• Nuclear Medicine and Molecular Imaging
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• 제40권2호
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• pp.96-105
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• 2006

Molecular imaging has its root in nuclear medicine and gene therapy monitoring. Therefore, recent progress in the development of non-invasive imaging technologies, particularly nuclear medicine, should allow molecular imaging to play a major role in the field of gene therapy. These tools have recently been validated in gene therapy models for continuous quantitative monitoring of the location, magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of radionuclide imaging technologies as they have been used in imaging gene delivery and gene expression for gene therapy applications. The studios published to date lend support that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human gene therapy.

• 한국소음진동공학회논문집
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• 제20권7호
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• pp.685-692
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• 2010

A hybrid mount for shipboard machinery installed on naval ships was developed. The mount is combined with a rubber mount and a piezostack actuator. The rubber mount is one of the most popular and effective passive mounts to have been applied to various vibration systems to date. The piezostack actuator is featured by a fast response time, small displacement and low power consumption. Through a series of experimental tests conducted in accordance with MIL-M-17185A(SHIPS), MIL-M-17508F(SH), and MIL-S-901D which are US military specifications related to the performance requirements of the mount, it has been confirmed that the hybrid mount shows more effective performance for use in naval ships.

• 한국컴퓨터정보학회논문지
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• 제23권1호
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• pp.139-145
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• 2018

This paper recommends flipped learning as a method to improve the learning abilities and the level of software utilization when it comes to using computers in children education institutes. Flipped learning enables a class fully making use of the up-to-date multimedia-related technology. Especially, flipped learning leads a participation-oriented class rather than lecture-based ones. Young child's teachers can, not only improve their capabilities to utilize multimedia, but also manage classes that follow the trend of the fourth industrial revolution. Therefore, this paper introduces the importance of media education when it comes to training preliminary teachers and suggests a flipped learning curriculum. This paper finds significance in future efficient education for raising creative and integrated thinking children.

• Nano
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• 제13권12호
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• pp.1850143.1-1850143.9
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• 2018

Natural biotemplates - such as bacteria, fungi and viruses - are used in nanostructured metal oxide production. The pollen can be found abundantly in nature, and their microcapsules can be easily isolated from the pollen by chemical treatments. To date, pollen microcapsules are mostly used as drug carriers and catalytic agent templates. In the present study, nanoporous-structured nickel oxide is produced using Pistachio pollen microcapsules. The raw pollen, chemically treated pollen and metal-coated pollen were characterized using scanning electron microscopy, Brunauer-Emmett-Teller (BET) surface area analysis, thermogravimetric analysis (TGA), differential thermal analysis (DTA) and X-ray diffraction (XRD) techniques. The natural Pistachio pollen which were procured from Gaziantep, Turkey, are spherical, with a diameter of approximately $23{\mu}m$. The maximum surface area obtained for nickel oxide-coated microcapsules is $228.82m^2/g$. This result shows that Pistachio pollen are an excellent candidate for the production of porous nanostructured materials for supercapacitor electrodes.

• 한국육종학회지
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• 제42권2호
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• pp.121-128
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• 2010

Finding alternative and renewable energy sources has become an important goal for plant scientists, especially with the demand for energy increasing worldwide and the supply of fossil fuel being depleted. The most important biofuel to date is bioethanol which is produced from sugars (sucrose and starch) found in corn and sugarcane. Second generation bioethanol is targeting studies that would allow the use of the cell wall (lignocellulose) as a source of carbon by non-food plants. Plant scientists, including breeders, agronomists, physiologists and molecular biologists, are working towards the development of new and improved energy crops especially, how to design crops for bioenergy production and increased biomass generation for biofuel purposes. This review focuses on: i) the current status of first generation bioenergy production, ii) the limitations of first and second generation bioenergy, and iii) ongoing research to overcome challenging issues in second generation bioenergy.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권10호
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• pp.3588-3607
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• 2021

