• BMB Reports
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• v.52 no.6
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• pp.409-414
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• 2019

Natural compounds isolated from medicinal herbs and plants have immense significance in maintaining bone health. Hydrolysable tannins have been shown to possess a variety of medicinal properties including antiviral, anticancer, and anti-osteoclastogenic activities. As a part of a study on the discovery of alternative agent against skeletal diseases, we isolated a hydrolysable tannin, 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-${\beta}$-D-glucose (DTOGG), from Galla Rhois and examined the effect on osteoclast formation and function. We found that DTOGG significantly inhibited receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation by downregulating the expression of the key regulator in osteoclastogenesis as well as osteoclast-related genes. Analysis of RANKL/RANK signaling revealed that DTOGG impaired activation of $I{\kappa}B{\alpha}$ and p65 in the nuclear factor kappa-lightchain-enhancer of activated B cells (NF-${\kappa}B$) signaling pathway. Furthermore, DTOGG reduced bone resorbing activity of osteoclasts, compared to the vehicle-treated control. These results suggest that DTOGG could be a useful natural compound to manage osteoclast-mediated skeletal diseases.

• Clinical and Experimental Reproductive Medicine
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• v.45 no.4
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• pp.163-169
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• 2018

Objective: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. Methods: Ninety 8-week-old female mice were randomly allocated into three treatment groups. The first group received an intraperitoneal injection of ZEA (2.5 mg/kg) on alternate days. The second group received ZEA (2.5 mg/kg) on alternate days plus oral saffron daily (50 mg/kg). The third group was treated with a vehicle of 1% dimethyl sulfoxide (DMSO) on alternate days, as a control. Ten mice were euthanized from each group at 30, 60, and 90 days of treatment. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol ($E_2$), and progesterone (P) were assessed. The uterus and ovaries were examined for changes in size or morphology. Results: Serum levels of LH, FSH, $E_2$, and P in the female mice treated with ZEA plus saffron were significantly higher than in those treated with ZEA alone, and were not significantly different from those treated with 1% DMSO. The female mice treated with ZEA alone showed a reduction in size of the uterus and abnormal architecture of the ovaries. Conclusion: The administration of saffron to female mice resulted in a significant reduction in ZEA-induced alterations in reproductive hormone levels, the size of the uterus, and the morphology of the ovaries.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.20 no.4
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• pp.57-70
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• 2021

This study aims to investigate the security demand about the traffic policing by analyzing civil complaints. Latent Dirichlet Allocation(LDA) was applied to extract key topics for 2,062 civil complaints data related to traffic policing from e-People. And additional analysis was made of reports of violations, which accounted for a high proportion. In this process, the consistency and convergence of keywords and representative documents were considered together. As a result of the analysis, complaints related to traffic police could be classified into 41 topics, including traffic safety facilities, passing through intersections(signals), provisional impoundment of vehicle plate, and personal mobility. It is necessary to strengthen crackdowns on violations at intersections and violations of motorcycles and take preemptive measures for the installation and operation of unmanned traffic control equipments, crosswalks, and traffic lights. In addition, it is necessary to publicize the recently amended laws a implemented policies, e-fine, procedure after crackdown.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.83-89
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• 2021

To improve the performance of self-driving cars, the introduction of V2X, a communication technology that connects vehicles, infrastructure, and vehicles, is essential. Even if traffic information of the other vehicle is known, the structure of the intersection and a distance calculation algorithm are required for accurate calculations at roundabouts. This paper proposes a design algorithm for a rotating intersection and implemented in Matlab that complies with the national design rules and enables accurate calculations. Assuming the roundabout and the entrance/exit path to be a circle, a method for measuring the distance between vehicles at an arbitrary point was proposed using the horizontal shift of the entrance circle to the main circle. The algorithm could be used in fully autonomous vehicles by designing a roundabout suitable for the terrain by arbitrarily varying the angle between branches and the radius of curvature of the entrance and exit roads, and transmitting a warning signal when a collision between two driving vehicles is expected.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.31 no.3
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• pp.411-422
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• 2021

The autonomous driving system mounted on the unmanned vehicle recognizes the external environment through several sensors and derives the optimum control value through it. Recently, studies on physical level attacks that maliciously manipulate sensor data by performing signal-injection attacks have been published. signal-injection attacks are performed at the physical level and are difficult to detect at the software level because the sensor measures erroneous data by applying physical manipulations to the surrounding environment. In order to detect a signal-injection attack, it is necessary to verify the dependability of the data measured by the sensor. As so far, various methods have been proposed to attempt physical level attacks against sensors mounted on autonomous driving systems. However, it is still insufficient that methods for defending and detecting the physical level attacks. In this paper, we demonstrate signal-injection attacks targeting MEMS sensors that are widely used in unmanned vehicles, and propose a method to detect the attack. We present a signal-injection detection model to analyze the accuracy of the proposed method, and verify its effectiveness in a laboratory environment.

