• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8715-8718
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• 2014

Background: ABVD (doxorubicin, bleomycin, vinblastine (Vb) and dacarbazine) is the standard regimen in Hodgkin's lymphoma (HL).Vincristine (O) is a mitotic spindle agent like Vb. We aimed to evaluate the efficacy and safety of O as a part of ABOD in HL. Materials and Methods: Patients who had ABOD were enrolled. Stage I-II HL were evaluated for unfavorable risk factors according to NCCN. National Cancer Institute Common Toxicity Criteria was used for toxicity. Results: Seventy-nine HL patients in our center between 2003 and 2007 were evaluated retrospectively. Median follow-up was 54 months. Most of the patients were male in their third decade. Median ABOD cycles were 6 (2-8). Primary refractory disease rate was 17.7% whereas it was 5.1% for early relapse and 5.1% for late relapse disease. Response rates were as 82.3% for complete response, 11.4% for partial response, 5.1% for stable disease and 1.3% for progressive disease. Half of relapsed patients had autologous stem cell transplantation. Estimated 5-year failure-free survival was 71% and significantly longer in early stage patients without risk factors, bulky disease or radiotherapy (RT) (p=0.05, p<0.0001, p=0.02; respectively). Estimated 5-year overall survival was 74% and significantly longer in those who had no RT (p=0.001). Dose modification rate was 5.1% and chemotherapy delay rate was 19%. There were no toxicity-related deaths. Conclusions: ABOD seems to be effective with managable toxicity in HL, even in those with poor prognostic factors.

• Journal of Astronomy and Space Sciences
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• v.26 no.4
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• pp.425-438
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• 2009

We reevaluate the Burton equation (Burton et al. 1975) of predicting Dst index using high quality hourly solar wind data supplied by the ACE satellite for the period from 1998 to 2006. Sixty magnetic storms with monotonously decreasing main phase are selected. In order to determine the injection term (Q) and the decay time ($\tau$) of the equation, we examine the relationships between $Dst^*$ and $VS_s$, ${\Delta}Dst^*$ and $VS_s$, and ${\Delta}Dst^*$ and $Dst^*$ during the magnetic storms. For this analysis, we take into account one hour of the propagation time from the ACE satellite to the magnetopause, and a half hour of the response time of the magnetosphere/ring current to he solar wind forcing. The injection term is found to be $Q(nT/h)\;=\;-3.56VS_s$ for $VS_s$ > 0.5mV/m and Q(nT=h) = 0 for $VB_s\;{\leq}\;0.5mV/m$. The $\tau$ (hour) is estimated as $0.060Dst^*\;+\;16.65$ for $Dst^*$ > -175nT and 6.15 hours for $Dst^*\;{\leq}\;-175nT$. Based on these empirical relationships, we predict the 60 magnetic storms and find that the correlation coefficient between the observed and predicted $Dst^*$ is 0.88. To evaluate the performance of our prediction scheme, the 60 magnetic storms are predicted again using the models by Burton et al. (1975) and O'Brien & McPherron (2000a). The correlation coefficients thus obtained are 0.85, the same value for both of the two models. In this respect, our model is slightly improved over the other two models as far as the correlation coefficients is concerned. Particularly our model does a better job than the other two models in predicting intense magnetic storms ($Dst^*\;{< \atop \sim}\;-200nT$).

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.2
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• pp.88-96
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• 2020

Stauntonia hexaphylla (SH) and Vaccinium bracteatum (VB) are herbal extracts widely used in food and traditional herbal medicine, and have the ability to perform a wide range of biological activities. We aimed to investigate the effects of the SH and VB combination (SHVB) on mice models of chronic restraint stress (CRS) and pentobarbital-induced sleeping behaviors to elucidate its possible mechanisms of action. CRS-exposed mice treated with SHVB showed significantly decreased immobility time, increased swimming and climbing times in the forced swim test (FST), and increased locomotor activity in the open field test (OFT). SHVB decreased serum CORT levels, but enhanced brain monoamine neurotransmitters. SHVB significantly decreased the sleep latency and increased total sleep duration in pentobarbital-induced sleeping behavior in mice. SHVB showed inhibitory effect on 5-HT_2A receptor-mediated ERK1/2 phosphorylation. These results suggest that SHVB has antidepressant and hypnotic effects by regulating the 5-HT_2A receptor.

• Journal of Korean Neurosurgical Society
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• v.45 no.6
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• pp.369-374
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• 2009

Objective : Percutaneous vertebroplasty (VP) can provide immediate stabilization in pathologic fractures of spinal tumors. However, long term follow-up data in cases of pathologic fractures are lacking. The authors report follow-up results of VP in 185 pathologic fractures of 102 spinal tumor patients. Methods : Percutaneous VP was performed at 185 vertebral bodies of 102 patients from 2001 to 2007. Retrospective analysis was done with medical records and radiological data. The change of visual analogue score (VAS), vertebral body (VB) height and kyphotic angle were measured preoperatively and on postoperative one day and at 3, 6, and 12 months. Results : The patients were composed of metastatic spine tumors (81%) and multiple myeloma (19%). Involved spinal segments were between T6 and L5. Mean follow-up period was 12.2 months. VAS for back pain was 8.24 preoperatively, 3.59 (postoperative one day), 4.08 (three months) and 5.22 (one year). VB compression ratio changed from 21.33% preoperatively to 13.82% (postoperative one day), 14.36% (three month), and 16.04% (one year). Kyphotic angle changed from $15.35^{\circ}$ preoperatively to $12.03^{\circ}$ (postoperative one day), $13.64^{\circ}$ (three month), and $15.61^{\circ}$ (one year). Conclusion : Immediate pain relief was definite after VP in pathologic compression fracture of osteolytic spinal disease. Although VAS was slightly increased on one year follow-up, VP effect was maintained without significant change. These results indicate that VP could be a safe and effective procedure as a palliative treatment of the spinal tumor patients.

