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Study on the Acetylcholinesterase Inhibitory Activity of Coumarin Derivatives  

Nam, Seung-Ok (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
Yun, Yong-Don (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
Park, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
Ryu, Jong-Hoon (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
Lee, Yong-Sup (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
Publication Information
YAKHAK HOEJI / v.55, no.6, 2011 , pp. 473-477 More about this Journal
Abstract
Alzheimer's disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.
Keywords
acetylcholinesterase; Alzheimer's disease; inhibitor; coumarin; scopoletin; memory;
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