YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Study on the Acetylcholinesterase Inhibitory Activity of Coumarin Derivatives

쿠마린 유도체의 아세틸콜린 에스테라제 저해활성 연구

  • Nam, Seung-Ok (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Yun, Yong-Don (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Park, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Ryu, Jong-Hoon (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Lee, Yong-Sup (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
  • 남승옥 (경희대학교 나노의약생명과학과) ;
  • 윤용돈 (경희대학교 나노의약생명과학과) ;
  • 박동현 (경희대학교 나노의약생명과학과) ;
  • 류종훈 (경희대학교 나노의약생명과학과) ;
  • 이용섭 (경희대학교 나노의약생명과학과)
  • Received : 2011.09.30
  • Accepted : 2011.11.15
  • Published : 2011.12.31
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Abstract

Alzheimer's disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.

Keywords

References

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