• Childhood Kidney Diseases
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• 제27권1호
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• pp.40-45
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• 2023

Tubulointerstitial nephritis and uveitis (TINU) syndrome is defined as the occurrence of tubulointerstitial nephritis and uveitis in the absence of other systemic diseases. Three pediatric cases have been reported in the Republic of Korea, and we now report a fourth case. A 15-year-old girl presented to the ophthalmology department with a 1-week history of bilateral ocular discomfort that worsened on the day of presentation with redness and pain in both eyes. She was diagnosed with bilateral uveitis, and her baseline examination revealed moderate renal dysfunction and mild proteinuria. A renal biopsy was performed and confirmed the diagnosis of TINU syndrome. She was started on steroid eye drops and a 12-week course of oral steroids at a dose of 40 mg/m²/day, which completely resolved the proteinuria and mild renal function to an estimated glomerular filtration rate of 60 mL/min/1.73 m². However, the uveitis did not improve, and despite the addition of oral methotrexate as a second-line treatment, the uveitis remains unresponsive to treatment over 21 months. Further evaluation and treatment are ongoing, and active therapeutic intervention is suggested even at a pediatric age, considering the lack of improvement in renal function and uveitis to date.

• Clinical and Experimental Pediatrics
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• 제58권10호
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• pp.374-379
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• 2015

Purpose: Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular signs of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and those without uveitis. Methods: We conducted a prospective study with 110 KD patients from January 2008 to June 2013. The study group (n=32, KD with uveitis) was compared with the control group (n=78, KD without uveitis). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, and level of alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), and N-terminal probrain natriuretic peptide (NT-pro BNP). Echocardiographic measurements and intravenous immunoglobulin responses were compared between the two groups. Results: The incidence of uveitis was 29.0%. Neutrophil counts and patient age were higher in the uveitis group than in the control group. ESR and CRP level were slightly increased in the uveitis group compared with the control group, but the difference between the two groups was not significant. No significant differences in coronary arterial complication and treatment responses were observed between the two groups. Conclusion: Uveitis is an important ocular sign in the diagnosis of incomplete KD. It is significantly associated with patient age and neutrophil count.

• Childhood Kidney Diseases
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• 제4권2호
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• pp.166-169
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• 2000

Tubulointerstitial nephritis and uveitis (TINU) is a rare syndrome of unknown etiology involving the kidney and the eye. This is the first case reput of TINU in Korea. The diagnosis of TINU was confirmed in a 15-year-old girl on the basis of pathologically proven tubulointerstitial nephritis and bilateral uveitis. Although the renal symptoms disappeared spontaneously, uveitis showed only partial response to topical steroid treatment and persisted fir more than 11 months. TINU should be included in the differential diagnosis of tubulointerstitial nephritis of unknown etiology.

• 한방안이비인후피부과학회지
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• 제15권2호
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• pp.237-243
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• 2002

Uveitis is a comprehensive term that indicates the inflammation of not only the uvea but also its adjacent tissues, and its etiology, clinical features and prognosis are various. We conducted 2 patients with uveitis seen at Won-Kwang University Kwang- Ju Oriental Medical Hospital in 2002. We treated uveitis in a twenty-nine years old man and a thirty years old woman with the complaint of decreased vision, glaring eye, blood-shot eye, pain of eye, tears in one's eye by herbal medicine (Se-An-Myung-Mok-Tang gami) and Acupunture. Usually, uveitis have chronic phase. We had a significant results. So we report this two cases.

• 한국임상수의학회지
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• 제37권5호
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• pp.286-291
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• 2020

A 15-year-old castrated male Persian (Case 1), an 1.5-year-old castrated male Bengal (Case 2), and an 1.5-year-old spayed female Russian Blue (Case 3) cats were presented with iris-color change and suspicious anterior chamber mass. Complete ophthalmic examination revealed a vascularized or blood tinted mass filling with anterior chamber accompanied by rubeosis iridis, dyscoria, keratic precipitates, and severe aqueous flare. Ocular ultrasonography showed an iridociliary mass with blood flow signal in Case 1. Abdominal ultrasonography also revealed suspicious metastatic involvements of liver and spleen in this cat. Case 2 and 3 were suspected of being infected with feline infectious peritonitis. Topical antibiotic/steroid combinations were prescribed to control the uveitis in all 3 cases, although enucleation was initially considered for palliative pain management in Case 1. Anterior chamber mass had almost completely disappeared after topical medications and uveitis has been successfully managed, remaining in sight, even though ocular hypertension developed 1 month later in Case 1.

