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http://dx.doi.org/10.15188/kjopp.2020.04.34.2.88

Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice  

Oh, Dool-Ri (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Kim, Yujin (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Jo, Ara (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Im, Sojeong (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Kim, Cho Een (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Jung, Myung-A (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Shin, Jawon (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Kang, Huwon (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Choi, Eun Jin (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Kim, Jaeyong (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Choi, Chulyung (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.34, no.2, 2020 , pp. 88-96 More about this Journal
Abstract
Stauntonia hexaphylla (SH) and Vaccinium bracteatum (VB) are herbal extracts widely used in food and traditional herbal medicine, and have the ability to perform a wide range of biological activities. We aimed to investigate the effects of the SH and VB combination (SHVB) on mice models of chronic restraint stress (CRS) and pentobarbital-induced sleeping behaviors to elucidate its possible mechanisms of action. CRS-exposed mice treated with SHVB showed significantly decreased immobility time, increased swimming and climbing times in the forced swim test (FST), and increased locomotor activity in the open field test (OFT). SHVB decreased serum CORT levels, but enhanced brain monoamine neurotransmitters. SHVB significantly decreased the sleep latency and increased total sleep duration in pentobarbital-induced sleeping behavior in mice. SHVB showed inhibitory effect on 5-HT2A receptor-mediated ERK1/2 phosphorylation. These results suggest that SHVB has antidepressant and hypnotic effects by regulating the 5-HT2A receptor.
Keywords
Stauntonia hexaphylla; Vaccinium bracteatum; Chronic restraint stress; Antidepressants; Serotonin 2A receptor;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Nutt D, Wilson S, Paterson L. Sleep disorders as core symptoms of depression. Dialogues Clin Neurosci. 2008;10(3):329-36.   DOI
2 American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed. Washington, DC. 2013.
3 Wichniak A, Wierzbicka A, Jernajczyk W. Sleep and antidepressant treatment. Curr Pharm Des. 2012;18(36):5802-17.   DOI
4 Chiba S, Numakawa T, Ninomiya M, Richards MC, Wakabayashi C, Kunugi H. Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuro-psychopharmacol. 2012;39(1):112-9.   DOI
5 Mahar I, Bambico FR, Mechawar N, Nobrega JN. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neurosci Biobehav Rev. 2014;38:173-92.   DOI
6 Vanover KE, Davis RE. Role of 5-HT2A receptor antagonists in the treatment of insomnia. Nat Sci Sleep. 2010;2:139-50.   DOI
7 Ikuta A. Stauntonia hexaphylla: in vitro culture and production of triterpenes. In: Bajaj YPS, editor. Biotechnology in Agriculture and Forestry Vol 241993:1993. p. 352-60.
8 Park YJ, Park YS, Towantakavanit K, et al. Chemical components and biological activity of Stauntonia hexaphylla. Korean J Plant Res. 2009;22:403-11.
9 Wang HB, Mayer R, Rucker G, Yang JJ, Matteson DS. A phenolic glycoside and triterpenoids from Stauntonia hexaphylla. Phytochemistry. 1998;47:467-70.   DOI
10 Hwang SH, Kwon SH, Kim SB, Lim SS. Inhibitory activities of Stauntonia hexaphylla leaf constituents on rat lens aldose reductase and formation of advanced lycation end products and antioxidant. BioMed Res International. 2017;2017:4273257.
11 Cheon YH, Baek JM, Park SH, et al. Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome-mediated degradation of c-Fos protein and suppression of NFATc1 expression. BMC Complement Altern Med. 2015;15:280.   DOI
12 Kim J, Kim H, Choi H, et al. Anti-inflammatory effects of a Stauntonia hexaphylla fruit Extract in lipopolysaccharide-activated RAW-264.7 macrophages and rats by carrageenan-induced hind paw swelling. Nutrients. 2018;10(1).
13 Lee G, Kim J, Kang H, Bae D, Choi CY. Antioxidant activities and hepato-protective effects of Stauntonia hexaphylla fruit extract against H2O2-induced oxidative stress and acetaminopheninduced toxicity. J Life Sci. 2018;28(6):708-17.   DOI
14 Hwang SH, Kwon SH, Kim SB, Lim SS. Inhibitory activities of Stauntonia hexaphylla leaf constituents on rat lens aldose reductase and formation of advanced glycation end products and antioxidant. BioMed Res International. 2017;2017:4273257.
