• 생약학회지
• /
• 제45권2호
• /
• pp.101-106
• /
• 2014

Marine-derived microbes have yielded a variety of metabolites so far. In the course of the project to find metabolites from marine microbes, an isolate of Penicillium glabrum (SF 5317) was selected for chemical investigation. A large scale culture of this strain in PDA media was extracted with an organic solvent and the extract was subjected to a serious of chromatography, which led to six metabolites. Their chemical structures were elucidated as sulochrin (1), questin (2), questinol (3), ergosterol (4), 3-methyldesmethoxyyangonin (5), and hydroxysulochrin (6) on the basis of spectroscopic data. To the best of our knowledge, this is the second isolation of compounds 5 and 6 in nature and especially 6 is isolated from Penicillium sp. for the first time.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2000년도 춘계학술대회
• /
• pp.15-16
• /
• 2000

Transient forebrain ischemia results in delayed neuronal death in the CA1 region of the hippocampus after injury, which is, at least in part, a consequence of excessive generation of reactive oxygen species. Previous in vitro studies using cell cultures or brain slices have demonstrated that phospholipase D (PLD) in the nervous system is involved in the signaling mechanism in response to a variety of agonists. Several recent studies have shown that reactive oxygen species stimulate phospholipase D (PLD) activity in several kinds of cells. Therefore, this raises the possibility that PLD activity is enhanced in the ischemic brain. Meanwhile, osteopontin (OPN) was initially identified as a sialoglycoprotein in bone, but has since been found in various tissues. Although not much is known about its function, OPN seems to play an important role in inflammation and tissue repair. Recently, it was reported that OPN was upregulated in the activated microglia after focal brain ischemia, suggesting that OPN might play a role in wound healing after a focal stroke.

• Biotechnology and Bioprocess Engineering:BBE
• /
• 제11권4호
• /
• pp.364-367
• /
• 2006

In order to enhance the repair of defects in articular cartilage via cell therapy with autologous chondrocytes, as well as with periosteum-derived progenitor cells (PDPCs), silkworm hemolymph (SH) and a variety of cartilage-specific extracellular matrices (ECMs) including type II collagen, proline, chondroitin 4-sulfate, and chondroitin 6-sulfate were assessed with regard to their efficacy as media supplements. SH, a known anti-apoptotic agent, was found to enhance cell growth, as was shown by the results of a 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assay. According to the results of reverse transcriptase polymerase chain reaction (RT-PCR) analyses, the cartilage-specific ECMs were found to stimulate the expression of hyaline cartilage-specific genes, most notably type II collagen and Sox9, in monolayer cultures of PDPCs.

• 한국실내디자인학회논문집
• /
• 제21권3호
• /
• pp.154-162
• /
• 2012

As media technology has made rapid progress, cultures in the world have spread fast. In addition, Korea wave spreading toward the world is taking shape as a brand that represents essential Koreanness. Such tendency has led attempts to seek Koreanness in the field of space design. The desire to escape from the absence of humanity that is based on mechanistic nature view has led a variety of ideas and concepts on space. In particular, concept of phenomenological space centering on human body has been emphasized. Merleau-Ponty found concept of phenomenological space that emphasizes awareness through experience of human body. In this thesis, orientation as situation, temporality as body, depth as consciousness, and correlational orientation which are key concepts of Merleau-Ponty's phenomenology were covered. Such concepts were used in analyzing the characteristics of Buseoksa Temple to present essential Koreanness.

• 한국수학교육학회지시리즈D:수학교육연구
• /
• 제8권1호
• /
• pp.1-18
• /
• 2004

Current interest in mathematics learning that focuses on understanding, mathematical reasoning and meaning making underscores the need to develop ways of analyzing classrooms that foster these types of learning. In this paper, the author show that the constructs of social and socio-mathematical norms, which grew out of taking a symbolic interactionist perspective, and Toulmins scheme for argumentation, as elaborated for mathematics education by Krummheuer [The ethnology of argumentation. In: The emergence of mathematical meaning: Interaction in classroom cultures (1995, pp. 229-269). Hillsdale, NJ: Erlbaum], provide us with means to analyze aspects of explanation, justification and argumentation in mathematics classrooms, including means through which they can be fostered. Examples from a variety of classrooms are used to clarify how these notions can inform instruction at all levels, from the elementary grades through university-level mathematics.