Covid-19 pandemic required all the world to use internet more actively. As a result, individuals and businesses are more open to digital threats. In order to provide security within the network, firewalls should be used. Firewalls act as a gateway between the corporate and the external networks. Therefore, it is more important than ever to choose the right firewall for each network. In this study, a new linear decision making model is proposed in order to find out the most suitable firewall and the estimates are completed according to this new model. Also, this model is compared with multi-objective optimization on the basis of ratio analysis (MOORA) method. This study distinguishes from other studies by proposing a new solution which ranks the firewall alternatives using linear and MOORA approaches. These approaches are used in many fields before but not in information technologies. Thus, this study can be considered quite innovative in terms of the problem it handles and the approaches used. It offers up-to-date and practical suggestions related to a decision making problem that has not been previously studied in the literature.

• Genomics & Informatics
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• 제19권3호
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• pp.25.1-25.5
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• 2021

The coronavirus disease 2019 (COVID-19) pandemic has led to a flood of research papers and the information has been updated with considerable frequency. For society to derive benefits from this research, it is necessary to promote sharing up-to-date knowledge from these papers. However, because most research papers are written in English, it is difficult for people who are not familiar with English medical terms to obtain knowledge from them. To facilitate sharing knowledge from COVID-19 papers written in English for Japanese speakers, we tried to construct a dictionary with an open license by assigning Japanese terms to MeSH unique identifiers (UIDs) annotated to words in the texts of COVID-19 papers. Using this dictionary, 98.99% of all occurrences of MeSH terms in COVID-19 papers were covered. We also created a curated version of the dictionary and uploaded it to Pub-Dictionary for wider use in the PubAnnotation system.

• Archives of Plastic Surgery
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• 제49권5호
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• pp.563-568
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• 2022

Rhinoplasty is one of the first surgical procedures described with evidence in the history of medicine. At first, these were performed for the reconstruction of traumatic defects caused by punishments, sequels of war, and then it had been reused after suffering from diseases such as syphilis. Many techniques have been developed from the need of aesthetics outcomes in this field. The objective of our work is to describe a modified approach of recycled dorsum preservation procedure that we have proposed as a safe and reliable technique. In this work, we have showed that this technique has a marked advantage of preserving the natural tissue with satisfactory postoperative result. We had no functional complications up to date. We recommend that every specialist in the field of rhinoplasty should be able to use it as a reproducible and feasible alternative.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.241-252
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• 2023

The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than 20 years before they were developed into drugs for commercial use. Nine ASO drugs have been approved to date. However, they target only rare genetic diseases, and the number of chemistries and mechanisms of action of ASOs are limited. Nevertheless, ASOs are accepted as a powerful modality for next-generation medicines as they can theoretically target all disease-related RNAs, including (undruggable) protein-coding RNAs and non-coding RNAs. In addition, ASOs can not only downregulate but also upregulate gene expression through diverse mechanisms of action. This review summarizes the achievements in medicinal chemistry that enabled the translation of the ASO concept into real drugs, the molecular mechanisms of action of ASOs, the structure-activity relationship of ASO-protein binding, and the pharmacology, pharmacokinetics, and toxicology of ASOs. In addition, it discusses recent advances in medicinal chemistry in improving the therapeutic potential of ASOs by reducing their toxicity and enhancing their cellular uptake.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2022년도 가을 학술논문 발표대회
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• pp.53-54
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• 2022

There is an increasing demand for prediction of asbestos concentration which has an fatal effect on human body. While demolishing asbestos, the dust scatters and makes workers be exposed to danger. Up to this date, however, factors that particularly influences have not considered in predicting asbestos concentration. Most of the studies could not quantify the distribution of asbestos. Also, they did not use nominal data on buildings as important factors. Therefore, this study aims to build an asbestos concentration prediction model by quantifying distribution of asbestos and using nominal data of buildings based on Artificial Neural Network (ANN). This model can give significant contribution of improving the safety of workers and be useful for finding effective ways to demolish asbestos in planning.