에 대한 경피적 척추 성형술 - 예비보고 - (Percutaneous Vertebroplasty in the Treatment of Vertebral Body Compression Fracture with Osteoporosis - Preliminary Report -)

  • 이상구;유찬종
    • Journal of Korean Neurosurgical Society
    • /
    • 제29권5호
    • /
    • pp.615-622
    • /
    • 2000
  • Objective : Percutaneous vertebroplasty is an effective and minimally invasive procedure consisting of the injection of a PMMA(polymethyl methacrylate) into the vertebral body compression fracture with osteoporosis. Matherials and Methods : Twenty-eight procedures were performed for vertebral body compression fractures with osteoporosis in 25 patients(22 women, 3 men). The mean age was 65.9 years old. The inclusion criteria for percutaneous vertebroplasty were 1) acute vertebral body compression fracture with osteoporosis, 2) expected high operative morbidity in old age, 3) no neurologic deficits, 4) no or minimal canal enchroachment, 5) patient refusal of invasive surgery. All patients underwent MR images before the procedure. Under local anesthesia, after the percutaneous needle puncture of the involved vertebra via a transpedicular approach and venography using the water soluble contrast material, PMMA injection was introduced into the fractured vertebral body. Results : The procedure was technically successful in all patients. All patients experienced excellent pain relief (complete pain relief ; 10, marked pain relief ; 14). One patient experienced marked pain relief, however, the patient died during the follow-up period due to stomach cancer. There were twelve paravertebral tissue leaks, twelve paravertebral venous plexus leaks, four epidural leaks and one intradiskal leak, but no clinically significant complications occurred in all patients. Conclusion : Percutaneous vertebraoplasty is a valuable procedure in the treatment of vertebral body compression fracture with osteoporosis, providing immediate pain relief and early mobilization. MRI is the most reliable diagnostic tool for identifying painful fractured vertebral body.

  • PDF

Outcome and Efficacy of Height Gain and Sagittal Alignment after Kyphoplasty of Osteoporotic Vertebral Compression Fractures

  • Lee, Tae-One;Jo, Dae-Jean;Kim, Sung-Min
    • Journal of Korean Neurosurgical Society
    • /
    • 제42권4호
    • /
    • pp.271-275
    • /
    • 2007
  • Objective : Although a significant correction of local kyphosis has been reported previously, only a few studies have investigated whether this correction leads to an improved overall sagittal alignment. The study objective was to determine whether an improvement in the local kyphotic angle improves the overall sagittal alignment. We examined and compared the effects of thoracic and lumbar level kyphoplasty procedures on local versus overall sagittal alignment of the spine. Methods : Thirty-eight patients with osteoporotic vertebral compression fractures who showed poor response to conventional, palliative medical therapy underwent single-level kyphoplasty. The pertinent clinical data of these patients, from June 2006 to November 2006, were reviewed retrospectively. We measured preoperative and postoperative vertebral body heights, which were classified as anterior, middle, or posterior fractured vertebral body heights. Furthermore, the local and overall sagittal angles after polymethylmethacrylate deposition were measured. Results : More height was gained at the thoracic level, and the middle vertebral height regained the most. A significant local kyphosis correction was observed at the fractured level, and the correction at larger spanning segments decreased with the distance from the fractured level. Conclusion : The inflatable balloon kyphoplasty procedure was the most effective in regaining the height of the thoracic fractured vertebra in the middle vertebral body. The kyphosis correction by kyphoplasty was mainly achieved in the fractured vertebral body. Sagittal angular correction decreased with an increase in the distance from the fractured vertebra. No significant improvement was observed in the overall sagittal alignment after kyphoplasty. Further studies in a larger population are required to clarify this issue.

Osteoplasty in Acute Vertebral Burst Fractures

  • Park, Sang-Kyu;Bak, Koang-Hum;Cheong, Jin-Hwan;Kim, Jae-Min;Kim, Choong-Hyun
    • Journal of Korean Neurosurgical Society
    • /
    • 제40권2호
    • /
    • pp.90-94
    • /
    • 2006
  • Objective : Acute vertebral burst fractures warrant extensive fixation and fusion on the spine. Osteoplasty [vertebroplasty with high density resin without vertebral expansion] has been used to treat osteoporotic vertebral compression fractures. We report our experiences with osteoplasty in acute vertebral burst fractures. Methods : Twenty-eight cases of acute vertebral burst fracture were operated with osteoplasty. Eighteen patients had osteoporosis concurrently. Preoperative MRI was performed in all cases to find fracture level and to evaluate the severity of injury. Preoperative CT revealed burst fracture in the series. The patients with severe ligament injury or spinal canal compromise were excluded from indication. Osteoplasty was performed under local anesthesia and high density polymethylmethacrylate[PMMA] was injected carefully avoiding cement leakage into spinal canal. The procedure was performed unilaterally in 21 cases and bilaterally in 7 cases. The patients were allowed to ambulate right after surgery. Most patients discharged within 5 days and followed up at least 6 months. Results : There were 12 men and 16 women with average age of 45.3[28-82]. Five patients had 2 level fractures and 2 patients had 3 level fractures. The average injection volume was 5.6cc per level Average VAS [Visual Analogue Scale] improved 26mm after surgery. The immediate postoperative X-ray showed 2 cases of filler spillage into spinal canal and 4 cases of leakage into the retroperitoneal space. One patient with intraspinal leakage was underwent the laminectomy to remove the resin. Conclusion : Osteoplasty is a safe and new treatment option in the burst fractures. Osteoplasty with minimally invasive technique reduced the hospital stay and recovery time in vertebral fracture patients.