• 수산해양교육연구
• /
• 제29권1호
• /
• pp.51-63
• /
• 2017

Rice Fields have provided large areas of open water for centuries in regions with a variety of rice-growing cultures, and, in addition to producing rice also provide other animal and/or plant food sources and medicinal plants, thus acting as wetland systems and helping to sustain livelihoods and human well-being in these regions. Also rice fields in many parts of the world support important wetland biodiversity, such as reptiles, amphibians, fish, crustacean, insects and mollusca, and play a significant ole in water-bird flyways and the conservation of water-bird populations. The purpose of this study is to find a way conservation of rice fields in connection with paddies's laws, for example, amend the Conservation of Wetlands Law or legislate for the conservation of paddies.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-1
• /
• pp.85-87
• /
• 2003

$\beta$-Lactams are historically and clinically representative antibiotics used for therapeutic purposes. In early days, penicillin (penam antibiotic) and cephalosporin (cephem antibiotic) were found in culture broth of two different filamentous fungi, Penicillium chrysogenum and Acremonium chrysogenum. Since 1970, a variety of $\beta$-lactam structures have been discovered from bacterial cultures including Streptomyces species, which are known as cephamycin, cephabacin (cephem antibiotics), clavulanic acid (oxopenam antibiotic), thienamycin (carbapenem antibiotic), and sulfazecin (monobactam antibiotic). (omitted)

• Child Studies in Asia-Pacific Contexts
• /
• 제2권2호
• /
• pp.123-132
• /
• 2012

The current study examined 3- and 4-year-olds' affective decision-making in a variety of cultural contexts by comparing European Canadian children to Chinese Canadian, Hong Kong Chinese, and mainland Chinese children (N = 245). All children were tested with a delay of gratification task in which children chose between an immediate reward of lower value and a delayed reward of higher value. Results showed that Chinese Canadian and Hong Kong Chinese children chose more delayed rewards than European Canadian children, with mainland Chinese children showing a trend toward more delayed rewards. Across cultures, 4-year-olds chose more delayed rewards than 3-year-olds; and among 4-year-olds, girls made more such choices than boys. The findings are consistent with previous findings that exposure to Chinese culture is associated with better cool executive function, but they also highlight the importance of examining development across diverse cultural contexts.

• Mycobiology
• /
• 제49권3호
• /
• pp.201-212
• /
• 2021

Truffles are the fruiting bodies of ascomycete fungi that form underground. Truffles are globally valued, culturally celebrated as aphrodisiacs, and highly sought-after delicacies in the culinary world. For centuries, naturalists have speculated about their mode of formation, and in cultures surrounding the Mediterranean Sea, many species have been prized as a delectable food source. Truffle fruiting bodies form underground and emit a variety of volatile organic compounds (VOCs). Truffle volatiles are believed to have evolved to attract animals that disperse their spores. The main VOCs identified from truffles include sulfur compounds, such as dimethyl sulfide (DMS) and dimethyl disulfide (DMDS); in addition, 1-octen-3-ol and 2-methyl-1-propanol have been found in most truffle species. Humans use pigs and dogs trained to detect truffle VOCs in order to find these prized subterranean macrofungi. Truffles have pharmacological potential, but until more reliable cultivation methods become available their high price means they are unlikely to see widespread use as medicinals.

• 한국동물위생학회지
• /
• 제35권4호
• /
• pp.289-294
• /
• 2012

Mycoplasmas are highly fastidious bacteria, difficult to culture and slow growing. Infections with Mycoplasma species can cause a variety of problems in living organisms and in vitro cell cultures. In this study, we investigated the usefulness of a genus-specific consensus PCR analysis method to detect Mycoplasma species. The developed consensus primer pairs MycoF and MycoR were designed specifically to amplify the 16S ribosomal RNA gene (rRNA) of Mycoplasma species by the optimized PCR system. The developed consensus PCR system effectively amplified 215 bp of Mycoplasma genus-specific region of 16S rRNA. In conclusion, we recommend this consensus PCR for monitoring Mycoplasma species in animals, human and cell culture system.