• Journal of the Korean Society of Marine Environment & Safety
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• v.21 no.1
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• pp.47-56
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• 2015

Under the conditions of invested actual changes of heeling angles during MV Sewol's sinking, this study proposes passengers' evacuation scenarios, which are based on the assumption of normal orders of evacuation being given to the passengers, and evaluates using a marine-specialized human evacuation simulation tool. As results, when the heeling angle is set as 0 degree or 30 degree, it is found out that almost every passengers can success to evacuate to the musterstations, even though the evacuation times are different depending on the scenarios and the walking speeds. Meanwhile, when the heeling angle is varied as the Sewol incident, 3.1 %(Scenario Sc-Va which set chutes on port side as evacuation routes), 11.1 %(Sc-Vb, every open decks of port side as evacuation routes) and 20.0 %(Sc-Vc, every open decks of port and AFT sides as evacuation routes) among 476 passengers can successfully reach to the musterstations from their cabins with the condition of average walking speed as 2.04 m/s on flat. And only 0.8 %(Sc-Va), 3.8 %(Sc-Vb) and 10.7 %(Sc-Vc) can success to evacuate with the condition of average walking speed as 1.48 m/s on flat.

• Journal of the Korean Ceramic Society
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• v.30 no.3
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• pp.199-205
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• 1993

Effects of grain size distribution on the breakdown voltage of ZnO varistors were investigated in the ZnO-Bi2O3-CoO-Sb2O3 and ZnO-Bi2O3-CoO-Sb2O3-Cr2O3 systems, respectively. The grain size was increased with increasing sintering temperature maintaining lognormal distribution in both systems. The width of grain size distribution of ZnO-Bi2O3-CoO-Sb2O3 system was narrower than that of ZnO-Bi2O3-CoO-Sb2O3 system. The breakdown voltage(Vb) was decreased by increasing sintering temperature(1000~135$0^{\circ}C$) and sintering time(0.5~5hr), due to the enhancement of ZnO grain growth. The current path of the ZnO varistor was dependent on the distribution of the largest grains (chains of long grains) between the electrodes.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.1561_1562
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• 2009

In this paper, designed triple-band antenna of PIFA(Planar Inverted-F Antenna) structure with U-slot. We designed optimal PIFA structure using Evolution Strategy(ES) about two U-slot parameters. We materialized API(Application Program Interface) about EM simulator and Excel using VB(Visual Basic). The result of ES for triple-band PIFA are resonant frequency of 430MHz, 910.5MHz, 2458.5MHz.

• Structural Engineering and Mechanics
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• v.41 no.5
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• pp.633-644
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• 2012

The paper presents the motion editor for the robotic movement in the study. The Motion Editor can edit all motions which we want to need. This method is easy when the beginners edit to motions of robots. And let them have interesting in robot control. This paper proposes two methods to edit movements. First, we edit the robot's movement in VB environment, and then we use the Motion Editor to make it. Finally, we compared merit and defect with two methods. Indeed, it is convenient when we use the Motion Editor.

• Microbiology and Biotechnology Letters
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• v.51 no.4
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• pp.542-544
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• 2023

Methicillin-resistant Staphylococcus pseudintermedius Z0118SP0130 was isolated from eye specimen of a companion dog in South Korea. The complete genome of Z0118SP0130 consisted of a 2,663,277 bp chromosome and there was no plasmid. The strain was identified as the sequence type 45 and contained a mecA gene which comprised of staphylococcal cassette chromosome mec type Vb (5C2&5). Antimicrobial resistance to erythromycin, clindamycin, quinupristin-dalfopristin, trimethoprim-sulfamethoxazole, mupirocin, oxacillin, streptomycin, and gentamicin was observed in the strain.

• International Journal of Control, Automation, and Systems
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• v.6 no.5
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• pp.767-775
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• 2008

Methods used for exploring marine resources and spaces include positioning a probe under water and then recalling it after a specified time. Hydro-acoustic Releasers are commonly used for positioning and retrieving of such exploration equipment. The most important factor in this kind of system is the reliability for recalling the instruments. The frequently used ultrasonic signal detection method can detect ultrasonic signals using a fixed comparator, but because of increased rates of errors due to outside interferences, information is repetitively acquired. This study presents an effective ultrasonic signal detection algorithm using the characteristics of a resonance and adaptive comparator Combined with the FSK+ASK modulator. As a result, approximately 8.8% of ultrasonic wave communication errors caused by background noise and transmission losses were reduced for effectively detecting ultrasonic waves. Furthermore, the resonance circuit's quality factor was enhanced (Q = 120 to 160). As such, the bias voltage of the transistor (Vb= 3.3 to 6.8V) was increased thereby enhancing the frequency's selectivity.