Acknowledgement
The authors would like to thank the medical illustrator Nari Claire Kim for the preparation of the excellent graphical abstract.
References
- Loos BG, Van Dyke TE. The role of inflammation and genetics in periodontal disease. Periodontol 2000 2020;83:26-39. https://doi.org/10.1111/prd.12297
- Haririan H, Andrukhov O, Bertl K, Lettner S, Kierstein S, Moritz A, et al. Microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis. J Periodontol 2014;85:819-28. https://doi.org/10.1902/jop.2013.130306
- Armingohar Z, Jorgensen JJ, Kristoffersen AK, Schenck K, Dembic Z. Polymorphisms in the interleukin-1 gene locus and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases. Scand J Immunol 2014;79:338-45. https://doi.org/10.1111/sji.12166
- Belibasakis GN, Reddi D, Bostanci N. Porphyromonas gingivalis induces RANKL in T-cells. Inflammation 2011;34:133-8. https://doi.org/10.1007/s10753-010-9216-1
- Ono T, Hayashi M, Sasaki F, Nakashima T. RANKL biology: bone metabolism, the immune system, and beyond. Inflamm Regen 2020;40:2. https://doi.org/10.1186/s41232-019-0111-3
- Yang M, Li L, Soh Y, Heo SM. Effects of omega-3 fatty acids and aspirin on Porphyromonas gingivalis-induced periodontitis in rats. J Periodontol 2019;90:1307-19. https://doi.org/10.1002/JPER.19-0063
- Dong X, Zeng Y, Liu Y, You L, Yin X, Fu J, et al. Aloe-emodin: a review of its pharmacology, toxicity, and pharmacokinetics. Phytother Res 2020;34:270-81. https://doi.org/10.1002/ptr.6532
- Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, et al. Emodin and aloe-emodin suppress breast cancer cell proliferation through ER α inhibition. Evid Based Complement Alternat Med 2013;2013:376123.
- Ipshita S, Kurian IG, Dileep P, Kumar S, Singh P, Pradeep AR. One percent alendronate and aloe vera gel local host modulating agents in chronic periodontitis patients with class II furcation defects: a randomized, controlled clinical trial. J Investig Clin Dent 2018;9:e12334. https://doi.org/10.1111/jicd.12334
- Pradeep AR, Garg V, Raju A, Singh P. Adjunctive local delivery of aloe vera gel in patients with type 2 diabetes and chronic periodontitis: a randomized, controlled clinical trial. J Periodontol 2016;87:268-74. https://doi.org/10.1902/jop.2015.150161
- Bueter CL, Specht CA, Levitz SM. Innate sensing of chitin and chitosan. PLoS Pathog 2013;9:e1003080. https://doi.org/10.1371/journal.ppat.1003080
- Koch BE, Stougaard J, Spaink HP. Keeping track of the growing number of biological functions of chitin and its interaction partners in biomedical research. Glycobiology 2015;25:469-82. https://doi.org/10.1093/glycob/cwv005
- Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, et al. Role of chitin and chitinase/ chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol 2011;73:479-501. https://doi.org/10.1146/annurev-physiol-012110-142250
- Boot RG, Blommaart EF, Swart E, Ghauharali-van der Vlugt K, Bijl N, Moe C, et al. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. J Biol Chem 2001;276:6770-8. https://doi.org/10.1074/jbc.M009886200
- Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004;304:1678-82. https://doi.org/10.1126/science.1095336
- Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 2007;447:92-6. https://doi.org/10.1038/nature05746
- Shen CR, Juang HH, Chen HS, Yang CJ, Wu CJ, Lee MH, et al. The correlation between chitin and acidic mammalian chitinase in animal models of allergic asthma. Int J Mol Sci 2015;16:27371-7. https://doi.org/10.3390/ijms161126033
- Van Steijn GJ, Amerongen AV, Veerman EC, Kasanmoentalib S, Overdijk B. Chitinase in whole and glandular human salivas and in whole saliva of patients with periodontal inflammation. Eur J Oral Sci 1999;107:328-37. https://doi.org/10.1046/j.0909-8836.1999.eos107503.x
- Verhulst MJ, Teeuw WJ, Bizzarro S, Muris J, Su N, Nicu EA, et al. A rapid, non-invasive tool for periodontitis screening in a medical care setting. BMC Oral Health 2019;19:87. https://doi.org/10.1186/s12903-019-0784-7
- Park MY, Kwon HJ, Sung MK. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Biosci Biotechnol Biochem 2009;73:828-32. https://doi.org/10.1271/bbb.80714
- Di Rosa M, Malaguarnera L. Chitinases as biomarkers in bone studies. Dordrecht: Springer; 2017.
- Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 2007;40:251-64. https://doi.org/10.1016/j.bone.2006.09.023
- Teitelbaum SL. Bone resorption by osteoclasts. Science 2000;289:1504-8. https://doi.org/10.1126/science.289.5484.1504
- Elisia I, Pae HB, Lam V, Cederberg R, Hofs E, Krystal G. Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators. J Immunol Methods 2018;452:26-31. https://doi.org/10.1016/j.jim.2017.10.004
- Choi HJ, Park YR, Nepal M, Choi BY, Cho NP, Choi SH, et al. Inhibition of osteoclastogenic differentiation by Ikarisoside A in RAW 264.7 cells via JNK and NF-kappaB signaling pathways. Eur J Pharmacol 2010;636:28-35. https://doi.org/10.1016/j.ejphar.2010.03.023
- Dawes C, Pedersen AM, Villa A, Ekstrom J, Proctor GB, Vissink A, et al. The functions of human saliva: a review sponsored by the World Workshop on Oral Medicine VI. Arch Oral Biol 2015;60:863-74. https://doi.org/10.1016/j.archoralbio.2015.03.004
- Heo SM, Haase EM, Lesse AJ, Gill SR, Scannapieco FA. Genetic relationships between respiratory pathogens isolated from dental plaque and bronchoalveolar lavage fluid from patients in the intensive care unit undergoing mechanical ventilation. Clin Infect Dis 2008;47:1562-70. https://doi.org/10.1086/593193
- Genco RJ, Genco FD. Common risk factors in the management of periodontal and associated systemic diseases: the dental setting and interprofessional collaboration. J Evid Based Dent Pract 2014;14 Suppl:4-16. https://doi.org/10.1016/j.jebdp.2014.03.003
- Giannobile WV, Wong DT. Salivary diagnostics: oral health and beyond! J Dent Res 2011;90:1153-4. https://doi.org/10.1177/0022034511420436
- Ozturk VO, Emingil G, Umeizudike K, Tervahartiala T, Gieselmann DR, Maier K, et al. Evaluation of active matrix metalloproteinase-8 (aMMP-8) chair-side test as a diagnostic biomarker in the staging of periodontal diseases. Arch Oral Biol 2021;124:104955. https://doi.org/10.1016/j.archoralbio.2020.104955
- Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Clin Periodontol 2018;45 Suppl 20:S149-61. https://doi.org/10.1111/jcpe.12945
- Van Steijn GJ, Amerongen AV, Veerman EC, Kasanmoentalib S, Overdijk B. Effect of periodontal treatment on the activity of chitinase in whole saliva of periodontitis patients. J Periodontal Res 2002;37:245-9. https://doi.org/10.1034/j.1600-0765.2002.00330.x
- Bertoldi C, Bellei E, Pellacani C, Ferrari D, Lucchi A, Cuoghi A, et al. Non-bacterial protein expression in periodontal pockets by proteome analysis. J Clin Periodontol 2013;40:573-82. https://doi.org/10.1111/jcpe.12050
- Andryianau G, Kowalski M, Piotrowicz MC, Rajkiewicz AA, Dymek B, Sklepkiewicz PL, et al. Benzoxazepine-derived selective, orally bioavailable inhibitor of human acidic mammalian chitinase. ACS Med Chem Lett 2020;11:1228-35. https://doi.org/10.1021/acsmedchemlett.0c00092
- Koralewski R, Dymek B, Mazur M, Sklepkiewicz P, Olejniczak S, Czestkowski W, et al. Discovery of OATD01, a first-in-class chitinase inhibitor as potential new therapeutics for idiopathic pulmonary fibrosis. J Med Chem 2020;63:15527-40. https://doi.org/10.1021/acs.jmedchem.0c01179
- Kim WJ, Soh Y, Heo SM. Recent advances of therapeutic targets for the treatment of periodontal disease. Biomol Ther (Seoul) 2021;29:263-7. https://doi.org/10.4062/biomolther.2021.001