• Pediatric Infection and Vaccine
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• 제12권2호
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• pp.195-201
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• 2005

목 적 : 우리나라에서 성인에 대한 대상포진에 대한 연구 자료는 많이 보고되고 있지만, 소아 청소년 영역에서 발생하는 대상포진에 대한 연구가 거의 없는 실정이다. 이에 최근 10년간 소아 청소년에서 대상포진의 역학과 임상양상을 조사하였고 수두 과거력과 예방접종 유무에 따라 나타나는 대상포진의 양상에 대하여 비교하였다. 방 법 : 1995년 7월부터 2005년 6월까지 10년간 경인지역 4개 대학병원에 대상포진으로 입원한 20세 이하 환아를 대상으로 의무기록을 후향적으로 조사하였고 누락된 기록이 있는 경우 전화를 통하여 확인하였다. 결 과 : 1) 최근 10년간 경인지역 20세 이하 소아 청소년에서 대상포진으로 입원한 환자수가 증가하는 추세이다. 2) 수두 예방접종 후에 대상포진의 발생이 증가되는지를 설명할 수는 없었다. 3) 입원 당시의 주증상은 3/4 환아에서 통증이 동반된 피부병변이었고 대부분 간기능 검사치는 정상이었고 주사용 acylcovir 치료를 받았다. 4) 입원치료 중 합병증이 동반된 경우는 17%이었고, 그 중 뇌수막염(41%)이 가장 많았다. 5) 예방접종 유무와 무관하게 수두 과거력이 있는 환아는 수두 과거력이 없던 환아들보다 대상포진에 의한 합병증 발생률이 높았다(P<0.05). 6) 수두 과거력이 없는 환아들 경우, 수두 예방접종을 시행한 환아는 접종하지 않는 환아보다 대상포진에 의한 합병증 발생률이 낮았다(P<0.01). 결 론 : 최근 10년간 경인지역 소아 청소년에서 대상포진으로 입원한 환아수가 증가하는 추세이었으나, 그 증가 원인과 수두백신이 대상포진의 증가에 영향을 주는가는 확인하지 못하였다. 본 연구자료의 제한점이 많지만, 연구 결과에 의하면 예방 접종력과 무관하게, 수두 과거력이 없는 환아들은 수두 과거력이 있는 환아들보다 합병증 발생률이 낮았고 수두 과거력이 없는 환아들 중에서는 예방접종을 시행한 환아들이 예방접종을 시행하지 않는 환아들보다 합병증 발생률이 낮았다. 올해부터 수두 예방접종이 기본접종으로 시행된 시점에서, 기본접종으로 시행되기 이전과 이후 발생되는 수두와 대상포진에 대한 역학연구가 필요할 것으로 생각된다.

• 대한후두음성언어의학회지
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• 제30권1호
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• pp.65-68
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• 2019

Herpes zoster oticus is one of complication of varicella zoster virus (VZV) reactivation in the geniculate ganglion of the facial nerve, which is the most common presentation of herpes zoster in the head and neck region. However, VZV infection of the larynx has rarely been described in the literature compared with Herpes zoster oticus. Moreover, zoster laryngopharyngitis simultaneously occurred with recurred Herpes zoster oticus which has no newly developing motor dysfunction has not been reported yet. Therefore, these diseases are difficult to diagnose due to its rareness. However, distinctive appearances such as unilateral herpetic mucosal eruptions and vesicles are useful and essential in making a quick and accurate diagnosis. Thus, we report a characteristic case of zoster laryngopharyngitis simultaneously occurred with recurred Herpes zoster oticus not accompanied by any newly developing motor palsy.

• 한방안이비인후피부과학회지
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• 제37권2호
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• pp.95-103
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• 2024

Objectives : This study aims to evaluate the effectiveness of incisional needle therapy, a type of Korean medicine treatment, on atrophic scars caused by herpes zoster and varicella. Methods : The patients with atrophic scars resulting from herpes zoster and varicella were treated with incisional needle therapy and the effectiveness of the treatment was evaluated with Physician's Global Assessment (PGA) and The Stony Brook Scar Evaluation Score (SBSES). Results : After treatment, all patients demonstrated improvements in PGA and SBSES. The PGA score improved to 3.73±0.40, with SBSES changing from 1.60±0.60 to 4.80±0.80. Conclusions : We suggest that incisional needle therapy demonstrates effectiveness in treating scars resulting from herpes zoster and varicella, indicating its potential as a viable therapeutic option for individuals affected by these conditions.

