• YAKHAK HOEJI
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• v.55 no.6
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• pp.473-477
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• 2011

Alzheimer's disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.

• Journal of Korean Institute of Industrial Engineers
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• v.33 no.3
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• pp.329-338
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• 2007

This paper presents a dispatching algorithm for nonidentical parallel machines problem considering rework, sequence dependent setup times and release times. For each pair of a machine and a job type, rework probability of each job on a machine can be known through historical data acquisition. The heuristic scheduling scheme named by EDDR (Earliest Due Date with Rework probability) algorithm is proposed in this paper making use of the rework probability. The proposed dispatching algorithm is measured by two objective function value: 1) total tardiness and 2) the number of reworked jobs, respectively. The extensive computational results show that the proposed algorithm gives very efficient schedules superior to the existing dispatching algorithms.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.9
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• pp.3401-3420
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• 2021

We provide a traceable ciphertext-policy attribute based encryption (CP-ABE) construction for monotone access structures (MAS) based on composite order bilinear groups, which is secure adaptively under the standard model. We construct this scheme by making use of an "encoding technique" which represents the MAS by their minimal sets to encrypt the messages. To date, for all traceable CP-ABE schemes, their encryption costs grow linearly with the MAS size, the decryption costs grow linearly with the qualified rows in the span programs. However, in our traceable CP-ABE, the ciphertext is linear with the minimal sets, and decryption needs merely three bilinear pairing computations and two exponent computations, which improves the efficiency extremely and has constant decryption. At last, the detailed security and traceability proof is given.

• Journal of Animal Reproduction and Biotechnology
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• v.37 no.1
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• pp.62-66
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• 2022

To date, the development of anticancer drugs has been conducted using two-dimensional (2D) cell culture systems. However, since cancer cells in the body are generated and developed in three-dimensional (3D) microenvironments, the use of 2D anticancer drug screening can make it difficult to accurately evaluate the anticancer effects of drug candidates. Therefore, as a step towards developing a cancer cell-friendly 3D microenvironment based on a combination of vinylsulfone-functionalized polyethylene glycol (PEG-VS) with dicysteine-containing crosslinker peptides with an intervening matrix metalloproteinase (MMP)-specific cleavage site, the types of MMPs secreted from human hepatocarcinoma HepG2 cells, a representative cancer cell, were analyzed transcriptionally and translationally. MMP3 was confirmed to be the most highly expressed protease secreted by HepG2 cells. This knowledge will be important in the design of a crosslinker necessary for the construction of PEG-based hydrogels customized for the 3D culture of HepG2 cells.

• International Journal of Stem Cells
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• v.16 no.3
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• pp.260-268
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• 2023

Intrauterine adhesion (IUA) can occur after trauma to the basal layer of the endometrium, contributing to severe complications in females, such as infertility and amenorrhea. To date, the proposed therapeutic strategies are targeted to relieve IUA, such as hysteroscopic adhesiolysis, Foley catheter balloon, and hyaluronic acid injection have been applied in the clinic. However, these approaches showed limited effects in alleviating endometrial fibrosis and thin endometrium. Mesenchymal stem cells (MSCs) can offer the potential for endometrium regeneration owing to reduce inflammation and release growth factors. On this basis, MSCs have been proposed as promising methods to treat intrauterine adhesion. However, due to the drawbacks of cell therapy, the possible therapeutic use of extracellular vesicles released by stem cells is raising increasing interest. The paracrine effect, mediated by MSCs derived extracellular vehicles (MSC-EVs), has recently been suggested as a mechanism for their therapeutic properties. Here, we summarizes the main pathological mechanisms involved in intrauterine adhesion, the biogenesis and characteristics of extracellular vesicles, explaining how these vesicles could provide new opportunities for MSCs.

• Korean Journal of Environment and Ecology
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• v.12 no.1
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• pp.30-41
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• 1998

This study analyzed urban greenspace area and vegetation structure by land use types for Kangnam-gu and Junglang-gu in Seoul different in income and building construction date. The study districts had a similar areal distribution of land use types. Residential lands accounted for about 32~37% of total area, natural lands, 19~22%, commercial and industrial lands(including transportation), 13~18%, and institutional lands, 13~17%. Greenspace covered only 20~30% of urban residential and commercial area in which human activities of living concentrate. Canopy stocking level in urban lands (all land uses except natural and agrecultural lands) was about 39% for Kangnam-gu and 50% for Junglang-gu, showing tree planting potential slightly higher in Kangnam-gu than in Junglang-gu. Woody plant cover was approximately 13%, and tree density was 3 trees/100m$^{2}$ forurban lands in both districts. The tree-age structure was largely characterized by young, growing tree population, and species diversity within a diameter class decreases as the diameter classes get larger. Urban lands of both districts had quite a similar species composition of woody plants (similarity indez of 0.70). Income and bulding construction date did not result in significant diference between the two districts in vegetation structure for urban lands. Some strategies were ezplored to solve problems found in the present greenspace structures. They included increase of biomass and greenspace area through minimization of unnecessary impervious surfaces, creation of multilayered and multiaged vegetation structures, and avoidance of intensive tree pruning and relocation of above ground utility lines.