• Journal of the Korean Institute of Gas
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• v.24 no.6
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• pp.55-60
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• 2020

As research and development of eco-friendly vehicles are expanding worldwide, additional devices of vehicles are reduced or deleted to increase the mileage, or research is being conducted to reduce weight. Among them, the multi-stage transmission that was applied to the internal combustion engine vehicle was deleted and replaced with a reducer, and the initial driving power is secured by increasing the torque through the control of the motor output value. However, since frequent motor speed change can result in a load increase, this study attempts to develop a compact and lightweight manual two-stage reducer with a general reducer structure. Therefore, a two-speed transmission with two gear ratio was designed by inserting a large gear and a small gear in a structure with a parallel shaft to connect the gears with a V-belt in the form of a parallel shaft reducer, and setting the gear ratio of the low and high gears respectively. In addition, power performance according to the rotational speed and load of the transmission was checked through a test, and the heat generation characteristics generated during driving were checked to verify the validity of the transmission.

• Journal of the Korea Convergence Society
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• v.13 no.3
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• pp.191-196
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• 2022

Unlike an international combustion engine car, a battery-powered electric vehicle requires an additional heat source for its heating system. A high-voltage coolant heater has the advantages of high efficiency and a wide operating temperature range. In its development, the geometry design of the coolant flow path is essential. This paper presents the thermal flow simulations of a 7kW high-voltage heater with symmetric serpentine flow channels arranged parallelly. The heater performance was evaluated from the simulation results in terms of the pressure and temperature differences and the flow uniformity. The proposed design showed a greater flow resistance and similar heat exchanging capability than the existing parallel serpentine design. It has the advantage of a relatively wide low-temperature surface area, where the control circuit board susceptible to high temperatures can be located.

• Journal of Biomedical Engineering Research
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• v.43 no.1
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• pp.27-34
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• 2022

Drunk driving defines a driver as unable to drive a vehicle safely due to drinking. To crack down on drunk driving, alcohol concentration evaluates through breathing and crack down on drinking using S-shaped courses. A method for assessing drunk driving without using BAC or BrAC is measurement via biosignal. Depending on the individual specificity of drinking, alcohol evaluation studies through various biosignals need to be conducted. In this study, we measure biosignals that are related to alcohol concentration, predict BrAC through SVM, and verify the effectiveness of the S-shaped course. Participants were 8 men who have a driving license. Subjects conducted a d2 test and a scenario evaluation of driving an S-shaped course when they attained BrAC's certain criteria. We utilized SVR to predict BrAC via biosignals. Statistical analysis used a one-way Anova test. Depending on the amount of drinking, there was a tendency to increase pupil size, HR, normLF, skin conductivity, body temperature, SE, and speed, while normHF tended to decrease. There was no apparent change in the respiratory rate and TN-E. The result of the D2 test tended to increase from 0.03% and decrease from 0.08%. Measured biosignals have enabled BrAC predictions using SVR models to obtain high Figs in primary and secondary cross-validations. In this study, we were able to predict BrAC through changes in biosignals and SVMs depending on alcohol concentration and verified the effectiveness of the S-shaped course drinking control method.

• Journal of Internet Computing and Services
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• v.23 no.3
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• pp.1-12
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• 2022

As the performance of Unmanned Aerial Vehicles (UAVs) are improving and the prices are lowering, it is expected that the use of UAVs will continuously grow in the future. It is important to always maintain control signal and video communication to operate remote UAVs stably, especially in military UAV operations, as unexpected jamming attacks can result in fatal UAV crashes. In this paper, to improve the network reliability and low latency when supporting UAV operations, the anti-jamming performance of Second generation Anti-jam Tactical UHF Radio for NATO (SATURN) networks is analyzed and enhanced by applying Forward Error Correction (FEC) and Minimum Shift Keying (MSK) modulation as well as Hamming code based multiple transmission techniques.

• Journal of Periodontal and Implant Science
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• v.52 no.5
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• pp.383-393
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• 2022

Purpose: Aloe-emodin (AE), a natural anthraquinone abundant in aloe plants and rhubarb (Rheum rhabarbarum), has long been used to treat chronic inflammatory diseases. However, AE's underlying mechanisms in periodontal inflammation have not been fully elucidated. Acidic mammalian chitinase (AMCase) is a potential biomarker involved in bone remodeling. This study aimed to evaluate AE's effect on periodontitis in rats and investigate AMCase expression. Methods: Eighteen Sprague-Dawley rats were separated into the following groups: healthy (group 1), disease (group 2), vehicle (group 3), AE high-dose (group 4), and AE low-dose (group 5). Porphyromonas gingivalis ligatures were placed in rats (groups 2-5) for 7 days. Groups 4 and 5 were then treated with AE for an additional 14 days. Saliva was collected from all groups, and probing pocket depth was measured in succession. Periodontal pocket tissues were subjected to histomorphometric analysis after the rats were sacrificed. Bone marrow-derived macrophages and murine macrophages were stimulated with receptor activator of nuclear factor-κB ligand (RANKL) and treated with different concentrations of AE. AMCase expression was detected from the analysis of saliva, periodontal pocket tissues, and differentiated osteoclasts. Results: Among rats with P. gingivalis-induced periodontitis, the alveolar bone resorption levels and periodontal pocket depth were significantly reduced after treatment with AE. AMCase protein expression was significantly higher in the disease group than in the healthy control (P<0.05). However, AE inhibited periodontal inflammation by downregulating AMCase expression in saliva and periodontal pocket tissue. AE significantly reduced RANKL-stimulated osteoclastogenesis by modulating AMCase (P<0.05). Conclusions: AE decreases alveolar bone loss and periodontal inflammation, suggesting that this natural anthraquinone has potential value as a novel therapeutic agent against periodontal disease.