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Monitoring Gene Therapy by Radionuclide Approaches  

Min, Jung-Joon (Institute for Molecular Photonic Imaging Research, Department of Nuclear Medicine, Chonnam National University Hwasun Hospital)
Publication Information
Nuclear Medicine and Molecular Imaging / v.40, no.2, 2006 , pp. 96-105 More about this Journal
Abstract
Molecular imaging has its root in nuclear medicine and gene therapy monitoring. Therefore, recent progress in the development of non-invasive imaging technologies, particularly nuclear medicine, should allow molecular imaging to play a major role in the field of gene therapy. These tools have recently been validated in gene therapy models for continuous quantitative monitoring of the location, magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of radionuclide imaging technologies as they have been used in imaging gene delivery and gene expression for gene therapy applications. The studios published to date lend support that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human gene therapy.
Keywords
molecular imaging; gene therapy; radionuclide imaging; positron emission tomography (PET);
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