• The Korean Journal of Pain
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• 제36권1호
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• pp.4-10
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• 2023

Herpes zoster (HZ) is a common disease in the aging population and immunocompromised individuals, with a lifetime risk of 20%-30% that increases with age. HZ is caused by reactivation of the varicella-zoster virus (VZV), which remains latent in the spinal dorsal root ganglia and cranial sensory ganglia after resolution of the primary VZV infection. The main focus of HZ management is rapid recovery from VZV infection as well as the reduction and prevention of zoster-associated pain (ZAP) and postherpetic neuralgia (PHN). The use of antivirals against VZV is essential in the treatment of HZ. However, limited antivirals are only licensed clinically for the treatment of HZ, including acyclovir, valacyclovir, famciclovir, brivudine, and amenamevir. Fortunately, some new antivirals against different types of Herpesviridae have been investigated and suggested as novel drugs against VZV. Therefore, this review focuses on discussing the difference in efficacy and safety in the currently licensed antivirals for the treatment of HZ, the applicability of future novel antivirals against VZV, and the preventive or therapeutic effects of these antivirals on ZAP or PHN.

• Tuberculosis and Respiratory Diseases
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• 제71권4호
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• pp.291-295
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• 2011

Varicella, more commonly known as chickenpox, is caused by the varicella-zoster virus. It is a common benign childhood illness. In adults, Varicella is uncommon but is more severely associated with complications including pneumonia, hepatitis, disseminated intravascular coagulation, encephalitis and myocarditis. A serious and life-threatening complication is the development of varicella-zoster virus pneumonia (VZVP). Although VZVP is well described in immunocompromised hosts, it is rarely seen in immunocompetent adults. The VZVP in healthy adults is more prevalent in cigarette smokers and during pregnancy. However, reports of VZVP in healthy adults are scarce in Korea. The authors report here a case of VZVP in an immunocompetent adult and present a literature review.

• Clinical and Experimental Pediatrics
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• 제46권10호
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• pp.1047-1050
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• 2003

저자들은 분만 10일 전 herpes zoster 진단받은 산모에서 출생한 환아에서 피부 병변 없이 신경학적 이상 증세만을 보이는 perinatal varicella infection 1례를 경험하였기에 보고하는 바이다.

• 대한기관식도과학회지
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• 제5권2호
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• pp.222-230
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• 1999

Varicella-zoster virus(VZV) becomes latent in the sensory ganglia after primary infection and emerges from latency to cause zoster in adults. After primary infection, VZV remains latent in the dorsal spinal ganglia. The mechanisms responsible for its reactivation and the clinical entity of herpes zoster are poorly understood. Reactivation of VZV is commonly known to manifest as Ramsay Hunt syndrome which is one of the VZV-associated neurologic diseases with facial paralysis, ear pain, and a characteristic herpetic auricular rash. It is now known that lesions of this syndrome can affect all cranial nerves. Central, cervical and peripheral effects of this syndrome is polyneuropathic in nature. VZV usually involves the 5th and 7th cranial nerves and less commonly the lower cranial nerves such as 9th and 10th. We report a treated case of healthy 40 years old male with VZV infection of the 5th, 9th and 10th cranial nerves. The patient typically showed herpetic vesicles in the auricle and temporal bone area without facial paralysis.

• The Korean Journal of Pain
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• 제21권1호
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• pp.71-73
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• 2008

Herpes zoster in childhood is uncommon, but it is more common in association with immunosuppression. Maternal varicella infection during pregnancy and varicella occurring in the newborn represent risk for childhood herpes zoster. However, some controversies persist on risk factors, diagnosis, and the natural history of childhood disease. We report a 10-year-old healthy boy with shingles and review the risk factors, prognosis, and treatment of pediatric zoster.

• The Korean Journal of Pain
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• 제28권3호
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• pp.177-184
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• 2015

Herpes zoster (HZ) is a transient disease caused by the reactivation of latent varicella zoster virus (VZV) in spinal or cranial sensory ganglia. It is characterized by a painful rash in the affected dermatome. Postherpetic neuralgia (PHN) is the most troublesome side effect associated with HZ. However, PHN is often resistant to current analgesic treatments such as antidepressants, anticonvulsants, opioids, and topical agents including lidocaine patches and capsaicin cream and can persist for several years. The risk factors for reactivation of HZ include advanced age and compromised cell-mediated immunity (CMI). Early diagnosis and treatment with antiviral agents plus intervention treatments is believed to shorten the duration and severity of acute HZ and reduce the risk of PHN. Prophylactic vaccination against VZV can be the best option to prevent or reduce the incidence of HZ and PHN. This review focuses on the pathophysiology, clinical features, and management of HZ and PHN, as well as the efficacy of the HZ vaccine.

• Clinical and Experimental Pediatrics
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• 제52권6호
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• pp.705-709
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• 2009

대상포진은 흔한 질환으로 여러 가지 합병증을 동반 할 수 있으나 대상포진에 동반되어 수막염이 생긴 경우는 보고는 많지 않다. 저자들은 15개월에 수두 예방접종을 시행 받았고, 5세 때 수두를 앓은 과거력이 있던 건강한 14세 남자 환아에서 대상포진에 동반되어 급성 무균성 수막염이 발생한 증례에서 뇌척수액에서 중합효소연쇄반응을 통해 VZV DNA를 검출한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.