15 Wang L, Jiang TY, Zhang H, Yao HY. Study on the extraction of black pigment from Vaccinium bracteatumThunb. leaves by enzyme and its stability. Sci Technol Food Industry. 2008;29(224-6).
16 Zhang J, Chu CJ, Li XL, et al. Isolation and identification of antioxidant compounds in Vaccinium bracteatum Thunb. by UHPLC-Q-TOF LC/MS and their kidney damage protection. J Funct Foods. 2014;11:62-70.   DOI
17 Hu J, Wang J, Li S, et al. Phytochemical compositions, antioxidant and antimicrobial activities analysis of extracts from Vaccinium bracteatum Thunb. leaves. J App Bot Food Qual. 2016;89:150-5.
18 Wang L, Zhang XT, Zhang HY, Yao HY, Zhang H. Effect of Vaccinium bracteatumThunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice. J Ethnopharmacol. 2010;130:465-9.   DOI
19 Wang L, Zhang Y, Xu M, et al. Antidiabetic activity of Vaccinium bracteatum Thunb. leaves' polysaccharide in STZ-induced diabetic mice. Int J Biol Macromol. 2013;61:317-21.   DOI
20 Wang L, Zhang XT, Yao HY. The protective effect of Vaccinium bracteatum Thunb. leaves and the extract against light injury of retina. J Xi'an Jiaotong Uni. 2006;27:284-7.
21 Kwon SH, Ma SX, Ko YH, et al. Vaccinium bracteatum Thunb. exerts anti-inflammatory activity by inhibiting NF-kappaB activation in BV-2 microglial cells. Biomolecules & Therapeutics. 2016;24(5):543-51.   DOI
22 Landa P, Skalova L, Bousova I, et al. In vitro antiproliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb. Pak J Pharm Sci. 2014;27:103-6.
23 Oh DR, Kim Y, Choi EJ, et al. Antidepressant-Like Effects of Vaccinium bracteatum in Chronic Restraint Stress Mice: Functional Actions and Mechanism Explorations. Am J Chin Med. 2018;46(2):357-87.   DOI
24 Oh DR, Kim Y, Choi EJ, et al. Antidepressant effects of Vaccinium bracteatum via protection against hydrogen peroxide-induced oxidative stress and apoptosis. Am J Chin Med. 2018;4:1-20.
25 Mah L, Szabuniewicz C, Fiocco A. Can anxiety damage the brain?. Curr Opin Psychiatry 2016;29:56-63.   DOI
26 Oh DR, Kim Y, Jo A, et al. Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABAA-ergic systems: involvement of 5-HT1A receptor agonistic activity. Biomed Pharmacother. 2019;109:2218-27.   DOI
27 Moreau M, Andre C, O'Connor JC, et al. Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior. Brain Behav Imm. 2008;22(7):1087-95.   DOI
28 Abelaira H, Reus G, Quevedo J. Animal models as tools to study the pathophysiology of depression. Braz J Psychiatry. 2013;35(2):S112-20.   DOI
29 Tafet GE, Idoyaga-Vargas VP, Abulafia DP, et al. Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression. Cogn Affect Behav Neurosci. 2001;1(4):388-93.   DOI
30 Siegel AM, Mathews SB. Diagnosis and Treatment of Anxiety in the Aging Woman. Curr psychiatry Rep. 2015;17(12):93.   DOI
31 Santos Moraes WA, Burke PR, Coutinho PL, et al. Sedative antidepressants and insomnia. Braz J Psychiatry. 2011;33(1):91-5.   DOI
32 Walf AA, Frye CA. A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior. Neuropsychopharmacology. 2006;31(6):1097-111.   DOI
33 Nollet M, Hicks H, McCarthy AP, et al. REM sleep's unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice. Proc Nat Acad Sci. U S A. 2019;116(7):2733-42.   DOI
34 Trajkovska V, Kirkegaard L, Krey G, et al. Activation of glucocorticoid receptors increases 5-HT2A receptor levels. Exp Neurol. 2009;218(1):83-91.   DOI
35 Shrivastava M, Dwivedi LK. Therapeutic potential of Hypericum perforatum : a review. Int J Res Pharm Sci. 2015;6(12):4982-8.