• Parasites, Hosts and Diseases
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• 제38권1호
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• pp.29-31
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• 2000

A toxoplasmic uveitis case was reported on the focus of impairment of pathological findings and serological antibody titers after chemotherapy. A chief complaint of a 60-year-old male was a decreased and blurred vision in his right eye for 2 weeks after experiencing tremendous stress and fatigue. A steroid therapy for 3 weeks was not effective and the retinal lesion became necrotic. Anti-Toxoplasma gondii antibody titer was checked to be a strong positive by both ELISA and indirect latex agglutination assay (lLA). He was treated with Fansidar F for 8 weeks. His vision improved as the necrotic lesion healed by scarring, but the antibody titers still remained very high without any signs of negative conversion. It is suggested to be a recurrent case of the past asymptomatic infection by presumed immune suppression caused by excessive stress.

• Parasites, Hosts and Diseases
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• 제61권3호
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• pp.310-316
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• 2023

In elderly patients, ocular toxoplasmosis is one of the most common etiologies of uveitis, which should be differentially diagnosed from ocular lymphoma, another common pathology of uveitis in older adults. The high level of interleukin (IL)-10 and an IL-10/IL-6 ratio higher than 1 (>1.0) are helpful parameters to diagnose ocular lymphoma. In this study, we used aqueous humor samples to detect 4 cases of ocular toxoplasmosis in patients with high levels of IL-10 and an IL-10/IL-6 ratio higher than 1. Our results show that ocular toxoplasmosis may be associated with increased cytokine levels in aqueous humor.

• 한국임상수의학회지
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• 제19권4호
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• pp.411-414
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• 2002

Eighty five canine eyes performed phacoemulsification for cataract extraction between January 1999 and December 2001 were reviewed. Mean age was 7.26 years old and main breed was poodle (37 dogs). Mature cataract was 51.76％, immature cataract 27.05% and hypermature 21.18％. Improvement of vision was detected in 75 (88.24%) of 85 eyes at 4 weeks after surgery. Postoperative complications were posterior capsular opacification(6), partial posterior synechia(5), glaucoma(3) and uveitis(2). Reasons for failure of visual improvement among the patients performed phacoemulsification were mainly related to development of postoperative anterior uveitis, secondary glaucoma and progressive retinal degeneration.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.99-102
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• 2016

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal failure, and a renal biopsy confirmed the diagnosis of acute tubulointerstitial nephritis. An extensive exclusion of all possible causes allowed a diagnosis of TINU syndrome. The patient was treated with a systemic corticosteroid (initially prednisolone, 2 mg/kg and later deflazacort 1 mg/kg) and topical steroid drops for 1 month. Azathioprine was later added to the treatment regimen and the systemic steroid was slowly tapered. The final outcome of renal-ocular disease was favorable in the patient. However, long-term follow-up is necessary to properly manage frequent relapses and incomplete renal recovery. TINU should be considered as a differential diagnosis in children with uveitis or acute renal failure.

• Parasites, Hosts and Diseases
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• 제50권3호
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• pp.229-231
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• 2012

Toxoplasma gondii is a zoonotic parasite resulting in human infections and one of the infectious pathogens leading to uveitis and retinochoroiditis. The present study was performed to assess T. gondii infection in 20 ocular patients with chronic irregular recurrent uveitis (20 aqueous humor and 20 peripheral blood samples) using PCR. All samples were analyzed by nested PCR targeting a specific B1 gene of T. gondii. The PCR-positive rate was 25% (5/20), including 5% (1) in blood samples, 25% (5) in aqueous humor samples, and 5% (1) in both sample types. A molecular screening test for T. gondii infection in ocular patients with common clinical findings of an unclear retinal margin and an inflammatory membrane over the retina, as seen by fundus examination, may be helpful for early diagnosis and treatment.