Asian Spine Journal

  • 제12권6호
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  • Pages.992-997
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  • 2018
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  • 1976-1902(pISSN)
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  • 1976-7846(eISSN)
대한척추외과학회 (Korean Society of Spine Surgery)
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Feasibility of Serum Pentosidine Level as a Potential Risk Factor for Osteoporotic Vertebral Compression Fracture

  • Choi, Dong-Hyuk (Department of Orthopaedic Surgery, Kwangju Christian Hospital) ;
  • Lee, Sang-Min (Department of Orthopaedic Surgery, Kwangju Christian Hospital) ;
  • Lim, Sung-An (Department of Orthopaedic Surgery, Kwangju Christian Hospital) ;
  • Choi, Yong-Soo (Department of Orthopaedic Surgery, Kwangju Christian Hospital)
  • 투고 : 2017.11.14
  • 심사 : 2018.05.08
  • 발행 : 2018.12.31
⟨ 이전 논문 다음 논문 ⟩

초록

Study Design: Feasibility study. Purpose: To evaluate the feasibility of using serum pentosidine level as a potential marker for osteoporotic vertebral compression fracture (OVCF). Overview of Literature: A review of previous studies suggests a negative correlation between serum pentosidine concentration and bone strength. However, it is unclear whether serum pentosidine level might be a potential marker of OVCF in Koreans. Methods: Forty patients who underwent bone mineral density examination were included in this study, and their serum pentosidine levels were prospectively analyzed. Serum pentosidine level was evaluated using enzyme-linked immunosorbent assay. Among all the patients, 11 with OVCF were assigned to the vertebral fracture group and 29 who did not have vertebral fracture were included in the non-fracture group. In addition, we used the Fracture Risk Assessment (FRAX) tool Korean version for assessing the 10-year probability of fracture. Results: There was a statistically significant difference in the mean serum pentosidine level (p=0.04) of the vertebral fracture group (110.8 ng/mL) and the non-fracture group (64.3 ng/mL). Logistic regression analyses showed that serum pentosidine was significantly associated with OVCF. The vertebral fracture group had significantly higher 10-year probability of major osteoporotic fracture as per FRAX than the non-fracture group. There was a positive correlation between pentosidine level and FRAX results (r=0.35, p=0.02). Conclusions: These results suggest that increased serum pentosidine level could be a potential marker for OVCF.

키워드

참고문헌

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