• Journal of Korean Medical classics
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• v.30 no.4
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• pp.1-17
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• 2017

Objective : Establishment and development of Woongihak on Korea requires detailed study into its contents including each period's Woongihak theory and clinical practices. Method : Woongihak is assumed to have been introduced during the Coreyo Dynasty. Then its development stage is divided into early, middle, later periods in Chosun dynasty, and the category further developed into the Japanese colonial period and then the post-liberation era. These periods were given respect to while medical textx and data related to Woongihak were collected and analyzed. Result & Conclusion : The general consensus is that Woongihak was introduced for the first time during the early period of Coryeo Dynasty, but there was no text around this era regarding Woongihak could have been found. Woongihak was found in Uibang-yuchwi, which entered Chosun Dynastyin early period and was published, where it annotated Sanghanjiggyeog, Saminbang, and eumjeungyaglye. Donguibogam, which was published during the middle period, introduced Woongi by hosting a sentence of Cheonjiungi, and Chochanggyeol was published during the late period and brought the level of Woongihak in Korea a step further. Lectures on Diagram of Woongihakw as published during the Japanese colonial era, but it lacks uniqueness since it was a translation of Suwenrushiyunqilunao. Another book published during this period was OunyukgiUihakbogam by Cho Wonhui. It brought a heavy influence on the generations to come because it drew up prescriptions through the Gaegun and Gaeggi or Date of Birth of Date of impregnation. It was easy to use and highly potent. The author of this paper also collected about 55 types of Woongi texts published after the liberation of Korea, but there are sure to be many that is missing from the collection.

• The korean journal of orthodontics
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• v.25 no.4
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• pp.415-423
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• 1995

In order to investigate the relationship between the menarche and the bone maturity of growing girls, the author interviewed about the date of menarche of 70 girls and assessed their bone maturity by hand-wrist radiographs. The results and conclusion were as iollows ; 1. The mean menarcheal age was $12.04{\pm}0.82$ year. 2. There was significant correlation between the time interval after menarche and the ossification stage. 3. The skeletal maturation level at menarche was stage SMI 7 and SMI 8. 4. There was statistically different among the time intervals after menarche according to the ossification stage. 5. The epiphyseal union of radius began about 2 years after menarche. According to this study, the probability of clinical use can be accepted in some range. In another words, skeletal age can be predicted by just interviewing the date and time interval of menarche without hand-wrist radiograph, also, with this information, the level of maxillofacial growth can be assessed.

• Korean journal of food and cookery science
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• v.7 no.4
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• pp.23-34
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• 1991

This study was to investigate consumer recognition of food safety and food additives. The results of this study are as follows: 1. When shopping for food, the food safety was rated as foremost concern for the respondents and the details checked most often were manufacture date, packing condition and axpiration date, respectively. When asked their opinion about harmful factors in relation to food safety, the most important consideration was food additives. The highest rating for credibility regarding the sources of information on food was given to scientists in university and institute, lowest one was given to food manufacturer. 2. Government regulation on the use of food additives was known to exist, but control of the uses of food additive was considered inadequate by 60% of the respondents. These results showed significant differences for age (p<0.05), for education level (p<.01) and for income (p<.05) respectively. 3. 47.9% of the respondents indicated that they were willing to purchase the additive free foods, although it was expensive. More than 70% made an effort to eat food with less food additive and were concerned about possible effects of food additives on health, showing significant differences for age (p<0.05), for education level (p<0.05) and for income (p<0.05). 4. Labeling for food additive found on food package was shown to be unsatisfactory, showing significant difference only for income (p<0.05) and more information about food was needed by over 91.3% of the respondents, showing significant difference for education level (p<0.05). 5. Although approximately 80% of the respondents were concerned about artificial preservative, artificial flavor, artificial color and artificial sweetener, the concern about artificial preservative was the highest. Primary causes that respondents felt fear toward food additives were the unknown harms and cancer, and primary sources that respondents got information on food were televison and radio, respectively. From these results, it was shown that consumer considered food safety important and they felt a great deal of concern about food additives.

• Asia pacific journal of information systems
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• v.20 no.3
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• pp.51-72
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• 2010

Given the extensive role of IS in everyday life and the increasing presence of women in IS users, understanding gender differences in individual technology continuance usage decisions is an important issue. Nevertheless, much of the large body of research on gender differences has just examined mean differences between women and men in terms of abilities, usage habit, and traits. Even though lots of psychology studies have shown that women, more than men, were influenced by affective factors, gender-affection-continuance use linkage has not been examined in the context of on-line shopping services. Therefore, the primary purpose of this paper is to seek to examine gender differences in terms of influence of affective factor in the context of IS continuance use. Meanwhile, IS continuance has been an important subject of study in the IT research area. To date, to explain why and how users are motivated to continue to use on-line shopping services, lots of theory-based research such as expectation-confirmation model (ECM) has been proposed. In particular, various affective factors have been proposed to explain continuance use of on-line shopping services recently. Affective factors have been regarded as essential factors for increasing relational strength and satisfaction. Several affective factors have been studied by prior IS adoption and continuance studies. Among them are enjoyment and anxiety. In IS continuance research, positive affect has been commonly and narrowly conceptualized and measured as the enjoyment which a person derives from using computers. Hence, in this study, we introduced intimacy factor, which was conceptually related to the quality of interactions and relationships in previous research. It also has been regarded as essential factors for strengthening human relationships. As a result, we have observed gender effect while examining intimacy-continuance bond. As expected based on the previous literatures, women seem to be more sensitive in affective factors. The contribution point here is that we find evidence in the context of on-line shopping services.