Radiographic evaluation of congenital vertebral anomalies in Korean raccoon dogs (Nyctereutes procyonoides koreensis)

  • Lee, Eun Gee;Park, Sool Yi;Lee, Kija;Jang, Min;Kim, Jong Taek;Choi, Sooyoung;Park, Inchul
    • Journal of Veterinary Science
    • /
    • 제22권4호
    • /
    • pp.52.1-52.8
    • /
    • 2021
  • Background: The normal vertebral anatomy of Korean raccoon dogs and their variants require research attention as a prerequisite for identifying pathologies and anomalies. Objectives: This retrospective study aimed at describing the vertebral formula and congenital vertebral anomalies in Korean raccoon dogs (Nyctereutes procyonoides koreensis). Methods: Radiographs of 82 raccoon dogs (42 males, 40 females) acquired from May 2013 to June 2020 in the Gangwon Wildlife Medical Rescue Center were reviewed to evaluate the cervical, thoracic, and lumbar vertebrae of the spine. Results: Normal morphology of all vertebrae was observed in 50 of the 82 raccoon dogs, and the vertebral formula was cervical 7, thoracic 13, and lumbar 7. Congenital vertebral anomalies were found in 32 raccoon dogs: transitional vertebrae (TV) in 31 and block vertebrae in 2. Two raccoon dogs had 2 types of vertebral anomalies: one had TV and block vertebra, and the other had 2 types of TV. Twenty-nine raccoon dogs had thoracolumbar TV (TTV) and 3 had lumbosacral TV. TTV was morphologically classified into 4 different types: unilateral extra-rib in 5 raccoon dogs, bilateral extra-ribs in 14, bilateral elongated transverse processes in 4, and an asymmetric mixed formation of extra-rib with elongated transverse process in 6. Conclusions: This study showed that TTV is common in Korean raccoon dogs, and that the vertebral formula is relatively diverse. The bilateral extra-ribs type TTV is the most common variant, which is almost similar to normal rib to be confused the radiographic evaluation.

색도플러 초음파검사에 의한 경추골동맥 기시부 관찰 (Visualization of the Origin of the Vertebral Arteries with Color Doppler Sonography)

  • 윤석환;이원홍;이대형
    • 대한방사선기술학회지:방사선기술과학
    • /
    • 제32권1호
    • /
    • pp.87-93
    • /
    • 2009
  • 배경/목적 : 경추골동맥 기시부의 동맥경화증은 경추기저 국소빈혈증의 위험인자 중 하나이기 때문에 경추골동맥 기시부를 확인해야 할 필요가 있다. 색도플러 초음파검사에 의한 경추골동맥 기시부의 관찰 및 평가는 기술적으로 어려움이 있으며, 특히 왼쪽 기시부는 더욱 그렇다. 이 연구의 목적은 색도플러 초음파검사 시경추골동맥 기시부의 관찰률을 높이는 것이다. 대상 및 방법 : 경동맥을 포함한 경추골동맥의 색도플러 초음파검사가 198명에 대해 시행되었다. 경추골동맥 기시부를 다른 혈관의 기시부와 더 쉽게 구분하기 위해 목 윗부분의 경추동맥에서부터 쇄골하동맥 측으로 검사를 시행하였다. 검사 기술적으로 경추골동맥 기시부가 바로누운자세의 자연스러운 위치에서 관찰되지 않을 경우, 초음파 트랜스듀서를 쇄골 측으로 밀고, 그래도 관찰되지 않을 경우 다른 손으로 어깨를 밀어 관찰을 시도하였다. 경추골동맥 기시부의 깊이와 위 세 가지 방법 및 그에 따른 관찰률을 확인하기 위하여, 검사된 초음파 영상에서 관찰된 경추골동맥 기시부의 위치를 3.0 cm 이하와 그 이상으로 구분하였다. 결 과 : 오른쪽 경추골동맥 기시부는 97%, 왼쪽 경추골동맥 기시부는 92%에서 관찰되었다. 3.0 cm 이하에서 관찰된 오른쪽 경추골동맥 기시부 중 자연스러운 자세, 트랜스듀서 밀기, 그리고 어깨 밀기에서 관찰된 경우는 각각 98.6%, 1.4%, 그리고 0.0%이었다. 그리고 3.0 cm 보다 더 깊은 위치에서 관찰된 오른쪽 경추골동맥 기시부 중 자연스러운 자세, 트랜스듀서 밀기, 그리고 어깨 밀기에서 관찰된 경우는 각각 81.2%, 14.6%, 그리고 4.2%이었다. 3.0 cm 이하에서 관찰된 왼쪽쪽 경추골동맥 기시부 중 자연스러운 자세, 트랜스듀서 밀기, 그리고 어깨 밀기에서 관찰된 경우는 각각 85.4%, 10.7%, 그리고 3.9%%이었다. 그리고 3.0 cm 보다 더 깊은 위치에서 관찰된 오른쪽 경추골동맥 기시부 중 자연스러운 자세, 트랜스듀서 밀기, 그리고 어깨 밀기에서 관찰된 경우는 각각 55.7%, 30.4%, 그리고 13.9%이었다. 결 론 : 경추골동맥의 색도플러 초음파검사에서 그 기시부가 바로누운자세의 자연스러운 위치에서 관찰되지 않을 경우, 초음파 트랜스듀서를 쇄골 측으로 밀거나 그래도 관찰되지 않을 경우 다른 손으로 어깨를 밀어 관찰을 시도한다면, 관찰률을 좀더 높일 수 있을 것으로 사료된다.

  • PDF